TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 522.642 | Formula: C34H30N6
H donors: 1 H acceptors: 4 LogP: 5.73 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: c1ccc(cc1)c1cc2cccnc2nc1c1ccc(cc1)CN1CCC(CC1)c1n[nH]c(c1)c1cccnc1
InChi: 1S/C34H30N6/c1-2-6-25(7-3-1)30-20-28-8-5-17-36-34(28)37-33(30)27-12-10-24(11-13-27)23-40-18-14-26(15-19-40)31-21-32(39-38-31)29-9-4-16-35-22-29/h1-13,16-17,20-22,26H,14-15,18-19,23H2,(H,38,39)
InChiKey: IWSLAUNTMQRBKP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0038	0.064	0.064
Mycobacterium ulcerans	carboxylesterase, LipT	0.0023	0.0239	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0423	0.1303
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0137	0.3244	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0023	0.0239	0.0736
Echinococcus granulosus	serine threonine protein kinase nrc	0.0058	0.117	0.3606
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0088	0.1947	0.1947
Trypanosoma brucei	rac serine-threonine kinase, putative	0.009	0.2013	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0477	0.0477
Onchocerca volvulus	Tyrosine kinase homolog	0.0367	0.9315	1
Echinococcus granulosus	NDR protein kinase	0.003	0.0423	0.1303
Echinococcus granulosus	Protein kinase C brain isozyme	0.003	0.0423	0.1303
Trichomonas vaginalis	AGC family protein kinase	0.009	0.2013	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.003	0.0423	0.0423
Brugia malayi	Carboxylesterase family protein	0.0023	0.0239	0.0239
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0023	0.0239	0.5
Echinococcus granulosus	serine:threonine protein kinase N2	0.003	0.0423	0.1303
Onchocerca volvulus		0.0023	0.0239	0.0256
Trichomonas vaginalis	AGC family protein kinase	0.009	0.2013	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0023	0.0239	0.0736
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0423	0.1303
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0024	0.0268	0.0826
Schistosoma mansoni	atypical protein kinase C	0.003	0.0423	0.1303
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0393	1	1
Onchocerca volvulus		0.0023	0.0239	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0268	0.0268
Echinococcus granulosus	protein kinase c epsilon type	0.003	0.0423	0.1303
Echinococcus multilocularis	Immunoglobulin	0.0024	0.0268	0.0826
Onchocerca volvulus		0.036	0.9125	0.9797
Echinococcus multilocularis	Glutaredoxin protein 5	0.0058	0.1152	0.3553
Loa Loa (eye worm)	hypothetical protein	0.0137	0.3244	0.3244
Echinococcus multilocularis	carboxylesterase 5A	0.0137	0.3244	1
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.003	0.0423	0.1303
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0061	0.1235	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0032	0.0477	0.147
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0239	0.0736
Brugia malayi	protein kinase C II.	0.003	0.0423	0.0423
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0023	0.0239	0.0736
Echinococcus granulosus	roundabout 2	0.0038	0.064	0.1974
Echinococcus granulosus	para nitrobenzyl esterase	0.0023	0.0239	0.0736
Brugia malayi	Carboxylesterase family protein	0.0023	0.0239	0.0239
Trichomonas vaginalis	AGC family protein kinase	0.009	0.2013	1
Echinococcus granulosus	protein kinase c iota type	0.003	0.0423	0.1303
Brugia malayi	Carboxylesterase family protein	0.0137	0.3244	0.3244
Schistosoma mansoni	vesicular amine transporter	0.0024	0.0268	0.0826
Loa Loa (eye worm)	acetylcholinesterase 1	0.0137	0.3244	0.3244
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0058	0.117	0.5
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.003	0.0423	0.1303
Echinococcus multilocularis	nervana 2	0.0058	0.1152	0.3553
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0268	0.0268
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0024	0.0268	0.0826
Schistosoma mansoni	acetylcholinesterase	0.0023	0.0239	0.0736
Echinococcus granulosus	serine/threonine protein kinase	0.0061	0.1235	0.3807
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0488	0.1405
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0023	0.0239	0.5
Schistosoma mansoni	tyrosine kinase	0.0015	0.0026	0.008
Loa Loa (eye worm)	AGC/PKN protein kinase	0.003	0.0423	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0239	0.0239
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0423	0.1303
Entamoeba histolytica	protein kinase, putative	0.0088	0.1947	0.9589
Echinococcus multilocularis	serine threonine protein kinase	0.003	0.0423	0.1303
Echinococcus multilocularis	roundabout 2	0.0038	0.064	0.1974
Trichomonas vaginalis	AGC family protein kinase	0.009	0.2013	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0239	0.0239
Echinococcus granulosus	BC026374 protein S09 family	0.0023	0.0239	0.0736
Echinococcus multilocularis	serine:threonine protein kinase N2	0.003	0.0423	0.1303
Echinococcus granulosus	neuroglian	0.003	0.0432	0.133
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.003	0.0423	0.1303
Echinococcus multilocularis	Immunoglobulin	0.0024	0.0268	0.0826
Schistosoma mansoni	serine/threonine-protein kinase	0.0061	0.1235	0.3807
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0423	0.1303
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.003	0.0423	0.1303
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0024	0.0268	0.0826
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.003	0.0423	0.0423
Echinococcus granulosus	nervana 2	0.0058	0.1152	0.3553
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0239	0.0239
Echinococcus multilocularis	acetylcholinesterase	0.0137	0.3244	1
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.003	0.0423	0.0423
Entamoeba histolytica	protein kinase, putative	0.009	0.2013	1
Trichomonas vaginalis	AGC family protein kinase	0.009	0.2013	1
Brugia malayi	Hr1 repeat family protein	0.003	0.0423	0.0423
Trichomonas vaginalis	AGC family protein kinase	0.003	0.0423	0.1037
Onchocerca volvulus		0.0023	0.0239	0.0256
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0058	0.1152	0.3553
Trichomonas vaginalis	AGC family protein kinase	0.003	0.0423	0.1037
Brugia malayi	Fibronectin type III domain containing protein	0.0024	0.0268	0.0268
Echinococcus granulosus	carboxylesterase 5A	0.0137	0.3244	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0061	0.1235	0.3807
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0023	0.0239	0.0736
Brugia malayi	hypothetical protein	0.0023	0.0239	0.0239
Toxoplasma gondii	AGC kinase	0.0088	0.1947	0.5
Echinococcus multilocularis	protein kinase c iota type	0.003	0.0423	0.1303
Echinococcus granulosus	Immunoglobulin	0.0024	0.0268	0.0826
Loa Loa (eye worm)	AGC/AKT protein kinase	0.009	0.2013	0.2013
Echinococcus granulosus	nervana 2	0.0058	0.1152	0.3553
Brugia malayi	Carboxylesterase family protein	0.0023	0.0239	0.0239
Echinococcus multilocularis	rac serine:threonine kinase	0.0061	0.1235	0.3807
Schistosoma mansoni	nephrin	0.003	0.0432	0.133
Loa Loa (eye worm)	hypothetical protein	0.0137	0.3244	0.3244
Trichomonas vaginalis	AGC family protein kinase	0.009	0.2013	1
Echinococcus granulosus	twitchin	0.0031	0.0449	0.1383
Brugia malayi	Protein kinase domain containing protein	0.003	0.0423	0.0423
Echinococcus granulosus	acetylcholinesterase	0.0137	0.3244	1
Onchocerca volvulus		0.0023	0.0239	0.0256
Schistosoma mansoni	gliotactin	0.0023	0.0239	0.0736
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.003	0.0423	0.1303
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0423	0.1303
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0023	0.0239	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0024	0.0268	0.0268
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0058	0.1152	0.3553
Echinococcus granulosus	neuroligin	0.0023	0.0239	0.0736
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0029	0.0405	0.094
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0268	0.0268
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0061	0.1235	0.5109
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0015	0.0017	0.0017
Giardia lamblia	Kinase, AGC PKA	0.0058	0.117	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0423	0.1303
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0058	0.117	0.3606
Loa Loa (eye worm)	AGC/NDR protein kinase	0.003	0.0423	0.0423
Echinococcus granulosus	Glutaredoxin protein 5	0.0058	0.1152	0.3553
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0268	0.0268
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0023	0.0239	0.0736
Echinococcus granulosus	protein kinase C gamma type	0.003	0.0423	0.1303
Entamoeba histolytica	protein kinase, putative	0.009	0.2013	1
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.003	0.0423	0.1303
Echinococcus granulosus	defective proboscis extension response	0.0024	0.0268	0.0826
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0239	0.0736
Echinococcus multilocularis	neuroglian	0.003	0.0432	0.133
Trichomonas vaginalis	AGC family protein kinase	0.003	0.0423	0.1037
Brugia malayi	Protein kinase domain containing protein	0.003	0.0423	0.0423
Brugia malayi	Protein kinase domain containing protein	0.009	0.2013	0.2013
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0058	0.117	0.3606
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0423	0.1303
Schistosoma mansoni	cell adhesion molecule	0.0032	0.0477	0.147
Brugia malayi	hypothetical protein	0.0024	0.0268	0.0268
Echinococcus multilocularis	nervana 2	0.0058	0.1152	0.3553
Loa Loa (eye worm)	carboxylesterase	0.0023	0.0239	0.0239
Onchocerca volvulus		0.0023	0.0239	0.0256
Loa Loa (eye worm)	carboxylesterase	0.0137	0.3244	0.3244
Echinococcus granulosus	acetylcholinesterase	0.0137	0.3244	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.003	0.0423	0.1303
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0239	0.0239
Brugia malayi	Carboxylesterase family protein	0.0137	0.3244	0.3244
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0239	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0239	0.0239
Trypanosoma cruzi	Protein kinase B	0.0061	0.1235	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.003	0.0423	0.1303
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.003	0.0423	0.0423
Brugia malayi	p70 ribosomal S6 kinase beta	0.0088	0.1947	0.1947
Trichomonas vaginalis	AGC family protein kinase	0.009	0.2013	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0268	0.0268
Schistosoma mansoni	serine/threonine kinase	0.003	0.0423	0.1303
Echinococcus multilocularis	neuroligin	0.0023	0.0239	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0239	0.0239
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0061	0.1235	0.5109
Echinococcus multilocularis	acetylcholinesterase	0.0137	0.3244	1
Loa Loa (eye worm)	carboxylesterase	0.0023	0.0239	0.0239
Brugia malayi	Carboxylesterase family protein	0.0023	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0038	0.064	0.064
Echinococcus multilocularis	protein kinase c epsilon type	0.003	0.0423	0.1303
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0058	0.117	0.5
Echinococcus multilocularis	serine:threonine protein kinase 38	0.003	0.0423	0.1303
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0023	0.0239	0.0736
Entamoeba histolytica	protein kinase 2, putative	0.0058	0.117	0.4697

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of Akt2 (unknown origin) by cell-based assay	ChEMBL.	18479914
IC50 (binding)		Inhibition of Akt1 (unknown origin) by cell-based assay	ChEMBL.	18479914
IC50 (binding)	0	Inhibition of Akt1 (unknown origin) by cell-based assay	ChEMBL.	18479914
IC50 (binding)	0	Inhibition of Akt2 (unknown origin) by cell-based assay	ChEMBL.	18479914
IC50 (binding)	= 250 nM	Inhibition of Akt1 (unknown origin)	ChEMBL.	18479914
IC50 (binding)	= 250 nM	Inhibition of Akt1 (unknown origin)	ChEMBL.	18479914
IC50 (binding)	= 900 nM	Inhibition of Akt2 (unknown origin)	ChEMBL.	18479914
IC50 (binding)	= 900 nM	Inhibition of Akt2 (unknown origin)	ChEMBL.	18479914
IC50 (binding)	> 50000 nM	Inhibition of PKA (unknown origin)	ChEMBL.	18479914
IC50 (binding)	> 50000 nM	Inhibition of PKC (unknown origin)	ChEMBL.	18479914
IC50 (binding)	> 50000 nM	Inhibition of SGK (unknown origin)	ChEMBL.	18479914

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL407733

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 511084