Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | methionine aminopeptidase 2, putative | 0.005 | 0.8682 | 0.773 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.005 | 0.8682 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0054 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0038 | 0.4193 | 1 |
Giardia lamblia | Methionine aminopeptidase | 0.005 | 0.8682 | 1 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0054 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.005 | 0.8682 | 0.8012 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.4193 | 0.1555 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.4193 | 0.1555 |
Toxoplasma gondii | aldose reductase, putative | 0.0038 | 0.4193 | 0.1246 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.005 | 0.8682 | 0.773 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.005 | 0.8682 | 0.8682 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.005 | 0.8682 | 0.773 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0036 | 0.3367 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0054 | 1 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0054 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0036 | 0.3367 | 0.8029 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.4193 | 0.4193 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0036 | 0.3367 | 0.8029 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0054 | 1 | 1 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.005 | 0.8682 | 1 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0054 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.005 | 0.8682 | 0.773 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.005 | 0.8682 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.005 | 0.8682 | 0.773 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.4193 | 0.4193 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0054 | 1 | 1 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0036 | 0.3367 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0054 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.005 | 0.8682 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.005 | 0.8682 | 0.8682 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.005 | 0.8682 | 0.773 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.005 | 0.8682 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.005 | 0.8682 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0038 | 0.4193 | 1 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.005 | 0.8682 | 0.8012 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0038 | 0.4193 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.005 | 0.8682 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0054 | 1 | 1 |
Brugia malayi | initiation factor 2-associated protein. | 0.005 | 0.8682 | 0.773 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.4193 | 0.4193 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0036 | 0.3367 | 0.5 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0054 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0054 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.4193 | 0.4193 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0054 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.005 | 0.8682 | 0.8012 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.4193 | 0.4193 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0036 | 0.3367 | 0.3367 |
Schistosoma mansoni | pol-related | 0.0038 | 0.4193 | 0.1555 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.6 uM | Inhibitory concentration of the compound against aldose reductase obtained from rat lens | ChEMBL. | 2491890 |
IC50 (binding) | = 980 uM | Inhibitory concentration of the compound against aldose reductase obtained from rat lens | ChEMBL. | 2491890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.