TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 271.354 | Formula: C17H21NO2
H donors: 1 H acceptors: 2 LogP: 5.32 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCc1ccc(c(c1)O)Oc1ccccn1
InChi: 1S/C17H21NO2/c1-2-3-4-5-8-14-10-11-16(15(19)13-14)20-17-9-6-7-12-18-17/h6-7,9-13,19H,2-5,8H2,1H3
InChiKey: GGLAALKBNDMDTG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	Get druggable targets OG5_130466	All targets in OG5_130466
Neospora caninum	enoyl-acyl carrier reductase, putative	Get druggable targets OG5_130466	All targets in OG5_130466
Trichomonas vaginalis	hypothetical protein	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium vivax	enoyl-acyl carrier protein reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium berghei	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	Get druggable targets OG5_130466	All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium falciparum	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium yoelii	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium knowlesi	enoyl-acyl carrier reductase, putative	Get druggable targets OG5_130466	All targets in OG5_130466

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0099	0.0139
Echinococcus multilocularis	musashi	0.0032	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0042	0.034	0.0476
Schistosoma mansoni	nuclear hormone receptor	0.0076	0.0704	0.0985
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0227	0.0318
Echinococcus multilocularis	cysteine protease	0.002	0.0099	0.0099
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0274	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0022	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Echinococcus multilocularis	lamin	0.0032	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0099	0.0438
Loa Loa (eye worm)	hypothetical protein	0.004	0.032	0.0448
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0257	0.113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0076	0.0704	0.0985
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0223	0.2272	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0257	0.113
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.034	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0182
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0076	0.0704	0.0985
Entamoeba histolytica	phosphofructokinase, putative	0.0127	0.1246	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0076	0.0704	0.0985
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.003	0.0134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.003	0.0134
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0015	0.0052	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1056	0.1479
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0076	0.0704	0.0985
Echinococcus multilocularis	sodium bile acid cotransporter	0.068	0.714	0.714
Onchocerca volvulus	Phospholipase A2 homolog	0.0519	0.5426	0.76
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0015	0.0052	0.0189
Loa Loa (eye worm)	hypothetical protein	0.004	0.032	0.0448
Onchocerca volvulus		0.0023	0.0132	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Loa Loa (eye worm)	PXA domain-containing protein	0.0022	0.013	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0244	0.0342
Leishmania major	cathepsin L-like protease	0.002	0.0099	0.0799
Echinococcus granulosus	FTZ F1 alpha	0.0076	0.0704	0.0985
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0076	0.0704	0.0985
Leishmania major	cathepsin L-like protease	0.002	0.0099	0.0799
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0053	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.013	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0227	0.0318
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0023	0.0132	0.0185
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.003	0.0245
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0076	0.0704	0.0985
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0244	0.0342
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0227	0.0318
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0036	0.0274	0.0384
Loa Loa (eye worm)	DR-78	0.0036	0.0274	0.0384
Brugia malayi	Cathepsin L-like precursor	0.002	0.0099	0.0139
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.004	0.032	0.0448
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0076	0.0704	0.0704
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Brugia malayi	Cathepsin L-like precursor	0.002	0.0099	0.0139
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0269	0.2758	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.004	0.032	0.0448
Brugia malayi	hypothetical protein	0.004	0.032	0.0448
Brugia malayi	A-kinase anchor protein 10, precursor	0.0022	0.013	0.0182
Toxoplasma gondii	phosphofructokinase PFKII	0.0034	0.0257	0.113
Schistosoma mansoni	lamin	0.0032	0.0227	0.0318
Schistosoma mansoni	hypothetical protein	0.0198	0.2003	0.2806
Echinococcus multilocularis	ecdysone induced protein 78C	0.0076	0.0704	0.0704
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0223	0.2272	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0132	0.0185
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.013	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0132	0.0185
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0068	0.0301
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0033	0.0264
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0001	0.0001
Brugia malayi	steroid hormone receptor	0.0076	0.0704	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0244	0.0342
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0099	0.0139
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0015	0.0052	0.0073
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0257	0.113
Mycobacterium ulcerans	hypothetical protein	0.0042	0.034	0.1295
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0001	0.0001
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0001	0.0001
Echinococcus multilocularis	expressed protein	0.0437	0.4544	0.4544
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0076	0.0704	0.0985
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.013	0.0182
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.034	0.1295
Toxoplasma gondii	cathepsin CPL	0.002	0.0099	0.0438
Schistosoma mansoni	coup transcription factor	0.0076	0.0704	0.0985
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.034	0.0476
Echinococcus granulosus	sodium bile acid cotransporter	0.068	0.714	1
Onchocerca volvulus		0.002	0.0099	0.0139
Plasmodium vivax	vivapain-2	0.002	0.0099	0.0438
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0274	0.0274
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.013	0.0571
Leishmania major	cathepsin L-like protease	0.0075	0.0686	0.5507
Schistosoma mansoni	organic anion transporter	0.0033	0.0244	0.0342
Mycobacterium tuberculosis	Possible oxidoreductase	0.0015	0.0052	0.0189
Schistosoma mansoni	follistatin	0.0023	0.0132	0.0185
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0053	0.0074
Echinococcus multilocularis	cysteine protease	0.002	0.0099	0.0099
Echinococcus granulosus	intermediate filament protein	0.0032	0.0227	0.0318
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0132	0.058
Onchocerca volvulus		0.0032	0.0227	0.0318
Trypanosoma brucei	pteridine reductase 1	0.0015	0.0052	0.0158
Loa Loa (eye worm)	hypothetical protein	0.002	0.0103	0.0144
Brugia malayi	Cathepsin L-like precursor	0.002	0.0099	0.0139
Entamoeba histolytica	phosphofructokinase, putative	0.0127	0.1246	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0099	0.0139
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0015	0.0052	0.0418
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0257	0.113
Schistosoma mansoni	6-phosphofructokinase	0.0127	0.1246	0.1745
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0132	0.058
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.034	0.1231
Loa Loa (eye worm)	hypothetical protein	0.068	0.714	1
Onchocerca volvulus		0.002	0.0099	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0076	0.0704	0.0985
Echinococcus granulosus	expressed protein	0.0437	0.4544	0.6365
Trichomonas vaginalis	hypothetical protein	0.0223	0.2272	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0033	0.0145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Loa Loa (eye worm)	6-phosphofructokinase	0.0127	0.1246	0.1745
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0157	0.069
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0076	0.0704	0.0985
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0023	0.0132	0.0185
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0132	0.058
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0076	0.0704	0.0985
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.034	0.0476
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0257	0.113
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0223	0.2272	1
Echinococcus granulosus	sodium bile acid cotransporter	0.068	0.714	1
Loa Loa (eye worm)	cysteine protease	0.002	0.0099	0.0139
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0015	0.0052	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0013	0.003	0.0043
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0001	0.0001
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0223	0.2272	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0042	0.034	0.0476
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0076	0.0704	0.0985
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0076	0.0704	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0052	0.0073
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.034	0.0476
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.004	0.032	0.0448
Toxoplasma gondii	ABC1 family protein	0.0042	0.034	0.1495
Onchocerca volvulus		0.068	0.714	1
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.001	0.0001	0.0002
Leishmania major	cathepsin L-like protease	0.002	0.0099	0.0799
Mycobacterium tuberculosis	Conserved protein	0.0042	0.034	0.1231
Schistosoma mansoni	nuclear receptor	0.0036	0.0274	0.0384
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.004	0.032	0.032
Echinococcus multilocularis	geminin	0.0198	0.2003	0.2003
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0127	0.1246	0.4517
Brugia malayi	nuclear receptor NHR-88	0.0036	0.0274	0.0384
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0076	0.0704	0.0985
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.013	0.013
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0099	0.0799
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.013	0.013
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0099	0.0099
Leishmania major	pteridine reductase 1	0.0015	0.0052	0.0418
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0157	0.022
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0076	0.0704	0.0985
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.013	0.013
Onchocerca volvulus	Phospholipase A2 homolog	0.0109	0.1056	0.1479
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.013	0.013
Brugia malayi	ecdysone receptor	0.0036	0.0274	0.0384
Brugia malayi	PXA domain containing protein	0.0022	0.013	0.0182
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.034	0.2529
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0257	0.113
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0223	0.2272	1
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0001	0.0001
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0132	0.0185
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Brugia malayi	photoreceptor-specific nuclear receptor	0.0076	0.0704	0.0985
Loa Loa (eye worm)	hypothetical protein	0.001	0.0001	0.0001
Echinococcus multilocularis	agrin	0.0023	0.0132	0.0132
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.034	0.1231
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0076	0.0704	0.0704
Trypanosoma cruzi	MFS transporter, putative	0.0033	0.0244	0.174
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.034	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0132	0.0185
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.013	0.0182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.032	0.0448
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0132	0.058
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0015	0.0052	0.0158
Brugia malayi	nuclear hormone receptor family member odr-7	0.0036	0.0274	0.0384
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0013	0.003	0.0043
Brugia malayi	beta-lactamase	0.0042	0.034	0.0476
Schistosoma mansoni	RAR-like nuclear receptor	0.0076	0.0704	0.0985
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.034	0.1495
Brugia malayi	hypothetical protein	0.0022	0.013	0.0182
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0022	0.013	0.0182
Echinococcus granulosus	lamin	0.0032	0.0227	0.0318
Leishmania major	cathepsin L-like protease	0.0075	0.0686	0.5507
Onchocerca volvulus		0.0036	0.0274	0.0384
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.034	0.1495
Loa Loa (eye worm)	RGS-3 protein	0.0022	0.013	0.0182
Loa Loa (eye worm)	beta-lactamase	0.0042	0.034	0.0476
Leishmania major	oxidoreductase-like protein	0.0015	0.0052	0.0418
Onchocerca volvulus		0.002	0.0099	0.0139
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0015	0.0052	0.0229
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0022	0.013	0.0182
Brugia malayi	tailless protein	0.0036	0.0274	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0047	0.0066
Echinococcus multilocularis	6 phosphofructokinase	0.0127	0.1246	0.1246
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0099	0.0438
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.032	0.0448
Schistosoma mansoni	retinoic acid receptor RXR	0.0076	0.0704	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0042	0.034	0.0476
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0076	0.0704	0.0985
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.034	0.1231
Mycobacterium ulcerans	6-phosphofructokinase	0.0127	0.1246	0.5377
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0076	0.0704	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.0074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Brugia malayi	6-phosphofructokinase	0.0127	0.1246	0.1745
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0244	0.0342
Entamoeba histolytica	hypothetical protein	0.0022	0.013	0.1041
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0127	0.1246	1
Brugia malayi	secreted modular calcium-binding protein 1	0.0023	0.0132	0.0185
Brugia malayi	6-phosphofructokinase	0.0127	0.1247	0.1747
Echinococcus granulosus	ecdysone induced protein 78C	0.0076	0.0704	0.0985
Echinococcus granulosus	thyroid hormone receptor alpha	0.0036	0.0274	0.0384
Echinococcus granulosus	lamin dm0	0.0032	0.0227	0.0318
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0033	0.0244	0.0342
Schistosoma mansoni	sodium-bile acid cotransporter	0.0287	0.295	0.4132
Echinococcus granulosus	6 phosphofructokinase	0.0127	0.1246	0.1745
Brugia malayi	conserved hypotetical protein	0.0036	0.0274	0.0384
Onchocerca volvulus		0.0033	0.0244	0.0342
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	0.0686	0.5385
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.013	0.0571
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0227	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.034	0.1495
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0124	0.0548
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0127	0.1246	1
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.034	0.2529
Onchocerca volvulus		0.0033	0.0244	0.0342
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.034	0.1231
Schistosoma mansoni	thyroid hormone receptor	0.0076	0.0704	0.0985
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0042	0.034	0.0476
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0076	0.0704	0.0985
Brugia malayi	Cathepsin L-like precursor	0.002	0.0099	0.0139
Onchocerca volvulus		0.0015	0.0052	0.0073
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.013	0.0182
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0033	0.0264
Schistosoma mansoni	agrin	0.0023	0.0132	0.0185
Echinococcus multilocularis	follistatin	0.0023	0.0132	0.0132
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0036	0.0274	0.0384
Brugia malayi	Cathepsin L-like precursor	0.002	0.0099	0.0139
Mycobacterium tuberculosis	Probable oxidoreductase	0.0015	0.0052	0.0189
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.013	0.013
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0157	0.069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Trichomonas vaginalis	phosphofructokinase, putative	0.0127	0.1246	0.5483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0099	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0244	0.0342
Onchocerca volvulus		0.0015	0.0052	0.0073
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0099	0.0099
Mycobacterium tuberculosis	Conserved protein	0.0042	0.034	0.1231
Schistosoma mansoni	zinc finger protein	0.0036	0.0274	0.0384
Onchocerca volvulus		0.002	0.0099	0.0139
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0023	0.0132	0.0185
Schistosoma mansoni	dihydropteridine reductase	0.0015	0.0052	0.0073
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0001	0.0001
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0076	0.0704	0.0704
Toxoplasma gondii	6-phosphofructokinase	0.0034	0.0257	0.113
Brugia malayi	SPARC precursor	0.0023	0.0132	0.0185
Onchocerca volvulus		0.0033	0.0244	0.0342
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0099	0.0139
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0036	0.0274	0.0384
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0099	0.0438
Brugia malayi	prostaglandin transporter	0.0033	0.0244	0.0342
Brugia malayi	hypothetical protein	0.0036	0.0274	0.0384
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0001	0.0002
Echinococcus multilocularis	sodium bile acid cotransporter	0.068	0.714	0.714
Schistosoma mansoni	DNA helicase recq5	0.001	0.0001	0.0001
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0099	0.0099
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.013	0.0182
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0034	0.0257	0.113
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0099	0.0139
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.013	0.0182
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.034	0.1231
Brugia malayi	phosphofructokinase	0.0127	0.1246	0.1745
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.013	0.0182
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0257	0.113
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.034	0.2529
Echinococcus multilocularis	lamin dm0	0.0032	0.0227	0.0227
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0015	0.0052	0.0073
Brugia malayi	orphan nuclear receptor NR2E1	0.0036	0.0274	0.0384
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0015	0.0052	0.0418
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0099	0.0438
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.013	0.0182
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0036	0.0274	0.0384
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0015	0.0052	0.0189
Loa Loa (eye worm)	nuclear hormone receptor	0.0036	0.0274	0.0384
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.034	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0132	0.0185
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0076	0.0704	0.0704
Echinococcus granulosus	nuclear receptor nhr 48	0.0036	0.0274	0.0384
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0023	0.0132	0.0185
Leishmania major	hypothetical protein, conserved	0.0042	0.034	0.2726
Onchocerca volvulus		0.0042	0.034	0.0476
Mycobacterium ulcerans	lipase LipD	0.0042	0.034	0.1295
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0127	0.1246	0.5377
Toxoplasma gondii	protease inhibitor PI2	0.0023	0.0132	0.058
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0022	0.013	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0047	0.0066
Echinococcus multilocularis	expressed protein	0.0023	0.0132	0.0132
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0223	0.2272	0.8237
Onchocerca volvulus	Protein ultraspiracle homolog	0.0076	0.0704	0.0985
Entamoeba histolytica	hypothetical protein	0.0022	0.013	0.1041
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0076	0.0704	0.0704
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0157	0.022
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0034	0.0257	0.2062
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0022	0.013	0.013
Echinococcus granulosus	sodium bile acid cotransporter	0.068	0.714	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0036	0.0274	0.0384
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0393	0.4081	0.5715
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0704	0.0985
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0257	0.113
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0015	0.0052	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0013	0.003	0.0043
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0036	0.0274	0.0384
Brugia malayi	ecdysteroid receptor	0.0076	0.0704	0.0985
Brugia malayi	regulator of G-protein signaling rgs-7	0.0022	0.013	0.0182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Onchocerca volvulus		0.0042	0.034	0.0476
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.034	0.1231
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0076	0.0704	0.0985
Onchocerca volvulus		0.002	0.0099	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0076	0.0704	0.0985
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.013	0.0182
Trypanosoma cruzi	cruzipain precursor, putative	0.0075	0.0686	0.5385
Brugia malayi	nuclear receptor NHR-88	0.0076	0.0704	0.0985
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Schistosoma mansoni	z-protein (S1r protein)	0.0022	0.013	0.0182
Loa Loa (eye worm)	hypothetical protein	0.004	0.032	0.0448
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0244	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0042	0.034	0.0476
Brugia malayi	nuclear receptor RXR	0.004	0.032	0.0448
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0052	0.0189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0015	0.0052	0.0052
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0223	0.2272	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0244	0.0342
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0157	0.022
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0022	0.013	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.013	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0182
Brugia malayi	PXA domain containing protein	0.0022	0.013	0.0182
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0076	0.0704	0.0985
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0033	0.0244	0.0244
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0244	0.0342
Entamoeba histolytica	hypothetical protein	0.0022	0.013	0.1041
Schistosoma mansoni	thyroid hormone receptor	0.0076	0.0704	0.0985
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0022	0.013	0.0571
Loa Loa (eye worm)	steroid hormone receptor	0.0076	0.0704	0.0985
Schistosoma mansoni	DNA helicase recq1	0.001	0.0001	0.0001
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0076	0.0704	0.0985
Brugia malayi	Sodium Bile acid symporter family protein	0.068	0.714	1
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.013	0.0182
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0076	0.0704	0.0985
Schistosoma mansoni	nuclear receptor	0.0036	0.0274	0.0384
Echinococcus multilocularis	regulator of G protein signaling	0.0022	0.013	0.013
Trypanosoma cruzi	major cysteine proteinase, putative	0.0059	0.0516	0.3982
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0704	0.0985
Onchocerca volvulus		0.0076	0.0704	0.0985
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0227	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0704	0.0985
Brugia malayi	hypothetical protein	0.0036	0.0274	0.0384
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0015	0.0052	0.0158
Brugia malayi	Nuclear hormone receptor-like 1	0.0076	0.0704	0.0985
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.013	0.0182
Chlamydia trachomatis	oxoacy-ACP reductase	0.0015	0.0052	0.0229
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0244	0.0342
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0099	0.0139
Brugia malayi	Nuclear hormone receptor E75	0.0036	0.0274	0.0384
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.013	0.0182
Echinococcus granulosus	agrin	0.0023	0.0132	0.0185
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0015	0.0052	0.0158
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0099	0.0139
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0244	0.0342
Brugia malayi	Cathepsin L-like precursor	0.0013	0.003	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0221	0.0309
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0036	0.0274	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0182
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0015	0.0052	0.0158
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.032	0.0448
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0022	0.013	0.0182
Mycobacterium ulcerans	beta-lactamase	0.0042	0.034	0.1295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0244	0.0342
Brugia malayi	Phospholipase A2 family protein	0.0109	0.1056	0.1479
Leishmania major	ATP-dependent phosphofructokinase	0.0127	0.1246	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0076	0.0704	0.0985
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0036	0.0274	0.0384
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0052	0.0073
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0071	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0013	0.003	0.0043
Brugia malayi	regulator of G-protein signaling egl-10	0.0022	0.013	0.0182
Onchocerca volvulus		0.0042	0.034	0.0476
Onchocerca volvulus		0.0036	0.0274	0.0384
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0257	0.113
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0015	0.0052	0.0418
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0076	0.0704	0.0985
Echinococcus granulosus	geminin	0.0198	0.2003	0.2806
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0099	0.0799
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0033	0.0244	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Brugia malayi	hypothetical protein	0.004	0.032	0.0448
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0099	0.0438
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0076	0.0704	0.0704
Echinococcus granulosus	follistatin	0.0023	0.0132	0.0185
Loa Loa (eye worm)	6-phosphofructokinase	0.0127	0.1246	0.1745
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0076	0.0704	0.0704
Schistosoma mansoni	6-phosphofructokinase	0.0127	0.1246	0.1745
Onchocerca volvulus		0.0032	0.0227	0.0318
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0036	0.0274	0.0384
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0099	0.0799
Brugia malayi	beta-lactamase family protein	0.0042	0.034	0.0476
Trypanosoma brucei	oxidoreductase-like protein	0.0015	0.0052	0.0158
Onchocerca volvulus		0.0033	0.0244	0.0342
Entamoeba histolytica	cysteine protease, putative	0.002	0.0099	0.0799
Loa Loa (eye worm)	fibroinase	0.002	0.0099	0.0139
Schistosoma mansoni	hypothetical protein	0.0198	0.2003	0.2806
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0157	0.0157
Brugia malayi	Nuclear hormone receptor E75	0.0036	0.0274	0.0384
Schistosoma mansoni	nuclear receptor nhr-48	0.0036	0.0274	0.0384
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0076	0.0704	0.0985
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.013	0.0571
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0101	0.0141
Echinococcus granulosus	cathepsin l1	0.002	0.0099	0.0139
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0036	0.0274	0.0384
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0076	0.0704	0.0985
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.013	0.0182
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0223	0.2272	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0076	0.0704	0.0985
Mycobacterium leprae	Probable lipase LipE	0.0042	0.034	0.1295
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0022	0.013	0.0182
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.013	0.0182
Trichomonas vaginalis	phosphofructokinase, putative	0.0127	0.1246	0.5483
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	0.0686	0.5385
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0015	0.0052	0.0189
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0033	0.0244	0.0342
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0071	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0182
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.013	0.0182
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0139
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0052	0.0073
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0015	0.0052	0.0229
Onchocerca volvulus		0.0013	0.003	0.0043
Brugia malayi	nuclear hormone receptor	0.0036	0.0274	0.0384
Entamoeba histolytica	phosphofructokinase, putative	0.0127	0.1246	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0099	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0042	0.034	0.0476
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0099	0.0438
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0257	0.113
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0015	0.0052	0.0229
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0257	0.113
Echinococcus multilocularis	nuclear receptor nhr 48	0.0036	0.0274	0.0274
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0099	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0076	0.0704	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0704	0.0985
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0036	0.0274	0.0274
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0033	0.0244	0.0342
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.0274	0.0384
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	0.0686	0.5385
Leishmania major	cathepsin L-like protease	0.002	0.0099	0.0799
Loa Loa (eye worm)	ctsf protein	0.002	0.0099	0.0139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.013	0.0182
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0017	0.0071	0.0311
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0034	0.0257	0.113
Brugia malayi	hypothetical protein	0.0033	0.0244	0.0342
Leishmania major	cathepsin L-like protease	0.0075	0.0686	0.5507
Echinococcus multilocularis	FTZ F1 alpha	0.0076	0.0704	0.0704
Echinococcus granulosus	Regulator of G protein signaling 20	0.0022	0.013	0.0182
Brugia malayi	intermediate filament protein	0.0032	0.0227	0.0318
Brugia malayi	hypothetical protein	0.0033	0.0244	0.0342
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0257	0.113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Schistosoma mansoni	lamin	0.0032	0.0227	0.0318
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0001	0.0002
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.013	0.0182
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0052	0.0189
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0036	0.0274	0.0384
Brugia malayi	nuclear receptor RXR	0.0036	0.0274	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0704	0.0985
Brugia malayi	cathepsin L-like precursor	0.0013	0.003	0.0043
Loa Loa (eye worm)	hypothetical protein	0.004	0.032	0.0448
Brugia malayi	beta-lactamase family protein	0.0042	0.034	0.0476
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.013	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0704	0.0985
Onchocerca volvulus	Bile acid receptor homolog	0.0076	0.0704	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0704	0.0985
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0076	0.0704	0.0985
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.013	0.0182
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0052	0.0073
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0076	0.0704	0.0985
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0099	0.0139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Trichomonas vaginalis	phosphofructokinase, putative	0.0127	0.1246	0.5483
Schistosoma mansoni	cathepsin F (C01 family)	0.0013	0.003	0.0043
Brugia malayi	hypothetical protein	0.0022	0.013	0.0182
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.034	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0182
Loa Loa (eye worm)	agrin synaptic family protein	0.0023	0.0132	0.0185
Echinococcus granulosus	cathepsin l1	0.0013	0.003	0.0043
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0068	0.0617	0.4816
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0099	0.0549
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0036	0.0274	0.0384
Echinococcus multilocularis	sodium bile acid cotransporter	0.068	0.714	0.714
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0022	0.013	0.0182
Loa Loa (eye worm)	phosphofructokinase	0.0127	0.1246	0.1745
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0076	0.0704	0.0985
Schistosoma mansoni	sodium-bile acid cotransporter related	0.068	0.714	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.034	0.1231
Mycobacterium tuberculosis	Conserved protein	0.0042	0.034	0.1231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0099	0.0438
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0015	0.0052	0.0073
Leishmania major	cathepsin L-like protease	0.002	0.0099	0.0799
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0076	0.0704	0.0985
Trichomonas vaginalis	phosphofructokinase, putative	0.0127	0.1246	0.5483
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0036	0.0274	0.0274
Plasmodium vivax	vivapain-2	0.002	0.0099	0.0438
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.0274	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0274	0.0384
Schistosoma mansoni	organic anion transporter	0.0033	0.0244	0.0342
Brugia malayi	Cathepsin L-like precursor	0.0013	0.003	0.0043
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0686	0.5385
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.034	0.1495
Loa Loa (eye worm)	hypothetical protein	0.004	0.032	0.0448
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0052	0.0189
Trichomonas vaginalis	esterase, putative	0.0042	0.034	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0519	0.5426	0.76
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0034	0.0257	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.034	0.1295
Brugia malayi	nuclear hormone receptor	0.0076	0.0704	0.0985
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0076	0.0704	0.0985
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.034	0.034
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.034	0.1295
Brugia malayi	nuclear receptor NHR-67	0.0036	0.0274	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0244	0.0342
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.013	0.0571
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.013	0.0182
Toxoplasma gondii	transporter, major facilitator family protein	0.0033	0.0244	0.1073
Brugia malayi	Steroid receptor seven-up type 2	0.0076	0.0704	0.0985
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0076	0.0704	0.0985
Onchocerca volvulus		0.0033	0.0244	0.0342
Onchocerca volvulus		0.002	0.0099	0.0139
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0036	0.0274	0.0274
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0127	0.1246	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0076	0.0704	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0704	0.0985
Mycobacterium tuberculosis	Possible oxidoreductase	0.0015	0.0052	0.0189
Onchocerca volvulus		0.002	0.0099	0.0139
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.013	0.013
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0015	0.0052	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0244	0.0342
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0099	0.0099
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0022	0.013	0.0182

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.06	Inhibition of Mycobacterium tuberculosis InhA	LITERATURE.	No reference
IC50 (binding)	= 11500 nM	Inhibition of 100 nM Mycobacterium tuberculosis H37RV InhA	ChEMBL.	18457948
IC50 (binding)	= 11500 nM	Inhibition of 100 nM Mycobacterium tuberculosis H37RV InhA	ChEMBL.	18457948
Ki (binding)	= 1 nM	Inhibition of Mycobacterium tuberculosis H37RV InhA	ChEMBL.	18457948
Ki (binding)	= 1 nM	Inhibition of Mycobacterium tuberculosis H37RV InhA	ChEMBL.	18457948
LogP	= 5.06	Partition coefficient, log P of the compound	ChEMBL.	18457948
MIC90 (functional)	= 2.1 ug ml-1	Antimicrobial activity against Mycobacterium tuberculosis H37RV	ChEMBL.	18457948
MIC90 (functional)	= 2.1 ug ml-1	Antimicrobial activity against Mycobacterium tuberculosis H37RV	ChEMBL.	18457948

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL264679

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 511406