TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 301.355 | Formula: C18H20FNO2
H donors: 1 H acceptors: 0 LogP: 3.15 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)C)O[C@@H](c1ccccc1)[C@@H]1CNCCO1
InChi: 1S/C18H20FNO2/c1-13-11-15(19)7-8-16(13)22-18(14-5-3-2-4-6-14)17-12-20-9-10-21-17/h2-8,11,17-18,20H,9-10,12H2,1H3/t17-,18-/m0/s1
InChiKey: CPNTXNSOEZESIH-ROUUACIJSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 3	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 3	620 aa	579 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1096	0.2425
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0104	0.1389
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0024	0.0174	0.0398
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0126	0.1774	0.1375
Onchocerca volvulus		0.0031	0.0297	0.0294
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0581	0.1327
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0195	0.0445
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0044	0.0495	0.1096
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.006	0.0137
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0043	0.0098
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.006	0.0137
Trichomonas vaginalis	esterase, putative	0.0042	0.0462	0.045
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0581	0.0524
Onchocerca volvulus		0.0044	0.0495	0.0765
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0268	0.4005	0.3968
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0581	0.1327
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.4373	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0462	0.0362
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0044	0.0495	0.0438
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0104	0.1389
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Brugia malayi	beta-lactamase family protein	0.0042	0.0462	0.1023
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0462	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0174	0.0385
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0462	0.6856
Brugia malayi	photoreceptor-specific nuclear receptor	0.0024	0.0174	0.0385
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.4373	0.9676
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0174	0.0385
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0019	0.0104	0.0238
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0581	0.1327
Trichomonas vaginalis	hypothetical protein	0.0652	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0462	0.0405
Mycobacterium ulcerans	lipase LipD	0.0042	0.0462	0.0362
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0024	0.0174	0.0385
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0462	0.0405
Onchocerca volvulus		0.0031	0.0297	0.0294
Plasmodium falciparum	transporter, putative	0.005	0.0581	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0297	0.0658
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0581	0.1284
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0395
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0581	0.1284
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0024	0.0174	0.0398
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0024	0.0174	0.0385
Echinococcus multilocularis	lamin dm0	0.0031	0.0297	0.068
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0395
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0462	0.0405
Echinococcus granulosus	serotonin transporter	0.0292	0.4373	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0395
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0297	0.0658
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0104	0.1389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0034	0.0074
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0019	0.0104	0.0045
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.006	0.0137
Trichomonas vaginalis	set domain proteins, putative	0.0276	0.413	0.4122
Loa Loa (eye worm)	hypothetical protein	0.005	0.0581	0.1284
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0581	0.1327
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0581	0.1327
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0462	0.1023
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0043	0.0098
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0044	0.0495	0.7362
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0506	0.1119
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0297	0.0658
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.006	0.0714
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.006	0.0714
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0174	0.0385
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0581	0.1327
Plasmodium falciparum	glutathione reductase	0.0055	0.0668	0.0612
Toxoplasma gondii	hypothetical protein	0.005	0.0581	0.0524
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Echinococcus multilocularis	thyroid hormone receptor alpha	0.017	0.2472	0.5653
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0395
Onchocerca volvulus		0.005	0.0581	0.0968
Schistosoma mansoni	bromodomain containing protein	0.0074	0.096	0.2196
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0652	1	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.0461	0.1054
Schistosoma mansoni	RAR-like nuclear receptor	0.0024	0.0174	0.0398
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0104	0.1389
Mycobacterium ulcerans	oxidoreductase	0.0044	0.0495	0.0395
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0301	0.452	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0024	0.0174	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0043	0.0094
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.452	0.4513
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.4373	0.9676
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0044	0.0495	0.7362
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.007	0.0895	0.2046
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0044	0.0495	0.0438
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0104	0.1389
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0084	0.1087
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0462	0.045
Loa Loa (eye worm)	hypothetical protein	0.0292	0.4373	0.9676
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0044	0.0495	0.0438
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0652	1	1
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0044	0.0495	0.1096
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0581	0.1284
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0174	0.0385
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0044	0.0495	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0024	0.0174	0.0385
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0126	0.1774	0.1725
Chlamydia trachomatis	oxoacy-ACP reductase	0.0044	0.0495	0.0395
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.006	0.0137
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0055	0.0668	0.1528
Trypanosoma cruzi	trypanothione reductase, putative	0.0019	0.0104	0.1389
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0044	0.0495	0.7362
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0019	0.0104	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Echinococcus granulosus	lamin	0.0031	0.0297	0.068
Trypanosoma brucei	pteridine reductase 1	0.0044	0.0495	0.7362
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0581	0.1327
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0581	0.1284
Onchocerca volvulus		0.0292	0.4373	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0195	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0174	0.0385
Loa Loa (eye worm)	glutathione reductase	0.0055	0.0668	0.1479
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.014	0.1994	0.1946
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0661	0.1463
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0462	0.1057
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.035	0.08
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0581	0.1327
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0174	0.0398
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.035	0.0292
Loa Loa (eye worm)	thioredoxin reductase	0.0055	0.0668	0.1479
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0174	0.0385
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0019	0.0104	0.1389
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0462	0.0362
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0581	0.1327
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0044	0.0495	0.0438
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0581	0.1327
Brugia malayi	follicle stimulating hormone receptor	0.0276	0.4122	0.9119
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0243	0.3605	0.7975
Onchocerca volvulus		0.0042	0.0462	0.0687
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.006	0.0133
Echinococcus multilocularis	geminin	0.0198	0.2899	0.6628
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0174	0.0385
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0019	0.0104	0.1389
Brugia malayi	intermediate filament protein	0.0031	0.0297	0.0658
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0276	0.4122	0.9119
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0019	0.0104	0.1389
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0581	0.0524
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0174	0.0385
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0024	0.0174	0.0398
Echinococcus granulosus	zinc finger protein	0.0023	0.0162	0.0371
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0174	0.0398
Plasmodium vivax	glutathione reductase, putative	0.0055	0.0668	0.0612
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0462	0.045
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0652	1	1
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0044	0.0495	0.0395
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0019	0.0104	0.0045
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0084	0.1087
Mycobacterium tuberculosis	Probable reductase	0.0126	0.1774	0.1725
Echinococcus multilocularis	zinc finger protein	0.0023	0.0162	0.0371
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.2899	0.2889
Onchocerca volvulus		0.0042	0.0462	0.0687
Schistosoma mansoni	hypothetical protein	0.0053	0.0639	0.1462
Echinococcus granulosus	histone lysine methyltransferase setb	0.0055	0.0661	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0462	0.1023
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0462	0.1057
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0044	0.0495	0.0395
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.006	0.0714
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0581	0.0524
Plasmodium vivax	thioredoxin reductase, putative	0.0055	0.0668	0.0612
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0024	0.0174	0.0398
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0044	0.0495	0.0438
Trichomonas vaginalis	glutathione reductase, putative	0.0019	0.0104	0.0091
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0019	0.0104	0.0045
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Brugia malayi	Pre-SET motif family protein	0.0243	0.3605	0.7975
Schistosoma mansoni	lamin	0.0031	0.0297	0.068
Leishmania major	trypanothione reductase	0.0055	0.0668	1
Echinococcus granulosus	FTZ F1 alpha	0.0024	0.0174	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0462	0.1023
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0581	0.1327
Schistosoma mansoni	hypothetical protein	0.0198	0.2899	0.6628
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0438
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.014	0.1994	0.1946
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0024	0.0174	0.0385
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0462	0.0405
Mycobacterium tuberculosis	Possible oxidoreductase	0.0044	0.0495	0.0438
Echinococcus granulosus	intermediate filament protein	0.0031	0.0297	0.068
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0113	0.0258
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0055	0.0661	0.1512
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0581	0.1327
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0116	0.0266
Leishmania major	pteridine reductase 1	0.0044	0.0495	0.7362
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.006	0.0137
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.035	0.08
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0019	0.0104	0.0045
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0055	0.0668	0.0612
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0044	0.0495	0.1133
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0104	0.1389
Loa Loa (eye worm)	hypothetical protein	0.005	0.0584	0.1291
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.452	0.4513
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Toxoplasma gondii	hypothetical protein	0.005	0.0581	0.0524
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0024	0.0174	0.0398
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0462	0.0405
Plasmodium falciparum	amino acid transporter, putative	0.005	0.0581	0.0524
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0174	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0288	0.0638
Mycobacterium tuberculosis	Probable oxidoreductase	0.0044	0.0495	0.0438
Brugia malayi	Bromodomain containing protein	0.0045	0.0504	0.1116
Echinococcus granulosus	geminin	0.0198	0.2899	0.6628
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0044	0.0495	0.0395
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0024	0.0174	0.0385
Plasmodium falciparum	thioredoxin reductase	0.0019	0.0104	0.0045
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0652	1	1
Brugia malayi	isocitrate dehydrogenase	0.0016	0.006	0.0133
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.4373	1
Brugia malayi	hypothetical protein	0.0156	0.2243	0.4962
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0462	0.1057
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.452	0.4513
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.007	0.0895	0.2046
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0044	0.0495	0.0395
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0104	0.1389
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0104	0.1389
Mycobacterium tuberculosis	Probable oxidoreductase	0.014	0.1994	0.1946
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0044	0.0495	0.7362
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0019	0.0104	0.0238
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0462	0.6856
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0174	0.0385
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0055	0.0661	0.1512
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.2899	0.2889
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0581	0.1327
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0024	0.0174	0.0398
Onchocerca volvulus		0.0042	0.0462	0.0687
Echinococcus multilocularis	ecdysone induced protein 78C	0.0024	0.0174	0.0398
Schistosoma mansoni	thyroid hormone receptor	0.017	0.2472	0.5653
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0395
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0024	0.0174	0.0385
Onchocerca volvulus		0.0035	0.035	0.0419
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.4373	0.9676
Trypanosoma brucei	oxidoreductase-like protein	0.0044	0.0495	0.7362
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0174	0.0385
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.014	0.1994	0.1606
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0044	0.0495	0.1096
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0462	0.6856
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0147	0.0088
Onchocerca volvulus		0.005	0.0581	0.0968
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.006	0.0133
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.0581	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0549	0.1214
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0581	0.1327
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0044	0.0495	0.1096
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.002	0.0116	0.0266
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0462	0.045
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0024	0.0174	0.0398
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0024	0.0174	0.0398
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0174	0.0398
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0024	0.0174	0.0385
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0217	0.0495
Schistosoma mansoni	lamin	0.0031	0.0297	0.068
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0462	0.0405
Loa Loa (eye worm)	hypothetical protein	0.005	0.0581	0.1284
Echinococcus granulosus	thioredoxin glutathione reductase	0.0055	0.0668	0.1528
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0024	0.0174	0.0385
Brugia malayi	Bromodomain containing protein	0.0088	0.1174	0.2598
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0024	0.0174	0.0398
Trichomonas vaginalis	glucosylceramidase, putative	0.0208	0.3065	0.3056
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0174	0.0385
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0024	0.0174	0.0398
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0462	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0174	0.0385
Plasmodium vivax	amine transporter, putative	0.005	0.0581	0.0524
Loa Loa (eye worm)	hypothetical protein	0.005	0.0581	0.1284
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0116	0.0266
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0024	0.0174	0.0398
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0019	0.0104	0.0238
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0581	0.1327
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0462	0.0405
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.2899	0.2889
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0182	0.0402
Toxoplasma gondii	ABC1 family protein	0.0042	0.0462	0.0405
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0044	0.0495	0.0035
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.2899	0.2889
Schistosoma mansoni	dihydropteridine reductase	0.0044	0.0495	0.1133
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0174	0.0385
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0462	0.045
Onchocerca volvulus		0.0276	0.413	0.9419
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0044	0.0495	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0024	0.0174	0.0385
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0044	0.0495	0.7362
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.0461	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0462	0.1023
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0438
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0462	0.0362
Loa Loa (eye worm)	steroid hormone receptor	0.0024	0.0174	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0156	0.2243	0.4962
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0044	0.0495	0.1133
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0104	0.1389
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0462	0.0405
Trypanosoma brucei	trypanothione reductase	0.0055	0.0668	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0024	0.0174	0.0398
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0195	0.0431
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0044	0.0495	0.7362
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0174	0.0385
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0174	0.0398
Brugia malayi	Steroid receptor seven-up type 2	0.0024	0.0174	0.0385
Loa Loa (eye worm)	hypothetical protein	0.005	0.0581	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0462	0.1023
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.006	0.0714
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0044	0.0495	0.0395
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.4373	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0126	0.1774	0.1725
Brugia malayi	PHD-finger family protein	0.0029	0.026	0.0575
Leishmania major	hypothetical protein, conserved	0.0042	0.0462	0.6856
Mycobacterium tuberculosis	Possible oxidoreductase	0.0044	0.0495	0.0438
Schistosoma mansoni	hypothetical protein	0.0018	0.0084	0.0193
Onchocerca volvulus		0.0156	0.2243	0.4927
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0024	0.0174	0.0398
Loa Loa (eye worm)	hypothetical protein	0.005	0.0581	0.1284
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0438
Brugia malayi	Pre-SET motif family protein	0.0035	0.035	0.0774
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.452	0.4513
Echinococcus granulosus	lamin dm0	0.0031	0.0297	0.068
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.2899	0.2889
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.0104	0.1389
Loa Loa (eye worm)	hypothetical protein	0.005	0.0581	0.1284
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0581	0.1327
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0034	0.0074
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0147	0.2103	0.481
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0462	0.1023
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.006	0.0137
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0044	0.0495	0.1133
Trichomonas vaginalis	mercuric reductase, putative	0.0019	0.0104	0.0091
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0024	0.0174	0.0398
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0195	0.0445
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0044	0.0495	0.0438
Onchocerca volvulus	Glucosylceramidase homolog	0.0198	0.2899	0.6488
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.452	0.4513
Leishmania major	oxidoreductase-like protein	0.0044	0.0495	0.7362
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0044	0.0495	0.0395
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0652	1	1
Loa Loa (eye worm)	hypothetical protein	0.0292	0.4373	0.9676
Echinococcus multilocularis	musashi	0.0031	0.0297	0.068
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0044	0.0495	0.0395
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0581	0.1327
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0297	0.0658
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.006	0.0137
Leishmania major	hypothetical protein, conserved	0.0018	0.0084	0.1087
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Schistosoma mansoni	hypothetical protein	0.0024	0.0182	0.0416
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0014	0.0025	0.0055
Brugia malayi	steroid hormone receptor	0.0024	0.0174	0.0385
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0044	0.0495	0.0395
Brugia malayi	nuclear receptor NHR-88	0.0024	0.0174	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0495	0.1096
Onchocerca volvulus		0.0044	0.0495	0.0765
Echinococcus multilocularis	FTZ F1 alpha	0.0024	0.0174	0.0398
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0652	1	1
Plasmodium falciparum	thioredoxin reductase	0.0055	0.0668	0.0612
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.2899	0.2889
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.452	0.4513
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.035	0.08
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0462	0.1057
Toxoplasma gondii	NADPH-glutathione reductase	0.0019	0.0104	0.0045
Echinococcus granulosus	methyl CpG binding domain protein 2	0.002	0.0116	0.0266
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0462	0.045
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0462	0.1023
Schistosoma mansoni	coup transcription factor	0.0024	0.0174	0.0398
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0024	0.0174	0.0398
Mycobacterium tuberculosis	Probable dehydrogenase	0.0126	0.1774	0.1725
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0462	0.1023
Schistosoma mansoni	hypothetical protein	0.0198	0.2899	0.6628
Brugia malayi	glutathione reductase	0.0055	0.0668	0.1479
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0581	0.0524
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0069	0.0152
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0044	0.0495	0.0438
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0147	0.2103	0.481
Schistosoma mansoni	thyroid hormone receptor	0.017	0.2472	0.5653
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.006	0.0714
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0055	0.0661	0.1512
Echinococcus multilocularis	lamin	0.0031	0.0297	0.068
Loa Loa (eye worm)	hypothetical protein	0.005	0.0581	0.1284
Trypanosoma brucei	ISWI complex protein	0.0018	0.0084	0.1087
Schistosoma mansoni	retinoic acid receptor RXR	0.0024	0.0174	0.0398
Toxoplasma gondii	thioredoxin reductase	0.0055	0.0668	0.0612
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0065	0.0005
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.033	0.0755
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0017	0.0068	0.0009
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0462	0.0405
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0581	0.1327
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0044	0.0495	0.0395
Brugia malayi	hypothetical protein	0.005	0.0581	0.1284
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0024	0.0174	0.0385
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0581	0.1284
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0581	0.1284
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0128	0.0282
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0395
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0581	0.1327
Brugia malayi	Thioredoxin reductase	0.0055	0.0668	0.1479
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0024	0.0174	0.0385
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0195	0.0182
Brugia malayi	ecdysteroid receptor	0.0024	0.0174	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0292	0.4373	0.9676
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0462	0.0405
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0395
Onchocerca volvulus		0.005	0.0581	0.0968
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0044	0.0495	0.0438
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0126	0.1774	0.1725
Schistosoma mansoni	zinc finger protein	0.0023	0.0162	0.0371
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0019	0.0104	0.0045
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.2899	0.2889
Trypanosoma cruzi	trypanothione reductase, putative	0.0055	0.0668	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0044	0.0495	0.7362
Mycobacterium ulcerans	short chain dehydrogenase	0.0044	0.0495	0.0395
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0652	1	1
Schistosoma mansoni	hypothetical protein	0.0147	0.2103	0.481
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0069	0.0152
Schistosoma mansoni	zinc finger protein	0.0018	0.0084	0.0193
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0104	0.1389
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0024	0.0174	0.0398
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0174	0.0398
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0217	0.0495
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0019	0.0104	0.0231
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0217	0.0495
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0024	0.0174	0.0385
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0126	0.1774	0.1725
Trichomonas vaginalis	glucosylceramidase, putative	0.0208	0.3065	0.3056
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.0104	0.1389
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0581	0.1327
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0044	0.0495	0.0395
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0301	0.452	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0581	0.1327
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0581	0.1327
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0297	0.068
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.4373	0.9676
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0014	0.0025	0.0055
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0195	0.0431
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0044	0.0495	0.0395
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0019	0.0104	0.1389
Brugia malayi	nuclear hormone receptor	0.0024	0.0174	0.0385
Brugia malayi	beta-lactamase family protein	0.0042	0.0462	0.1023
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0462	0.1023
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0019	0.0104	0.0045
Loa Loa (eye worm)	oxidoreductase	0.0044	0.0495	0.1096
Plasmodium vivax	SET domain protein, putative	0.0035	0.035	0.0292
Echinococcus multilocularis	serotonin transporter	0.0292	0.4373	1
Plasmodium falciparum	glutathione reductase	0.0019	0.0104	0.0045
Brugia malayi	beta-lactamase	0.0042	0.0462	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0174	0.0385
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0256
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0024	0.0174	0.0385

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of histamine H1 receptor (unknown origin)	ChEMBL.	18387300
Activity (binding)	0	Inhibition of histamine H1 receptor (unknown origin)	ChEMBL.	18387300
Ki (binding)	= 18 nM	Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells	ChEMBL.	18387300
Ki (binding)	= 18 nM	Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells	ChEMBL.	18387300
Ki (binding)	= 185 nM	Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells	ChEMBL.	18387300
Ki (binding)	= 185 nM	Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells	ChEMBL.	18387300
Ki (binding)	= 1250 nM	Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells	ChEMBL.	18387300
Ki (binding)	= 1250 nM	Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells	ChEMBL.	18387300

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL427563

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 511455