Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.9179 | 0.9179 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.9179 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.9179 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.9179 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.9179 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.9179 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Toxicity against wild type yeast MDY326 assessed as 2 fold reduction of cell growth | ChEMBL. | 17404221 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.