Detailed information for compound 511869

Basic information

Technical information
  • TDR Targets ID: 511869
  • Name: (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6- amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-( diaminomethylideneamino)-2-[[(2S)-1-[(2S)-5-( diaminomethylideneamino)-2-[[(2S)-2,5-diamino -5-oxopentanoyl]amino]pentanoyl]pyrrolidine-2 -carbonyl]amino]pentanoyl]amino]-4-methylpent anoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H- imidazol-5-yl)propanoyl]amino]hexanoyl]amino] acetyl]pyrrolidine-2-carbonyl]amino]-4-methyl sulfanylbutanoyl]pyrrolidine-2-carbonyl]amino ]-3-phenylpropanoic acid
  • MW: 1550.83 | Formula: C69H111N23O16S
  • H donors: 19 H acceptors: 17 LogP: -6.3 Rotable bonds: 61
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)CCSC)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(=O)N)N)CCCNC(=N)N)CCCNC(=N)N)CC(C)C)CO
  • InChi: 1S/C69H111N23O16S/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-/m0/s1
  • InChiKey: XXCCRHIAIBQDPX-PEWBXTNBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2,5-diamino-5-oxo-pentanoyl]amino]-5-guanidino-pentanoyl]pyrrolidine-2-carbonyl]amino]-5-guanidino-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-hydroxy-propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanyl-butanoyl]pyrrolidine-2-carbonyl]amino]-3-phenyl-propanoic acid
  • (2S)-2-[[[(2S)-1-[(2S)-2-[[[(2S)-1-[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[[(2S)-1-[(2S)-2-[[(2S)-2,5-diamino-1,5-dioxopentyl]amino]-5-guanidino-1-oxopentyl]-2-pyrrolidinyl]-oxomethyl]amino]-5-guanidino-1-oxopentyl]amino]-4-methyl-1-oxopentyl]amino]-3-hydroxy-1-oxopropyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropyl]amino]-1-oxohexyl]amino]-1-oxoethyl]-2-pyrrolidinyl]-oxomethyl]amino]-4-(methylthio)-1-oxobutyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-phenylpropanoic acid
  • (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-azanyl-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-[bis(azanyl)methylideneamino]-2-[[(2S)-1-[(2S)-5-[bis(azanyl)methylideneamino]-2-[[(2S)-2,5-bis(azanyl)-5-oxo-pentanoyl]amino]pentanoyl]pyrrolidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-hydroxy-propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]ethanoyl]pyrrolidin-2-yl]carbonylamino]-4-methylsulfanyl-butanoyl]pyrrolidin-2-yl]carbonylamino]-3-phenyl-propanoic acid
  • (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2,5-diamino-5-keto-pentanoyl]amino]-5-guanidino-pentanoyl]prolyl]amino]-5-guanidino-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-hydroxy-propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]acetyl]prolyl]amino]-4-(methylthio)butanoyl]prolyl]amino]-3-phenyl-propionic acid
  • apelin-13 peptide
  • AIDS-093725
  • AIDS093725
  • APELIN-13
  • Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apelin receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor apelin receptor 380 aa 325 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0249 0.0257
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0249 0.0248
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.001 0.004 0.0066
Trichomonas vaginalis thymidylate kinase, putative 0.007 0.136 0.2278
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0181 0.3806 0.3933
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0017 0.0179 0.0178
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0061 0.1148 0.1185
Schistosoma mansoni amine GPCR 0.0181 0.3806 0.3805
Brugia malayi hypothetical protein 0.001 0.004 0.004
Plasmodium vivax thymidylate kinase, putative 0.007 0.136 0.1701
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0017 0.0179 0.0207
Brugia malayi Dopamine receptor 0.0181 0.3806 0.3933
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0249 0.0398
Brugia malayi RNase H family protein 0.0044 0.0785 0.0811
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0453 0.0742
Schistosoma mansoni neuropeptide receptor 0.0181 0.3806 0.3805
Schistosoma mansoni dihydrofolate reductase 0.0448 0.9675 0.9675
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Entamoeba histolytica hypothetical protein 0.002 0.0249 0.0327
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0023 0.031 0.0309
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Loa Loa (eye worm) RecQ helicase 0.0021 0.0274 0.0283
Brugia malayi DNA polymerase family B containing protein 0.0017 0.0179 0.0184
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0845 0.0874
Echinococcus granulosus axis inhibition protein axin 0.002 0.0249 0.0257
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0309 0.0319
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0344 0.7393 1
Schistosoma mansoni thymidylate kinase 0.007 0.136 0.1359
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0181 0.3806 0.3933
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0845 0.0836
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0168 0.0174
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0077 0.008
Trichomonas vaginalis reverse transcriptases, putative 0.001 0.004 0.0043
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0181 0.3806 0.3933
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0168 0.0129
Echinococcus granulosus g protein coupled receptor 0.0181 0.3806 0.3933
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0044 0.0785 0.5206
Brugia malayi DNA polymerase delta catalytic subunit 0.0017 0.0179 0.0184
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0249 0.0248
Entamoeba histolytica hypothetical protein 0.002 0.0249 0.0327
Echinococcus granulosus 7tm_1 domain containing protein 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0013 0.0093 0.0096
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0249 0.0257
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0009 0.0014 0.0015
Echinococcus granulosus serotonin receptor 0.0181 0.3806 0.3933
Echinococcus multilocularis fmrfamide receptor 0.0181 0.3806 0.3933
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0309 0.0366
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0181 0.3806 0.3933
Schistosoma mansoni hypothetical protein 0.001 0.004 0.0039
Leishmania major trypanothione reductase 0.0047 0.0845 0.1074
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0181 0.3806 0.3933
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Echinococcus granulosus lamin dm0 0.0027 0.0397 0.0409
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0309 0.043
Plasmodium vivax DNA polymerase alpha, putative 0.0049 0.0895 0.1061
Schistosoma mansoni myosin xvIII 0.0181 0.3806 0.3805
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0249 0.0398
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0181 0.3806 0.3805
Schistosoma mansoni hypothetical protein 0.001 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0084 0.1649 0.1704
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0453 0.0742
Echinococcus granulosus bloom syndrome protein 0.0021 0.0274 0.0282
Onchocerca volvulus 0.0181 0.3806 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0453 0.0453
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0017 0.0188 0.0253
Loa Loa (eye worm) hypothetical protein 0.002 0.0249 0.0258
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0168 0.0174
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0845 0.0993
Loa Loa (eye worm) hypothetical protein 0.002 0.0249 0.0258
Loa Loa (eye worm) dihydrofolate reductase 0.0448 0.9675 1
Entamoeba histolytica thymidine kinase, putative 0.0277 0.592 1
Echinococcus granulosus ribonuclease H1 0.0044 0.0785 0.0811
Schistosoma mansoni neuropeptide receptor 0.0181 0.3806 0.3805
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0309 0.0499
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.001 0.004 0.004
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Brugia malayi Dopamine receptor protein 2 0.0181 0.3806 0.3933
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0168 0.0151
Schistosoma mansoni protein kinase 0.001 0.004 0.0039
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0249 0.0257
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0181 0.3806 0.3933
Echinococcus granulosus neuropeptide FF receptor 2 0.0181 0.3806 0.3933
Echinococcus granulosus neuropeptide Y receptor 0.0181 0.3806 0.3933
Schistosoma mansoni hypothetical protein 0.0181 0.3806 0.3805
Schistosoma mansoni neuropeptide F-like receptor 0.0181 0.3806 0.3805
Trypanosoma cruzi thymidylate kinase, putative 0.007 0.136 0.1795
Onchocerca volvulus 0.0181 0.3806 1
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.007 0.136 0.137
Brugia malayi Serotonin receptor 0.0181 0.3806 0.3933
Echinococcus multilocularis neuropeptide Y receptor 0.0181 0.3806 0.3933
Echinococcus granulosus neuropeptide Y receptor 0.0181 0.3806 0.3933
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0073 0.0074
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0017 0.0179 0.0178
Echinococcus granulosus alpha 1A adrenergic receptor 0.0181 0.3806 0.3933
Giardia lamblia Thymidine kinase 0.0277 0.592 1
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.2191 0.2909
Brugia malayi thymidylate kinase 0.007 0.136 0.1405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Echinococcus granulosus neuropeptide s receptor 0.0181 0.3806 0.3933
Echinococcus granulosus sex peptide receptor 0.0181 0.3806 0.3933
Trichomonas vaginalis DNA polymerase II, putative 0.0027 0.0393 0.0642
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Brugia malayi intermediate filament protein 0.0027 0.0397 0.0409
Echinococcus granulosus G protein coupled receptor 139 0.0181 0.3806 0.3933
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.0922 0.1199
Echinococcus granulosus g protein coupled receptor 0.0181 0.3806 0.3933
Brugia malayi reverse transcriptase 0.001 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Brugia malayi RNase H family protein 0.0044 0.0785 0.0811
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0453 0.0742
Echinococcus multilocularis g-protein coupled receptor 0.0181 0.3806 0.3933
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0168 0.0174
Loa Loa (eye worm) hypothetical protein 0.0017 0.018 0.0186
Trichomonas vaginalis thymidine kinase, putative 0.0277 0.592 1
Brugia malayi RE15519p 0.0181 0.3806 0.3933
Giardia lamblia Ribonuclease H 0.0044 0.0785 0.1325
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.2173 0.2214
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0176 0.0175
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.2173 0.2214
Onchocerca volvulus 0.0181 0.3806 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Echinococcus multilocularis orexin receptor type 2 0.0181 0.3806 0.3933
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0106 0.2148 0.2188
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0453 0.0742
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.2437 0.2488
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0168 0.026
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0027 0.0393 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0017 0.0179 0.0076
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Brugia malayi hypothetical protein 0.002 0.0249 0.0257
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0249 0.0257
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0344 0.7393 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0168 0.0095
Schistosoma mansoni serine/threonine protein kinase 0.001 0.004 0.0039
Trypanosoma cruzi ribonuclease H1, putative 0.0044 0.0785 0.1014
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0017 0.0179 0.014
Schistosoma mansoni intermediate filament proteins 0.0027 0.0397 0.0396
Echinococcus multilocularis O glycosyltransferase 0.0041 0.071 0.0733
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0309 0.0499
Echinococcus multilocularis g protein coupled receptor 0.0181 0.3806 0.3933
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0181 0.3806 0.3933
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0027 0.0393 0.0355
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus granulosus lamin 0.0027 0.0397 0.0409
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0274 0.044
Brugia malayi DNA polymerase alpha catalytic subunit 0.0049 0.0895 0.0924
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0017 0.0179 0.0076
Onchocerca volvulus 0.0181 0.3806 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0168 0.0151
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0344 0.7393 1
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0249 0.0258
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.2191 0.219
Brugia malayi putative neuropeptide receptor NPR1 0.0181 0.3806 0.3933
Schistosoma mansoni lamin 0.0027 0.0397 0.0396
Onchocerca volvulus 0.0027 0.0397 0.0948
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0181 0.3806 0.3933
Brugia malayi 6-phosphofructokinase 0.0108 0.2191 0.2264
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0249 0.0398
Echinococcus granulosus tachykinin peptides receptor 99D 0.0181 0.3806 0.3933
Onchocerca volvulus 0.0027 0.0397 0.0948
Brugia malayi Zinc knuckle family protein 0.001 0.004 0.004
Brugia malayi hypothetical protein 0.002 0.0249 0.0257
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0249 0.0258
Giardia lamblia Reverse transcriptase/endonuclease 0.001 0.004 0.0066
Schistosoma mansoni hypothetical protein 0.0181 0.3806 0.3805
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2191 0.3686
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0845 0.0873
Leishmania major thymidylate kinase-like protein 0.007 0.136 0.1776
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0249 0.0398
Trypanosoma brucei thymidine kinase 0.0277 0.592 0.5904
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Entamoeba histolytica Thymidylate kinase, putative 0.007 0.136 0.2222
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Brugia malayi larval opioid receptor 0.0181 0.3806 0.3933
Brugia malayi Tachykinin-like peptides receptor 99D 0.0181 0.3806 0.3933
Echinococcus multilocularis rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Loa Loa (eye worm) melatonin receptor type 1A 0.0181 0.3806 0.3934
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0168 0.026
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.2191 0.2265
Toxoplasma gondii DNA polymerase 0.0017 0.0179 0.0241
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0309 0.032
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0027 0.0393 0.0481
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0057 0.0024
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0181 0.3806 0.3933
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0453 0.0742
Brugia malayi follicle stimulating hormone receptor 0.0409 0.8819 0.9114
Mycobacterium ulcerans thymidylate synthase 0.0106 0.2148 0.2157
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0057 0.0018
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.001 0.004 0.0043
Schistosoma mansoni biogenic amine receptor 0.0181 0.3806 0.3805
Schistosoma mansoni ap endonuclease 0.0023 0.0309 0.0308
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.2191 0.2926
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0017 0.0179 0.0184
Brugia malayi hypothetical protein 0.0051 0.0922 0.0952
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0309 0.0319
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0181 0.3806 0.3933
Schistosoma mansoni biogenic amine (5HT) receptor 0.0181 0.3806 0.3805
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0017 0.0179 0.0369
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0249 0.0248
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0181 0.3806 0.3933
Onchocerca volvulus 0.0181 0.3806 1
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0249 0.0257
Onchocerca volvulus 0.0181 0.3806 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.004 0.004
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0041 0.0707 0.073
Echinococcus multilocularis g protein coupled receptor 0.0181 0.3806 0.3933
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.2191 0.219
Toxoplasma gondii thioredoxin reductase 0.0047 0.0845 0.1142
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0017 0.0179 0.0189
Schistosoma mansoni alpha-1 adrenergic receptor 0.0181 0.3806 0.3805
Echinococcus granulosus thymidylate synthase 0.0106 0.2148 0.2219
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0168 0.0226
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0453 0.0306
Echinococcus multilocularis serotonin receptor 0.0181 0.3806 0.3933
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0017 0.0179 0.0184
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0061 0.1148 0.1185
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0453 0.0611
Echinococcus granulosus RNA directed DNA polymerase 0.001 0.004 0.004
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0249 0.0257
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0309 0.0319
Brugia malayi PXA domain containing protein 0.002 0.0249 0.0257
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0453 0.0611
Loa Loa (eye worm) neuropeptide F receptor 0.0181 0.3806 0.3934
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0055 0.1016 0.098
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0181 0.3806 0.3805
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0181 0.3806 0.3933
Echinococcus multilocularis sex peptide receptor 0.0181 0.3806 0.3933
Onchocerca volvulus 0.0181 0.3806 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0181 0.3806 0.3933
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0181 0.3806 0.3805
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0077 0.008
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0084 0.1649 0.4273
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Schistosoma mansoni hypothetical protein 0.0181 0.3806 0.3805
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0249 0.0257
Brugia malayi Dihydrofolate reductase 0.0448 0.9675 1
Trypanosoma brucei thymidylate kinase, putative 0.007 0.136 0.1325
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0181 0.3806 0.3805
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0077 0.0051
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0309 0.1233
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.2173 0.2214
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0249 0.0248
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0453 0.0611
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.2191 0.2264
Echinococcus granulosus rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Echinococcus granulosus rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Schistosoma mansoni axis inhibition protein axin 0.002 0.0249 0.0248
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Brugia malayi neuropeptide F receptor 0.0181 0.3806 0.3933
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0168 0.0174
Schistosoma mansoni opsin-like receptor 0.0181 0.3806 0.3805
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0448 0.9675 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0181 0.3806 0.3933
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0845 0.0873
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0249 0.0257
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2191 0.3686
Brugia malayi hypothetical protein 0.001 0.004 0.004
Onchocerca volvulus 0.0181 0.3806 1
Schistosoma mansoni biogenic amine receptor 0.0181 0.3806 0.3805
Echinococcus granulosus rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0017 0.0188 0.0223
Loa Loa (eye worm) RGS-3 protein 0.002 0.0249 0.0258
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.004 0.004
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0017 0.0179 0.014
Plasmodium falciparum thioredoxin reductase 0.0016 0.0168 0.0226
Onchocerca volvulus 0.0181 0.3806 1
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0249 0.0258
Entamoeba histolytica hypothetical protein 0.002 0.0249 0.0327
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0181 0.3806 0.3933
Onchocerca volvulus DNA polymerase homolog 0.0017 0.0179 0.0369
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0181 0.3806 0.3805
Trypanosoma brucei ingi protein (ORF1) 0.0055 0.1016 0.098
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.012 0.0161
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.2191 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0453 0.0742
Leishmania major thymidine kinase, putative 0.0277 0.592 0.7993
Brugia malayi putative neuropeptide receptor 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.002 0.0249 0.0258
Trichomonas vaginalis thymidylate kinase, putative 0.007 0.136 0.2278
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0073 0.0074
Echinococcus granulosus neuropeptides capa receptor 0.0181 0.3806 0.3933
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.001 0.004 0.0066
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus multilocularis rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0249 0.0257
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0017 0.0179 0.0178
Loa Loa (eye worm) thymidylate kinase 0.007 0.136 0.1406
Onchocerca volvulus Putative thymidylate kinase 0.007 0.136 0.3505
Brugia malayi Melatonin receptor type 1A 0.0181 0.3806 0.3933
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0309 0.028
Echinococcus granulosus fmrfamide receptor 0.0181 0.3806 0.3933
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Brugia malayi G protein-coupled receptor F59B2.13 0.0181 0.3806 0.3933
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0168 0.0061
Loa Loa (eye worm) G-protein coupled receptor 0.0181 0.3806 0.3934
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0168 0.0173
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Brugia malayi reverse transcriptase 0.001 0.004 0.004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0181 0.3806 0.3934
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0168 0.0174
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.2173 0.0978
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0017 0.0179 0.0184
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0017 0.0179 0.0279
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0249 0.0257
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0168 0.0007
Echinococcus multilocularis neuropeptides capa receptor 0.0181 0.3806 0.3933
Schistosoma mansoni hypothetical protein 0.0181 0.3806 0.3805
Echinococcus granulosus allatostatin A receptor 0.0181 0.3806 0.3933
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.004 0.07 0.0946
Echinococcus granulosus neuropeptides capa receptor 0.0181 0.3806 0.3933
Echinococcus multilocularis rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.2191 0.2233
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0168 0.0174
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.2191 0.1
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Toxoplasma gondii thymidylate kinase 0.007 0.136 0.1839
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0181 0.3806 0.3933
Plasmodium falciparum thioredoxin reductase 0.0047 0.0845 0.1142
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0061 0.1148 0.1147
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0017 0.0179 0.0166
Mycobacterium tuberculosis Probable reductase 0.0107 0.2173 0.2214
Loa Loa (eye worm) hypothetical protein 0.0012 0.0082 0.0085
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0168 0.0055
Loa Loa (eye worm) hypothetical protein 0.0027 0.0397 0.041
Echinococcus granulosus hypothetical protein 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Brugia malayi hypothetical protein 0.001 0.004 0.004
Plasmodium falciparum thymidylate kinase 0.007 0.136 0.1839
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0082 0.0085
Trichomonas vaginalis thymidine kinase, putative 0.0277 0.592 1
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0017 0.0179 0.0301
Brugia malayi G-protein coupled receptor 0.0181 0.3806 0.3933
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0309 0.0271
Onchocerca volvulus 0.0181 0.3806 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus multilocularis allatostatin A receptor 0.0181 0.3806 0.3933
Echinococcus granulosus thymidylate kinase 0.007 0.136 0.1405
Loa Loa (eye worm) TYRA-2 protein 0.0181 0.3806 0.3934
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0168 0.0061
Schistosoma mansoni adenoreceptor 0.0181 0.3806 0.3805
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0017 0.0179 0.0184
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0181 0.3806 0.3933
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0017 0.0179 0.0301
Schistosoma mansoni phosphoglucomutase 0.0044 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Loa Loa (eye worm) hypothetical protein 0.002 0.0249 0.0258
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0249 0.0257
Schistosoma mansoni biogenic amine (5HT) receptor 0.0181 0.3806 0.3805
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0168 0.0151
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0168 0.0151
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Echinococcus multilocularis dihydrofolate reductase 0.0448 0.9675 1
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0028 0.0418 0.0514
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0093 0.0095
Onchocerca volvulus 0.0181 0.3806 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.2437 0.2488
Schistosoma mansoni histamine h1 receptor 0.0181 0.3806 0.3805
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0049 0.0895 0.1209
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0274 0.0282
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0181 0.3806 0.3934
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0168 0.0129
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0168 0.0226
Echinococcus granulosus expressed protein 0.0389 0.8385 0.8666
Schistosoma mansoni opsin-like receptor 0.0181 0.3806 0.3805
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0309 0.0521
Echinococcus multilocularis g protein coupled receptor 0.0181 0.3806 0.3933
Echinococcus multilocularis lamin 0.0027 0.0397 0.0409
Brugia malayi neuropeptide F receptor 0.0181 0.3806 0.3933
Schistosoma mansoni neuropeptide receptor 0.0181 0.3806 0.3805
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0041 0.071 0.0709
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0181 0.3806 0.3934
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.001 0.004 0.0043
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0249 0.0258
Plasmodium vivax glutathione reductase, putative 0.0047 0.0845 0.0993
Echinococcus multilocularis fmrfamide receptor 0.0181 0.3806 0.3933
Echinococcus granulosus axis inhibition protein axin 0.002 0.0249 0.0257
Schistosoma mansoni neuropeptide f receptor 76f 0.0181 0.3806 0.3805
Onchocerca volvulus 0.0106 0.2148 0.5597
Mycobacterium ulcerans hypothetical protein 0.0016 0.0162 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Echinococcus granulosus O glycosyltransferase 0.0041 0.071 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0249 0.0248
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.2191 0.2203
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0249 0.0248
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0181 0.3806 0.3805
Echinococcus granulosus g-protein coupled receptor 0.0181 0.3806 0.3933
Echinococcus multilocularis neuropeptide s receptor 0.0181 0.3806 0.3933
Echinococcus granulosus KRAB A domain containing protein 0.001 0.004 0.004
Schistosoma mansoni amine GPCR 0.0181 0.3806 0.3805
Brugia malayi GnHR receptor homolog 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Trypanosoma brucei trypanothione reductase 0.0047 0.0845 0.0809
Schistosoma mansoni amine GPCR 0.0181 0.3806 0.3805
Brugia malayi G protein-coupled receptor 0.0181 0.3806 0.3933
Schistosoma mansoni growth hormone secretagogue receptor 0.0181 0.3806 0.3805
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0453 0.0742
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0453 0.0611
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.2191 0.2265
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0168 0.0095
Echinococcus multilocularis G-protein coupled receptor, putative 0.0181 0.3806 0.3933
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0181 0.3806 0.3933
Echinococcus granulosus neuropeptide receptor A26 0.0181 0.3806 0.3933
Plasmodium falciparum glutathione reductase 0.0016 0.0168 0.0226
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0168 0.0167
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0106 0.2148 0.0947
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.1016 0.098
Loa Loa (eye worm) thymidylate synthase 0.0106 0.2148 0.222
Trypanosoma brucei ribonuclease H1 0.0044 0.0785 0.0749
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0017 0.0179 0.014
Onchocerca volvulus 0.0181 0.3806 1
Echinococcus multilocularis musashi 0.0027 0.0397 0.0409
Schistosoma mansoni regulator of G protein signaling 0.002 0.0249 0.0248
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0453 0.0763
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0249 0.0257
Treponema pallidum NADH oxidase 0.0016 0.0168 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Brugia malayi Serotonin receptor 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Brugia malayi hypothetical protein 0.0181 0.3806 0.3933
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0181 0.3806 0.3934
Brugia malayi reverse transcriptase 0.001 0.004 0.004
Schistosoma mansoni phosphoglucomutase 0.0044 0.0785 0.0785
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0249 0.0257
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.2437 0.1295
Echinococcus granulosus 7TM GPCR rhodopsin 0.0181 0.3806 0.3933
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Trichomonas vaginalis ribonuclease H1, putative 0.0044 0.0785 0.1306
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0168 0.0226
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus granulosus dihydrofolate reductase 0.0448 0.9675 1
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0249 0.0248
Echinococcus multilocularis thymidylate synthase 0.0106 0.2148 0.2219
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0181 0.3806 0.3933
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0274 0.044
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0274 0.0282
Schistosoma mansoni ap endonuclease 0.0023 0.0309 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0249 0.0257
Trypanosoma cruzi thymidine kinase, putative 0.0277 0.592 0.7998
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.004 0.004
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0448 0.9675 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0397 0.0409
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Schistosoma mansoni amine GPCR 0.0181 0.3806 0.3805
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.00000000011827
Onchocerca volvulus 0.0181 0.3806 1
Echinococcus multilocularis expressed protein 0.0389 0.8385 0.8666
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0009 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus multilocularis G protein coupled receptor 139 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Brugia malayi dihydrofolate reductase family protein 0.0448 0.9675 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0168 0.0129
Schistosoma mansoni neuropeptide F-like receptor 0.0181 0.3806 0.3805
Echinococcus multilocularis RNA directed DNA polymerase 0.001 0.004 0.004
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0453 0.0453
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0124 0.0127
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Schistosoma mansoni lamin 0.0027 0.0397 0.0396
Leishmania major hypothetical protein, conserved 0.0028 0.0418 0.0491
Toxoplasma gondii exonuclease III APE 0.0023 0.0309 0.0417
Schistosoma mansoni biogenic amine receptor 0.0181 0.3806 0.3805
Echinococcus granulosus somatostatin receptor 0.0181 0.3806 0.3933
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0168 0.0174
Echinococcus granulosus dro:myosuppressin receptor 0.0181 0.3806 0.3933
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0168 0.0129
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2191 0.364
Echinococcus multilocularis neuropeptide receptor A26 0.0181 0.3806 0.3933
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0168 0.0095
Echinococcus multilocularis thymidylate kinase 0.007 0.136 0.1405
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2191 0.3686
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Onchocerca volvulus 0.0181 0.3806 1
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2191 0.364
Echinococcus multilocularis dro:myosuppressin receptor 0.0181 0.3806 0.3933
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2191 0.3686
Echinococcus granulosus g protein coupled receptor 0.0181 0.3806 0.3933
Schistosoma mansoni phosphoglucomutase 0.0044 0.0785 0.0785
Echinococcus multilocularis neuropeptide receptor 0.0181 0.3806 0.3933
Trypanosoma brucei RNA helicase, putative 0.0463 1 1
Echinococcus granulosus orexin receptor type 2 0.0181 0.3806 0.3933
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.002 0.0249 0.0258
Brugia malayi thymidylate synthase 0.0106 0.2148 0.2219
Brugia malayi ORL1-like opioid receptor 0.0181 0.3806 0.3933
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.2173 0.2214
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0017 0.0179 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Echinococcus multilocularis neuropeptide Y receptor 0.0181 0.3806 0.3933
Trichomonas vaginalis thymidine kinase, putative 0.0277 0.592 1
Brugia malayi glutathione reductase 0.0047 0.0845 0.0873
Onchocerca volvulus Neuropeptide F receptor homolog 0.0181 0.3806 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0309 0.0256
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0309 0.0242
Echinococcus granulosus neuropeptide receptor 0.0181 0.3806 0.3933
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0249 0.0257
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0077 0.0051
Echinococcus granulosus peptide allatostatin:somatostatin 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0309 0.0728
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0181 0.3806 0.3805
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0017 0.0179 0.0184
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0397 0.041
Echinococcus granulosus tm gpcr rhodopsin 0.0181 0.3806 0.3933
Brugia malayi Cytochrome P450 family protein 0.0012 0.0077 0.0079
Loa Loa (eye worm) G-protein coupled receptor 0.0181 0.3806 0.3934
Trypanosoma cruzi ribonuclease H1, putative 0.0044 0.0785 0.1014
Giardia lamblia DNA polymerase alpha subunit A 0.0051 0.0942 0.159
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0249 0.0398
Schistosoma mansoni axis inhibition protein axin 0.002 0.0249 0.0248
Onchocerca volvulus Ribonuclease H1 homolog 0.0044 0.0785 0.198
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0017 0.0179 0.0076
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0015
Giardia lamblia CDC8 0.007 0.136 0.2296
Toxoplasma gondii ribonuclease HI protein 0.0044 0.0785 0.1061
Trichomonas vaginalis reverse transcriptases, putative 0.001 0.004 0.0043
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0249 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Brugia malayi RNase H family protein 0.0044 0.0785 0.0811
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.2191 0.216
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0017 0.0179 0.0279
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0249 0.0257
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Trypanosoma cruzi thymidine kinase, putative 0.0277 0.592 0.7998
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.001 0.004 0.0066
Brugia malayi sulfakinin receptor protein 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Giardia lamblia O-linked GlcNAc transferase 0.004 0.07 0.1181
Brugia malayi 6-phosphofructokinase 0.0108 0.2191 0.2264
Echinococcus multilocularis ribonuclease H1 0.0044 0.0785 0.0811
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0168 0.0226
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0249 0.0257
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0249 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0922 0.1536
Loa Loa (eye worm) hypothetical protein 0.0026 0.0386 0.0399
Brugia malayi hypothetical protein 0.001 0.004 0.004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0453 0.0611
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0453 0.1434
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0448 0.9675 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0309 0.0417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Onchocerca volvulus 0.0181 0.3806 1
Schistosoma mansoni amine GPCR 0.0181 0.3806 0.3805
Brugia malayi Thioredoxin reductase 0.0047 0.0845 0.0873
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0077 0.008
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0017 0.0179 0.0185
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0344 0.7393 0.7382
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.0922 0.0915
Loa Loa (eye worm) neuropeptide F receptor 0.0181 0.3806 0.3934
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.007 0.136 1
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0077 0.0037
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0017 0.0179 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0181 0.3806 0.3933
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0168 0.0133
Echinococcus granulosus neuropeptide receptor 0.0181 0.3806 0.3933
Echinococcus multilocularis neuropeptide FF receptor 2 0.0181 0.3806 0.3933
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0017 0.0179 0.0369
Echinococcus granulosus biogenic amine 5HT receptor 0.0181 0.3806 0.3933
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0181 0.3806 0.3805
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.001 0.004 0.0066
Echinococcus multilocularis somatostatin receptor 0.0181 0.3806 0.3933
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0453 0.0674
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0027 0.0393 0.0642
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.2437 0.2488
Schistosoma mansoni regulator of G protein signaling 0.002 0.0249 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0249 0.0398
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Schistosoma mansoni opsin-like receptor 0.0181 0.3806 0.3805
Leishmania major cytochrome p450-like protein 0.0012 0.0077 0.0027
Trypanosoma brucei ingi protein (ORF1) 0.0055 0.1016 0.098
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0017 0.0179 0.0184
Loa Loa (eye worm) glutathione reductase 0.0047 0.0845 0.0874
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0041 0.0707 0.0731
Loa Loa (eye worm) hypothetical protein 0.002 0.0249 0.0258
Chlamydia trachomatis dihydrofolate reductase 0.0448 0.9675 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0124 0.0128
Echinococcus granulosus intermediate filament protein 0.0027 0.0397 0.0409
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0181 0.3806 1
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2191 0.364
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0397 0.041
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Schistosoma mansoni scy1(yeast) protein kinase-like 0.001 0.004 0.0039
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0181 0.3806 0.3933
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0181 0.3806 0.3933
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0181 0.3806 0.3933
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0409 0.8819 0.9115
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0249 0.0257
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0344 0.7393 1
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0028 0.0418 0.0514
Chlamydia trachomatis thymidylate kinase 0.007 0.136 0.126
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0181 0.3806 0.3805
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0168 0.0174
Echinococcus multilocularis lamin dm0 0.0027 0.0397 0.0409
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0017 0.0179 0.0241
Treponema pallidum ribonuclease H (rnhA) 0.0044 0.0785 0.3074
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0344 0.7393 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0168 0.0282
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0168 0.0173
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0453 0.0306
Echinococcus granulosus rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Brugia malayi Cytochrome P450 family protein 0.0012 0.0077 0.0079
Brugia malayi PXA domain containing protein 0.002 0.0249 0.0257
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0181 0.3806 0.3805
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0168 0.0174
Echinococcus multilocularis serotonin receptor 0.0181 0.3806 0.3933
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0181 0.3806 0.3805
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.004 0.004
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0106 0.2148 0.2147
Echinococcus multilocularis neuropeptide receptor 0.0181 0.3806 0.3933
Loa Loa (eye worm) phosphofructokinase 0.0108 0.2191 0.2265
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.004 0.004
Mycobacterium ulcerans thymidylate kinase 0.007 0.136 0.1337
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0168 0.0173
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Leishmania major ribonuclease H1, putative 0.0044 0.0785 0.0992
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0093 0.0095
Onchocerca volvulus 0.0181 0.3806 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Brugia malayi AKH receptor 0.0181 0.3806 0.3933
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0218 0.0293
Brugia malayi Dopamine receptor protein 1 0.0181 0.3806 0.3933
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0249 0.0257
Trypanosoma cruzi thymidylate kinase, putative 0.007 0.136 0.1795
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0017 0.0179 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0181 0.3806 0.3805
Echinococcus granulosus rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0017 0.0179 0.0279
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0181 0.3806 0.3933
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.2173 0.2214
Schistosoma mansoni regulator of G protein signaling 0.002 0.0249 0.0248
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0309 0.0343
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0168 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0181 0.3806 0.3933
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.004 0.004
Toxoplasma gondii DNA polymerase family B protein 0.0017 0.0179 0.0241
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0845 0.1095
Trypanosoma brucei thymidylate kinase, putative 0.007 0.136 0.1325
Brugia malayi phosphofructokinase 0.0108 0.2191 0.2264
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0181 0.3806 0.3805
Schistosoma mansoni thymidylate kinase 0.007 0.136 0.1359
Schistosoma mansoni regulator of G protein signaling 0.002 0.0249 0.0248
Trypanosoma brucei unspecified product 0.0055 0.1016 0.098
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0181 0.3806 0.3805
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0249 0.0257
Treponema pallidum thymidylate kinase (tmk) 0.007 0.136 0.5905
Schistosoma mansoni regulator of G protein signaling 0.002 0.0249 0.0248
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0309 0.0366
Schistosoma mansoni hypothetical protein 0.007 0.136 0.1359
Brugia malayi Zinc knuckle family protein 0.001 0.004 0.004
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.2191 0.2264
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0249 0.0398
Loa Loa (eye worm) hypothetical protein 0.0181 0.3806 0.3934
Echinococcus granulosus tm gpcr rhodopsin 0.0181 0.3806 0.3933
Echinococcus multilocularis rhodopsin orphan GPCR 0.0181 0.3806 0.3933
Giardia lamblia O-linked GlcNAc transferase 0.0024 0.0331 0.0557
Brugia malayi G-protein coupled receptor 0.0181 0.3806 0.3933
Plasmodium falciparum glutathione reductase 0.0047 0.0845 0.1142
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0249 0.0257
Schistosoma mansoni neuropeptide receptor 0.0181 0.3806 0.3805
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0057 0.0073
Onchocerca volvulus 0.0181 0.3806 1
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0017 0.0179 0.0184

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.87 nM Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization ChEMBL. 24755525
Emax (functional) = 100 % Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization relative to pyr-apelin-13 ChEMBL. 24755525
Kcat/Km (binding) = 2 10^6/M/s Ratio of Kcat to Km for ACE2 (unknown origin) ChEMBL. 18324760
Kcat/Km (binding) = 2 10^6/M/s Ratio of Kcat to Km for ACE2 (unknown origin) ChEMBL. 18324760

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.