TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 495.571 | Formula: C24H21N3O5S2
H donors: 1 H acceptors: 6 LogP: 3.8 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)COc1ccc(cc1)CN(S(=O)(=O)c1ccccc1)Cc1ccc(cc1)c1nnsc1
InChi: 1S/C24H21N3O5S2/c28-24(29)16-32-21-12-8-19(9-13-21)15-27(34(30,31)22-4-2-1-3-5-22)14-18-6-10-20(11-7-18)23-17-33-26-25-23/h1-13,17H,14-16H2,(H,28,29)
InChiKey: YMJHXDOXNYUOPD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0062	0.6595
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0451	0.1729
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0089	0.0903	0.3527
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Leishmania major	cytochrome p450-like protein	0.0023	0.0111	0.1193
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0564	0.216
Entamoeba histolytica	hypothetical protein	0.004	0.0307	0.0621
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0438	0.1713
Entamoeba histolytica	CAAX amino terminal protease family	0.0018	0.0048	0.0028
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0023	0.0023
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.009	0.0916	1
Loa Loa (eye worm)	NADH-ubiquinone oxidoreductase 51 kDa subunit	0.009	0.0916	0.351
Onchocerca volvulus		0.0033	0.0225	0.064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0038	0.0287	0.0287
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0038	0.0287	0.3119
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0.009	0.0916	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0036	0.0036
Entamoeba histolytica	hypothetical protein	0.004	0.0307	0.0621
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0111	0.0426
Echinococcus multilocularis		0.0015	0.0002	0.0002
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0023	0.0023
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0023	0.0081
Loa Loa (eye worm)	acetylcholinesterase 1	0.0225	0.2556	0.9792
Entamoeba histolytica	CAAX amino terminal protease family	0.0018	0.0048	0.0028
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0018	0.0048	0.0504
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0038	0.0287	0.1116
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0038	0.0287	0.0287
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0036	0.013
Schistosoma mansoni	gliotactin	0.0038	0.0287	0.1116
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0626	0.6828
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0225	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0287	0.11
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0438	0.1706
Echinococcus multilocularis	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.009	0.0916	0.0916
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0062	0.0059
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0038	0.0287	0.1124
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0016	0.0023	0.0089
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0036	0.0138
Brugia malayi	Carboxylesterase family protein	0.0038	0.0287	0.1093
Brugia malayi	intermediate filament protein	0.003	0.0187	0.0708
Trichomonas vaginalis	spcc417.12 protein, putative	0.0038	0.0287	0.0849
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0564	0.2199
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0287	0.11
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0287	0.11
Leishmania major	hypothetical protein, conserved	0.0016	0.0023	0.0225
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0564	0.2199
Loa Loa (eye worm)	cytochrome P450	0.0015	0.0002	0.0008
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0023	0.0225
Mycobacterium ulcerans	membrane protein ComEA	0.002	0.0069	0.0731
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0036	0.037
Echinococcus multilocularis	musashi	0.003	0.0187	0.0187
Brugia malayi	Carboxylesterase family protein	0.0225	0.2556	0.9792
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative	0.009	0.0916	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0036	0.0141
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0062	0.0062
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0024	0.0091
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.054	0.054
Mycobacterium leprae	putative cytochrome p450	0.0015	0.0002	0.5
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.054	0.2062
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0307	0.1195
Onchocerca volvulus	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog	0.0048	0.041	0.1265
Chlamydia trachomatis	hypothetical protein	0.0018	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0451	0.1729
Echinococcus granulosus	GPCR family 2	0.0016	0.0024	0.0093
Toxoplasma gondii	hypothetical protein	0.0018	0.0048	0.2063
Onchocerca volvulus		0.003	0.0187	0.0509
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0048	0.0504
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.0089	0.0903	0.9855
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0024	0.0093
Plasmodium vivax	SET domain protein, putative	0.0033	0.0225	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0062	0.0087
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.0018	0.0048	0.0504
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0438	0.0438
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0451	0.1722
Brugia malayi	CAAX amino terminal protease family protein	0.0089	0.0903	0.3454
Brugia malayi	Pre-SET motif family protein	0.0229	0.2611	1
Giardia lamblia	DNA repair protein RAD52	0.0377	0.4404	1
Echinococcus multilocularis	neuroligin	0.0038	0.0287	0.0287
Onchocerca volvulus		0.003	0.0187	0.0509
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0038	0.0287	0.1116
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0091	0.0934	0.3647
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)	0.009	0.0916	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0024	0.0085
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0024	0.0083
Onchocerca volvulus		0.0038	0.0287	0.0849
Echinococcus multilocularis	CAAX prenyl protease 2	0.0089	0.0903	0.0903
Onchocerca volvulus		0.0038	0.0287	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0225	0.0863
Schistosoma mansoni	jumonji domain containing protein	0.0061	0.0564	0.2199
Loa Loa (eye worm)	fibroinase	0.0017	0.0036	0.0138
Leishmania major	cathepsin L-like protease	0.0017	0.0036	0.037
Brugia malayi	jmjC domain containing protein	0.0016	0.0023	0.0079
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0023	0.0089
Leishmania major	cathepsin L-like protease	0.0017	0.0036	0.037
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.0018	0.0048	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0287	0.11
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0036	0.0138
Brugia malayi	NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor	0.009	0.0916	0.3505
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0016	0.0023	0.0921
Loa Loa (eye worm)	carboxylesterase	0.0038	0.0287	0.11
Echinococcus multilocularis	carboxylesterase 5A	0.0225	0.2556	0.2556
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0934	0.3577
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0111	0.0426
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0024	0.0024
Onchocerca volvulus		0.0261	0.2995	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0038	0.0287	0.3119
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0048	0.0504
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0024	0.0083
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.054	0.5884
Echinococcus multilocularis	cysteine protease	0.0017	0.0036	0.0036
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0023	0.0081
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0023	0.0089
Entamoeba histolytica	hypothetical protein	0.004	0.0307	0.0621
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0438	0.1713
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.0557	0.6068
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0934	0.3577
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0061	0.0564	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0029	0.018	0.069
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0038	0.0287	0.3119
Toxoplasma gondii	CAAX amino terminal protease family protein	0.0018	0.0048	0.2063
Schistosoma mansoni	hypothetical protein	0.0035	0.0253	0.0984
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0111	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0253	0.0971
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0062	0.1934
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0069	0.0731
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0062	0.0654
Toxoplasma gondii	hypothetical protein	0.0018	0.0048	0.2063
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0023	0.0087
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0225	0.0881
Echinococcus granulosus	neuroligin	0.0038	0.0287	0.1124
Schistosoma mansoni	BC026374 protein (S09 family)	0.0038	0.0287	0.1116
Echinococcus granulosus	acetylcholinesterase	0.0225	0.2556	1
Brugia malayi	Carboxylesterase family protein	0.0225	0.2556	0.9792
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.0089	0.0903	0.9855
Brugia malayi	jmjC domain containing protein	0.0016	0.0023	0.0079
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0036	0.037
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0062	0.0654
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0062	0.0087
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0038	0.0287	0.1116
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0062	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0023	0.0087
Schistosoma mansoni	NADH-ubiquinone oxidoreductase	0.009	0.0916	0.3579
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0036	0.0036
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0229	0.2611	1
Entamoeba histolytica	hypothetical protein	0.004	0.0307	0.0621
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0111	0.1193
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0038	0.0287	0.3119
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0062	0.0654
Entamoeba histolytica	CAAX prenyl protease family	0.0089	0.0903	0.1985
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.024	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0036	0.0138
Echinococcus granulosus	carboxylesterase 5A	0.0225	0.2556	1
Mycobacterium leprae	Conserved hypothetical protein	0.0015	0.0002	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0438	0.1706
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0903	0.3459
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0036	0.0141
Schistosoma mansoni	ap endonuclease	0.0019	0.0062	0.0234
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.009	0.0916	0.2975
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0023	0.0087
Leishmania major	cathepsin L-like protease	0.0017	0.0036	0.037
Onchocerca volvulus		0.0038	0.0287	0.0849
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0038	0.0287	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0024	0.0091
Echinococcus granulosus	lysine specific demethylase 5A	0.0061	0.0564	0.2206
Brugia malayi	jmjC domain containing protein	0.0061	0.0564	0.2153
Loa Loa (eye worm)	hypothetical protein	0.0225	0.2556	0.9792
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0111	0.1193
Onchocerca volvulus		0.0085	0.0861	0.279
Brugia malayi	jmjC domain containing protein	0.0061	0.0564	0.2153
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0225	0.0874
Toxoplasma gondii	cathepsin CPL	0.0017	0.0036	0.1517
Onchocerca volvulus		0.0038	0.0287	0.0849
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0062	0.0237
Mycobacterium ulcerans	integral membrane protein	0.0018	0.0048	0.0504
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0036	0.013
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0023	0.0023
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0024	0.0024
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0036	0.3395
Echinococcus granulosus	cathepsin l1	0.0017	0.0036	0.0141
Schistosoma mansoni	lamin	0.003	0.0187	0.0723
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0023	0.0087
Loa Loa (eye worm)	hypothetical protein	0.003	0.0187	0.0715
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.0089	0.0903	0.293
Brugia malayi	Carboxylesterase family protein	0.0038	0.0287	0.1093
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0016	0.0023	0.0225
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0111	0.1193
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.0626	0.6828
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.009	0.0916	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0024	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0287	0.11
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0107	0.1128	0.2501
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0038	0.0287	0.0849
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0438	0.1677
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.054	0.5884
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0062	0.0654
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0626	0.6828
Echinococcus granulosus	cytochrome P450 2K1	0.0015	0.0002	0.0008
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0492	0.1884
Plasmodium falciparum	protease, putative	0.0018	0.0048	0.6506
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0187	0.0708
Echinococcus granulosus	lamin	0.003	0.0187	0.073
Plasmodium vivax	vivapain-2	0.0017	0.0036	0.0656
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0062	0.0242
Mycobacterium tuberculosis	Probable integral membrane protein	0.0018	0.0048	0.0504
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0225	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0024	0.0085
Mycobacterium ulcerans	NADH dehydrogenase I subunit F	0.009	0.0916	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0059	0.054	0.5884
Schistosoma mansoni	hypothetical protein	0.0016	0.0024	0.0085
Schistosoma mansoni	intermediate filament proteins	0.003	0.0187	0.0723
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0062	0.0229
Leishmania major	cathepsin L-like protease	0.0017	0.0036	0.037
Onchocerca volvulus		0.0091	0.0934	0.3034
Loa Loa (eye worm)	carboxylesterase	0.0225	0.2556	0.9792
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0059	0.054	0.2106
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0036	0.0036
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0377	0.4404	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0019	0.0073
Echinococcus multilocularis	lysine specific demethylase 5A	0.0061	0.0564	0.0564
Echinococcus granulosus	NADH dehydrogenase ubiquinone flavoprotein 1	0.009	0.0916	0.3584
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.009	0.0916	0.2975
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0062	1
Echinococcus granulosus	BC026374 protein S09 family	0.0038	0.0287	0.1124
Brugia malayi	Carboxylesterase family protein	0.0038	0.0287	0.1093
Schistosoma mansoni	hypothetical protein	0.004	0.0307	0.1195
Brugia malayi	jmjC domain containing protein	0.0016	0.0023	0.0079
Echinococcus multilocularis	para nitrobenzyl esterase	0.0038	0.0287	0.0287
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0036	0.0036
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0016	0.0023	0.0921
Loa Loa (eye worm)	ctsf protein	0.0017	0.0036	0.0138
Brugia malayi	hypothetical protein	0.0038	0.0287	0.1093
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0023	0.0089
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0023	0.0081
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0023	0.0081
Brugia malayi	hypothetical protein	0.004	0.0307	0.117
Echinococcus multilocularis	lamin dm0	0.003	0.0187	0.0187
Schistosoma mansoni	ap endonuclease	0.0019	0.0062	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0287	0.11
Schistosoma mansoni	acetylcholinesterase	0.0038	0.0287	0.1116
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0036	0.013
Echinococcus granulosus	intermediate filament protein	0.003	0.0187	0.073
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0016	0.0023	0.0023
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0307	0.0307
Echinococcus multilocularis	acetylcholinesterase	0.0225	0.2556	0.2556
Echinococcus granulosus	lamin dm0	0.003	0.0187	0.073
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0111	0.0418
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0036	0.013
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0111	0.1193
Echinococcus granulosus	CAAX prenyl protease 2	0.0089	0.0903	0.3533
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0036	0.0133
Leishmania major	cathepsin L-like protease	0.0066	0.0626	0.6828
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0451	0.1722
Plasmodium vivax	protease, putative	0.0018	0.0048	0.1258
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0036	0.0133
Toxoplasma gondii	exonuclease III APE	0.0019	0.0062	0.2677
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0225	0.0225
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0225	0.2556	0.9792
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0091	0.0934	0.3647
Brugia malayi	Cytochrome P450 family protein	0.0034	0.024	0.0911
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0036	0.013
Leishmania major	cathepsin L-like protease	0.0066	0.0626	0.6828
Onchocerca volvulus		0.0038	0.0287	0.0849
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.0089	0.0903	0.9855
Leishmania major	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.009	0.0916	1
Trypanosoma brucei	CAAX amino terminal protease, putative	0.0089	0.0903	0.9855
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0225	0.2556	1
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0089	0.0903	0.3527
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0225	0.0874
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0307	0.1202
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0036	0.013
Entamoeba histolytica	hypothetical protein	0.0107	0.1128	0.2501
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0287	0.11
Loa Loa (eye worm)	carboxylesterase	0.0038	0.0287	0.11
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0059	0.054	0.5884
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0023	0.0023
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0626	0.6828
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0438	0.1706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Loa Loa (eye worm)	cysteine protease	0.0017	0.0036	0.0138
Echinococcus granulosus	acetylcholinesterase	0.0225	0.2556	1
Echinococcus multilocularis	acetylcholinesterase	0.0225	0.2556	0.2556
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0438	0.1671
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0023	0.0225
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0036	0.3395
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0061	0.0564	0.2206
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0023	0.0081
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase I subunit F	0.009	0.0916	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0187	0.0715
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0187	0.0715
Brugia malayi	Pre-SET motif family protein	0.0033	0.0225	0.0856
Leishmania major	cathepsin L-like protease	0.0017	0.0036	0.037
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0225	0.0225
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0438	0.0438
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Leishmania major	cathepsin L-like protease	0.0066	0.0626	0.6828
Echinococcus multilocularis	cysteine protease	0.0017	0.0036	0.0036
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0024	0.0093
Schistosoma mansoni	lamin	0.003	0.0187	0.0723
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0036	0.013
Plasmodium vivax	vivapain-2	0.0017	0.0036	0.0656
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0019	0.0065
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0062	0.0654
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0253	0.0964
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0036	0.3395
Echinococcus granulosus	para nitrobenzyl esterase	0.0038	0.0287	0.1124
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0111	0.0426
Treponema pallidum	nitrogen fixation protein (rnfC)	0.002	0.0069	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.0455	0.4954
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Brugia malayi	Carboxylesterase family protein	0.0038	0.0287	0.1093
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0023	0.0089
Brugia malayi	jmjC domain containing protein	0.0016	0.0023	0.0079
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.054	0.2112
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0023	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0023	0.0087
Giardia lamblia	Hypothetical protein	0.0089	0.0903	0.1937
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0225	0.0874
Echinococcus multilocularis	lamin	0.003	0.0187	0.0187
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0211	0.0824
Brugia malayi	Trypsin family protein	0.0091	0.0934	0.3571
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0626	0.6828
Trichomonas vaginalis	set domain proteins, putative	0.0261	0.2995	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 54.1 uM	Inhibition of PTP1B (unknown origin)	ChEMBL.	18372175
IC50 (binding)	= 54.1 uM	Inhibition of PTP1B (unknown origin)	ChEMBL.	18372175

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 511929