TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.901 | Formula: C23H23ClN3O2-
H donors: 1 H acceptors: 1 LogP: 4.36 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(Cn1c2ccccc2n(c1=N)Cc1ccccc1)COc1ccccc1.[Cl-]
InChi: 1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H/p-1
InChiKey: KDMXJFUGIDGZQL-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0046	0.0153	0.0204
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0132	0.2132	0.7209
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0359	0.0313
Leishmania major	beta tubulin	0.0166	0.2921	1
Entamoeba histolytica	tubulin gamma chain	0.0101	0.1412	0.4675
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0132	0.2132	0.7209
Echinococcus multilocularis	tubulin alpha chain	0.0152	0.2584	0.2876
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Echinococcus granulosus	short transient receptor potential channel 6	0.0083	0.1008	0.1061
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0166	0.2921	0.3264
Echinococcus granulosus	tubulin alpha chain	0.0152	0.2584	0.2876
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.0683	0.0686
Echinococcus multilocularis	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Schistosoma mansoni	tubulin subunit alpha	0.0152	0.2584	0.2519
Leishmania major	epsilon tubulin, putative	0.0101	0.1412	0.466
Trichomonas vaginalis	tubulin, putative	0.0057	0.0401	0.0807
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0108	0.1574	0.3895
Chlamydia trachomatis	dihydrofolate reductase	0.0345	0.7056	0.5
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0132	0.2132	0.7209
Loa Loa (eye worm)	alpha-tubulin	0.0152	0.2584	0.2947
Trichomonas vaginalis	tubulin alpha chain, putative	0.0057	0.0401	0.0807
Trichomonas vaginalis	tubulin gamma chain, putative	0.0101	0.1412	0.3469
Loa Loa (eye worm)	tubulin beta chain	0.0166	0.2921	0.3331
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0218	0.4117	0.4641
Echinococcus granulosus	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Loa Loa (eye worm)	BEN-1 protein	0.0166	0.2921	0.3331
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0359	0.0274
Echinococcus granulosus	tubulin alpha 1C chain	0.0152	0.2584	0.2876
Echinococcus multilocularis	tubulin alpha 3 chain	0.0152	0.2584	0.2876
Schistosoma mansoni	inositol transporter	0.0046	0.0153	0.0066
Schistosoma mansoni	tubulin subunit beta	0.0166	0.2921	0.2859
Schistosoma mansoni	tubulin subunit alpha	0.0152	0.2584	0.2519
Brugia malayi	Tubulin beta-1 chain	0.0166	0.2921	0.3264
Loa Loa (eye worm)	BEN-1 protein	0.0166	0.2921	0.3331
Plasmodium falciparum	alpha tubulin 2	0.0152	0.2584	0.8808
Giardia lamblia	Beta tubulin	0.0166	0.2921	1
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0345	0.7056	1
Trypanosoma brucei	beta tubulin	0.0166	0.2921	1
Schistosoma mansoni	inositol transporter	0.0046	0.0153	0.0066
Echinococcus multilocularis	dihydrofolate reductase	0.0345	0.7056	0.8026
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0046	0.0153	0.0076
Schistosoma mansoni	alpha tubulin	0.0152	0.2584	0.2519
Brugia malayi	alpha-tubulin	0.0152	0.2584	0.2876
Trypanosoma cruzi	alpha tubulin, putative	0.0152	0.2584	0.8808
Echinococcus multilocularis	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Leishmania major	beta tubulin	0.0166	0.2921	1
Giardia lamblia	Alpha-tubulin	0.0152	0.2584	0.8808
Echinococcus multilocularis	peroxisome assembly protein 26	0.0152	0.2584	0.2876
Echinococcus granulosus	transient receptor potential gamma protein	0.0123	0.1924	0.2116
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0132	0.2132	0.7209
Trichomonas vaginalis	tubulin beta chain, putative	0.0166	0.2921	0.7444
Trichomonas vaginalis	tubulin beta chain, putative	0.0152	0.2584	0.6557
Brugia malayi	Sodium:solute symporter family protein	0.0046	0.0153	0.0076
Schistosoma mansoni	alpha tubulin	0.0152	0.2584	0.2519
Leishmania major	beta tubulin	0.0166	0.2921	1
Trypanosoma brucei	alpha tubulin, putative	0.0057	0.0401	0.1084
Echinococcus granulosus	tubulin alpha chain	0.0152	0.2584	0.2876
Echinococcus granulosus	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Echinococcus multilocularis	tubulin alpha chain	0.0152	0.2584	0.2876
Trichomonas vaginalis	tubulin alpha chain, putative	0.0057	0.0401	0.0807
Plasmodium vivax	tubulin alpha chain, putative	0.0152	0.2584	0.8808
Schistosoma mansoni	tubulin subunit epsilon	0.0101	0.1412	0.1337
Echinococcus granulosus	tubulin delta chain	0.0044	0.0095	0.0009
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0166	0.2921	0.7444
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0152	0.2584	0.6557
Echinococcus granulosus	tubulin gamma 1 chain	0.0101	0.1412	0.1526
Leishmania major	beta tubulin	0.0166	0.2921	1
Echinococcus multilocularis	tubulin epsilon chain	0.0101	0.1412	0.1526
Trichomonas vaginalis	tubulin, putative	0.0057	0.0401	0.0807
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0166	0.2921	0.7444
Echinococcus granulosus	TRP transient receptor potential channel	0.0049	0.0225	0.016
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0359	0.0313
Schistosoma mansoni	transient receptor potential channel 4	0.0123	0.1924	0.1853
Brugia malayi	Cell division protein ftsZ	0.0044	0.0095	0.0009
Giardia lamblia	Beta tubulin	0.0166	0.2921	1
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0044	0.0095	0.5
Leishmania major	beta tubulin	0.0166	0.2921	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Brugia malayi	Tubulin alpha chain	0.0152	0.2584	0.2876
Schistosoma mansoni	high-affinity choline transporter	0.042	0.877	0.8759
Schistosoma mansoni	tubulin subunit beta	0.0166	0.2921	0.2859
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0132	0.2132	0.7209
Toxoplasma gondii	alpha tubulin TUBA1	0.0152	0.2584	0.8808
Trichomonas vaginalis	tubulin alpha chain, putative	0.0101	0.1412	0.3469
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0345	0.7056	1
Entamoeba histolytica	tubulin family protein	0.0166	0.2921	1
Trypanosoma brucei	beta tubulin	0.0166	0.2921	1
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Echinococcus granulosus	Tubulin alpha 1 chain	0.0152	0.2584	0.2876
Echinococcus multilocularis	tubulin beta 1 chain	0.0166	0.2921	0.3264
Leishmania major	beta tubulin	0.0166	0.2921	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0083	0.1008	0.1061
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0046	0.0153	0.0076
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0359	0.0274
Echinococcus multilocularis	tubulin alpha 3 chain	0.0152	0.2584	0.2876
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0101	0.1412	0.466
Echinococcus multilocularis	tubulin alpha chain	0.0152	0.2584	0.2876
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.0401	0.0807
Echinococcus granulosus	tubulin subunit beta	0.0166	0.2921	0.3264
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Echinococcus granulosus	transient receptor potential ion channel A	0.0113	0.1699	0.1856
Loa Loa (eye worm)	tubulin alpha 2	0.0108	0.1574	0.1794
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0067	0.0623	0.0617
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0046	0.0153	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0153	0.0174
Leishmania major	beta tubulin	0.0166	0.2921	1
Trypanosoma cruzi	tubulin gamma chain	0.0101	0.1412	0.466
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0152	0.2584	0.6557
Leishmania major	beta tubulin	0.0166	0.2921	1
Leishmania major	beta tubulin	0.0166	0.2921	1
Trypanosoma brucei	beta tubulin	0.0101	0.1412	0.466
Schistosoma mansoni	sodium/solute symporter	0.0046	0.0153	0.0066
Echinococcus granulosus	tubulin subunit TubB	0.0152	0.2584	0.2876
Brugia malayi	tubulin alpha chain - mouse	0.0152	0.2584	0.2876
Echinococcus granulosus	beta tubulin	0.0166	0.2921	0.3264
Echinococcus granulosus	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Plasmodium falciparum	alpha tubulin 1	0.0152	0.2584	0.8808
Schistosoma mansoni	tubulin subunit alpha	0.0044	0.0095	0.0008
Leishmania major	beta tubulin	0.0166	0.2921	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0166	0.2921	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0359	0.0313
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0108	0.1574	0.1794
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0132	0.2132	0.7209
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1267	0.1445
Schistosoma mansoni	transient receptor potential channel	0.0083	0.1008	0.093
Echinococcus multilocularis	tubulin alpha chain	0.0152	0.2584	0.2876
Giardia lamblia	Gamma tubulin	0.0101	0.1412	0.466
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0067	0.0623	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1574	0.1794
Brugia malayi	beta-tubulin, identical	0.0166	0.2921	0.3264
Trichomonas vaginalis	tubulin, putative	0.0166	0.2921	0.7444
Brugia malayi	dihydrofolate reductase family protein	0.0345	0.7056	0.8026
Schistosoma mansoni	lipoxygenase	0.0067	0.0623	0.0541
Trypanosoma brucei	tubulin gamma chain	0.0101	0.1412	0.466
Echinococcus granulosus	Tubulin alpha 1 chain	0.0152	0.2584	0.2876
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Brugia malayi	tubulin alpha-2 chain	0.0152	0.2584	0.2876
Schistosoma mansoni	tubulin subunit beta	0.0166	0.2921	0.2859
Trypanosoma brucei	epsilon tubulin	0.0101	0.1412	0.466
Trichomonas vaginalis	tubulin gamma chain, putative	0.0166	0.2921	0.7444
Brugia malayi	GH02984p	0.042	0.877	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0166	0.2921	0.3331
Brugia malayi	Tubulin alpha chain	0.0044	0.0095	0.0009
Echinococcus multilocularis	tubulin alpha 1C chain	0.0152	0.2584	0.2876
Trichomonas vaginalis	tubulin alpha chain, putative	0.0057	0.0401	0.0807
Loa Loa (eye worm)	tubulin beta chain	0.0044	0.0095	0.0108
Echinococcus granulosus	peroxisome assembly protein 26	0.0152	0.2584	0.2876
Echinococcus granulosus	tubulin alpha chain	0.0152	0.2584	0.2876
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0359	0.0409
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0152	0.2584	0.2876
Plasmodium vivax	tubulin beta chain, putative	0.0166	0.2921	1
Trypanosoma brucei	alpha tubulin	0.0152	0.2584	0.8808
Leishmania major	beta tubulin	0.0166	0.2921	1
Echinococcus multilocularis	tubulin subunit TubB	0.0152	0.2584	0.2876
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0152	0.2584	0.6557
Echinococcus multilocularis	transient receptor potential gamma protein	0.0123	0.1924	0.2116
Trypanosoma brucei	alpha tubulin	0.0152	0.2584	0.8808
Echinococcus granulosus	high affinity choline transporter 1	0.042	0.877	1
Echinococcus granulosus	dihydrofolate reductase	0.0345	0.7056	0.8026
Schistosoma mansoni	tubulin subunit beta	0.0166	0.2921	0.2859
Trichomonas vaginalis	tubulin beta chain, putative	0.0152	0.2584	0.6557
Echinococcus multilocularis	tubulin subunit beta	0.0166	0.2921	0.3264
Echinococcus multilocularis	beta tubulin	0.0166	0.2921	0.3264
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0152	0.2584	0.2876
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.0683	0.0686
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0359	0.0313
Schistosoma mansoni	tubulin subunit delta	0.0044	0.0095	0.0008
Echinococcus granulosus	beta tubulin	0.0166	0.2921	0.3264
Brugia malayi	Transient-receptor-potential like protein	0.0049	0.0225	0.016
Onchocerca volvulus		0.0057	0.0401	1
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0046	0.0153	0.0076
Echinococcus granulosus	sodium:glucose cotransporter	0.0046	0.0153	0.0076
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0359	0.0274
Brugia malayi	Tubulin beta chain	0.0044	0.0095	0.0009
Echinococcus granulosus	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Trichomonas vaginalis	tubulin beta chain, putative	0.0152	0.2584	0.6557
Loa Loa (eye worm)	alpha-tubulin	0.0152	0.2584	0.2947
Trypanosoma cruzi	beta tubulin, putative	0.0166	0.2921	1
Echinococcus multilocularis	tubulin alpha	0.0101	0.1412	0.1526
Loa Loa (eye worm)	hypothetical protein	0.042	0.877	1
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0345	0.7056	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0152	0.2584	0.2876
Echinococcus granulosus	Tubulin alpha 1 chain	0.0152	0.2584	0.2876
Echinococcus granulosus	short transient receptor potential channel 6	0.0083	0.1008	0.1061
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Trypanosoma brucei	beta tubulin	0.0166	0.2921	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0101	0.1412	0.466
Leishmania major	gamma-tubulin	0.0101	0.1412	0.466
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0152	0.2584	0.2876
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0069	0.0683	0.0845
Plasmodium vivax	tubulin gamma chain, putative	0.0101	0.1412	0.466
Plasmodium vivax	tubulin alpha chain, putative	0.0152	0.2584	0.8808
Loa Loa (eye worm)	tubulin beta-2A chain	0.0166	0.2921	0.3331
Leishmania major	beta tubulin	0.0166	0.2921	1
Loa Loa (eye worm)	tubulin alpha 2	0.0108	0.1574	0.1794
Leishmania major	beta tubulin	0.0166	0.2921	1
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.3892	1
Brugia malayi	Dihydrofolate reductase	0.0345	0.7056	0.8026
Plasmodium vivax	tubulin epsilon chain, putative	0.0101	0.1412	0.466
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.0683	0.0845
Brugia malayi	Tubulin alpha-2 chain	0.0152	0.2584	0.2876
Echinococcus granulosus	tubulin alpha 3 chain	0.0152	0.2584	0.2876
Loa Loa (eye worm)	tubulin alpha chain	0.0152	0.2584	0.2947
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0049	0.0225	0.016
Echinococcus granulosus	tubulin alpha	0.0101	0.1412	0.1526
Echinococcus granulosus	tubulin beta 4A class IVa	0.0166	0.2921	0.3264
Loa Loa (eye worm)	tubulin gamma chain	0.0101	0.1412	0.161
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0152	0.2584	0.2947
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0046	0.0153	0.0076
Schistosoma mansoni	alpha tubulin	0.0152	0.2584	0.2519
Toxoplasma gondii	beta tubulin	0.0166	0.2921	1
Plasmodium falciparum	tubulin gamma chain	0.0101	0.1412	0.466
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Schistosoma mansoni	tubulin subunit gamma	0.0101	0.1412	0.1337
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Brugia malayi	Tubulin gamma chain	0.0101	0.1412	0.1526
Brugia malayi	Tubulin beta chain	0.0057	0.0401	0.0362
Echinococcus multilocularis	high affinity choline transporter 1	0.042	0.877	1
Leishmania major	beta tubulin	0.0166	0.2921	1
Echinococcus granulosus	tubulin beta 1 chain	0.0166	0.2921	0.3264
Trypanosoma brucei	epsilon tubulin	0.0101	0.1412	0.466
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.0575	0.0656
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0057	0.0401	0.0807
Loa Loa (eye worm)	tubulin beta-4 chain	0.0166	0.2921	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0218	0.4117	0.4694
Echinococcus granulosus	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Trichomonas vaginalis	tubulin beta chain, putative	0.0152	0.2584	0.6557
Plasmodium falciparum	tubulin beta chain	0.0166	0.2921	1
Echinococcus granulosus	tubulin epsilon chain	0.0101	0.1412	0.1526
Trypanosoma brucei	beta tubulin	0.0166	0.2921	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.0683	0.0845
Echinococcus granulosus	tubulin alpha chain	0.0152	0.2584	0.2876
Brugia malayi	Tubulin alpha-2 chain	0.0152	0.2584	0.2876
Leishmania major	beta tubulin	0.0166	0.2921	1
Schistosoma mansoni	tubulin subunit beta	0.0166	0.2921	0.2859
Entamoeba histolytica	tubulin alpha-1 chain	0.0152	0.2584	0.8812
Trypanosoma brucei	epsilon tubulin	0.0101	0.1412	0.466
Echinococcus granulosus	tubulin alpha 1C chain	0.0152	0.2584	0.2876
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Echinococcus multilocularis	tubulin gamma 1 chain	0.0101	0.1412	0.1526
Trichomonas vaginalis	tubulin beta chain, putative	0.0152	0.2584	0.6557
Echinococcus multilocularis	beta tubulin	0.0166	0.2921	0.3264
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0359	0.0313
Echinococcus multilocularis	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Leishmania major	beta tubulin	0.0166	0.2921	1
Giardia lamblia	Alpha-tubulin	0.0152	0.2584	0.8808
Loa Loa (eye worm)	beta-tubulin	0.0166	0.2921	0.3331
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0095	0.1267	0.1445
Echinococcus multilocularis	short transient receptor potential channel 6	0.0083	0.1008	0.1061
Schistosoma mansoni	dihydrofolate reductase	0.0345	0.7056	0.7031
Trichomonas vaginalis	tubulin alpha chain, putative	0.0166	0.2921	0.7444
Loa Loa (eye worm)	tubulin alpha 2	0.0051	0.0257	0.0293
Trypanosoma brucei	alpha tubulin	0.0152	0.2584	0.8808
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Echinococcus multilocularis	tubulin delta chain	0.0044	0.0095	0.0009
Echinococcus granulosus	solute carrier family 5	0.0046	0.0153	0.0076
Schistosoma mansoni	tubulin subunit beta	0.0166	0.2921	0.2859
Loa Loa (eye worm)	tubulin alpha chain	0.0152	0.2584	0.2947
Trichomonas vaginalis	tubulin gamma chain, putative	0.0101	0.1412	0.3469
Echinococcus multilocularis	tubulin alpha 1C chain	0.0152	0.2584	0.2876
Echinococcus multilocularis	hypothetical protein	0.0152	0.2584	0.2876
Loa Loa (eye worm)	hypothetical protein	0.0152	0.2584	0.2947
Leishmania major	beta tubulin	0.0166	0.2921	1
Echinococcus multilocularis	tubulin alpha chain	0.0152	0.2584	0.2876
Echinococcus multilocularis	solute carrier family 5	0.0046	0.0153	0.0076
Trypanosoma brucei	alpha tubulin	0.0152	0.2584	0.8808
Trichomonas vaginalis	tubulin beta chain, putative	0.0152	0.2584	0.6557
Leishmania major	alpha tubulin	0.0152	0.2584	0.8808
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0046	0.0153	0.0076
Schistosoma mansoni	tubulin subunit beta	0.0044	0.0095	0.0008
Schistosoma mansoni	transient receptor potential channel	0.0123	0.1924	0.1853
Trypanosoma cruzi	epsilon tubulin, putative	0.0101	0.1412	0.466
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1924	0.2194
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0069	0.0683	0.208
Entamoeba histolytica	tubulin family protein	0.0166	0.2921	1
Giardia lamblia	Beta tubulin	0.0166	0.2921	1
Treponema pallidum	cell division protein FtsZ	0.0044	0.0095	0.5
Schistosoma mansoni	tubulin subunit alpha	0.0152	0.2584	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0783	0.0893
Leishmania major	beta tubulin	0.0166	0.2921	1
Echinococcus granulosus	alpha tubulin	0.0152	0.2584	0.2876
Entamoeba histolytica	tubulin alpha chain, putative	0.0152	0.2584	0.8812
Echinococcus multilocularis	Tubulin beta 2C chain	0.0166	0.2921	0.3264
Loa Loa (eye worm)	dihydrofolate reductase	0.0345	0.7056	0.8046
Plasmodium falciparum	tubulin epsilon chain, putative	0.0101	0.1412	0.466
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0225	0.0257
Toxoplasma gondii	alpha-tubulin I, putative	0.0152	0.2584	0.8808
Echinococcus granulosus	tubulin alpha chain	0.0152	0.2584	0.2876
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0069	0.0683	0.0601
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0095	0.1267	0.3088
Toxoplasma gondii	beta-tubulin, putative	0.0166	0.2921	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0069	0.0683	0.0686
Schistosoma mansoni	transient receptor potential channel	0.0083	0.1008	0.093
Echinococcus multilocularis	transient receptor potential ion channel A	0.0113	0.1699	0.1856

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Effect on localization of chitin synthase Chs3p in CHS6 deficient yeast MDY335 assessed as induction of chitin bud scars at 25 uM by fluorescence microscopy	ChEMBL.	17404221
Activity (functional)	< 50 %	Growth inhibition of gga1/2 deficient yeast MDY327 cells assessed as cell growth at 25 uM relative to wildtype	ChEMBL.	17404221
Activity (functional)	= 50 %	Growth inhibition of apl2/4 deficient yeast MDY334 cells assessed as cell growth at 25 uM relative to wildtype	ChEMBL.	17404221
Activity (functional)	= 50 %	Growth inhibition of yeast MDY330 carrying temperature sensitive allele of clathrin heavy chain gene assessed as cell growth at 25 uM relative to wildtype	ChEMBL.	17404221
Activity (functional)	= 70 %	Growth inhibition of wild type yeast MDY326 assessed as cell growth at 25 uM	ChEMBL.	17404221

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 529015

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 511948