Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.002 | 0.6891 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.002 | 0.6891 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.6891 | 0.6807 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.6891 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0262 | 0.0000000057248 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0262 | 0.5 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.6891 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0262 | 0.0262 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.083 | 0.0856 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.6891 | 0.4724 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.6891 | 0.6807 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.6891 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.002 | 0.6891 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.6891 | 0.6891 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.002 | 0.6891 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.6891 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.6891 | 0.6891 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.6891 | 0.6807 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0262 | 0.0381 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.6891 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.6891 | 0.5 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.6891 | 0.4724 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.6891 | 0.6807 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0262 | 0.0262 |
Brugia malayi | Bloom's syndrome protein homolog | 0.002 | 0.6891 | 0.4724 |
Echinococcus granulosus | bloom syndrome protein | 0.002 | 0.6891 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.002 | 0.6891 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 1 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.002 | 0.6891 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Toxicity in human liver microsomes assessed as formation of monooxidized +16 dalton glutathione conjugates by GSH trapping technique | ChEMBL. | 18370375 |
Activity (ADMET) | 0 | Toxicity in mouse liver microsomes assessed as formation of monooxidized +16 dalton glutathione conjugates by GSH trapping technique | ChEMBL. | 18370375 |
Activity (ADMET) | 0 | Toxicity in human liver microsomes assessed as formation of -15 dalton ketone derived glutathione conjugates by GSH trapping technique | ChEMBL. | 18370375 |
Activity (ADMET) | 0 | Toxicity in mouse liver microsomes assessed as formation of -15 dalton ketone derived glutathione conjugates by GSH trapping technique | ChEMBL. | 18370375 |
Activity (ADMET) | = 0.76 | Dermal toxicity in CBA/Ca mouse assessed as skin sensitization stimulation index by measuring increase in [3H]thymidine incorporation at 0.1% w/v administered on ear dorsum by local lymph node assay relative to control | ChEMBL. | 18370375 |
Activity (ADMET) | = 2.1 | Dermal toxicity in CBA/Ca mouse assessed as skin sensitization stimulation index by measuring increase in [3H]thymidine incorporation at 1% w/v administered on ear dorsum by local lymph node assay relative to control | ChEMBL. | 18370375 |
Activity (ADMET) | = 5.06 | Dermal toxicity in CBA/Ca mouse assessed as skin sensitization stimulation index by measuring increase in [3H]thymidine incorporation at 5% w/v administered on ear dorsum by local lymph node assay relative to control | ChEMBL. | 18370375 |
Activity (ADMET) | = 5.34 | Dermal toxicity in CBA/Ca mouse assessed as skin sensitization stimulation index by measuring increase in [3H]thymidine incorporation at 10% w/v administered on ear dorsum by local lymph node assay relative to control | ChEMBL. | 18370375 |
Activity (ADMET) | = 7.3 | Dermal toxicity in CBA/Ca mouse assessed as skin sensitization stimulation index by measuring increase in [3H]thymidine incorporation at 20% w/v administered on ear dorsum by local lymph node assay relative to control | ChEMBL. | 18370375 |
Activity (ADMET) | = 0.18 mM | Dermal toxicity in CBA/Ca mouse assessed as drug level inducing 3 times increase in skin sensitization stimulation index by measuring [3H]thymidine incorporation relative to control | ChEMBL. | 18370375 |
Activity (ADMET) | = 0.18 mM | Dermal toxicity in CBA/Ca mouse assessed as drug level inducing 3 times increase in skin sensitization stimulation index by measuring [3H]thymidine incorporation relative to control | ChEMBL. | 18370375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.