Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.3279 | 0.4618 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.6892 | 0.9906 | 1 |
Brugia malayi | thymidylate synthase | 0.6892 | 0.9906 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0169 | 0.0067 | 0.0068 |
Mycobacterium ulcerans | thymidylate synthase | 0.6892 | 0.9906 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6956 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0169 | 0.0067 | 0.0068 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.6956 | 1 | 0.5 |
Onchocerca volvulus | 0.6892 | 0.9906 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6956 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.6892 | 0.9906 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0169 | 0.0067 | 0.0068 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6892 | 0.9906 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.6956 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0169 | 0.0067 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.6892 | 0.9906 | 1 |
Brugia malayi | hypothetical protein | 0.3279 | 0.4618 | 0.4662 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.6956 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.6892 | 0.9906 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0169 | 0.0067 | 0.0068 |
Mycobacterium tuberculosis | Hypothetical protein | 0.3279 | 0.4618 | 0.4626 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0169 | 0.0067 | 0.0068 |
Brugia malayi | Dihydrofolate reductase | 0.0169 | 0.0067 | 0.0068 |
Echinococcus multilocularis | thymidylate synthase | 0.6892 | 0.9906 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.