Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.101 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.101 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fold change (functional) | = 0 | Increase in acetylated histone H3 level in human HCT116 cells at 10 uM after 24 hrs relative to control | ChEMBL. | 18348516 |
Fold change (functional) | = 1.98 | Increase in p21waf1 re-expression in human HCT116 cells at 10 uM after 24 hrs relative to control | ChEMBL. | 18348516 |
Fold change (functional) | = 11.68 | Increase in acetylated histone H4 level in human HCT116 cells at 10 uM after 24 hrs relative to control | ChEMBL. | 18348516 |
Fold change (functional) | = 101.36 | Increase in acetylated alpha tubulin level in human HCT116 cells at 10 uM after 24 hrs relative to control | ChEMBL. | 18348516 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HCT116 cells assessed as cell viability after 96 hrs by MTS reduction assay | ChEMBL. | 18348516 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HCT116 cells assessed as cell viability after 96 hrs by MTS reduction assay | ChEMBL. | 18348516 |
Inhibition (binding) | = 16.5 % | Inhibition of human HDAC in HeLa cells at 1 uM | ChEMBL. | 18348516 |
Inhibition (binding) | = 16.5 % | Inhibition of human HDAC in HeLa cells at 1 uM | ChEMBL. | 18348516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.