Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Echinococcus multilocularis | geminin | 0.0195 | 0.5365 | 1 |
Plasmodium vivax | vivapain-1 | 0.0134 | 0.3516 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0134 | 0.3516 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5365 | 1 |
Plasmodium vivax | unspecified product | 0.0134 | 0.3516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5365 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0329 | 0.0934 |
Plasmodium vivax | unspecified product | 0.0125 | 0.3246 | 0.9231 |
Echinococcus granulosus | geminin | 0.0195 | 0.5365 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.119 | 0.119 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0001 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.119 | 0.119 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0329 | 0.0329 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.119 | 0.119 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0639 | 0.1191 |
Onchocerca volvulus | 0.0348 | 1 | 0.5 | |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0329 | 0.0934 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0329 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0329 | 0.0329 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0329 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0329 | 0.0934 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0639 | 0.0639 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0329 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0329 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.119 | 0.119 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 30 % | Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 18293907 |
Activity (functional) | = 30 % | Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 18293907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.