Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peroxidasin | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.00515295 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | 0.00515295 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.00515295 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.00515295 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | 0.00515295 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Brugia malayi | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00515295 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00515295 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00515295 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.00515295 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0.98 | Genotoxicity against Salmonella typhimurium TA 1535/pSK1002 assessed as induction of umu operon expression in presence of rat liver S9 fraction | ChEMBL. | 18341274 |
Activity (ADMET) | = 1.02 | Genotoxicity against Salmonella typhimurium NM2009 assessed as induction of umu operon expression in presence of rat liver S9 fraction | ChEMBL. | 18341274 |
Activity (ADMET) | = 1.04 | Genotoxicity against Salmonella typhimurium TA 1535/pSK1002 assessed as induction of umu operon expression | ChEMBL. | 18341274 |
Activity (ADMET) | = 1.22 | Genotoxicity against Salmonella typhimurium NM2009 assessed as induction of umu operon expression | ChEMBL. | 18341274 |
ED50 (functional) | = 3.18 mg kg-1 | Antimalarial activity against Plasmodium berghei ANKA infected po dosed mouse | ChEMBL. | 18341274 |
ED50 (functional) | = 3.18 mg kg-1 | Antimalarial activity against Plasmodium berghei ANKA infected po dosed mouse | ChEMBL. | 18341274 |
IC50 (functional) | = 5.2 nM | Antimalarial activity against Plasmodium berghei | ChEMBL. | 18341274 |
IC50 (functional) | = 5.2 nM | Antimalarial activity against Plasmodium berghei | ChEMBL. | 18341274 |
IC50 (functional) | = 5.2 nM | Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting | ChEMBL. | 21888440 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium berghei | ChEMBL23 | 18341274 | |
Plasmodium falciparum | ChEMBL23 | 21888440 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.