Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Toxoplasma gondii | pantoate-beta-alanine ligase | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Neospora caninum | pantoate--beta-alanine ligase, putative | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0725 | 1 | 0.5 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0725 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0242 | 0 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 0 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0 | 0.5 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0725 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7130 nM | Inhibition of Mycobacterium tuberculosis pantothenate synthetase | ChEMBL. | 18335974 |
IC50 (binding) | = 7130 nM | Inhibition of Mycobacterium tuberculosis pantothenate synthetase | ChEMBL. | 18335974 |
Inhibition (functional) | = 14 % | Antibacterial activity against Mycobacterium tuberculosis at 128 uM by MABA assay | ChEMBL. | 18335974 |
Inhibition (functional) | = 14 % | Antibacterial activity against Mycobacterium tuberculosis at 128 uM by LORA assay | ChEMBL. | 18335974 |
Inhibition (functional) | = 14 % | Antibacterial activity against Mycobacterium tuberculosis at 128 uM by MABA assay | ChEMBL. | 18335974 |
Inhibition (functional) | = 14 % | Antibacterial activity against Mycobacterium tuberculosis at 128 uM by LORA assay | ChEMBL. | 18335974 |
Inhibition (binding) | = 79 % | Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 100 uM | ChEMBL. | 18335974 |
Inhibition (binding) | = 79 % | Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 100 uM | ChEMBL. | 18335974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.