Detailed information for compound 512665

Basic information

Technical information
  • TDR Targets ID: 512665
  • Name: 7-(benzylamino)-2-(3,4,5-trimethoxyphenyl)qui noline-5,8-dione
  • MW: 430.453 | Formula: C25H22N2O5
  • H donors: 1 H acceptors: 3 LogP: 3.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)c1ccc2c(n1)C(=O)C(=CC2=O)NCc1ccccc1
  • InChi: 1S/C25H22N2O5/c1-30-21-11-16(12-22(31-2)25(21)32-3)18-10-9-17-20(28)13-19(24(29)23(17)27-18)26-14-15-7-5-4-6-8-15/h4-13,26H,14H2,1-3H3
  • InChiKey: QNURRDQOBQHECG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-(phenylmethylamino)-2-(3,4,5-trimethoxyphenyl)quinoline-5,8-dione
  • 7-(benzylamino)-2-(3,4,5-trimethoxyphenyl)quinoline-5,8-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0137 0.2987 0.2986
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0043 0.0783 0.1667
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0236 0.0329
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.003 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0032 0.008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0236 0.0462
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.003 0.0074
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni coup transcription factor 0.001 0.0032 0.008
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0057 0.1111 0.2778
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0496 0.0495
Schistosoma mansoni neuropeptide receptor 0.001 0.003 0.0074
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0318 0.0317
Schistosoma mansoni adenoreceptor 0.001 0.003 0.0074
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.003 0.0029
Echinococcus multilocularis lamin 0.0027 0.0428 0.0427
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0032 0.008
Brugia malayi nuclear receptor NHR-88 0.001 0.0032 0.0065
Schistosoma mansoni lamin 0.0027 0.0428 0.1114
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0236 0.0788
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.003 0.0029
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0137 0.2987 0.7786
Echinococcus multilocularis allatostatin A receptor 0.001 0.003 0.0029
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 0.5512
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus granulosus g protein coupled receptor 0.001 0.003 0.0029
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.003 0.0074
Onchocerca volvulus 0.024 0.5368 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0032 0.0067
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.003 0.0029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.003 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0032 0.008
Schistosoma mansoni ap endonuclease 0.0019 0.0236 0.0614
Entamoeba histolytica adenosine deaminase, putative 0.0174 0.3836 1
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0137 0.2987 0.7706
Echinococcus multilocularis neuropeptide receptor 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.01 0.0213
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.003 0.0029
Brugia malayi Dopamine receptor protein 1 0.001 0.003 0.0061
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.003 0.0063
Echinococcus granulosus intermediate filament protein 0.0027 0.0428 0.0427
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.003 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0032 0.0065
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0137 0.2987 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Echinococcus multilocularis sex peptide receptor 0.001 0.003 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0318 0.0826
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0496 0.1291
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0296 0.0441
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0067
Brugia malayi GnHR receptor homolog 0.001 0.003 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Echinococcus granulosus lamin 0.0027 0.0428 0.0427
Schistosoma mansoni adenosine deaminase 0.0174 0.3836 1
Schistosoma mansoni amine GPCR 0.001 0.003 0.0074
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0137 0.2987 1
Echinococcus granulosus G protein coupled receptor 139 0.001 0.003 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.003 0.0074
Schistosoma mansoni neuropeptide receptor 0.001 0.003 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.003 0.0074
Echinococcus granulosus somatostatin receptor 0.001 0.003 0.0029
Trypanosoma brucei AMP deaminase, putative 0.0057 0.1111 0.3585
Loa Loa (eye worm) hypothetical protein 0.005 0.0958 0.2041
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.003 0.0029
Treponema pallidum adenosine deaminase 0.0174 0.3836 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0031
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0236 0.0614
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.003 0.0029
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.003 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0032 0.008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0032 0.0031
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.003 0.0063
Leishmania major adenine aminohydrolase 0.0174 0.3836 1
Entamoeba histolytica hypothetical protein 0.0023 0.0318 0.0678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0067
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.003 0.0029
Onchocerca volvulus 0.005 0.0958 0.1738
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.003 0.0029
Brugia malayi Dopamine receptor protein 2 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0318 0.0678
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0032 0.008
Echinococcus multilocularis musashi 0.0027 0.0428 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0065
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.003 0.0029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0236 0.0596
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.003 0.0061
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 1
Schistosoma mansoni hypothetical protein 0.001 0.003 0.0074
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.003 0.0063
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0032 0.008
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0318 0.0317
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni histamine h1 receptor 0.001 0.003 0.0074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0428 0.0913
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0318 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0318 0.0482
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0318 0.0317
Loa Loa (eye worm) hypothetical protein 0.0117 0.2519 0.5369
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.003 0.0061
Mycobacterium ulcerans cytidine deaminase 0.0054 0.1057 0.2594
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Echinococcus granulosus neuropeptide receptor 0.001 0.003 0.0029
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.009 0.1886 0.3437
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0083 0.0178
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.003 0.0029
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 0.5512
Entamoeba histolytica cytidine deaminase, putative 0.0054 0.1057 0.2636
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0137 0.2987 0.7786
Trypanosoma cruzi AMP deaminase, putative 0.0057 0.1111 0.3585
Brugia malayi hypothetical protein 0.0023 0.0318 0.0675
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0137 0.2987 0.7786
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0054 0.1057 0.2279
Echinococcus granulosus hypothetical protein 0.001 0.003 0.0029
Trichomonas vaginalis cytidine deaminase, putative 0.0054 0.1057 0.1875
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0083 0.0072
Echinococcus granulosus neuropeptide Y receptor 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0032 0.0031
Plasmodium falciparum AMP deaminase, putative 0.0057 0.1111 0.2893
Trypanosoma cruzi AMP deaminase, putative 0.0057 0.1111 0.3585
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Onchocerca volvulus 0.003 0.0496 0.0874
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0236 0.0329
Loa Loa (eye worm) hypothetical protein 0.0023 0.0318 0.0678
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0137 0.2987 0.7737
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0318 0.0675
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.003 0.0029
Echinococcus multilocularis fmrfamide receptor 0.001 0.003 0.0029
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0318 0.0675
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0043 0.0783 0.2465
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0318 0.0482
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.003 0.0074
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.003 0.0063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0065
Brugia malayi follicle stimulating hormone receptor 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0137 0.2987 0.2986
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.003 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni amine GPCR 0.001 0.003 0.0074
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0043 0.0783 0.2465
Brugia malayi larval opioid receptor 0.001 0.003 0.0061
Leishmania major AMP deaminase, putative 0.0057 0.1111 0.2778
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.003 0.0074
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0032 0.0004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.00000000024618
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0236 0.0462
Echinococcus granulosus g protein coupled receptor 0.001 0.003 0.0029
Brugia malayi G protein-coupled receptor 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.003 0.0074
Echinococcus multilocularis AMP deaminase 2 0.0057 0.1111 0.111
Schistosoma mansoni adenosine deaminase-related 0.0174 0.3836 1
Echinococcus multilocularis serotonin receptor 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0496 0.0495
Loa Loa (eye worm) hypothetical protein 0.003 0.0496 0.1058
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0496 0.1291
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0318 0.0317
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.003 0.0029
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0236 0.0235
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0318 0.0675
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0057 0.1111 0.2778
Loa Loa (eye worm) hypothetical protein 0.009 0.1886 0.4019
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0318 0.0675
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0137 0.2987 1
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.003 0.0029
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0137 0.2987 0.7786
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0129 0.0334
Brugia malayi Cytochrome P450 family protein 0.0012 0.0083 0.0175
Onchocerca volvulus Adenosine deaminase homolog 0.0174 0.3836 0.713
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.003 0.0029
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0047 0.0895 0.1569
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.003 0.0029
Schistosoma mansoni amine GPCR 0.001 0.003 0.0074
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0057 0.1111 0.3585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0137 0.2987 0.2986
Echinococcus granulosus orexin receptor type 2 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0318 0.0826
Plasmodium falciparum adenosine deaminase 0.0174 0.3836 1
Echinococcus granulosus neuropeptides capa receptor 0.001 0.003 0.0029
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0065
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0318 0.0317
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0496 0.0495
Loa Loa (eye worm) hypothetical protein 0.0013 0.0088 0.0189
Schistosoma mansoni ap endonuclease 0.0019 0.0236 0.0614
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Echinococcus multilocularis g protein coupled receptor 0.001 0.003 0.0029
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0318 0.0826
Echinococcus granulosus neuropeptides capa receptor 0.001 0.003 0.0029
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0318 0.0317
Schistosoma mansoni biogenic amine receptor 0.001 0.003 0.0074
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0043 0.0783 0.2465
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.003 0.0063
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0296 0.0295
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.003 0.0074
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.003 0.0029
Schistosoma mansoni neuropeptide receptor 0.001 0.003 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0318 0.0826
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0137 0.2987 0.7786
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Brugia malayi adenosine monophosphate deaminase 0.0057 0.1111 0.2365
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0137 0.2987 0.775
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0318 0.0826
Brugia malayi PXA domain containing protein 0.0023 0.0318 0.0675
Echinococcus granulosus cytidine deaminase 0.0054 0.1057 0.1056
Brugia malayi Melatonin receptor type 1A 0.001 0.003 0.0061
Schistosoma mansoni hypothetical protein 0.001 0.003 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.0027 0.0417 0.0888
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.01 0.0099
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Brugia malayi ORL1-like opioid receptor 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0318 0.0826
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0047 0.0895 0.1905
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.003 0.0074
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0958 0.2495
Onchocerca volvulus AMP deaminase 2 homolog 0.0057 0.1111 0.2025
Brugia malayi hypothetical protein 0.0023 0.0318 0.0675
Brugia malayi neuropeptide F receptor 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.003 0.0029
Brugia malayi Serotonin receptor 0.001 0.003 0.0061
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0083 0.0072
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Brugia malayi Serotonin receptor 0.001 0.003 0.0061
Leishmania major cytochrome p450-like protein 0.0012 0.0083 0.0056
Echinococcus granulosus g protein coupled receptor 0.001 0.003 0.0029
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.003 0.0061
Brugia malayi G-protein coupled receptor 0.001 0.003 0.0061
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0137 0.2987 0.7786
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Brugia malayi steroid hormone receptor 0.001 0.0032 0.0065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.003 0.0029
Entamoeba histolytica hypothetical protein 0.0023 0.0318 0.0678
Trichomonas vaginalis set domain proteins, putative 0.024 0.5368 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 0.5512
Onchocerca volvulus 0.0027 0.0428 0.0747
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0318 0.0482
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0032 0.008
Schistosoma mansoni opsin-like receptor 0.001 0.003 0.0074
Echinococcus granulosus g-protein coupled receptor 0.001 0.003 0.0029
Onchocerca volvulus 0.0054 0.1057 0.1924
Loa Loa (eye worm) hypothetical protein 0.0017 0.0194 0.0414
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0137 0.2987 0.775
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.003 0.0029
Schistosoma mansoni intermediate filament proteins 0.0027 0.0428 0.1114
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0134 0.0285
Brugia malayi G-protein coupled receptor 0.001 0.003 0.0061
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0137 0.2987 1
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0318 0.0678
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0318 0.0317
Trypanosoma cruzi AMP deaminase, putative 0.0057 0.1111 0.3585
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.003 0.0061
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0032 0.0065
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0318 0.0317
Echinococcus granulosus adenosine deaminase 0.0174 0.3836 0.3835
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.003 0.0029
Echinococcus multilocularis g protein coupled receptor 0.001 0.003 0.0029
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0318 0.0317
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.003 0.0029
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0137 0.2987 0.2986
Brugia malayi Pre-SET motif family protein 0.003 0.0496 0.1056
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.003 0.0029
Trypanosoma brucei AMP deaminase, putative 0.0057 0.1111 0.3585
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Schistosoma mansoni thyroid hormone receptor 0.001 0.0032 0.008
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0318 0.0675
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0318 0.0482
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0496 0.1291
Entamoeba histolytica AMP deaminase, putative 0.0057 0.1111 0.2778
Echinococcus multilocularis serotonin receptor 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.009 0.1884 0.6229
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.003 0.0063
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0032 0.008
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0083 0.0178
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.003 0.0061
Brugia malayi sulfakinin receptor protein 0.001 0.003 0.0061
Echinococcus multilocularis neuropeptide receptor 0.001 0.003 0.0029
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.003 0.0063
Giardia lamblia Cytidine deaminase 0.0054 0.1057 0.3536
Brugia malayi Dopamine receptor 0.001 0.003 0.0061
Schistosoma mansoni hypothetical protein 0.001 0.003 0.0074
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0236 0.0278
Onchocerca volvulus 0.0057 0.1111 0.2025
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.019 0.0493
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0137 0.2987 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0032 0.0031
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0235 0.061
Entamoeba histolytica AMP deaminase, putative 0.0057 0.1111 0.2778
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0318 0.0678
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0318 0.0826
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Plasmodium vivax adenosine/AMP deaminase, putative 0.0057 0.1111 0.2639
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0032 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.003 0.0029
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.003 0.0074
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.047 0.0469
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.009 0.1886 0.4019
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0318 0.0678
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.009 0.1886 0.1885
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.003 0.0074
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.003 0.0029
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0318 0.0678
Trichomonas vaginalis adenosine deaminase, putative 0.0174 0.3836 0.7112
Echinococcus multilocularis g-protein coupled receptor 0.001 0.003 0.0029
Toxoplasma gondii exonuclease III APE 0.0019 0.0236 0.0614
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0137 0.2987 0.775
Brugia malayi cytidine deaminase, identical 0.0054 0.1057 0.2251
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0318 0.0317
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0318 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0057 0.1111 0.3585
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0174 0.3836 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0031
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0043 0.0783 0.2465
Schistosoma mansoni neuropeptide receptor 0.001 0.003 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0031
Loa Loa (eye worm) AMP deaminase 0.0057 0.1111 0.2367
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.003 0.0029
Brugia malayi Cytochrome P450 family protein 0.0012 0.0083 0.0175
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0318 0.0317
Schistosoma mansoni biogenic amine receptor 0.001 0.003 0.0074
Brugia malayi Pre-SET motif family protein 0.0211 0.4692 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0088 0.0189
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0137 0.2987 0.7641
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0496 0.1291
Echinococcus granulosus lamin dm0 0.0027 0.0428 0.0427
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.003 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0318 0.0482
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0043 0.0783 0.2465
Brugia malayi neuropeptide F receptor 0.001 0.003 0.0061
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0236 0.0235
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.003 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0318 0.0826
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0065
Schistosoma mansoni nuclear hormone receptor 0.001 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0236 0.0502
Echinococcus granulosus bloom syndrome protein 0.0022 0.0296 0.0295
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus multilocularis expressed protein 0.0439 1 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0318 0.0317
Onchocerca volvulus 0.0054 0.1057 0.1924
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.003 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0067
Trypanosoma cruzi cytidine deaminase-like protein 0.0054 0.1057 0.3401
Trypanosoma cruzi AMP deaminase, putative 0.0057 0.1111 0.3585
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 0.5512
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.003 0.0074
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0032 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0065
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0296 0.0441
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.003 0.0029
Trypanosoma cruzi AMP deaminase, putative 0.0057 0.1111 0.3585
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0032 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0065
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.009 0.1884 0.6306
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0047 0.0897 0.1834
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0318 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.003 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0236 0.0596
Echinococcus multilocularis fmrfamide receptor 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0174 0.3836 0.8176
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0318 0.0826
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0134 0.0283
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0137 0.2987 0.6365
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0318 0.0317
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0054 0.1057 0.2753
Loa Loa (eye worm) hypothetical protein 0.0023 0.0318 0.0678
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Brugia malayi RE15519p 0.001 0.003 0.0061
Schistosoma mansoni opsin-like receptor 0.001 0.003 0.0074
Onchocerca volvulus 0.0027 0.0428 0.0747
Schistosoma mansoni thyroid hormone receptor 0.001 0.0032 0.008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Echinococcus multilocularis tumor protein p63 0.0342 0.7746 0.7745
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0428 0.0911
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.003 0.0029
Trypanosoma brucei AMP deaminase, putative 0.0057 0.1111 0.3585
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0318 0.0675
Brugia malayi putative neuropeptide receptor 0.001 0.003 0.0061
Trypanosoma brucei cytidine deaminase 0.0054 0.1057 0.3401
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.01 0.0099
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.009 0.1886 0.3437
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0137 0.2987 1
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.009 0.1884 0.6229
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.003 0.0029
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0057 0.1111 0.2778
Loa Loa (eye worm) hypothetical protein 0.0027 0.0428 0.0913
Schistosoma mansoni myosin xvIII 0.001 0.003 0.0074
Echinococcus multilocularis lamin dm0 0.0027 0.0428 0.0427
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.009 0.1886 0.1885
Echinococcus granulosus allatostatin A receptor 0.001 0.003 0.0029
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0174 0.3836 1
Echinococcus granulosus sex peptide receptor 0.001 0.003 0.0029
Brugia malayi intermediate filament protein 0.0027 0.0428 0.0911
Mycobacterium ulcerans adenosine deaminase 0.0174 0.3836 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.003 0.0074
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.4692 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.009 0.1886 0.4019
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0318 0.0317
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0137 0.2987 0.7786
Entamoeba histolytica adenosine deaminase, putative 0.0174 0.3836 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0318 0.0826
Leishmania major cytidine deaminase-like protein 0.0054 0.1057 0.2636
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0065
Echinococcus granulosus neuropeptide receptor 0.001 0.003 0.0029
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.009 0.1884 0.6229
Echinococcus granulosus neuropeptide s receptor 0.001 0.003 0.0029
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0137 0.2987 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0318 0.0317
Brugia malayi AKH receptor 0.001 0.003 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0318 0.0482
Echinococcus multilocularis cytidine deaminase 0.0054 0.1057 0.1056
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0318 0.0678
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0032 0.0031
Leishmania major hypothetical protein, conserved 0.0057 0.1111 0.2778
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.003 0.0074
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0083 0.0072
Schistosoma mansoni AMP deaminase 0.0057 0.1111 0.2893
Trypanosoma cruzi AMP deaminase 2, putative 0.0057 0.1111 0.3585
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0318 0.0317
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.003 0.0074
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0318 0.0317
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0083 0.0178
Echinococcus granulosus FTZ F1 alpha 0.001 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0031
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0117 0.2519 0.5369
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Plasmodium vivax adenosine deaminase, putative 0.0174 0.3836 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0318 0.0482
Brugia malayi Adenosine/AMP deaminase family protein 0.0174 0.3836 0.8176
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0054 0.1057 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus multilocularis g protein coupled receptor 0.001 0.003 0.0029
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0095 0.1998 0.4258
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.003 0.0029
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.003 0.0074
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.003 0.0061
Schistosoma mansoni amine GPCR 0.001 0.003 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.003 0.0029
Brugia malayi PXA domain containing protein 0.0023 0.0318 0.0675
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus multilocularis somatostatin receptor 0.001 0.003 0.0029
Schistosoma mansoni amine GPCR 0.001 0.003 0.0074
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0137 0.2987 0.775
Echinococcus multilocularis orexin receptor type 2 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0117 0.2519 0.5369
Echinococcus multilocularis neuropeptide s receptor 0.001 0.003 0.0029
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.009 0.1884 0.4828
Trichomonas vaginalis adenosine deaminase, putative 0.0174 0.3836 0.7112
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0032 0.0004
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.003 0.0074
Echinococcus granulosus fmrfamide receptor 0.001 0.003 0.0029
Onchocerca volvulus 0.001 0.0032 0.0004
Echinococcus granulosus serotonin receptor 0.001 0.003 0.0029
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.003 0.0029
Echinococcus granulosus AMP deaminase 2 0.0057 0.1111 0.111
Loa Loa (eye worm) hypothetical protein 0.0023 0.0318 0.0678
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.003 0.0074
Echinococcus granulosus tumor protein p63 0.0342 0.7746 0.7745
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Brugia malayi nuclear hormone receptor 0.001 0.0032 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.003 0.0029
Trichomonas vaginalis cytidine deaminase, putative 0.0054 0.1057 0.1875
Brugia malayi ecdysteroid receptor 0.001 0.0032 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0031
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0137 0.2987 1
Loa Loa (eye worm) TYRA-2 protein 0.001 0.003 0.0063
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0318 0.0826
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0137 0.2987 0.5
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0318 0.0826
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0031
Schistosoma mansoni opsin-like receptor 0.001 0.003 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0318 0.0317
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0054 0.1057 0.3401
Plasmodium vivax SET domain protein, putative 0.003 0.0496 0.098
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni hypothetical protein 0.001 0.003 0.0074
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0318 0.0317
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0137 0.2987 0.775
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0032 0.0067
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0296 0.0629
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0032 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.003 0.0029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.003 0.0074
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0095 0.1998 0.4258
Toxoplasma gondii AMP deaminase 0.0057 0.1111 0.2893
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.003 0.0029
Schistosoma mansoni biogenic amine receptor 0.001 0.003 0.0074
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0174 0.3836 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0428 0.0913
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.003 0.0029
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.003 0.0029
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0137 0.2987 0.5512
Schistosoma mansoni lamin 0.0027 0.0428 0.1114
Loa Loa (eye worm) RecQ helicase 0.0022 0.0296 0.0631
Loa Loa (eye worm) hypothetical protein 0.0117 0.2519 0.5369
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0032 0.008
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0057 0.1111 0.3585
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0032 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0174 0.3836 1
Echinococcus multilocularis adenosine deaminase 0.0174 0.3836 0.3835
Entamoeba histolytica hypothetical protein 0.0023 0.0318 0.0678
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.003 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0496 0.1291
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0236 0.0596
Echinococcus granulosus neuropeptide Y receptor 0.001 0.003 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0236 0.0504
Echinococcus granulosus neuropeptide receptor A26 0.001 0.003 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0318 0.0826
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0063
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0057 0.1111 0.2367
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0236 0.0408
Brugia malayi hypothetical protein 0.001 0.003 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0067

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to N-terminal ATP binding site of Hsp90 (unknown origin) at 100 uM after 30 mins ChEMBL. 18363347
Activity (binding) 0 Binding affinity to N-terminal ATP binding site of Hsp90 (unknown origin) at 100 uM after 30 mins ChEMBL. 18363347
Activity (functional) 0 Cytotoxicity against human NCI60 cells ChEMBL. 18363347
Activity (functional) 0 Antiangiogenic activity in HUVEC assessed as cord length at 1.0 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) 0 Antiangiogenic activity in HUVEC assessed as cord length at 0.1 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) 0 Antiangiogenic activity in HUVEC assessed as cord length at 0.01 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) 0 Antiangiogenic activity in HUVEC assessed as cord length at 0.001 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) 0 Antiangiogenic activity in HUVEC assessed as number of junctions at 0.001 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 14 % Effect on HUVEC growth at 10 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 14 % Effect on HUVEC growth at 10 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 50 % Antiangiogenic activity in HUVEC assessed as number of junctions at 1.0 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 50 % Antiangiogenic activity in HUVEC assessed as number of junctions at 0.1 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 50 % Antiangiogenic activity in HUVEC assessed as number of junctions at 0.01 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 50 % Antiangiogenic activity in HUVEC assessed as number of junctions at 1.0 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 50 % Antiangiogenic activity in HUVEC assessed as number of junctions at 0.1 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 50 % Antiangiogenic activity in HUVEC assessed as number of junctions at 0.01 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 64 % Effect on HUVEC growth at 1.0 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 64 % Effect on HUVEC growth at 1.0 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 75 % Antiangiogenic activity in HUVEC assessed as cord length at 10 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 75 % Antiangiogenic activity in HUVEC assessed as cord length at 10 ug/ml after 24 hrs relative to control ChEMBL. 18363347
Activity (functional) = 91 % Effect on HUVEC growth at 0.1 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 91 % Effect on HUVEC growth at 0.1 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 102 % Effect on HUVEC growth at 0.001 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 102 % Effect on HUVEC growth at 0.001 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 118 % Effect on HUVEC growth at 0.01 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 118 % Effect on HUVEC growth at 0.01 ug/ml relative to control ChEMBL. 18363347
Activity (functional) = 0.35 ug ml-1 Growth inhibition of human MCF7 cells after 48 hrs by sulforodamine B assay ChEMBL. 18363347
Activity (functional) = 0.35 ug ml-1 Growth inhibition of human MCF7 cells after 48 hrs by sulforodamine B assay ChEMBL. 18363347
Activity (functional) = 0.43 ug ml-1 Growth inhibition of human NCI-H460 cells after 48 hrs by sulforodamine B assay ChEMBL. 18363347
Activity (functional) = 0.43 ug ml-1 Growth inhibition of human NCI-H460 cells after 48 hrs by sulforodamine B assay ChEMBL. 18363347
Activity (ADMET) = 1.9 ug ml-1 Growth inhibition of HUVEC after 48 hrs by sulforhodamine B assay ChEMBL. 18363347
Activity (ADMET) = 1.9 ug ml-1 Growth inhibition of HUVEC after 48 hrs by sulforhodamine B assay ChEMBL. 18363347
Log TGI (functional) = 4.2 Cytotoxicity against human NCI60 cells ChEMBL. 18363347
pGI50 (functional) = 5.57 Cytotoxicity against human NCI60 cells ChEMBL. 18363347

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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