Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0139 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0139 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to N-terminal ATP binding site of Hsp90 (unknown origin) at 100 uM after 30 mins | ChEMBL. | 18363347 | |
Activity (binding) | 0 | Binding affinity to N-terminal ATP binding site of Hsp90 (unknown origin) at 100 uM after 30 mins | ChEMBL. | 18363347 |
Log LC50 (functional) | = 4.18 | Cytotoxicity against human NCI60 cells | ChEMBL. | 18363347 |
Log TGI (functional) | = 4.72 | Cytotoxicity against human NCI60 cells | ChEMBL. | 18363347 |
pGI50 (functional) | = 5.45 | Cytotoxicity against human NCI60 cells | ChEMBL. | 18363347 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.