Detailed information for compound 512816

Basic information

Technical information
  • TDR Targets ID: 512816
  • Name: N-[1-[(2-bromophenyl)methyl]pyrazol-4-yl]-5-t ert-butyl-4,5,6,7-tetrahydro-1,2-benzoxazole- 3-carboxamide
  • MW: 457.364 | Formula: C22H25BrN4O2
  • H donors: 1 H acceptors: 3 LogP: 4.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1noc2c1CC(CC2)C(C)(C)C)Nc1cnn(c1)Cc1ccccc1Br
  • InChi: 1S/C22H25BrN4O2/c1-22(2,3)15-8-9-19-17(10-15)20(26-29-19)21(28)25-16-11-24-27(13-16)12-14-6-4-5-7-18(14)23/h4-7,11,13,15H,8-10,12H2,1-3H3,(H,25,28)
  • InChiKey: YUKFFCYLIWEUEE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-[(2-bromophenyl)methyl]-4-pyrazolyl]-5-tert-butyl-4,5,6,7-tetrahydro-1,2-benzoxazole-3-carboxamide
  • N-[1-(2-bromobenzyl)pyrazol-4-yl]-5-tert-butyl-4,5,6,7-tetrahydroindoxazene-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) Get druggable targets OG5_129569 All targets in OG5_129569
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) Get druggable targets OG5_129569 All targets in OG5_129569
Toxoplasma gondii pantoate-beta-alanine ligase Get druggable targets OG5_129569 All targets in OG5_129569
Mycobacterium ulcerans pantoate--beta-alanine ligase Get druggable targets OG5_129569 All targets in OG5_129569
Neospora caninum pantoate--beta-alanine ligase, putative Get druggable targets OG5_129569 All targets in OG5_129569
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0223 0.3178
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0088 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.066 0.5455
Leishmania major cathepsin L-like protease 0.0017 0.0034 0.0354
Echinococcus multilocularis 0.0017 0.004 0.003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0284 0.2347
Plasmodium vivax sentrin-specific protease 2, putative 0.0013 0.0011 0.0028
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0171
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0115 0.0951
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0089
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0678 0.1505
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0225 0.0267
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0242 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Brugia malayi Cathepsin L-like precursor 0.0017 0.0034 0.0283
Echinococcus multilocularis zinc finger protein 0.0022 0.007 0.006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.015 0.0178
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0171
Echinococcus granulosus sentrin specific protease 8 0.0013 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.004 0.0184 0.0218
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0225 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Echinococcus multilocularis protein patched 0.0042 0.0193 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0077
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0067
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.034 1
Mycobacterium leprae putative cytochrome p450 0.0017 0.004 0.0053
Schistosoma mansoni hypothetical protein 0.004 0.0184 0.0218
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0016 0.0118
Plasmodium falciparum sentrin-specific protease 1 0.0013 0.0011 0.0028
Brugia malayi Cathepsin L-like precursor 0.0017 0.0034 0.0283
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.004 0.008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0678 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Onchocerca volvulus 0.0049 0.0238 0.1717
Trypanosoma brucei ISWI complex protein 0.0015 0.0024 0.0405
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.004 0.0053
Toxoplasma gondii cathepsin CPL 0.0017 0.0034 0.0053
Brugia malayi jmjC domain containing protein 0.0093 0.0514 0.4248
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0047 0.0036
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0016 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0089
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0047 0.0055
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0034 0.0248
Schistosoma mansoni cpg binding protein 0.0056 0.0284 0.0337
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.034 0.0403
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0622 0.1366
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0034 0.0354
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0016 0.0027
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0016 0.0171
Schistosoma mansoni hypothetical protein 0.0803 0.4967 0.5894
Plasmodium vivax SET domain protein, putative 0.003 0.0121 0.7965
Leishmania major cathepsin L-like protease 0.0017 0.0034 0.0354
Echinococcus multilocularis cpg binding protein 0.0061 0.0316 0.0306
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.004 0.0053
Onchocerca volvulus Alhambra homolog 0.0028 0.0109 0.0784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0095 0.0781
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0034 0.0404
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0029
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0126
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0223 0.2625
Schistosoma mansoni bromodomain containing protein 0.0065 0.0338 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Loa Loa (eye worm) oxidoreductase 0.0014 0.0016 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0137 0.0296
Brugia malayi Bromodomain containing protein 0.0037 0.0165 0.136
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0725 0.4483 1
Leishmania major cathepsin L-like protease 0.0063 0.0326 0.4724
Echinococcus granulosus cathepsin l1 0.0017 0.0034 0.0041
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0193 0.0229
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.004 0.008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0034 0.0283
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0805 0.0956
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0514 0.061
Brugia malayi Pre-SET motif family protein 0.003 0.0121 0.0997
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.004 0.008
Brugia malayi MAP kinase sur-1 0.005 0.0242 0.1999
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0543 0.6392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0034 0.0041
Onchocerca volvulus 0.0013 0.0011 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0137 0.0296
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0011 0.0013
Leishmania major cytochrome p450-like protein 0.0017 0.004 0.0442
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0223 0.1841
Leishmania major cathepsin L-like protease 0.0017 0.0034 0.0354
Leishmania major cytochrome p450-like protein 0.0026 0.0095 0.1256
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0167 0.0199
Echinococcus multilocularis geminin 0.0333 0.2017 0.2009
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.0135
Brugia malayi Cytochrome P450 family protein 0.0055 0.0277 0.2286
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0223 0.1841
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0137 0.0296
Brugia malayi CHE-14 protein 0.0042 0.0193 0.1596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0027
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.004 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0025 0.003
Echinococcus granulosus cpg binding protein 0.0061 0.0316 0.0375
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.004 0.0053
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0011 0.0089
Brugia malayi Bromodomain containing protein 0.0076 0.0409 0.338
Echinococcus granulosus sentrin specific protease 1 0.0013 0.0011 0.0013
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0011 0.0013
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0725 0.4483 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0016 0.0434
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0146 0.0849 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Plasmodium vivax vivapain-2 0.0017 0.0034 0.1731
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0146 0.0136
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0225 0.0215
Loa Loa (eye worm) hypothetical protein 0.0098 0.0543 0.4482
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.004 0.0053
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0193 0.0183
Entamoeba histolytica hypothetical protein 0.0036 0.0154 0.1809
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.004 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0242 0.1746
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0223 0.2625
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.004 0.0053
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0016 0.0135
Loa Loa (eye worm) hypothetical protein 0.0047 0.0225 0.1859
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.0135
Brugia malayi Cytochrome P450 family protein 0.0026 0.0095 0.0781
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.004 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0083 0.0099
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0242 1
Echinococcus multilocularis microtubule associated protein 2 0.1354 0.8428 0.8426
Loa Loa (eye worm) hypothetical protein 0.0035 0.0149 0.123
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0095 0.2547
Brugia malayi Cathepsin L-like precursor 0.0017 0.0034 0.0283
Leishmania major cathepsin L-like protease 0.0017 0.0034 0.0354
Trypanosoma cruzi ISWI complex protein 0.0015 0.0024 0.0405
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1211 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0095 0.0781
Entamoeba histolytica cysteine protease, putative 0.0017 0.0034 0.0404
Trypanosoma brucei protein kinase, putative 0.005 0.0242 0.703
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0126
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0242 0.3466
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0016 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0678 0.1482
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0223 0.0462
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.004 0.0053
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.002 0.0024
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Brugia malayi Pre-SET motif family protein 0.0204 0.1211 1
Brugia malayi hypothetical protein 0.0036 0.0154 0.1268
Echinococcus multilocularis peregrin 0.0031 0.0123 0.0113
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0095 0.2547
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.004 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0242 0.0287
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0016 0.0013
Echinococcus granulosus zinc finger protein 0.0022 0.007 0.0083
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0016 0.0013
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0016 0.0013
Onchocerca volvulus 0.0017 0.0034 0.0248
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0179 0.0168
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0223 0.0462
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0011 0.0089
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.004 0.0442
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.034 0.2807
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.004 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0326 0.9582
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0034 0.0283
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0077
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.004 0.0053
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0109 0.0129
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0178 0.0211
Brugia malayi PHD-finger family protein 0.0014 0.0021 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0047 0.0385
Loa Loa (eye worm) hypothetical protein 0.0037 0.0165 0.1364
Echinococcus multilocularis expressed conserved protein 0.0134 0.0769 0.0759
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0242 0.1746
Loa Loa (eye worm) hypothetical protein 0.004 0.018 0.1483
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0678 0.1482
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Schistosoma mansoni hypothetical protein 0.0036 0.0154 0.0182
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0178 0.0211
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.1596
Brugia malayi jmjC domain containing protein 0.0039 0.0178 0.1471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.0135
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0016 0.0027
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0292 0.8539
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0126
Leishmania major cytochrome p450-like protein 0.0017 0.004 0.0442
Echinococcus granulosus jumonji domain containing protein 0.004 0.0179 0.0212
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.034 1
Trichomonas vaginalis helicase, putative 0.0013 0.0011 0.0077
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0178 0.1471
Schistosoma mansoni hypothetical protein 0.004 0.0184 0.0218
Schistosoma mansoni microtubule-associated protein tau 0.1354 0.8428 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0223 0.1841
Brugia malayi cytochrome P450 0.0017 0.004 0.0332
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.0049 0.0236 0.195
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0678 0.0805
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0678 0.1482
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0135
Brugia malayi PHD-finger family protein 0.0027 0.0103 0.0851
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0242 0.703
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0121 0.0143
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0035 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0034 0.0041
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0034 0.0248
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0034 0.0248
Loa Loa (eye worm) hypothetical protein 0.0049 0.0238 0.1966
Leishmania major cathepsin L-like protease 0.0063 0.0326 0.4724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Onchocerca volvulus 0.0017 0.0034 0.0248
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.034 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0687 0.0816
Echinococcus multilocularis cysteine protease 0.0017 0.0034 0.0024
Schistosoma mansoni cytochrome P450 0.0017 0.004 0.0048
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0242 0.0232
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0223 0.0462
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0242 0.1746
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0316 0.0375
Onchocerca volvulus 0.0056 0.0284 0.2049
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.004 0.0066
Onchocerca volvulus 0.0014 0.0016 0.0118
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.002 0.0009
Onchocerca volvulus 0.0017 0.0034 0.0248
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0016 0.0027
Loa Loa (eye worm) cytochrome P450 0.0017 0.004 0.0332
Onchocerca volvulus 0.0014 0.0016 0.0118
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0223 0.0488
Schistosoma mansoni patched 1 0.0042 0.0193 0.0229
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0016 0.0434
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0126
Echinococcus multilocularis sentrin specific protease 7 0.0146 0.0849 0.0839
Onchocerca volvulus 0.0047 0.0223 0.1607
Brugia malayi PHD-finger family protein 0.0028 0.0109 0.0898
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0034 0.0404
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0089
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0149 1
Leishmania major cathepsin L-like protease 0.0063 0.0326 0.4724
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0193 0.1596
Echinococcus granulosus tumor protein p63 0.0335 0.2031 0.241
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0016 0.0118
Echinococcus granulosus expressed conserved protein 0.0134 0.0769 0.0912
Echinococcus granulosus geminin 0.0333 0.2017 0.2393
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.004 0.0053
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.004 0.008
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.004 0.008
Entamoeba histolytica hypothetical protein 0.0036 0.0154 0.1809
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0223 0.0462
Entamoeba histolytica hypothetical protein 0.0036 0.0154 0.1809
Echinococcus granulosus dnaJ subfamily B 0.0803 0.4967 0.5894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0109 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0149 0.123
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0514 0.0504
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0238 0.0282
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0016 0.0193
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0089
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.004 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Echinococcus granulosus expressed conserved protein 0.0092 0.0506 0.06
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0016 0.0171
Schistosoma mansoni hypothetical protein 0.004 0.0184 0.0218
Loa Loa (eye worm) hypothetical protein 0.0069 0.0363 0.2997
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0242 0.0517
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0242 0.1746
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0034 0.1731
Echinococcus granulosus peregrin 0.0031 0.0123 0.0146
Mycobacterium ulcerans hypothetical protein 0.0047 0.0223 0.0462
Loa Loa (eye worm) hypothetical protein 0.0051 0.0252 0.2084
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0121 0.011
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.004 0.0053
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0241 0.701
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0016 0.0084
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0088 0.0078
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.004 0.008
Schistosoma mansoni cpg binding protein 0.0061 0.0316 0.0375
Toxoplasma gondii pantoate-beta-alanine ligase 0.0725 0.4483 1
Schistosoma mansoni hypothetical protein 0.0017 0.004 0.0048
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0299 0.2466
Brugia malayi Cathepsin L-like precursor 0.0017 0.0034 0.0283
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0223 0.3178
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0223 0.1841
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0077
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0149 0.0297
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Onchocerca volvulus 0.0014 0.0016 0.0118
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.004 0.0053
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0016 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0027
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0167 0.0157
Loa Loa (eye worm) cysteine protease 0.0017 0.0034 0.0283
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.004 0.008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0154 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0223 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Brugia malayi CXXC zinc finger family protein 0.0056 0.0284 0.2347
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0034 0.1731
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.004 0.008
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0552 0.0655
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.034 0.4003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0106 0.0126
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0095 0.0175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Plasmodium falciparum phd finger protein, putative 0.0028 0.0109 0.71
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.004 0.0053
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0025 0.003
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.004 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0543 0.0533
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0725 0.4483 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0242 0.703
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.004 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0077
Echinococcus granulosus sentrin specific protease 7 0.0146 0.0849 0.1007
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0016 0.0019
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0242 0.3466
Loa Loa (eye worm) hypothetical protein 0.0047 0.0223 0.1841
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.0135
Loa Loa (eye worm) hypothetical protein 0.0035 0.0149 0.123
Schistosoma mansoni hypothetical protein 0.0333 0.2017 0.2393
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0678 0.0805
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0077
Brugia malayi Cathepsin L-like precursor 0.0017 0.0034 0.0283
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0326 0.9582
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0016 0.0135
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0034 0.0024
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0034 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Echinococcus multilocularis cysteine protease 0.0017 0.0034 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0109 0.0898
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.004 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0077
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0146 0.0849 0.1007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0109 0.0129
Brugia malayi Cathepsin L-like precursor 0.0017 0.0034 0.0283
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0025 0.0014
Onchocerca volvulus 0.0017 0.0034 0.0248
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0057 0.0468
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0223 0.0462
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0025 0.0014
Brugia malayi Bromodomain containing protein 0.0031 0.0123 0.1018
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.004 0.0053
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.034 0.2807
Leishmania major cathepsin L-like protease 0.0017 0.0034 0.0354
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0543 0.4482
Schistosoma mansoni zinc finger protein 0.0015 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0225 0.0267
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0149 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0154 0.0182
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0095 0.0781
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.004 0.0896
Onchocerca volvulus 0.0232 0.1386 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.004 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0034 0.0717
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0016 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.004 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0034 0.0248
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.004 0.0896
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.017
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0016 0.0171
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.034 0.0329
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0121 0.0143
Echinococcus granulosus microtubule associated protein 2 0.1354 0.8428 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0011 0.0013
Schistosoma mansoni cpg binding protein 0.0061 0.0316 0.0375
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.015 0.014
Schistosoma mansoni hypothetical protein 0.0028 0.0109 0.0129
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0543 0.0644
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0242 0.1999
Plasmodium vivax vivapain-2 0.0017 0.0034 0.1731
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0016 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0242 0.703
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0242 0.703
Onchocerca volvulus 0.0017 0.0034 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0034 0.1731
Brugia malayi Cytochrome P450 family protein 0.0017 0.004 0.0332
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0109 0.71
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0678 0.0805
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0035 0.0024
Giardia lamblia PHD finger protein 15 0.0028 0.0109 0.4238
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0178 0.0211
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0678 0.1493
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0223 0.2625
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0039 0.0318
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0283
Plasmodium vivax sentrin-specific protease 1, putative 0.0013 0.0011 0.0028
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0011 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.004 0.008
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0034 0.0248
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0898
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.004 0.008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0149 0.123
Loa Loa (eye worm) hypothetical protein 0.0047 0.0223 0.1841
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0242 0.0232
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.004 0.0896
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0095 0.2547
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0223 0.0462
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0016 0.0027
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0223 0.0462
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0016 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0137 0.0296
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.034 0.0403
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0034 0.0041
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0316 0.0305
Loa Loa (eye worm) ctsf protein 0.0017 0.0034 0.0283
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0326 0.9582
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0109 0.0219
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0089
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0277 0.2286
Onchocerca volvulus 0.0017 0.0034 0.0248
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0034 0.0024
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.004 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0034 0.0041
Leishmania major hypothetical protein, conserved 0.0015 0.0024 0.02
Brugia malayi MH2 domain containing protein 0.0116 0.066 0.5455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0034 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0193 0.1393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Schistosoma mansoni hypothetical protein 0.0333 0.2017 0.2393
Trichomonas vaginalis Sentrin-specific protease, putative 0.0013 0.0011 0.0077
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0027
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.004 0.008
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0394 0.0468
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0242 0.703
Brugia malayi Cytochrome P450 family protein 0.0026 0.0095 0.0781
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0034 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0223 0.0488
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0326 0.9582
Echinococcus multilocularis tumor protein p63 0.0335 0.2031 0.2023
Loa Loa (eye worm) hypothetical protein 0.0045 0.0211 0.1746
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.066 0.5455
Loa Loa (eye worm) hypothetical protein 0.0035 0.0149 0.123
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1386 1
Echinococcus multilocularis dnaJ subfamily B 0.0803 0.4967 0.4962
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0011 0.0089
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0149 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0035 0.0041
Loa Loa (eye worm) fibroinase 0.0017 0.0034 0.0283
Onchocerca volvulus 0.0014 0.0016 0.0118
Onchocerca volvulus 0.003 0.0121 0.0871
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0034 0.0248
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.004 0.0053
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.034 0.493
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0016 0.0019
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0013 0.0011 0.0077
Echinococcus multilocularis protein dispatched 1 0.0048 0.023 0.022
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0223 0.3178
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0035 0.0041
Schistosoma mansoni zinc finger protein 0.0022 0.007 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0077
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0193 0.0229
Onchocerca volvulus 0.0017 0.0034 0.0248
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.004 0.0053
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0154 0.0143
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.004 0.008
Entamoeba histolytica hypothetical protein 0.0036 0.0154 0.1809
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0678 0.0668
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0016 0.0027
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0149 0.0323
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0805 0.0795
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0034 0.0283
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0242 0.0287
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0109 0.0219
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.004 0.008
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.004 0.0896
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0223 0.0462
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.004 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.9582
Trypanosoma cruzi ISWI complex protein 0.0015 0.0024 0.0405
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0088 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.004 0.008
Echinococcus multilocularis expressed conserved protein 0.0092 0.0506 0.0495
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0121 0.0246

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 140 nM Inhibition of Mycobacterium tuberculosis pantothenate synthetase ChEMBL. 18335974
IC50 (binding) = 140 nM Inhibition of Mycobacterium tuberculosis pantothenate synthetase ChEMBL. 18335974
Inhibition (functional) = 24 % Antibacterial activity against Mycobacterium tuberculosis at 128 uM by LORA assay ChEMBL. 18335974
Inhibition (functional) = 24 % Antibacterial activity against Mycobacterium tuberculosis at 128 uM by LORA assay ChEMBL. 18335974
Inhibition (functional) = 73 % Antibacterial activity against Mycobacterium tuberculosis at 128 uM by MABA assay ChEMBL. 18335974
Inhibition (functional) = 73 % Antibacterial activity against Mycobacterium tuberculosis at 128 uM by MABA assay ChEMBL. 18335974
Inhibition (binding) = 94 % Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 100 uM ChEMBL. 18335974
Inhibition (binding) = 94 % Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 100 uM ChEMBL. 18335974

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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