Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.3019 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.1463 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2653 | 0.6553 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.2068 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.3567 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0914 | 0.0914 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0914 | 0.4422 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.1463 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.2104 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.2617 | 0.2617 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.3567 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.3567 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0914 | 0.0914 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0914 | 0.4422 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.3567 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.3567 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.0914 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.3567 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.1463 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.1463 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Inhibition of HRV14 3C protease in presence of dithiothreitol | ChEMBL. | 18248816 |
Activity (functional) | 0 | Antiviral activity against HSV2 | ChEMBL. | 18248816 |
Activity (functional) | 0 | Antiviral activity against WSN influenza A virus | ChEMBL. | 18248816 |
ID50 (functional) | = 25 ug ml-1 | Antiviral activity against HRV14 | ChEMBL. | 18248816 |
Inflection point (functional) | > 4 | Antiviral activity against HRV14 | ChEMBL. | 18248816 |
Inhibition (binding) | = 4 % | Inhibition of HRV14 3C protease at 0.1 uM | ChEMBL. | 18248816 |
Inhibition (binding) | = 4 % | Inhibition of HRV14 3C protease at 0.1 uM | ChEMBL. | 18248816 |
Inhibition (binding) | = 23 % | Inhibition of HRV14 3C protease at 1 uM | ChEMBL. | 18248816 |
Inhibition (binding) | = 23 % | Inhibition of HRV14 3C protease at 1 uM | ChEMBL. | 18248816 |
Inhibition (binding) | = 85 % | Inhibition of HRV14 3C protease at 10 uM | ChEMBL. | 18248816 |
Inhibition (binding) | = 85 % | Inhibition of HRV14 3C protease at 10 uM | ChEMBL. | 18248816 |
Maximal non-toxic dose 50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human HeLa cells after 5 days | ChEMBL. | 18248816 |
Maximal non-toxic dose 50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human HeLa cells after 5 days | ChEMBL. | 18248816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.