Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0369 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0369 | 0.5 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0369 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0369 | 0.5 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0369 | 0.5 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0369 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0369 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0369 | 0.5 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0369 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 10 % | Inhibition of human recombinant 17beta-HSD1 expressed in Sf9 insect cells at 100 nM | ChEMBL. | 18324762 |
Inhibition (binding) | < 10 % | Inhibition of human recombinant 17beta-HSD1 expressed in Sf9 insect cells at 1 uM | ChEMBL. | 18324762 |
Inhibition (binding) | < 10 % | Inhibition of human recombinant 17beta-HSD1 expressed in Sf9 insect cells at 100 nM | ChEMBL. | 18324762 |
Inhibition (binding) | < 10 % | Inhibition of human recombinant 17beta-HSD1 expressed in Sf9 insect cells at 1 uM | ChEMBL. | 18324762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.