Detailed information for compound 51350

Basic information

Technical information
  • TDR Targets ID: 51350
  • Name: 6-[4-(diethylamino)phenyl]-4-ethoxy-N-(2H-tet razol-5-yl)pyridine-2-carboxamide
  • MW: 381.432 | Formula: C19H23N7O2
  • H donors: 2 H acceptors: 5 LogP: 2.76 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(nc(c1)c1ccc(cc1)N(CC)CC)C(=O)Nc1n[nH]nn1
  • InChi: 1S/C19H23N7O2/c1-4-26(5-2)14-9-7-13(8-10-14)16-11-15(28-6-3)12-17(20-16)18(27)21-19-22-24-25-23-19/h7-12H,4-6H2,1-3H3,(H2,21,22,23,24,25,27)
  • InChiKey: COONHWJQJIRHDW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[4-(diethylamino)phenyl]-4-ethoxy-N-(2H-tetrazol-5-yl)-2-pyridinecarboxamide
  • 6-[4-(diethylamino)phenyl]-4-ethoxy-N-(2H-1,2,3,4-tetrazol-5-yl)pyridine-2-carboxamide
  • 6-[4-(diethylamino)phenyl]-4-ethoxy-N-(2H-tetrazol-5-yl)picolinamide
  • 6-(4-diethylaminophenyl)-4-ethoxy-N-(2H-tetrazol-5-yl)pyridine-2-carboxamide
  • 6-(4-diethylaminophenyl)-4-ethoxy-N-(2H-tetrazol-5-yl)-2-pyridinecarboxamide
  • 6-(4-diethylaminophenyl)-4-ethoxy-N-(2H-tetrazol-5-yl)picolinamide
  • 6-(4-diethylaminophenyl)-4-ethoxy-N-(2H-1,2,3,4-tetrazol-5-yl)pyridine-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0801 0.1026
Mycobacterium ulcerans thymidylate synthase 0.0125 0.1663 0.213
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0461 0.059
Brugia malayi hypothetical protein 0.0275 0.3833 0.491
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0087 0.0087
Echinococcus multilocularis ets variant gene 4 0.0011 0.001 0.001
Onchocerca volvulus 0.009 0.1156 0.1481
Echinococcus granulosus purine nucleoside phosphorylase 0.055 0.7807 0.7807
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.1171 0.1499
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.092 0.092
Mycobacterium leprae probable uridine phosphorylase 0.0114 0.1502 0.1924
Echinococcus granulosus dnaJ subfamily B 0.0475 0.6736 0.6736
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0143
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0109 0.143 0.1832
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0717 0.0919
Plasmodium falciparum thioredoxin reductase 0.0038 0.0401 0.1671
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1502 0.1924
Toxoplasma gondii exonuclease III APE 0.0022 0.0171 0.0715
Entamoeba histolytica recQ family DNA helicase 0.0022 0.0171 0.1141
Echinococcus multilocularis purine nucleoside phosphorylase 0.055 0.7807 0.7807
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0069 0.086 0.3585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.086 0.086
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0171 0.0171
Echinococcus multilocularis purine nucleoside phosphorylase 0.055 0.7807 0.7807
Treponema pallidum pfs protein (pfs) 0.0114 0.1502 1
Schistosoma mansoni cpg binding protein 0.0035 0.0366 0.0366
Echinococcus granulosus death domain containing protein 0.0017 0.0097 0.0097
Schistosoma mansoni gabp alpha 0.0074 0.092 0.092
Echinococcus granulosus purine nucleoside phosphorylase 0.055 0.7807 0.7807
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0308 0.1285
Plasmodium vivax thioredoxin reductase, putative 0.0109 0.143 0.5961
Brugia malayi Bloom's syndrome protein homolog 0.0072 0.0893 0.1144
Toxoplasma gondii thioredoxin reductase 0.0109 0.143 0.5961
Plasmodium falciparum purine nucleoside phosphorylase 0.0114 0.1502 0.6258
Brugia malayi MTAP 0.0114 0.1502 0.1924
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0087
Toxoplasma gondii Purine nucleoside phosphorylase 0.0114 0.1502 0.6258
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0114 0.1502 0.1924
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0068 0.01
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0562 0.2341
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0114 0.1502 0.1924
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.001 0.0014
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0114 0.1502 0.1924
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0194 0.0249
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0068 0.0282
Mycobacterium tuberculosis Probable dehydrogenase 0.0248 0.3449 0.4417
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0038 0.0401 0.1671
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0114 0.1502 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.055 0.7807 0.7807
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.055 0.7807 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.019 0.26 0.3824
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0401 0.1671
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0114 0.1502 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0038 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0275 0.3833 0.5637
Schistosoma mansoni hypothetical protein 0.0369 0.5197 0.5197
Brugia malayi thymidylate synthase 0.0125 0.1663 0.213
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0114 0.1502 0.1502
Leishmania major nucleoside phosphorylase-like protein 0.0114 0.1502 0.6258
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0171 0.0714
Treponema pallidum ATP-dependent DNA helicase 0.0022 0.0171 0.1141
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0552 0.0707
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0194 0.0249
Loa Loa (eye worm) hypothetical protein 0.0088 0.1132 0.1665
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0114 0.1502 0.6258
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0038 0.0401 0.0514
Loa Loa (eye worm) hypothetical protein 0.0042 0.0459 0.0675
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.0364
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0068 0.0282
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0461 0.0461
Echinococcus granulosus purine nucleoside phosphorylase 0.055 0.7807 0.7807
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.1171 0.4878
Brugia malayi MH2 domain containing protein 0.0136 0.1824 0.2337
Toxoplasma gondii endonuclease IV APN 0.0089 0.1144 0.4769
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0801 0.1026
Echinococcus multilocularis survival motor neuron protein 1 0.0275 0.3833 0.3833
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0043 0.0475 0.0475
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.1171 0.1171
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0176 0.24 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0086 0.1094 0.1094
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0089 0.1144 0.1466
Brugia malayi glutathione reductase 0.0109 0.143 0.1832
Echinococcus granulosus purine nucleoside phosphorylase 0.055 0.7807 0.7807
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0038 0.0401 0.1671
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0171 0.0715
Trypanosoma brucei uridine phosphorylase 0.0114 0.1502 0.6258
Schistosoma mansoni dihydrofolate reductase 0.0051 0.0592 0.0592
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0338 0.0497
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.1171 0.4878
Schistosoma mansoni elf1 0.0011 0.001 0.001
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.055 0.7807 1
Echinococcus granulosus methylthioadenosine phosphorylase 0.0114 0.1502 0.1502
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.001 0.001
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0125 0.1663 0.213
Trichomonas vaginalis set domain proteins, putative 0.0546 0.7758 0.9937
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.1171 0.4878
Schistosoma mansoni hypothetical protein 0.0369 0.5197 0.5197
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0114 0.1502 0.1924
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0041 0.0041
Brugia malayi follicle stimulating hormone receptor 0.0264 0.3676 0.4708
Brugia malayi transcription factor E74 isoform 0.0011 0.001 0.0012
Mycobacterium tuberculosis Probable oxidoreductase 0.0276 0.385 0.4931
Mycobacterium tuberculosis Hypothetical protein 0.0059 0.0715 0.0916
Schistosoma mansoni methylthioadenosine phosphorylase 0.0114 0.1502 0.1502
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.086 0.086
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.086 0.086
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.001 0.001
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0114 0.1502 0.1924
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0114 0.1502 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0038 0.0401 0.1671
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.001 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0038 0.0401 0.1671
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0248 0.3449 0.4417
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0068 0.0087
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0114 0.1502 0.6258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.086 0.086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0401 0.1671
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0717 0.0717
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0465 0.1938
Loa Loa (eye worm) dihydrofolate reductase 0.0051 0.0592 0.0871
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0028 0.0256 0.0328
Echinococcus granulosus cpg binding protein 0.0035 0.0366 0.0366
Schistosoma mansoni DNA helicase recq1 0.0043 0.0475 0.0475
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0171 0.0715
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0465 0.0465
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0171 0.1142
Schistosoma mansoni ets-related 0.0223 0.3087 0.3087
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0436 0.616 0.616
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.1171 0.1171
Loa Loa (eye worm) thymidylate synthase 0.0125 0.1663 0.2445
Toxoplasma gondii hypothetical protein 0.0031 0.0308 0.1285
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0114 0.1502 0.1924
Echinococcus multilocularis thymidylate synthase 0.0125 0.1663 0.1663
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0038 0.0401 0.1671
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0021 0.0159 0.0664
Mycobacterium ulcerans purine nucleoside phosphorylase 0.055 0.7807 1
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0125 0.1663 0.1663
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0068 0.0282
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0089 0.1144 0.4769
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0673 0.0673
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0176 0.24 1
Toxoplasma gondii NADPH-glutathione reductase 0.0038 0.0401 0.1671
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0087 0.0087
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0087 0.0364
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0276 0.385 0.4931
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0171 0.0714
Brugia malayi Pre-SET motif family protein 0.048 0.68 0.871
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0248 0.3449 0.4417
Trichomonas vaginalis glutathione reductase, putative 0.0038 0.0401 0.0514
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0801 0.0801
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0465 0.0596
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0097 0.0097
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0114 0.1502 0.6258
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0087 0.0087
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0465 0.0465
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0063 0.0765 0.1125
Leishmania major protein kinase, putative 0.0015 0.0068 0.0282
Schistosoma mansoni lamin 0.009 0.1156 0.1156
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.001 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0012 0.0012
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0059 0.0715 0.298
Brugia malayi Fli-1 protein 0.0223 0.3087 0.3954
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0097 0.0124
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0171 0.1142
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.001 0.0014
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0465 0.0596
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0114 0.1502 0.1924
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0465 0.0465
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0248 0.3449 0.4417
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0801 0.334
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0087 0.0364
Brugia malayi Dihydrofolate reductase 0.0051 0.0592 0.0758
Echinococcus granulosus single minded 2 0.0042 0.0461 0.0461
Brugia malayi Ets-domain containing protein 0.0011 0.001 0.0012
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0562 0.072
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0717 0.0919
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0087 0.0112
Brugia malayi Ets-domain containing protein 0.0074 0.092 0.1178
Echinococcus multilocularis Ankyrin 0.0017 0.0099 0.0099
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0401 0.1671
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0097 0.0097
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0068 0.0087
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0043 0.0475 0.0699
Echinococcus granulosus geminin 0.0369 0.5197 0.5197
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.0813 0.0813
Toxoplasma gondii phosphorylase family protein 0.0114 0.1502 0.6258
Chlamydia trachomatis dihydrofolate reductase 0.0051 0.0592 0.3943
Echinococcus granulosus intermediate filament protein 0.009 0.1156 0.1156
Loa Loa (eye worm) uridine phosphorylase 0.0114 0.1502 0.2209
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.001 0.001
Onchocerca volvulus 0.009 0.1156 0.1481
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0171 0.1465
Onchocerca volvulus 0.0033 0.0338 0.0433
Loa Loa (eye worm) hypothetical protein 0.0069 0.086 0.1265
Echinococcus multilocularis cpg binding protein 0.0035 0.0366 0.0366
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0114 0.1502 0.2209
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0475 0.1981
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0176 0.24 1
Echinococcus granulosus dihydrofolate reductase 0.0051 0.0592 0.0592
Onchocerca volvulus 0.0125 0.1663 0.213
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.048 0.68 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0068 0.0087
Echinococcus multilocularis dihydrofolate reductase 0.0051 0.0592 0.0592
Plasmodium vivax glutathione reductase, putative 0.0109 0.143 0.5961
Onchocerca volvulus 0.0069 0.086 0.1102
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0465 0.0596
Brugia malayi hypothetical protein 0.0141 0.1903 0.2437
Schistosoma mansoni hypothetical protein 0.0475 0.6736 0.6736
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.1824 0.2683
Echinococcus multilocularis purine nucleoside phosphorylase 0.055 0.7807 0.7807
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.0364
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.001 0.001
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0038 0.0401 0.267
Trypanosoma brucei trypanothione reductase 0.0109 0.143 0.5961
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0308 0.2053
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0252
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0483 0.0483
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.1171 0.1499
Loa Loa (eye worm) hypothetical protein 0.0043 0.0483 0.071
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.001 0.001
Mycobacterium tuberculosis Probable reductase 0.0248 0.3449 0.4417
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0807 0.3363
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0171 0.0252
Leishmania major protein kinase, putative 0.0015 0.0068 0.0282
Loa Loa (eye worm) hypothetical protein 0.0091 0.1171 0.1722
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0125 0.1663 0.213
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0043 0.0475 0.0475
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0248 0.3449 0.4417
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0038 0.0401 0.1671
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0068 0.0068
Trichomonas vaginalis mercuric reductase, putative 0.0038 0.0401 0.0514
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0171 0.022
Loa Loa (eye worm) RecQ helicase 0.0072 0.0893 0.1313
Schistosoma mansoni methylthioadenosine phosphorylase 0.0114 0.1502 0.1502
Echinococcus multilocularis purine nucleoside phosphorylase 0.055 0.7807 0.7807
Schistosoma mansoni blooms syndrome DNA helicase 0.005 0.0577 0.0577
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0038 0.0401 0.1671
Echinococcus multilocularis protein C ets 2 0.0011 0.001 0.001
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0051 0.0592 0.0758
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0051 0.0592 0.0758
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0465 0.0465
Echinococcus multilocularis geminin 0.0369 0.5197 0.5197
Toxoplasma gondii phosphorylase family protein 0.0114 0.1502 0.6258
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0114 0.1502 0.6258
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0043 0.0475 0.0475
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0038 0.0401 0.1671
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0801 0.0801
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0038 0.0401 0.0514
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.0364
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0552 0.0812
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0068 0.0087
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0068 0.0282
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0114 0.1502 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0171 0.0171
Brugia malayi Probable ClpP-like protease 0.0091 0.1171 0.1499
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.001 0.001
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0475 0.0609
Mycobacterium ulcerans epimerase 0.0023 0.0194 0.0249
Brugia malayi PAS domain containing protein 0.0057 0.0673 0.0863
Loa Loa (eye worm) hypothetical protein 0.0042 0.0459 0.0675
Loa Loa (eye worm) hypothetical protein 0.0051 0.0589 0.0866
Echinococcus multilocularis musashi 0.009 0.1156 0.1156
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0159 0.1061
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0171 0.022
Schistosoma mansoni netrin receptor unc5 0.0017 0.0097 0.0097
Giardia lamblia UPL-1 0.0114 0.1502 0.1924
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0171 0.0715
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0038 0.0401 0.0514
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.1171 0.1499
Loa Loa (eye worm) fli-1 protein 0.0223 0.3087 0.454
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0043 0.0475 0.1981
Brugia malayi Thioredoxin reductase 0.0109 0.143 0.1832
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0465 0.0465
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0401 0.1671
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0171 0.0715
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0738 0.1085
Brugia malayi CXXC zinc finger family protein 0.0033 0.0338 0.0433
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0465 0.1938
Schistosoma mansoni hypothetical protein 0.0017 0.0097 0.0097
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0097 0.0143
Schistosoma mansoni hypothetical protein 0.0056 0.0666 0.0666
Brugia malayi hypoxia-induced factor 1 0.0175 0.2388 0.3059
Trichomonas vaginalis DNA helicase recq, putative 0.0072 0.0893 0.1144
Loa Loa (eye worm) hypothetical protein 0.009 0.1156 0.17
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0038 0.0401 0.1671
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0068 0.0087
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.001 0.001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.1171 0.7795
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0089 0.1144 0.1466
Mycobacterium tuberculosis Hypothetical protein 0.0114 0.1502 0.1924
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.001 0.0014
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.055 0.7807 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0014
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.092 0.1353
Brugia malayi Pre-SET motif family protein 0.0069 0.086 0.1102
Echinococcus granulosus bloom syndrome protein 0.0072 0.0893 0.0893
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0069 0.086 0.086
Echinococcus multilocularis bloom syndrome protein 0.0072 0.0893 0.0893
Giardia lamblia NADH oxidase lateral transfer candidate 0.0038 0.0401 0.0514
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.001 0.001
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0068 0.0451
Echinococcus multilocularis microtubule associated protein 2 0.0701 1 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0087 0.0364
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.001 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.009 0.1156 0.17
Echinococcus granulosus purine nucleoside phosphorylase 0.055 0.7807 0.7807
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0068 0.0087
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0171 0.022
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0114 0.1502 0.6258
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0086 0.1094 0.1094
Echinococcus granulosus purine nucleoside phosphorylase 0.055 0.7807 0.7807
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0114 0.1502 1
Loa Loa (eye worm) intermediate filament protein 0.009 0.1156 0.17
Brugia malayi Protein kinase domain containing protein 0.0017 0.0097 0.0124
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0465 0.3097
Brugia malayi dihydrofolate reductase family protein 0.0051 0.0592 0.0758
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0038 0.0401 0.0401
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0171 0.0171
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0114 0.1502 0.6258
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0087 0.0364
Schistosoma mansoni purine nucleoside phosphorylase 0.055 0.7807 0.7807
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0041 0.0061
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0248 0.3449 0.4417
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0068 0.0087
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0114 0.1502 0.1924
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0038 0.0401 0.0514
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0097 0.0097
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0051 0.0592 0.0758
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0194 0.0249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0401 0.1671
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0715 0.0916
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0068 0.0068
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0475 0.0609
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0087 0.0112
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0043 0.0475 0.0475
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0171 0.0715
Loa Loa (eye worm) hypothetical protein 0.0369 0.5192 0.7635
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0171 0.0715
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0146
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.001 0.0012
Entamoeba histolytica hypothetical protein 0.0114 0.1502 1
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0194 0.0249
Brugia malayi intermediate filament protein 0.009 0.1156 0.1481
Echinococcus granulosus thioredoxin glutathione reductase 0.0109 0.143 0.143
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0087 0.0364
Mycobacterium ulcerans hypothetical protein 0.0023 0.0194 0.0249
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0114 0.1502 0.6258
Loa Loa (eye worm) hypothetical protein 0.0436 0.616 0.906
Schistosoma mansoni ap endonuclease 0.0022 0.0171 0.0171
Echinococcus multilocularis thioredoxin glutathione reductase 0.0109 0.143 0.143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0401 0.1671
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0176 0.24 1
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0461 0.059
Mycobacterium ulcerans endonuclease IV 0.0089 0.1144 0.1466
Loa Loa (eye worm) thioredoxin reductase 0.0109 0.143 0.2104
Chlamydia trachomatis AMP nucleosidase 0.0114 0.1502 1
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0039 0.005
Onchocerca volvulus 0.0056 0.0666 0.0854
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.001 0.001
Schistosoma mansoni survival motor neuron protein 0.0056 0.0666 0.0666
Onchocerca volvulus 0.0546 0.776 0.9939
Loa Loa (eye worm) hypoxia-induced factor 1 0.0175 0.2388 0.3512
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0114 0.1502 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.01
Schistosoma mansoni uridine phosphorylase 0.0114 0.1502 0.1502
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.086 0.086
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0038 0.0401 0.1671
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0171 0.022
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0012 0.0012
Plasmodium vivax SET domain protein, putative 0.0069 0.086 0.3585
Brugia malayi Intermediate filament tail domain containing protein 0.009 0.1156 0.1481
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0014
Brugia malayi Death domain containing protein 0.0017 0.0097 0.0124
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.1171 1
Schistosoma mansoni ets-related 0.0011 0.001 0.001
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0068 0.0282
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0114 0.1502 0.1924
Loa Loa (eye worm) hypothetical protein 0.0023 0.0194 0.0286
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0012 0.0012
Echinococcus multilocularis purine nucleoside phosphorylase 0.055 0.7807 0.7807
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0308 0.0395
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0114 0.1502 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0038 0.0401 0.1671
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0087 0.0128
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0801 0.0801
Echinococcus granulosus Ankyrin 0.0017 0.0099 0.0099
Echinococcus granulosus lamin 0.009 0.1156 0.1156
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0801 0.1026
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0465 0.0596
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0465 0.0465
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0562 0.2341
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0068 0.0282
Echinococcus granulosus thymidylate synthase 0.0125 0.1663 0.1663
Echinococcus granulosus protein C ets 2 0.0011 0.001 0.001
Echinococcus multilocularis lamin 0.009 0.1156 0.1156
Brugia malayi uridine phosphorylase family protein 0.0114 0.1502 0.1924
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0038 0.0401 0.1671
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0194 0.0249
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0475 0.0699
Mycobacterium leprae Possible regulatory protein 0.0015 0.0068 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0038 0.0401 0.0514
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0562 0.2341
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0465 0.1938
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0038 0.0401 0.3426
Echinococcus multilocularis purine nucleoside phosphorylase 0.0436 0.616 0.616
Echinococcus granulosus uridine phosphorylase 1 0.0114 0.1502 0.1502
Echinococcus granulosus survival motor neuron protein 1 0.0275 0.3833 0.3833
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0176 0.24 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0114 0.1502 0.1924
Loa Loa (eye worm) hypothetical protein 0.0042 0.0465 0.0684
Brugia malayi Ets-domain containing protein 0.0074 0.092 0.1178
Echinococcus multilocularis lamin dm0 0.009 0.1156 0.1156
Loa Loa (eye worm) glutathione reductase 0.0109 0.143 0.2104
Schistosoma mansoni DNA helicase recq5 0.0043 0.0475 0.0475
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0038 0.0401 0.3426
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.001 0.001
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.1171 0.7795
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.086 0.086
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.055 0.7807 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.1171 0.1171
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0089 0.1144 0.4769
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0044 0.049 0.2044
Schistosoma mansoni uridine phosphorylase 0.0114 0.1502 0.1502
Leishmania major trypanothione reductase 0.0109 0.143 0.5961
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0038 0.0401 0.1671
Brugia malayi isocitrate dehydrogenase 0.0016 0.0087 0.0112
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0066 0.0807 0.3361
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0068 0.0087
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0097 0.0097
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0038 0.0401 0.1671
Echinococcus multilocularis uridine phosphorylase 1 0.0114 0.1502 0.1502
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0087
Schistosoma mansoni microtubule-associated protein tau 0.0701 1 1
Onchocerca volvulus 0.0042 0.0461 0.059
Plasmodium falciparum thioredoxin reductase 0.0109 0.143 0.5961
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0114 0.1502 0.1924
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0465 0.0596
Chlamydia trachomatis endonuclease IV 0.0089 0.1144 0.7621
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0038 0.0401 0.0401
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.055 0.7807 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0475 0.1981
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0068 0.0087
Onchocerca volvulus 0.0015 0.0068 0.0087
Schistosoma mansoni methylthioadenosine phosphorylase 0.0114 0.1502 0.1502
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.1171 0.7795
Loa Loa (eye worm) hypothetical protein 0.0089 0.1144 0.1683
Schistosoma mansoni cpg binding protein 0.0033 0.0338 0.0338
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0171 0.0714
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0483 0.0483
Brugia malayi hypothetical protein 0.019 0.26 0.3331
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1502 0.1924
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0068 0.0068
Trypanosoma cruzi trypanothione reductase, putative 0.0109 0.143 0.5961
Schistosoma mansoni purine nucleoside phosphorylase 0.055 0.7807 0.7807
Schistosoma mansoni cpg binding protein 0.0035 0.0366 0.0366
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0087
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0012 0.0012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0264 0.3676 0.5406
Treponema pallidum uridine phosphorylase (udp) 0.0114 0.1502 1
Schistosoma mansoni ap endonuclease 0.0022 0.0171 0.0171
Schistosoma mansoni ets 0.0011 0.001 0.001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0087 0.0364
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0465 0.0465
Entamoeba histolytica recQ family helicase, putative 0.0049 0.0562 0.3741
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0068 0.0087
Schistosoma mansoni intermediate filament proteins 0.009 0.1156 0.1156
Plasmodium falciparum glutathione reductase 0.0038 0.0401 0.1671
Echinococcus granulosus lamin dm0 0.009 0.1156 0.1156
Brugia malayi Uncoordinated protein 44 0.0017 0.0097 0.0124
Treponema pallidum NADH oxidase 0.0038 0.0401 0.267
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.1824 0.2683
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0308 0.1285
Echinococcus granulosus purine nucleoside phosphorylase 0.055 0.7807 0.7807
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0089 0.1144 0.1466
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0068 0.0282
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0068 0.0068
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0465 0.0465
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0717 0.0919
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0276 0.385 0.4931
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0171 0.022
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0114 0.1502 0.1924
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.055 0.7807 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0436 0.616 0.616
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0801 0.1026
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0028 0.0256 0.0328
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0038 0.0401 0.1671
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0465 0.1938
Schistosoma mansoni single-minded 0.0057 0.0673 0.0673
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0045 0.0502 0.2094
Schistosoma mansoni lamin 0.009 0.1156 0.1156
Mycobacterium tuberculosis Conserved hypothetical protein 0.0114 0.1502 0.1924
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0176 0.24 1
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.6736 0.6736
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0097 0.0097
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0717 0.0717
Giardia lamblia Sgs1 DNA helicase, putative 0.0043 0.0475 0.0609
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0097 0.0124
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0666 0.0854
Brugia malayi hypothetical protein 0.0059 0.0715 0.0916
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.1171 0.4878
Echinococcus granulosus purine nucleoside phosphorylase 0.055 0.7807 0.7807
Plasmodium falciparum glutathione reductase 0.0109 0.143 0.5961
Trichomonas vaginalis DNA helicase recq1, putative 0.0072 0.0893 0.1144
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0401 0.1671
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0068 0.0087
Leishmania major methylthioadenosine phosphorylase, putative 0.0114 0.1502 0.6258
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0916 0.0916
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0171 0.022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0276 0.385 0.4931

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) ND 0 % Inhibition of passive cutaneous anaphylaxis in male Sprague-Dawley rats following 3 mg/kg p.o. administration; No data. ChEMBL. 6137568
Inhibition (functional) ND 0 % Antiallergic activity against passive cutaneous anaphylaxis (PCA) in male Sprague-Dawley rats (10 mg/kg oral administration) ChEMBL. 6137568
Inhibition (functional) = 44 % Antiallergic activity against passive cutaneous anaphylaxis(PCA) in male Sprague-Dawley rats after 0.3 mg/kg oral administration ChEMBL. 6137568
Inhibition (functional) = 66 % Antiallergic activity against passive cutaneous anaphylaxis(PCA) in male Sprague-Dawley rats after 1.0 mg/kg oral administration ChEMBL. 6137568

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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