Detailed information for compound 513585

Basic information

Technical information
  • TDR Targets ID: 513585
  • Name: [1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-pho sphonoethyl]phosphonic acid
  • MW: 434.316 | Formula: C20H20O7P2
  • H donors: 5 H acceptors: 7 LogP: 1.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OP(=O)(C(P(=O)(O)O)(Cc1cccc(c1)c1ccc(cc1)c1ccccc1)O)O
  • InChi: 1S/C20H20O7P2/c21-20(28(22,23)24,29(25,26)27)14-15-5-4-8-19(13-15)18-11-9-17(10-12-18)16-6-2-1-3-7-16/h1-13,21H,14H2,(H2,22,23,24)(H2,25,26,27)
  • InChiKey: MPBUFKZCEBTBSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphono-ethyl]phosphonic acid
  • B28

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geranylgeranyl diphosphate synthase 1 Starlite/ChEMBL References
Saccharomyces cerevisiae farnesyltranstransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Schistosoma japonicum ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative Get druggable targets OG5_129071 All targets in OG5_129071
Echinococcus granulosus geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Trypanosoma cruzi polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania braziliensis polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania donovani polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Brugia malayi geranylgeranyl pyrophosphate synthetase Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania major polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase Get druggable targets OG5_129071 All targets in OG5_129071
Treponema pallidum octaprenyl-diphosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Trypanosoma cruzi polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Candida albicans geranylgeranyl diphosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Schistosoma japonicum Geranylgeranyl pyrophosphate synthetase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania mexicana polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Trypanosoma congolense Hydroxyneurosporene synthase (CrtC)/Polyprenyl synthetase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania infantum polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative geranylgeranyl diphosphate synthase 1 300 aa 317 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis porcupine, putative 0.0022 0.0034 0.012
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0062 0.052 0.052
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0062 0.052 0.4371
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.004
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0062 0.052 0.7921
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.0051 0.0389 0.0389
Echinococcus granulosus intermediate filament protein 0.0057 0.0451 0.0451
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0103 0.1005 0.1175
Schistosoma mansoni nuclear hormone receptor 0.0103 0.1005 0.1005
Leishmania major importin beta-1 subunit, putative 0.0023 0.0055 0.0197
Brugia malayi hypothetical protein 0.0055 0.0426 0.0498
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0255 0.2805 0.2805
Schistosoma mansoni ran 0.0021 0.003 0.003
Brugia malayi nuclear receptor NHR-67 0.0049 0.0357 0.0417
Loa Loa (eye worm) hypothetical protein 0.02 0.215 0.2513
Onchocerca volvulus 0.006 0.0495 0.1736
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.1157 0.1157
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0738 0.2588
Schistosoma mansoni ap endonuclease 0.0038 0.0232 0.0232
Loa Loa (eye worm) hhat protein 0.0022 0.0034 0.004
Brugia malayi RNA binding protein 0.0069 0.0601 0.0703
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.0357 0.0357
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0034 0.0464
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0414 0.0484
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0034 0.0034
Brugia malayi Steroid receptor seven-up type 2 0.0103 0.1005 0.1175
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0739 0.8556 0.8556
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0232 0.314
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0011 0.0013
Toxoplasma gondii hypothetical protein 0.0028 0.0109 0.0704
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0232 0.3153
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0103 0.1005 0.1175
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0014 0.0014
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0414 0.1477
Brugia malayi MH2 domain containing protein 0.0139 0.1433 0.1675
Brugia malayi hypothetical protein 0.0055 0.0426 0.0498
Echinococcus multilocularis acetylcholinesterase 0.0408 0.462 0.462
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1433 0.1675
Echinococcus multilocularis snurportin 1 0.0308 0.3437 0.3437
Echinococcus multilocularis musashi 0.0057 0.0451 0.0451
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0055 0.0197
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0081 0.0738 0.0738
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0321 0.0321
Brugia malayi Carboxylesterase family protein 0.0069 0.0596 0.0696
Loa Loa (eye worm) hypothetical protein 0.0164 0.1729 0.2021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0127
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0357 0.0357
Schistosoma mansoni cpg binding protein 0.006 0.0495 0.0495
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0022 0.0034 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0069 0.0596 0.0696
Loa Loa (eye worm) DR-78 0.0049 0.0357 0.0417
Echinococcus multilocularis acetylcholinesterase 0.0408 0.462 0.462
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0164 0.1729 0.2021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.1151 1
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0062 0.052 0.052
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0103 0.1005 0.1005
Echinococcus granulosus lamin 0.0057 0.0451 0.0451
Schistosoma mansoni gliotactin 0.0069 0.0596 0.0596
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0062 0.052 0.4371
Loa Loa (eye worm) hypothetical protein 0.0103 0.1005 0.1175
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.0357 0.0357
Schistosoma mansoni sodium-dependent amino acid transporter 0.0028 0.0109 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0601 0.0601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0103 0.1005 0.1175
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0103 0.1005 0.1005
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0062 0.052 1
Echinococcus multilocularis neuroligin 0.0069 0.0596 0.0596
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0149 0.0149
Brugia malayi nuclear receptor RXR 0.0055 0.0426 0.0498
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0062 0.052 0.052
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0232 0.0271
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0034 0.0034
Giardia lamblia Farnesyl diphosphate synthase 0.0062 0.052 0.7047
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0034 0.0464
Loa Loa (eye worm) polyprenyl synthetase 0.0062 0.052 0.0608
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0109 0.0109
Onchocerca volvulus Bile acid receptor homolog 0.0103 0.1005 0.3524
Schistosoma mansoni lamin 0.0057 0.0451 0.0451
Echinococcus multilocularis serotonin transporter 0.0164 0.1729 0.1729
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0426 0.0426
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0255 0.2805 0.2805
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0109 0.0109
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0495 0.0579
Loa Loa (eye worm) hypothetical protein 0.0069 0.0596 0.0696
Onchocerca volvulus 0.0069 0.0596 0.2089
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0232 0.0271
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0062 0.052 0.1823
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0201 0.0235
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0034 0.0034
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0414 0.0414
Brugia malayi hypothetical protein 0.0041 0.027 0.0316
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0321 0.0375
Schistosoma mansoni cpg binding protein 0.0064 0.0536 0.0536
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0389 0.0389
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0164 0.1729 0.1729
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0014 0.0014
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.027 0.4905
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0414 0.0414
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0255 0.2805 0.3278
Leishmania major glycerol uptake protein, putative 0.0022 0.0034 0.0122
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0232 0.314
Loa Loa (eye worm) hypothetical protein 0.0408 0.462 0.54
Brugia malayi hypothetical protein 0.0049 0.0357 0.0417
Treponema pallidum sodium- and chloride- dependent transporter 0.0164 0.1729 0.6116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0321
Echinococcus granulosus RUN 0.0041 0.027 0.027
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0062 0.052 0.1854
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.027 0.027
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0028 0.0109 0.0109
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0414 0.0414
Brugia malayi Doublecortin family protein 0.0041 0.027 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0103 0.1005 0.1175
Schistosoma mansoni neuroligin 3 (S09 family) 0.0069 0.0596 0.0596
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0109 0.0127
Onchocerca volvulus 0.0034 0.0179 0.0626
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0109 0.0127
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0028 0.0109 0.0109
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0062 0.052 0.1854
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0232 0.0713
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.1351 0.1351
Loa Loa (eye worm) hypothetical protein 0.0408 0.462 0.54
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0069 0.0596 0.2089
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0034 0.0034
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0022 0.0034 0.0093
Onchocerca volvulus 0.0049 0.0357 0.125
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.1351 0.1351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0321 0.0321
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.0357 0.0357
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.171 0.1998
Echinococcus multilocularis RUN 0.0041 0.027 0.027
Schistosoma mansoni glutathione synthetase 0.0062 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0056 0.0439 0.0513
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0062 0.052 0.052
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.0357 0.0417
Plasmodium vivax amine transporter, putative 0.0028 0.0109 0.1611
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0062 0.052 0.7047
Schistosoma mansoni importin beta-1 0.0029 0.012 0.012
Schistosoma mansoni sterol O-acyltransferase 1 0.0221 0.2407 0.2407
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0389 0.0389
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0109 0.0109
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0357 0.0357
Schistosoma mansoni ran 0.0021 0.003 0.003
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0601 0.0601
Onchocerca volvulus 0.0103 0.1005 0.3524
Onchocerca volvulus Protein ultraspiracle homolog 0.0103 0.1005 0.3524
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0022 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Echinococcus multilocularis ubiquitin specific protease 41 0.0081 0.0738 0.0738
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1314 0.1314
Onchocerca volvulus 0.0259 0.2852 1
Loa Loa (eye worm) serotonin transporter b 0.0164 0.1729 0.2021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Echinococcus multilocularis lamin dm0 0.0057 0.0451 0.0451
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.0357 0.0417
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0109 0.0704
Entamoeba histolytica Ran family GTPase 0.0021 0.003 0.0403
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.0357 0.0357
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0414 0.3427
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0028 0.0109 0.0127
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0103 0.1005 0.1175
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0109 0.0109
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0414 0.1477
Schistosoma mansoni steroid hormone receptor ad4bp 0.0103 0.1005 0.1005
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0022 0.0034 0.0034
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0062 0.052 0.7047
Trypanosoma cruzi polyprenyl synthase, putative 0.0255 0.2805 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0028 0.0109 0.0109
Onchocerca volvulus 0.0069 0.0596 0.2089
Echinococcus multilocularis para nitrobenzyl esterase 0.0069 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0103 0.1005 0.1175
Echinococcus granulosus carboxylesterase 5A 0.0408 0.462 0.462
Echinococcus granulosus importin subunit beta 1 0.0029 0.012 0.012
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.1157 0.1157
Plasmodium falciparum amino acid transporter, putative 0.0028 0.0109 0.1611
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0103 0.1005 0.1175
Toxoplasma gondii hypothetical protein 0.0028 0.0109 0.0704
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0738 0.2631
Brugia malayi hypothetical protein 0.0049 0.0357 0.0417
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0062 0.052 0.5
Trypanosoma cruzi GUP1, putative 0.0022 0.0034 0.0122
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0103 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.004
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0081 0.0738 0.0738
Leishmania major hypothetical protein, conserved 0.0022 0.0034 0.0122
Echinococcus granulosus sterol O acyltransferase 1 0.0221 0.2407 0.2407
Echinococcus multilocularis FTZ F1 alpha 0.0103 0.1005 0.1005
Trypanosoma cruzi polyprenyl synthase, putative 0.0255 0.2805 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.012 0.1629
Echinococcus multilocularis carboxylesterase 5A 0.0408 0.462 0.462
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0034 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1433 0.1675
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0081 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.074 0.857 0.857
Loa Loa (eye worm) hypothetical protein 0.0069 0.0596 0.0696
Echinococcus granulosus cpg binding protein 0.0064 0.0536 0.0536
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.027 0.027
Loa Loa (eye worm) hhat protein 0.0022 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0426 0.0498
Brugia malayi MBOAT family protein 0.0022 0.0034 0.004
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0022 0.0034 0.0034
Schistosoma mansoni intermediate filament proteins 0.0057 0.0451 0.0451
Brugia malayi Cytochrome P450 family protein 0.0036 0.0201 0.0235
Brugia malayi Hhat protein 0.0022 0.0034 0.004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0601 0.0703
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0739 0.8556 0.8556
Echinococcus multilocularis ecdysone induced protein 78C 0.0103 0.1005 0.1005
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0064 0.0075
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0064 0.0075
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0389 0.0454
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0109 0.0109
Brugia malayi Pre-SET motif family protein 0.0228 0.2481 0.2899
Brugia malayi Carboxylesterase family protein 0.0069 0.0596 0.0696
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.171 0.1998
Brugia malayi Polyprenyl synthetase family protein 0.0062 0.052 0.0608
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0081 0.0738 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0055 0.0194
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0255 0.2805 0.2805
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.2481 0.2899
Schistosoma mansoni hypothetical protein 0.0111 0.1098 0.1098
Brugia malayi steroid hormone receptor 0.0103 0.1005 0.1175
Schistosoma mansoni retinoic acid receptor RXR 0.0103 0.1005 0.1005
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0022 0.0034 0.0034
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0414 0.5613
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.0357 0.0417
Brugia malayi nuclear receptor NHR-88 0.0049 0.0357 0.0417
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1005 0.1175
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0022 0.0034 0.0034
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0049 0.0357 0.0357
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0321 0.0375
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0062 0.052 0.8577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0103 0.1005 0.1175
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0232 0.0232
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0034 0.004
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0357 0.0357
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0022 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0103 0.1005 0.1175
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0127
Brugia malayi hypothetical protein 0.0041 0.027 0.0316
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0739 0.8556 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0423 0.4806 0.4806
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0103 0.1005 0.1005
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0414 0.0414
Onchocerca volvulus 0.0164 0.1729 0.6062
Loa Loa (eye worm) norepinephrine transporter 0.0164 0.1729 0.2021
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0103 0.1005 0.1175
Trypanosoma brucei protein kinase, putative 0.0054 0.0414 0.5613
Brugia malayi nuclear hormone receptor 0.0103 0.1005 0.1175
Brugia malayi nuclear hormone receptor 0.0049 0.0357 0.0417
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0069 0.0596 0.0596
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0034 0.0464
Leishmania major glycerol uptake protein, putative 0.0022 0.0034 0.0122
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0357 0.0417
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.027 0.4905
Schistosoma mansoni microtubule-associated protein tau 0.0726 0.8401 0.8401
Brugia malayi hypothetical protein 0.0069 0.0596 0.0696
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0034 0.004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0103 0.1005 0.1005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0103 0.1005 0.1175
Loa Loa (eye worm) hypothetical protein 0.0041 0.027 0.0316
Leishmania major farnesyl pyrophosphate synthase 0.0062 0.052 0.1854
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0179 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0103 0.1005 0.1175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0103 0.1005 0.1175
Schistosoma mansoni RAR-like nuclear receptor 0.0103 0.1005 0.1005
Brugia malayi tailless protein 0.0049 0.0357 0.0417
Onchocerca volvulus 0.0049 0.0357 0.125
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0106
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0103 0.1005 0.1005
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.012 0.0807
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0103 0.1005 0.1005
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0601 0.0601
Onchocerca volvulus 0.0069 0.0596 0.2089
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0739 0.8556 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0408 0.462 0.462
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0357 0.0357
Echinococcus multilocularis geminin 0.074 0.857 0.857
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0127
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0596 0.0596
Trypanosoma cruzi GUP1, putative 0.0022 0.0034 0.0122
Loa Loa (eye worm) hypothetical protein 0.0069 0.0596 0.0696
Trichomonas vaginalis ran, putative 0.0021 0.003 0.0104
Loa Loa (eye worm) hypothetical protein 0.0081 0.0738 0.0862
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0022 0.0034 0.0034
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.0426 0.0426
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.1098 0.1284
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0062 0.052 0.052
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0232 0.0812
Echinococcus multilocularis thyroid hormone receptor alpha 0.0236 0.2578 0.2578
Leishmania major glycerol uptake protein, putative 0.0022 0.0034 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0034 0.012
Brugia malayi RNA, U transporter 1 0.0082 0.0752 0.0879
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0055 0.0194
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0062 0.052 0.1823
Schistosoma mansoni hypothetical protein 0.0051 0.0389 0.0389
Echinococcus granulosus snurportin 1 0.0308 0.3437 0.3437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0103 0.1005 0.1175
Schistosoma mansoni polycystin 1-related 0.0041 0.027 0.027
Entamoeba histolytica hypothetical protein 0.0023 0.0055 0.0751
Mycobacterium ulcerans carboxylesterase, LipT 0.0069 0.0596 1
Echinococcus granulosus geminin 0.074 0.857 0.857
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0179 0.0179
Onchocerca volvulus 0.0069 0.0596 0.2089
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0389 0.0454
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0103 0.1005 0.1005
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0062 0.052 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.027 0.027
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0062 0.052 1
Onchocerca volvulus 0.0057 0.0451 0.1583
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0081 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Leishmania major polyprenyl synthase, putative 0.0255 0.2805 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0034 0.0464
Entamoeba histolytica hypothetical protein 0.0022 0.0034 0.0464
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0103 0.1005 0.1005
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0022 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.0069 0.0596 0.0696
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0062 0.052 0.1823
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0103 0.0103
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0062 0.052 0.8577
Echinococcus granulosus tar DNA binding protein 0.0069 0.0601 0.0601
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0426 0.0498
Schistosoma mansoni trans-prenyltransferase 0.0062 0.052 0.052
Onchocerca volvulus 0.0022 0.0034 0.012
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0414 0.1477
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0034 0.0034
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.0357 0.0357
Trichomonas vaginalis set domain proteins, putative 0.0259 0.2852 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0412 0.4668 0.4668
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0109 0.0109
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.3437 0.4017
Leishmania major solanesyl-diphosphate synthase, putative 0.0062 0.052 0.1854
Leishmania major cytochrome p450-like protein 0.0024 0.0064 0.0228
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.027 0.027
Echinococcus granulosus serotonin transporter 0.0164 0.1729 0.1729
Loa Loa (eye worm) hypothetical protein 0.0103 0.1005 0.1175
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0034 0.0464
Schistosoma mansoni hypothetical protein 0.0132 0.1351 0.1351
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0179 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0601 0.0601
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0739 0.8556 0.8556
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Schistosoma mansoni hypothetical protein 0.0051 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0069 0.0596 0.0696
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0179 0.0179
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0389 0.0454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0321
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0081 0.0738 0.0738
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0103 0.1005 0.1175
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0109 0.0704
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0232 0.0232
Schistosoma mansoni thyroid hormone receptor 0.0236 0.2578 0.2578
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0062 0.052 0.1854
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0034 0.012
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0106
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0426 0.0498
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0103 0.1005 0.1005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0103 0.1005 0.1005
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0109 0.1611
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0022 0.0034 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0232 0.0812
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0062 0.052 0.8577
Schistosoma mansoni zinc finger protein 0.0022 0.0034 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0321 0.0321
Loa Loa (eye worm) solute carrier family 6 member 4 0.0164 0.1729 0.2021
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0103 0.1005 0.1175
Schistosoma mansoni loxhd1 0.0041 0.027 0.027
Plasmodium falciparum transporter, putative 0.0028 0.0109 0.1611
Echinococcus multilocularis sterol O acyltransferase 1 0.0221 0.2407 0.2407
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.012
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0062 0.052 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.0426 0.0426
Onchocerca volvulus 0.0041 0.027 0.0947
Brugia malayi MBOAT family protein 0.0022 0.0034 0.004
Schistosoma mansoni zinc finger protein 0.0049 0.0357 0.0357
Echinococcus granulosus microtubule associated protein 2 0.0726 0.8401 0.8401
Brugia malayi diacylglycerol acyltransferase 0.0022 0.0034 0.004
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0022 0.0034 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0103 0.1005 0.1175
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0232 0.0826
Schistosoma mansoni hypothetical protein 0.086 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0179 0.0179
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0106
Echinococcus multilocularis cpg binding protein 0.0064 0.0536 0.0536
Leishmania major GTP-binding protein, putative 0.0021 0.003 0.0106
Loa Loa (eye worm) doublecortin family protein 0.0041 0.027 0.0316
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0414 0.1477
Loa Loa (eye worm) hypothetical protein 0.0051 0.0389 0.0454
Schistosoma mansoni hypothetical protein 0.0041 0.027 0.027
Brugia malayi Importin beta-1 subunit 0.0029 0.012 0.0141
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0138 0.0162
Echinococcus granulosus lamin dm0 0.0057 0.0451 0.0451
Brugia malayi ecdysone receptor 0.0049 0.0357 0.0417
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0109 0.0109
Loa Loa (eye worm) carboxylesterase 0.0069 0.0596 0.0696
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0738 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1005 0.1175
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0055 0.0426 0.0498
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0103 0.1005 0.1005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0103 0.1005 0.1005
Schistosoma mansoni lamin 0.0057 0.0451 0.0451
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0064 0.0228
Echinococcus granulosus acetylcholinesterase 0.0408 0.462 0.462
Schistosoma mansoni hypothetical protein 0.0051 0.0389 0.0389
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0596 0.0596
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0081 0.0738 0.2588
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0109 0.0127
Brugia malayi nuclear receptor NHR-88 0.0103 0.1005 0.1175
Schistosoma mansoni BC026374 protein (S09 family) 0.0069 0.0596 0.0596
Echinococcus multilocularis BC026374 protein (S09 family) 0.0069 0.0596 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0103 0.1005 0.1175
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.0426 0.0426
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0414 0.1477
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0451 0.0528
Echinococcus granulosus para nitrobenzyl esterase 0.0069 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0111 0.1098 0.1284
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0103 0.1005 0.1005
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0062 0.052 0.8577
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0109 0.0109
Loa Loa (eye worm) carboxylesterase 0.0408 0.462 0.54
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0022 0.0034 0.0034
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0738 0.2631
Echinococcus multilocularis GPCR, family 2 0.0051 0.0389 0.0389
Brugia malayi nuclear receptor RXR 0.0049 0.0357 0.0417
Echinococcus granulosus ecdysone induced protein 78C 0.0103 0.1005 0.1005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0109 0.0109
Echinococcus granulosus neuroligin 0.0069 0.0596 0.0596
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0451 0.0528
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0127
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0062 0.052 0.052
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0055 0.0194
Schistosoma mansoni lipoxygenase 0.0116 0.1157 0.1157
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0232 0.0826
Leishmania major glycerol uptake protein, putative 0.0022 0.0034 0.0122
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0127
Loa Loa (eye worm) steroid hormone receptor 0.0103 0.1005 0.1175
Schistosoma mansoni hypothetical protein 0.0308 0.3437 0.3437
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.0357 0.0417
Loa Loa (eye worm) hypothetical protein 0.0164 0.1729 0.2021
Schistosoma mansoni thyroid hormone receptor 0.0236 0.2578 0.2578
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0414 0.1452
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0062 0.052 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0138 0.0162
Entamoeba histolytica vacuolar protein sorting 26 0.0022 0.0034 0.0464
Loa Loa (eye worm) hypothetical protein 0.0057 0.0451 0.0528
Schistosoma mansoni ap endonuclease 0.0038 0.0232 0.0232
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0064 0.0868
Echinococcus granulosus GPCR family 2 0.0051 0.0389 0.0389
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0062 0.052 0.7921
Echinococcus multilocularis microtubule associated protein 2 0.0726 0.8401 0.8401
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0028 0.0109 0.0109
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0103 0.1005 0.3524
Schistosoma mansoni nuclear receptor 0.0049 0.0357 0.0357
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0451 0.0528
Brugia malayi intermediate filament protein 0.0057 0.0451 0.0528
Loa Loa (eye worm) hypothetical protein 0.0069 0.0596 0.0696
Loa Loa (eye worm) hypothetical protein 0.0041 0.027 0.0316
Loa Loa (eye worm) polyprenyl synthetase 0.0062 0.052 0.0608
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0022 0.0034 0.0034
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.003 0.003
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.0357 0.0357
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0414 0.1452
Onchocerca volvulus 0.0069 0.0596 0.2089
Onchocerca volvulus 0.0028 0.0109 0.0381
Brugia malayi Carboxylesterase family protein 0.0069 0.0596 0.0696
Toxoplasma gondii hypothetical protein 0.0022 0.0034 0.0041
Brugia malayi MBOAT family protein 0.0022 0.0034 0.004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0103 0.1005 0.1005
Plasmodium falciparum importin beta, putative 0.0029 0.012 0.1846
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0064 0.0228
Loa Loa (eye worm) hypothetical protein 0.0034 0.0179 0.0209
Schistosoma mansoni nuclear receptor 0.0049 0.0357 0.0357
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0403
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0103 0.1005 0.1005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0081 0.0738 0.0862
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0109 0.0109
Echinococcus granulosus BC026374 protein S09 family 0.0069 0.0596 0.0596
Schistosoma mansoni rab6-interacting 0.0041 0.027 0.027
Onchocerca volvulus 0.0028 0.0109 0.0381
Brugia malayi Nuclear hormone receptor-like 1 0.0103 0.1005 0.1175
Plasmodium vivax importin-beta 2, putative 0.0029 0.012 0.1846
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0034 0.0464
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0034 0.0122
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0596 0.0596
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0103 0.1005 0.1175
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.171 0.1998
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0103 0.1005 0.1175
Echinococcus granulosus acetylcholinesterase 0.0408 0.462 0.462
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0034 0.004
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0062 0.052 0.7047
Brugia malayi hypothetical protein 0.0028 0.0109 0.0127
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0062 0.052 0.7921
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0357 0.0417
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0127
Toxoplasma gondii exonuclease III APE 0.0038 0.0232 0.1801
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0022 0.0034 0.0034
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0081 0.0738 1
Schistosoma mansoni acetylcholinesterase 0.0069 0.0596 0.0596
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0357 0.125
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0255 0.2805 0.3278
Brugia malayi ecdysteroid receptor 0.0103 0.1005 0.1175
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.027 0.027
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0109 0.0127
Treponema pallidum octaprenyl-diphosphate synthase 0.0255 0.2805 1
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0022 0.0034 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0103 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0426 0.0498
Loa Loa (eye worm) hypothetical protein 0.0164 0.1729 0.2021
Brugia malayi photoreceptor-specific nuclear receptor 0.0103 0.1005 0.1175
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0414 0.1477
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0034 0.0034
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0414 0.5613
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0103 0.1005 0.1175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0321
Echinococcus multilocularis importin subunit beta 1 0.0029 0.012 0.012
Brugia malayi Carboxylesterase family protein 0.0408 0.462 0.54
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0034 0.0122
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0034 0.0034
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0109 0.0109
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0179 0.1327
Loa Loa (eye worm) hypothetical protein 0.0221 0.2407 0.2813
Echinococcus multilocularis lamin 0.0057 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Brugia malayi Polyprenyl synthetase family protein 0.0062 0.052 0.0608
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0232 0.314
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.0357 0.0357
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0062 0.052 0.7047
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0403
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.012 0.1629
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0062 0.052 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0389 0.0389
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0081 0.0738 0.2588
Schistosoma mansoni coup transcription factor 0.0103 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Schistosoma mansoni hypothetical protein 0.074 0.857 0.857
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0103 0.1005 0.1005
Loa Loa (eye worm) RNA binding protein 0.0069 0.0601 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0103 0.1005 0.1175
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0357 0.0357
Leishmania major glycerol uptake protein, putative 0.0022 0.0034 0.0122
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0062 0.052 0.7921
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0414 0.1452
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0232 0.0826
Schistosoma mansoni hypothetical protein 0.0056 0.0445 0.0445
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.027 0.027
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0109 0.0109
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0064 0.0075
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0601 0.0703
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0596 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0034 0.012
Loa Loa (eye worm) acetylcholinesterase 1 0.0408 0.462 0.54
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0232 0.4119
Echinococcus multilocularis dnaJ subfamily B 0.086 1 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0179 0.3036
Onchocerca volvulus 0.0028 0.0109 0.0381
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.0357 0.0417
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0022 0.0034 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0179 0.0179
Brugia malayi Carboxylesterase family protein 0.0408 0.462 0.54
Trichomonas vaginalis spcc417.12 protein, putative 0.0069 0.0596 0.2089
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0022 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0127
Brugia malayi Cytochrome P450 family protein 0.0024 0.0064 0.0075
Brugia malayi TAR-binding protein 0.0069 0.0601 0.0703
Loa Loa (eye worm) carboxylesterase 0.0069 0.0596 0.0696
Mycobacterium tuberculosis Carboxylesterase LipT 0.0069 0.0596 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0103 0.1005 0.1175
Loa Loa (eye worm) hypothetical protein 0.0055 0.0426 0.0498
Brugia malayi CXXC zinc finger family protein 0.006 0.0495 0.0579
Schistosoma mansoni sodium/chloride dependent transporter 0.0164 0.1729 0.1729
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0081 0.0738 0.0738
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0062 0.052 0.1854
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.0357 0.0417
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0028 0.0109 0.0109
Brugia malayi MAP kinase sur-1 0.0054 0.0414 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0103 0.1005 0.1175
Brugia malayi Cytochrome P450 family protein 0.0024 0.0064 0.0075
Schistosoma mansoni rab6-interacting 0.0041 0.027 0.027
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.0357 0.0417
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0357 0.125
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0109 0.0704
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0179 0.0179
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0069 0.0596 0.0596
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0103 0.1005 0.1005
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0081 0.0738 0.2631
Brugia malayi MBOAT family protein 0.0022 0.0034 0.004
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0062 0.052 0.052
Schistosoma mansoni lipoxygenase 0.0041 0.027 0.027
Onchocerca volvulus 0.0041 0.027 0.0947
Loa Loa (eye worm) hypothetical protein 0.0055 0.0426 0.0498
Brugia malayi conserved hypotetical protein 0.0049 0.0357 0.0417
Brugia malayi MBOAT family protein 0.0022 0.0034 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0389 0.0389
Brugia malayi Carboxylesterase family protein 0.0069 0.0596 0.0696
Loa Loa (eye worm) hypothetical protein 0.0163 0.171 0.1998
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0601 0.0601
Brugia malayi Pre-SET motif family protein 0.0034 0.0179 0.0209
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0141
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0103 0.1005 0.1005
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0414 0.1452
Schistosoma mansoni cpg binding protein 0.0064 0.0536 0.0536
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0414 0.0414
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0062 0.052 0.7047
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0232 0.4119
Trichomonas vaginalis transmembrane protein nessy, putative 0.0022 0.0034 0.012
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0022 0.0034 0.0041
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0062 0.052 1
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0601 0.0703
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0321 0.0321
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.0426 0.0498
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Loa Loa (eye worm) histone methyltransferase 0.002 0.0014 0.0016
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0109 0.0127
Echinococcus granulosus ubiquitin specific protease 41 0.0081 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0049 0.0357 0.0417
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0062 0.052 0.1854
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0357 0.0357
Onchocerca volvulus 0.0057 0.0451 0.1583

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.1 Inhibition of human recombinant geranylgeranyl diphosphate synthase ChEMBL. 18800762
IC50 (binding) = 0.07 uM Inhibition of Saccharomyces cerevisiae GGPPS ChEMBL. 17535895
IC50 (binding) = 0.07 uM Inhibition of Saccharomyces cerevisiae GGPPS ChEMBL. 17535895
IC50 (binding) = 0.72 uM Inhibition of human GGPPS ChEMBL. 17535895
IC50 (binding) = 0.72 uM Inhibition of human GGPPS ChEMBL. 17535895
IC50 (binding) = 0.72 uM Inhibition of human recombinant geranylgeranyl diphosphate synthase ChEMBL. 18800762
IC50 (binding) = 0.91 uM Inhibition of Escherichia coli UPPS ChEMBL. 17535895
IC50 (binding) = 2.7 uM Inhibition of Sulfolobus solfataricus HPPS ChEMBL. 17535895
IC50 (binding) = 870 uM Inhibition of Escherichia coli OPPS ChEMBL. 17535895
Ki (binding) = 0.02 uM Binding affinity to human GGPPS ChEMBL. 17535895
Ki (binding) = 0.02 uM Binding affinity to human GGPPS ChEMBL. 17535895
Ki (binding) = 0.03 uM Binding affinity to Saccharomyces cerevisiae GGPPS ChEMBL. 17535895
Ki (binding) = 0.03 uM Binding affinity to Saccharomyces cerevisiae GGPPS ChEMBL. 17535895
Log IC50 (binding) = 6 Inhibition of Escherichia coli UPPS ChEMBL. 17535895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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