Detailed information for compound 513592

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.357 | Formula: C19H16F3N5O3
  • H donors: 4 H acceptors: 4 LogP: 2.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)Nc1cn(nc1C(=O)N)c1ccc(c(c1)C(F)(F)F)c1ccc(cc1C)O
  • InChi: 1S/C19H16F3N5O3/c1-9-6-11(28)3-5-12(9)13-4-2-10(7-14(13)19(20,21)22)27-8-15(25-18(24)30)16(26-27)17(23)29/h2-8,28H,1H3,(H2,23,29)(H3,24,25,30)
  • InChiKey: LLQGNSYWIFSDCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0626 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1665 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0027 0.0333 0.2061
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0038 0.0052
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.1614 0.1609
Plasmodium falciparum importin beta, putative 0.0028 0.0347 0.0341
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0012 0.0094 0.0139
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0015 0.0134 0.0779
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0011 0.0068 0.0062
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0011 0.0068 0.0381
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0015 0.0134 0.1578
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0011 0.0068 0.0387
Schistosoma mansoni copper ABC transporter ATPase 0.0011 0.0068 0.0098
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0239 0.3747 0.3621
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0015 0.0134 0.0779
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.027 0.0265
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1614 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0176 0.0361
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0197 0.1155
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0347 0.2056
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0006 0.0012
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0034 0.0442 0.0677
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.036 0.0949
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0012 0.0094 0.0139
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1665 1
Trypanosoma cruzi DNA-directed RNA polymerase III, putative 0.0012 0.0094 0.0539
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0126 0.1933 0.2989
Entamoeba histolytica DNA-directed RNA polymerase subunit, putative 0.0012 0.0094 0.0551
Brugia malayi hypothetical protein 0.0019 0.0207 0.0556
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0027 0.0333 0.1971
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0012 0.0094 0.0246
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.027 0.0265
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0258 0.0537
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0034 0.0442 0.2628
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0207 0.0314
Leishmania major calcium motive p-type ATPase, putative 0.0027 0.0333 0.1971
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB2, putative 0.0012 0.0094 0.0089
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0197 0.1474
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0006 0.0002
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0206 0.3211 0.4969
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0012 0.0094 0.0246
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0027 0.0333 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0176 0.0361
Echinococcus granulosus RUN 0.0019 0.0207 0.0314
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1614 1
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0011 0.0068 0.0062
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.2187 0.3382
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0207 0.0428
Schistosoma mansoni cation-transporting ATPase 0.0011 0.0068 0.0098
Schistosoma mansoni polycystin 1-related 0.0019 0.0207 0.0314
Echinococcus granulosus Na:K ATPase alpha subunit 0.0076 0.1118 0.1726
Schistosoma mansoni ran 0.0021 0.0228 0.0346
Schistosoma mansoni lipoxygenase 0.0054 0.0768 0.1184
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0038 0.0069
Echinococcus multilocularis nervana 2 0.0206 0.3211 0.4969
Leishmania major copper-transporting ATPase-like protein, putative 0.0011 0.0068 0.0375
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0011 0.0068 0.0062
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0034 0.0442 0.2628
Echinococcus granulosus snurportin 1 0.0299 0.4712 0.7296
Plasmodium vivax importin-beta 2, putative 0.0028 0.0347 0.0341
Trypanosoma cruzi P-type H+-ATPase, putative 0.0022 0.0243 0.1436
Brugia malayi E1-E2 ATPase family protein 0.0022 0.0243 0.0654
Plasmodium vivax copper-transporting ATPase, putative 0.0011 0.0068 0.0062
Echinococcus multilocularis nervana 2 0.0126 0.1933 0.2989
Schistosoma mansoni hypothetical protein 0.0407 0.6457 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0273
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0016 0.0157 0.0419
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0126 0.1933 0.2989
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1665 1
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0027 0.0333 0.0508
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.1614 0.4299
Onchocerca volvulus 0.0083 0.1227 0.3811
Plasmodium vivax DNA-directed RNA polymerase II subunit RPB2, putative 0.0012 0.0094 0.0089
Trypanosoma brucei calcium-translocating P-type ATPase 0.0027 0.0333 0.1971
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0261 0.162
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0228 0.272
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0011 0.0068 0.0421
Treponema pallidum cation-transporting ATPase, P-type 0.0011 0.0068 0.0169
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.036 0.0294
Schistosoma mansoni rab6-interacting 0.0019 0.0207 0.0314
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.036 0.2202
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0228 0.0222
Schistosoma mansoni ATPase 0.0034 0.0442 0.0677
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0019 0.0203 0.0545
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0034 0.0442 0.2736
Leishmania major calcium-translocating P-type ATPase 0.0034 0.0442 0.2628
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.6457 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0176 0.0361
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1614 1
Plasmodium falciparum DNA-directed RNA polymerase I subunit RPA2, putative 0.0009 0.0038 0.0033
Echinococcus granulosus cation transporting ATPase 13A3 0.0011 0.0068 0.0098
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0207 0.0314
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0347 0.053
Brugia malayi E1-E2 ATPase family protein 0.0011 0.0068 0.0174
Loa Loa (eye worm) hypothetical protein 0.0023 0.027 0.0563
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0065 0.0942 0.0937
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0016 0.0157 0.0921
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.1614 0.1609
Trypanosoma brucei P-type H+-ATPase, putative 0.0022 0.0243 0.1431
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0011 0.0068 0.0174
Brugia malayi calcium ATPase 0.0012 0.0094 0.0246
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.1208 0.7474
Leishmania major P-type ATPase, putative 0.0027 0.0333 0.1971
Schistosoma mansoni hypothetical protein 0.0052 0.0729 0.1123
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.1208 0.7474
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0027 0.0333 0.0508
Schistosoma mansoni loxhd1 0.0019 0.0207 0.0314
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0442 0.2736
Leishmania major RNA polymerase I second largest subunit, putative 0.0009 0.0038 0.0196
Echinococcus granulosus cpg binding protein 0.003 0.0383 0.0586
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0011 0.0068 0.0387
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1665 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1665 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0132
Brugia malayi 6-phosphofructokinase 0.0107 0.1614 0.4417
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0228 0.1343
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0569 0.6888
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0011 0.0068 0.0387
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0197 0.0192
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0442 0.2736
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0176 0.017
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1665 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0027 0.0333 0.1976
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1614 0.3417
Entamoeba histolytica DNA-directed RNA polymerase subunit, putative 0.0012 0.0094 0.0551
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.027 0.1646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.016 0.0155
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0011 0.0068 0.0062
Echinococcus granulosus nervana 2 0.0206 0.3211 0.4969
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.036 0.0354
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0176 0.017
Schistosoma mansoni ap endonuclease 0.0019 0.0197 0.0299
Brugia malayi RNA, U transporter 1 0.008 0.1179 0.3222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.027 0.0265
Schistosoma mansoni cpg binding protein 0.0029 0.0356 0.0545
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.016 0.0155
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.036 0.0354
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0206 0.3211 0.4969
Brugia malayi AMP-binding enzyme family protein 0.0023 0.027 0.0729
Brugia malayi Doublecortin family protein 0.0019 0.0207 0.0556
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0023 0.0267 0.0261
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.027 0.1646
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0034 0.0442 0.2628
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0011 0.0068 0.0772
Trypanosoma cruzi calpain cysteine peptidase, putative 0.011 0.1665 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.027 0.0729
Plasmodium vivax calcium-transporting ATPase, putative 0.0034 0.0442 0.0436
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0569 0.3528
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0132
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0347 0.0725
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.036 0.0354
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0442 0.2711
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.2123 0.3283
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.4712 1
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0239 0.3747 1
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0626 1 1
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0027 0.0333 0.09
Giardia lamblia Copper-transporting P-type ATPase 0.0011 0.0068 0.0276
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0012 0.0094 0.0139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0176 0.0361
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0207 0.0314
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0011 0.0068 0.0098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.016 0.0155
Trypanosoma brucei calpain, putative 0.011 0.1665 1
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.1208 0.7474
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0003
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.011 0.1665 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0197 0.0529
Brugia malayi AMP-binding enzyme family protein 0.0023 0.027 0.0729
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0034 0.0442 0.2628
Loa Loa (eye worm) acetyltransferase 0.0142 0.2187 0.4635
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0012 0.0094 0.1092
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0442 0.2711
Trichomonas vaginalis cation-transporting ATPase, putative 0.0022 0.0243 0.1506
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0239 0.3747 0.3743
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0228 0.0472
Loa Loa (eye worm) hypothetical protein 0.0017 0.0176 0.0361
Plasmodium vivax cation transporting ATPase, putative 0.0011 0.0068 0.0062
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0207 0.0314
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0197 0.1222
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1614 0.9694
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1614 0.9695
Loa Loa (eye worm) hypothetical protein 0.0019 0.0207 0.0428
Schistosoma mansoni rab6-interacting 0.0019 0.0207 0.0314
Entamoeba histolytica Ran family GTPase 0.0021 0.0228 0.138
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0261 0.162
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.1208 0.7474
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0011 0.0068 0.0062
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.027 0.0265
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0011 0.0068 0.0276
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0034 0.0442 0.0677
Trypanosoma brucei DNA-directed RNA polymerase III, putative 0.0012 0.0094 0.0534
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0442 0.2736
Trypanosoma brucei hypothetical protein 0.011 0.1665 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0347 0.4173
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0027 0.0333 0.0508
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0012 0.0094 0.1092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.016 0.0155
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0197 0.0407
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0034 0.0442 0.2632
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0873 0.1345
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.036 0.4332
Brugia malayi Cytochrome P450 family protein 0.0022 0.0258 0.0697
Schistosoma mansoni ap endonuclease 0.0019 0.0197 0.0299
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0006 0.0012
Trypanosoma brucei RNA polymerase I second largest subunit 0.0009 0.0038 0.0196
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.2187 0.3382
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.036 0.223
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0034 0.0442 0.2711
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0197 0.1222
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0027 0.0333 0.0508
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0197 0.0192
Loa Loa (eye worm) hypothetical protein 0.0049 0.0681 0.1435
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0206 0.3211 0.4969
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0176 0.017
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0016 0.0157 0.0323
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0003
Echinococcus multilocularis calcium transporting atpase 0.0027 0.0333 0.0508
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0058 0.0837 0.0832
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0027 0.0333 0.0508
Echinococcus granulosus nervana 2 0.0126 0.1933 0.2989
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0012 0.0094 0.0139
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0072 0.1052 0.2874
Echinococcus granulosus cation transporting atpase worm 0.0011 0.0068 0.0098
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0207 0.0314
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0347 0.2056
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0197 0.0192
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0228 0.0346
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0034 0.0442 0.0677
Plasmodium vivax P-type ATPase4, putative 0.0034 0.0442 0.0436
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0126 0.1933 0.2989
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0038 0.0052
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1665 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0003
Loa Loa (eye worm) E1-E2 ATPase 0.0022 0.0243 0.0504
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0012 0.0094 0.0139
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0011 0.0068 0.0062
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0006 0.0003
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0626 1 1
Brugia malayi follicle stimulating hormone receptor 0.0233 0.3649 1
Leishmania major calcium-transporting ATPase, putative 0.0027 0.0333 0.1971
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0034 0.0442 0.3736
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0012 0.0094 0.0584
Leishmania major P-type H -ATPase, putative 0.0022 0.0243 0.1431
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0011 0.0068 0.0421
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0011 0.0068 0.0387
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.1614 0.2494
Schistosoma mansoni DNA-directed rna polymerase II subunit 0.0012 0.0094 0.0139
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0023 0.0267 0.0261
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0006 0.0003
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0015 0.0134 0.0273
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0034 0.0442 0.533
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0034 0.0442 0.0677
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0011 0.0068 0.0062
Brugia malayi Na,K-ATPase alpha subunit 0.0083 0.1227 0.3355
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.036 0.223
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0239 0.3747 0.3704
Loa Loa (eye worm) hypothetical protein 0.0016 0.0157 0.0323
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1665 1
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0027 0.0333 0.2727
Trypanosoma brucei cation-transporting ATPase, putative 0.0011 0.0068 0.0375
Brugia malayi Importin beta-1 subunit 0.0028 0.0347 0.0939
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0825 1
Echinococcus multilocularis nervana 2 0.0126 0.1933 0.2989
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.027 0.1646
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0019 0.0203 0.1228
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0034 0.0442 0.0677
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0197 0.0192
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0176 0.0108
Toxoplasma gondii P-type ATPase PMA1 0.0022 0.0243 0.2908
Loa Loa (eye worm) hypothetical protein 0.0206 0.3211 0.681
Plasmodium falciparum copper-transporting ATPase 0.0011 0.0068 0.0062
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0027 0.0333 0.4
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1665 1
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC2, putative 0.0012 0.0094 0.0089
Echinococcus granulosus dnaJ subfamily B 0.0407 0.6457 1
Brugia malayi phosphofructokinase 0.0107 0.1614 0.4417
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0356 0.0745
Mycobacterium ulcerans hypothetical protein 0.0023 0.027 0.0265
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0207 0.0202
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1614 0.2494
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0442 0.2736
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0006 0.0002
Entamoeba histolytica DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide, putative 0.0012 0.0094 0.0551
Echinococcus multilocularis cation transporting ATPase 13A1 0.0011 0.0068 0.0098
Schistosoma mansoni cation-transporting atpase worm 0.0011 0.0068 0.0098
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0197 0.1155
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1614 0.2494
Trypanosoma brucei DNA-directed RNA polymerase II subunit 2, putative 0.0012 0.0094 0.0534
Onchocerca volvulus 0.0023 0.027 0.0826
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0626 1 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0027 0.0333 0.1976
Loa Loa (eye worm) phosphofructokinase 0.0107 0.1614 0.3417
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.027 0.1596
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.011 0.1665 1
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0126 0.1933 0.2989
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0012 0.0094 0.0188
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.027 0.0265
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0083 0.1227 0.1222
Leishmania major importin beta-1 subunit, putative 0.0023 0.0261 0.1542
Leishmania major proton motive ATPase, putative 0.0011 0.0068 0.0375
Schistosoma mansoni transmemberane protein 0.0206 0.3211 0.4969
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0569 0.6888
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0012 0.0094 0.0246
Trypanosoma brucei calcium-transporting ATPase, putative 0.0016 0.0157 0.0915
Onchocerca volvulus 0.0019 0.0207 0.0629
Schistosoma mansoni hypothetical protein 0.0019 0.0207 0.0314
Onchocerca volvulus 0.0126 0.1933 0.6014
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0011 0.0068 0.0062
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0012 0.0094 0.0139
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0228 0.1338
Entamoeba histolytica hypothetical protein 0.0023 0.0261 0.159
Trypanosoma cruzi RNA polymerase I second largest subunit, putative 0.0009 0.0038 0.0202
Leishmania major GTP-binding protein, putative 0.0021 0.0228 0.1338
Loa Loa (eye worm) hypothetical protein 0.0034 0.0442 0.0926
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0012 0.0094 0.0188
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0442 0.2736
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.0138
Plasmodium vivax DNA-directed RNA polymerase I subunit RPA2, putative 0.0009 0.0038 0.0033
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0006 0.0006
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1665 1
Echinococcus multilocularis RUN 0.0019 0.0207 0.0314
Echinococcus multilocularis cpg binding protein 0.003 0.0383 0.0586
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0003
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.1614 0.4301
Plasmodium vivax DNA-directed RNA polymerase III subunit, putative 0.0012 0.0094 0.0089
Toxoplasma gondii P-type ATPase4, putative 0.0034 0.0442 0.533
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1614 0.3417
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.1208 0.7474
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0006 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0197 0.0299
Echinococcus multilocularis cation transporting atpase worm 0.0011 0.0068 0.0098
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0034 0.0442 0.2628
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.001 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.027 0.0265
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0011 0.0068 0.0098
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.036 0.4332
Brugia malayi calcium ATPase 0.0015 0.0134 0.0355
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.027 0.1596
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.2187 0.5989
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0034 0.0442 0.0677
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0011 0.0068 0.0098
Brugia malayi Membrane calcium atpase protein 3 0.0027 0.0333 0.09
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0206 0.3211 0.4969
Toxoplasma gondii exonuclease III APE 0.0019 0.0197 0.235
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0006 0.0002
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0083 0.1227 0.2595
Loa Loa (eye worm) calcium ATPase 0.0019 0.0203 0.042
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0012 0.0094 0.0519
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.036 0.223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0207 0.0428
Schistosoma mansoni hypothetical protein 0.0299 0.4712 0.7296
Schistosoma mansoni importin beta-1 0.0028 0.0347 0.053
Echinococcus granulosus nervana 2 0.0126 0.1933 0.2989
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0442 0.2736
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.036 0.4332
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1614 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0626 1 1
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0027 0.0333 0.0508
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0012 0.0094 0.0584
Trypanosoma cruzi DNA-directed RNA polymerase II subunit 2, putative 0.0008 0.0027 0.0134
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0011 0.0068 0.0174
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0006 0.0006
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0442 0.2736
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0206 0.3211 0.4969
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0027 0.0333 0.0508
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0011 0.0068 0.0772
Echinococcus multilocularis snurportin 1 0.0299 0.4712 0.7296
Loa Loa (eye worm) hypothetical protein 0.0206 0.3211 0.681
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.1614 0.2494
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.036 0.0354
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0034 0.0442 0.0436
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.027 0.0265
Schistosoma mansoni type V p-type atpase isoform 0.0011 0.0068 0.0098
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0442 0.2711
Schistosoma mansoni ATPase 0.0034 0.0442 0.0677
Schistosoma mansoni lipoxygenase 0.0019 0.0207 0.0314
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.1614 0.9694
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0072 0.1052 0.2797
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0083 0.1227 0.1895
Echinococcus multilocularis copper transporting ATPase 1 0.0011 0.0068 0.0098
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0228 0.1343
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0011 0.0068 0.0421
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0011 0.0068 0.0062
Brugia malayi 6-phosphofructokinase 0.0107 0.1614 0.4417
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.011 0.1665 1
Leishmania major P-type H -ATPase, putative 0.0022 0.0243 0.1431
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1614 1
Trypanosoma cruzi P-type H+-ATPase, putative 0.0022 0.0243 0.1436
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0569 0.3528
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0768 0.1184
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0569 0.0564
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0207 0.0202
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0206 0.3211 0.4969
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0197 0.1192
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.027 0.0708
Echinococcus multilocularis cation transporting ATPase 13A3 0.0011 0.0068 0.0098
Plasmodium falciparum calcium-transporting ATPase 0.0027 0.0333 0.0327
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0076 0.1118 0.1726
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0569 0.0875
Echinococcus multilocularis nervana 2 0.0206 0.3211 0.4969
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0206 0.3211 0.4969
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0176 0.017
Trypanosoma brucei P-type H+-ATPase, putative 0.0022 0.0243 0.1431
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0019 0.0203 0.1228
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1614 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.1227 0.2595
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0011 0.0068 0.0375
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0012 0.0094 0.0539
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.0138
Schistosoma mansoni cpg binding protein 0.003 0.0383 0.0586
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0513 0.0508
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0626 1 1
Onchocerca volvulus 0.0019 0.0207 0.0629
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.001 0.0008
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0015 0.0134 0.0798
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0006 0.0012
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0034 0.0442 0.2632
Onchocerca volvulus 0.0029 0.0356 0.1094
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0006 0.0006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1665 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.036 0.223
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.036 0.223
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0012 0.0094 0.0139
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0228 0.0612
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.036 0.2979
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0034 0.0442 0.0436
Loa Loa (eye worm) hypothetical protein 0.0061 0.088 0.1857
Schistosoma mansoni cpg binding protein 0.003 0.0383 0.0586
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0206 0.3211 0.4969
Loa Loa (eye worm) DNA-directed RNA polymerase 0.001 0.0059 0.0113
Loa Loa (eye worm) hypothetical protein 0.0023 0.027 0.0563
Echinococcus granulosus calcium transporting atpase 0.0027 0.0333 0.0508
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0207 0.0314
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0006 0.0035
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.036 0.0294
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.027 0.0265
Echinococcus granulosus nervana 2 0.0206 0.3211 0.4969
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0012 0.0094 0.0139
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.001 0.0008
Toxoplasma gondii DNA-directed RNA polymerase I RPA2 0.0009 0.0038 0.0409
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.036 0.223
Echinococcus granulosus cation transporting ATPase 13A1 0.0011 0.0068 0.0098
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0034 0.0442 0.2632
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1614 1
Trichomonas vaginalis DNA-directed RNA polymerase III subunit, putative 0.0012 0.0094 0.0584
Trypanosoma brucei calpain-like protein, putative 0.011 0.1665 1
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0015 0.0134 0.0355
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0228 0.0222
Trypanosoma cruzi cation-transporting ATPase, putative 0.0011 0.0068 0.0381
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.027 0.0265
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0072 0.1052 0.2223
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0197 0.1161
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0442 0.2736
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0068 0.0421
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0011 0.0068 0.0167
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0027 0.0333 0.0508
Loa Loa (eye worm) hypothetical protein 0.0023 0.027 0.0563
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0197 0.0515
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0228 0.1755
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0011 0.0068 0.0062
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0036 0.0087
Onchocerca volvulus 0.0206 0.3211 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0513 0.44
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0006 0.0035
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0076 0.1118 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0768 0.1184
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.3649 0.774
Brugia malayi CXXC zinc finger family protein 0.0029 0.0356 0.0965
Schistosoma mansoni ran 0.0021 0.0228 0.0346
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0012 0.0094 0.0519
Schistosoma mansoni DNA-directed RNA polymerase I subunit 0.0009 0.0038 0.0052
Schistosoma mansoni cation-transporting atpase worm 0.0011 0.0068 0.0098
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0011 0.0068 0.0381
Trypanosoma cruzi P-type H+-ATPase, putative 0.0015 0.0134 0.0779
Leishmania major DNA-directed RNA polymerase polypeptide, putative 0.0012 0.0094 0.0534
Loa Loa (eye worm) hypothetical protein 0.0059 0.0854 0.1801
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.027 0.1596
Echinococcus granulosus importin subunit beta 1 0.0028 0.0347 0.053
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0626 1 1
Brugia malayi hypothetical protein 0.0019 0.0207 0.0556
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.027 0.0708
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0197 0.1161
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0261 0.162
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0239 0.3747 1
Trichomonas vaginalis ran, putative 0.0021 0.0228 0.1411
Echinococcus granulosus copper transporting ATPase 1 0.0011 0.0068 0.0098
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0513 0.3156
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.036 0.223
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0076 0.1118 0.1726
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0197 0.0299
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0011 0.0068 0.0167
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0261 0.1547
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0228 0.0346
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0034 0.0442 0.533
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.001 0.0008

Activities

Activity type Activity value Assay description Source Reference
permeability (ADMET) = 3 10^-6 cm/s Permeability across dog MDCK cells expressing MRP2 ChEMBL. 17371800
Ratio (ADMET) = 2.78 Ratio of permeability from basolateral to apical side over apical to basolateral side of human Caco2 cell membrane at 10 uM in presence of MRP1 inhibitor MK571 ChEMBL. 17371800
Ratio (ADMET) = 33.5 Ratio of permeability from basolateral to apical side over apical to basolateral side of human Caco2 cell membrane at 10 uM ChEMBL. 17371800

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.