Activity (binding)
|
= 43 %
|
Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control
|
ChEMBL.
|
18457386
|
Concentration (binding)
|
= 0.00003 M
|
Concentration of the compound for complete inactivation of alanine aminotransferase
|
ChEMBL.
|
7288825
|
GI50 (functional)
|
-6.544
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-5.827
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-5.779
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-5.755
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-5.744
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-5.739
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-5.736
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-5.735
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-5.677
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
= 188 nM
|
Growth inhibitory activity against human cancer cell line in the NCI
|
ChEMBL.
|
15743190
|
IC50 (functional)
|
= -4.9
|
Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay
|
ChEMBL.
|
19734910
|
IC50 (functional)
|
= -4.9
|
Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay
|
ChEMBL.
|
19734910
|
IC50 (functional)
|
= -4.9
|
Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay
|
ChEMBL.
|
19734910
|
IC50 (functional)
|
= -4.9
|
Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay
|
ChEMBL.
|
19734910
|
IC50 (functional)
|
= -4.9
|
Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay
|
ChEMBL.
|
19734910
|
IC50 (functional)
|
= -4.9
|
Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay
|
ChEMBL.
|
19734910
|
IC50 (functional)
|
= -4.8
|
Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay
|
ChEMBL.
|
19734910
|
IC50 (binding)
|
= 10 nM
|
Inhibition of PKC (unknown origin)
|
ChEMBL.
|
18077363
|
IC50 (binding)
|
= 24 nM
|
Inhibition of PKCepsilon (unknown origin)
|
ChEMBL.
|
18077363
|
IC50 (binding)
|
= 24 nM
|
Inhibition of PKCepsilon (unknown origin)
|
ChEMBL.
|
18077363
|
IC50 (binding)
|
= 900 nM
|
Inhibition of PKA (unknown origin)
|
ChEMBL.
|
18077363
|
IC50 (functional)
|
= 1.24 ug ml-1
|
Growth inhibition of human HeLa S3 cells after 72 hrs
|
ChEMBL.
|
10395504
|
IC50 (binding)
|
< 200 ug ml-1
|
Inhibition of HIV1 RT
|
ChEMBL.
|
1710653
|
IC50 (binding)
|
= 1.54 uM
|
Inhibition of human AChE by Ellman's method
|
ChEMBL.
|
23062825
|
IC50 (functional)
|
= 2.99 uM
|
Antiproliferative activity against human HL60 cells assessed as inhibition of cell viability after 48 hrs by WST-1 assay
|
ChEMBL.
|
26026362
|
IC50 (binding)
|
= 3.78 uM
|
Inhibition of electric eel AChE by Ellman's method
|
ChEMBL.
|
23062825
|
IC50 (functional)
|
= 4.63 uM
|
In vitro cytotoxicity for human ovarian tumor A2780 cells
|
ChEMBL.
|
15999988
|
IC50 (binding)
|
= 6.33 uM
|
Inhibition of horse BChE by Ellman's method
|
ChEMBL.
|
23062825
|
IC50 (binding)
|
= 7 uM
|
Inhibition of Rac1b GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay
|
ChEMBL.
|
19716293
|
IC50 (binding)
|
= 10.34 uM
|
Inhibition of human BChE by Ellman's method
|
ChEMBL.
|
23062825
|
IC50 (binding)
|
= 100 uM
|
Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assay
|
ChEMBL.
|
18925736
|
IC50 (binding)
|
> 100 uM
|
Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay
|
ChEMBL.
|
19716293
|
IC50 (binding)
|
> 100 uM
|
Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay
|
ChEMBL.
|
19716293
|
ID50 (binding)
|
= 0.000004 M
|
Inhibitory activity of the compound against alanine aminotransferase was measured
|
ChEMBL.
|
7288825
|
Inhibition (binding)
|
= 0.8 %
|
Inhibition of electric eel AChE-mediated amyloid beta (1 to 40) fibril formation at 1 uM after 24 hrs by thioflavin T fluorescence method
|
ChEMBL.
|
23062825
|
Inhibition (binding)
|
= 13 %
|
Effect of glutathione on alanine aminotransferase inhibition by the compound at 10E-5
|
ChEMBL.
|
7288825
|
Inhibition (binding)
|
= 23 %
|
Effect of thioethanol on alanine aminotransferase inhibition by the compound at 10E-5
|
ChEMBL.
|
7288825
|
Inhibition (binding)
|
= 35 %
|
Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay
|
ChEMBL.
|
19716293
|
Inhibition (binding)
|
= 40 %
|
Effect of cysteine on alanine aminotransferase inhibition by the compound at 10E-5
|
ChEMBL.
|
7288825
|
Inhibition (binding)
|
= 48.5 %
|
Inhibition of electric eel AChE-mediated amyloid beta (1 to 40) fibril formation at 5 uM after 24 hrs by thioflavin T fluorescence method
|
ChEMBL.
|
23062825
|
Inhibition (binding)
|
= 49 %
|
Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay
|
ChEMBL.
|
19716293
|
Inhibition (binding)
|
= 65 %
|
Inhibition of electric eel AChE-mediated amyloid beta (1 to 40) fibril formation at 10 uM after 24 hrs by thioflavin T fluorescence method
|
ChEMBL.
|
23062825
|
Inhibition (binding)
|
= 75.94 %
|
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method
|
ChEMBL.
|
23062825
|
Inhibition (binding)
|
= 83.5 %
|
Inhibition of horse BChE at 2 mg/ml by Ellman's method
|
ChEMBL.
|
23062825
|
Inhibition (binding)
|
= 88.4 %
|
Inhibition of electric eel AChE-mediated amyloid beta (1 to 40) fibril formation at 100 uM after 24 hrs by thioflavin T fluorescence method
|
ChEMBL.
|
23062825
|
Ki (binding)
|
= 0.32 uM
|
Competitive inhibition of human AChE using acetyl thiocholine iodide as substrate by Lineweaver-Burk double-reciprocal analysis
|
ChEMBL.
|
23062825
|
Ki (binding)
|
= 0.48 uM
|
Competitive inhibition of electric eel AChE using acetyl thiocholine iodide as substrate by Lineweaver-Burk double-reciprocal analysis
|
ChEMBL.
|
23062825
|
Ki (binding)
|
= 0.92 uM
|
Uncompetitive inhibition of electric eel AChE using acetyl thiocholine iodide as substrate by Lineweaver-Burk double-reciprocal analysis
|
ChEMBL.
|
23062825
|
Ki (binding)
|
= 1.12 uM
|
Uncompetitive inhibition of human AChE using acetyl thiocholine iodide as substrate by Lineweaver-Burk double-reciprocal analysis
|
ChEMBL.
|
23062825
|
Ki (binding)
|
= 106 uM
|
Displacement of Flu-Bak peptide from recombinant antiapoptopic Bcl-w protein by fluorescence polarization assay
|
ChEMBL.
|
17227711
|
Ki (binding)
|
= 171 uM
|
Displacement of Flu-Bak peptide from recombinant antiapoptopic Bcl2 protein by fluorescence polarization assay
|
ChEMBL.
|
17227711
|
MSD (ADMET)
|
= 1.1 day
|
Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 25 mg/kg, iv
|
ChEMBL.
|
10395504
|
MSD (ADMET)
|
= 10 day
|
Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 12.5 mg/kg, iv
|
ChEMBL.
|
10395504
|
MSD (ADMET)
|
= 10 day
|
Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 6.25 mg/kg, iv
|
ChEMBL.
|
10395504
|
Potency (functional)
|
1.8526 uM
|
PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488774]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
2.0596 uM
|
PUBCHEM_BIOASSAY: Validation screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463097, AID463113, AID493165, AID493166, AID504806, AID504809]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 2.8184 um
|
PUBCHEM_BIOASSAY: Validation of Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 2.8184 um
|
PUBCHEM_BIOASSAY: Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 3.1623 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 3.1623 um
|
PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 3.1623 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
5.6234 uM
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 12.5893 um
|
PUBCHEM_BIOASSAY: qHTS Validation Assay for Identification of Novel General Anesthetics. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (binding)
|
= 12.5893 um
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 12.5893 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 14.1254 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
14.5769 uM
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 15.8489 um
|
PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
18.8876 uM
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 19.9526 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
19.9526 uM
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 21.3313 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 22.3872 um
|
PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 25.1189 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 28.1838 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 31.6228 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 39.8107 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
44.6684 uM
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 56.2341 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Protection (binding)
|
= 5 %
|
Effect of cysteine on alanine aminotransferase inhibition by the compound at 10E-5
|
ChEMBL.
|
7288825
|
Protection (binding)
|
= 55 %
|
Effect of thioethanol on alanine aminotransferase inhibition by the compound at 10E-5
|
ChEMBL.
|
7288825
|
Protection (binding)
|
= 70 %
|
Effect of glutathione on alanine aminotransferase inhibition by the compound at 10E-5
|
ChEMBL.
|
7288825
|
T/C (functional)
|
= 12 %
|
Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 25 mg/kg, iv administered on day 1 after 30 days relative to control
|
ChEMBL.
|
10395504
|
T/C (functional)
|
= 111 %
|
Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 12.5 mg/kg, iv administered on day 1 after 30 days relative to control
|
ChEMBL.
|
10395504
|
T/C (functional)
|
= 111 %
|
Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 6.25 mg/kg, iv administered on day 1 after 30 days relative to control
|
ChEMBL.
|
10395504
|
Thermal melting change (binding)
|
= -6.6 degrees C
|
Delta TM value showing the stabilisation of MAP2K6 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -5.3 degrees C
|
Delta TM value showing the stabilisation of CAMK1D produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -4.4 degrees C
|
Delta TM value showing the stabilisation of CLK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -4.4 degrees C
|
Delta TM value showing the stabilisation of PIM1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -4.2 degrees C
|
Delta TM value showing the stabilisation of MST4 (2) produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -3.9 degrees C
|
Delta TM value showing the stabilisation of CHEK2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -3.8 degrees C
|
Delta TM value showing the stabilisation of PAK4 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -3.5 degrees C
|
Delta TM value showing the stabilisation of CDKL1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -3.3 degrees C
|
Delta TM value showing the stabilisation of PAK6 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -3.1 degrees C
|
Delta TM value showing the stabilisation of PIM2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -3.1 degrees C
|
Delta TM value showing the stabilisation of PLK4 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -2.6 degrees C
|
Delta TM value showing the stabilisation of OSR1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -2.5 degrees C
|
Delta TM value showing the stabilisation of NEK6 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -2.4 degrees C
|
Delta TM value showing the stabilisation of SLK produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.7 degrees C
|
Delta TM value showing the stabilisation of PAK5 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.6 degrees C
|
Delta TM value showing the stabilisation of CAMKK2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.5 degrees C
|
Delta TM value showing the stabilisation of GSK3B produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.3 degrees C
|
Delta TM value showing the stabilisation of AMPKA2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.3 degrees C
|
Delta TM value showing the stabilisation of RSK2a produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.3 degrees C
|
Delta TM value showing the stabilisation of TNIK produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.2 degrees C
|
Delta TM value showing the stabilisation of NEK2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.1 degrees C
|
Delta TM value showing the stabilisation of CAMK1G produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1.1 degrees C
|
Delta TM value showing the stabilisation of LOK produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1 degrees C
|
Delta TM value showing the stabilisation of CDK6 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1 degrees C
|
Delta TM value showing the stabilisation of CLK3 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -1 degrees C
|
Delta TM value showing the stabilisation of MST4(1) produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.9 degrees C
|
Delta TM value showing the stabilisation of MEK2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.9 degrees C
|
Delta TM value showing the stabilisation of PIM3 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.8 degrees C
|
Delta TM value showing the stabilisation of CAMK2D produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.8 degrees C
|
Delta TM value showing the stabilisation of DRAK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.7 degrees C
|
Delta TM value showing the stabilisation of PDK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.6 degrees C
|
Delta TM value showing the stabilisation of CAMK4 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.6 degrees C
|
Delta TM value showing the stabilisation of VRK3 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.5 degrees C
|
Delta TM value showing the stabilisation of ERK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.4 degrees C
|
Delta TM value showing the stabilisation of RIOK2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.4 degrees C
|
Delta TM value showing the stabilisation of MPSK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.4 degrees C
|
Delta TM value showing the stabilisation of MST1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.4 degrees C
|
Delta TM value showing the stabilisation of PBK produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.3 degrees C
|
Delta TM value showing the stabilisation of ERK3 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.3 degrees C
|
Delta TM value showing the stabilisation of RSK2b produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.3 degrees C
|
Delta TM value showing the stabilisation of YSK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.2 degrees C
|
Delta TM value showing the stabilisation of CAMK2G produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.2 degrees C
|
Delta TM value showing the stabilisation of CLK2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.2 degrees C
|
Delta TM value showing the stabilisation of CK1G2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.2 degrees C
|
Delta TM value showing the stabilisation of ASK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.2 degrees C
|
Delta TM value showing the stabilisation of PCTK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= -0.1 degrees C
|
Delta TM value showing the stabilisation of VRK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0 degrees C
|
Delta TM value showing the stabilisation of CK1G1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0 degrees C
|
Delta TM value showing the stabilisation of PLK1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0 degrees C
|
Delta TM value showing the stabilisation of VRK2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0.1 degrees C
|
Delta TM value showing the stabilisation of CAMK2B produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0.1 degrees C
|
Delta TM value showing the stabilisation of DAPK3 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0.1 degrees C
|
Delta TM value showing the stabilisation of NDR1 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0.2 degrees C
|
Delta TM value showing the stabilisation of CDK2 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0.2 degrees C
|
Delta TM value showing the stabilisation of CK1G3 produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0.3 degrees C
|
Delta TM value showing the stabilisation of JAK1~B produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0.6 degrees C
|
Delta TM value showing the stabilisation of CAMK2A produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 0.6 degrees C
|
Delta TM value showing the stabilisation of p38beta produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 1.4 degrees C
|
Delta TM value showing the stabilisation of PRKACA produced by compound binding
|
ChEMBL.
|
18077363
|
Thermal melting change (binding)
|
= 1.7 degrees C
|
Delta TM value showing the stabilisation of DMPK1 produced by compound binding
|
ChEMBL.
|
18077363
|