Detailed information for compound 513704

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.435 | Formula: C22H21N5O
  • H donors: 1 H acceptors: 3 LogP: 4.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(n(n1)c1nc2nc3CCCCc3c(c2c(=O)[nH]1)c1ccccc1)C
  • InChi: 1S/C22H21N5O/c1-13-12-14(2)27(26-13)22-24-20-19(21(28)25-22)18(15-8-4-3-5-9-15)16-10-6-7-11-17(16)23-20/h3-5,8-9,12H,6-7,10-11H2,1-2H3,(H,23,24,25,28)
  • InChiKey: OGKDENQGPCOMGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0069 0.006
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0479 0.1591 0.1583
Echinococcus multilocularis nmda type glutamate receptor 0.037 0.1215 0.1206
Schistosoma mansoni hypothetical protein 0.046 0.1526 0.1748
Chlamydia trachomatis neutral amino acid transporter 0.0479 0.1591 0.4119
Schistosoma mansoni glutamate receptor AMPA 0.0622 0.2083 0.2386
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0364 0.0355
Entamoeba histolytica phosphofructokinase, putative 0.0213 0.0676 0.5302
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0069 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0101 0.0292 0.0291
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0142 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.014 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0071
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0057 0.014 0.0131
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.014 0.0626
Loa Loa (eye worm) PXA domain-containing protein 0.0057 0.014 0.014
Onchocerca volvulus 0.037 0.1215 0.3314
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.037 0.1215 0.4329
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0069 0.0005
Schistosoma mansoni rab6-interacting 0.0019 0.001 0.0011
Echinococcus multilocularis Regulator of G protein signaling 20 0.0057 0.014 0.0131
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.014 0.1139
Treponema pallidum glutamate/aspartate transporter 0.0479 0.1591 0.5752
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0164 0.0197
Loa Loa (eye worm) hypothetical protein 0.0057 0.014 0.014
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0185 0.0185
Echinococcus granulosus GPCR family 3 C terminal 0.0365 0.1198 0.1189
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0069 0.0081
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0036 0.0069 0.0432
Brugia malayi Guanylyl cyclase protein 23 0.037 0.1215 0.1476
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0076 0.0067
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Schistosoma mansoni tyrosine kinase 0.037 0.1215 0.1392
Brugia malayi Receptor family ligand binding region containing protein 0.037 0.1215 0.1476
Loa Loa (eye worm) RGS-3 protein 0.0057 0.014 0.014
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0142 1
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0747 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.0168
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.014 0.0437
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0142 0.2795
Echinococcus granulosus Excitatory amino acid transporter 0.1081 0.3661 0.3655
Onchocerca volvulus 0.0036 0.0069 0.0182
Brugia malayi hypothetical protein 0.0019 0.001 0.0009
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0036 0.0069 0.1743
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0103
Schistosoma mansoni loxhd1 0.0019 0.001 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0069 0.0212
Chlamydia trachomatis glutamate symporter 0.1081 0.3661 1
Entamoeba histolytica hypothetical protein 0.037 0.1215 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.014 0.014
Schistosoma mansoni metabotropic glutamate receptor 0.1254 0.4254 0.4874
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0806 0.2716 1
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0364 0.0417
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0069 0.0079
Loa Loa (eye worm) RecQ helicase 0.0021 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0101 0.0292 0.0291
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0855 0.2882 0.3302
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0069 0.4806
Entamoeba histolytica hypothetical protein 0.0057 0.014 0.0625
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0094 0.1311
Echinococcus multilocularis glutamate receptor 2 0.0669 0.2243 0.2235
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0069 0.0081
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0094 0.0084
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0431 0.1425 0.1632
Schistosoma mansoni z-protein (S1r protein) 0.0057 0.014 0.0161
Brugia malayi Receptor family ligand binding region containing protein 0.0735 0.2469 0.3003
Loa Loa (eye worm) hypothetical protein 0.0631 0.2112 0.2112
Loa Loa (eye worm) hypothetical protein 0.0057 0.014 0.014
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0069 0.0081
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0164 0.0878
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1081 0.3661 0.3655
Loa Loa (eye worm) hypothetical protein 0.008 0.0218 0.0218
Schistosoma mansoni regulator of G protein signaling 0.0057 0.014 0.0161
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0036 0.0069 0.4613
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0069 0.0212
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0227 0.0723 0.0722
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.0747 0.0738
Loa Loa (eye worm) RGC/RGC protein kinase 0.037 0.1215 0.1214
Brugia malayi metabotropic GABA-B receptor subtype 2 0.037 0.1215 0.1476
Schistosoma mansoni hypothetical protein 0.0309 0.1006 0.1152
Schistosoma mansoni lipoxygenase 0.0019 0.001 0.0011
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0213 0.0676 0.5
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1959 0.6679 0.6676
Echinococcus multilocularis regulator of G protein signaling 3 0.0057 0.014 0.0131
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0364 0.261
Schistosoma mansoni ap endonuclease 0.0057 0.014 0.0161
Echinococcus multilocularis GPCR, family 3, C terminal 0.0365 0.1198 0.1189
Trichomonas vaginalis phosphofructokinase, putative 0.0213 0.0676 0.2135
Loa Loa (eye worm) hypothetical protein 0.0394 0.13 0.1299
Echinococcus granulosus neutral amino acid transporter 0.1081 0.3661 0.3655
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0142 0.0441
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0142 0.0441
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0142 1
Trichomonas vaginalis phosphofructokinase, putative 0.0213 0.0676 0.2135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0033 0.0096
Schistosoma mansoni hypothetical protein 0.0036 0.0069 0.0079
Loa Loa (eye worm) glutamate receptor 0.2406 0.8215 0.8214
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0094 0.0266
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1038 0.3514 0.3507
Echinococcus multilocularis lamin dm0 0.008 0.0218 0.0209
Echinococcus multilocularis atrial natriuretic peptide receptor 0.037 0.1215 0.1206
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.2555 0.8729 1
Trichomonas vaginalis phosphofructokinase, putative 0.0213 0.0676 0.2135
Echinococcus granulosus glutamate receptor subunit protein glur 0.0356 0.1166 0.1157
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0036 0.0069 0.0068
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.0253 0.0243
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0071
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0309 0.1006 0.0997
Schistosoma mansoni lipoxygenase 0.0054 0.0128 0.0147
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0094 0.022
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0076 0.0067
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0735 0.2469 0.2468
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.037 0.1215 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0071
Echinococcus granulosus excitatory amino acid transporter 2 0.1081 0.3661 0.3655
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0057 0.014 0.014
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0071 0.0062
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0479 0.1591 0.1823
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0071 0.0062
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.037 0.1215 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.014 0.014
Brugia malayi Regulator of G protein signaling domain containing protein 0.0057 0.014 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0094 0.029
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0069 0.0081
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0103
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0069 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0349 0.04
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.037 0.1215 0.4329
Brugia malayi metabotropic glutamate receptor type 2 0.1254 0.4254 0.5177
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.014 0.0161
Plasmodium vivax SET domain protein, putative 0.0118 0.0349 1
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0091 0.0108
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0057 0.014 0.0131
Mycobacterium ulcerans 6-phosphofructokinase 0.0213 0.0676 0.556
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0253 0.029
Echinococcus granulosus atrial natriuretic peptide receptor 0.037 0.1215 0.1206
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Echinococcus granulosus nmda type glutamate receptor 0.037 0.1215 0.1206
Onchocerca volvulus Poor gastrulation protein homolog 0.0365 0.1198 0.3267
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0069 0.006
Loa Loa (eye worm) RGC/RGC protein kinase 0.037 0.1215 0.1214
Loa Loa (eye worm) hypothetical protein 0.037 0.1215 0.1214
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0069 0.0212
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0015 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0213 0.0676 0.2135
Echinococcus multilocularis geminin 0.0165 0.051 0.0501
Loa Loa (eye worm) hypothetical protein 0.0057 0.014 0.014
Schistosoma mansoni ATP-binding cassette transporter 0.0622 0.2083 0.2386
Echinococcus granulosus tyrosine kinase 0.037 0.1215 0.1206
Schistosoma mansoni lamin 0.008 0.0218 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0094 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.014 0.0437
Onchocerca volvulus 0.0101 0.0292 0.0792
Echinococcus granulosus metabotropic glutamate receptor 2 0.2041 0.6961 0.6958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0071
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1421 0.4829 0.4824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.0168
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.037 0.1215 0.3049
Schistosoma mansoni axis inhibition protein axin 0.0057 0.014 0.0161
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.037 0.1215 0.1214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0072 0.0221
Brugia malayi Regulator of G protein signaling domain containing protein 0.0057 0.014 0.0168
Echinococcus granulosus excitatory amino acid transporter 2 0.1081 0.3661 0.3655
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0057 0.014 0.0161
Echinococcus granulosus lamin dm0 0.008 0.0218 0.0209
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0071
Onchocerca volvulus 0.0129 0.0388 0.1055
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0227 0.0723 0.0828
Echinococcus granulosus excitatory amino acid transporter 3 0.1081 0.3661 0.3655
Schistosoma mansoni intermediate filament proteins 0.008 0.0218 0.025
Loa Loa (eye worm) phosphofructokinase 0.0213 0.0676 0.0676
Brugia malayi hypothetical protein 0.0057 0.014 0.0168
Brugia malayi PXA domain containing protein 0.0057 0.014 0.0168
Echinococcus multilocularis musashi 0.008 0.0218 0.0209
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0738 0.2481 0.2474
Loa Loa (eye worm) 6-phosphofructokinase 0.0213 0.0676 0.0676
Echinococcus granulosus collagen alpha 1VII chain 0.0036 0.0069 0.0059
Brugia malayi Excitatory amino acid transporter 0.1081 0.3661 0.4455
Schistosoma mansoni regulator of G protein signaling 0.0057 0.014 0.0161
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0142 0.0441
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0142 0.2795
Loa Loa (eye worm) hypothetical protein 0.037 0.1215 0.1214
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0069 0.0081
Loa Loa (eye worm) CUTiclin family member 0.0036 0.0069 0.0068
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0364 0.2981
Echinococcus multilocularis regulator of G protein signaling 3 0.0057 0.014 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.0168
Chlamydia trachomatis glutamine binding protein 0.037 0.1215 0.3049
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0218 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0071
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0123
Loa Loa (eye worm) hypothetical protein 0.0735 0.2469 0.2468
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1038 0.3514 0.3507
Brugia malayi Pre-SET motif family protein 0.0822 0.2769 0.3369
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.014 0.0437
Echinococcus granulosus neutral amino acid transporter A 0.1081 0.3661 0.3655
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0349 0.04
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0069 0.0081
Echinococcus multilocularis neutral amino acid transporter A 0.1081 0.3661 0.3655
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Echinococcus granulosus lamin 0.008 0.0218 0.0209
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.014 0.067
Schistosoma mansoni 6-phosphofructokinase 0.0213 0.0676 0.0775
Brugia malayi intermediate filament protein 0.008 0.0218 0.0263
Echinococcus multilocularis axis inhibition protein axin 0.0057 0.014 0.0131
Schistosoma mansoni serine-rich repeat protein 0.046 0.1526 0.1748
Schistosoma mansoni polycystin 1-related 0.0019 0.001 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0069 0.0079
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0227 0.0723 0.0714
Onchocerca volvulus 0.0036 0.0069 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0063 0.0193
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.014 0.0131
Trichomonas vaginalis set domain proteins, putative 0.0936 0.316 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.1081 0.3661 0.3655
Loa Loa (eye worm) glutamate receptor 1 0.0669 0.2243 0.2242
Loa Loa (eye worm) intermediate filament protein 0.008 0.0218 0.0218
Brugia malayi M-phase phosphoprotein, mpp8 0.0101 0.0292 0.0353
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0164 0.0164
Echinococcus multilocularis glutamate receptor 4 0.0047 0.0104 0.0094
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0118 0.0349 0.034
Loa Loa (eye worm) hypothetical protein 0.0057 0.014 0.014
Plasmodium vivax thrombospondin-related anonymous protein 0.0036 0.0069 0.1743
Schistosoma mansoni regulator of G protein signaling 0.0057 0.014 0.0161
Echinococcus granulosus axis inhibition protein axin 0.0057 0.014 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.0168
Loa Loa (eye worm) hypothetical protein 0.0078 0.0213 0.0213
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0069 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.014 0.0437
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0738 0.2481 0.2474
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0069 0.006
Onchocerca volvulus 0.037 0.1215 0.3314
Brugia malayi A-kinase anchor protein 10, precursor 0.0057 0.014 0.0168
Schistosoma mansoni glutamate receptor kainate 0.0622 0.2083 0.2386
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0164 0.0155
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0142 0.0275
Echinococcus granulosus glutamate receptor 4 0.0047 0.0104 0.0094
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0356 0.1166 0.1157
Leishmania major extracellular receptor, putative 0.037 0.1215 1
Loa Loa (eye worm) glutamate receptor 2 0.0622 0.2083 0.2082
Treponema pallidum glutamate transporter 0.0479 0.1591 0.5752
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0069 0.0081
Echinococcus multilocularis metabotropic glutamate receptor 5 0.2925 1 1
Echinococcus granulosus nmda type glutamate receptor 0.0679 0.2277 0.227
Schistosoma mansoni hypothetical protein 0.0365 0.1198 0.1372
Onchocerca volvulus 0.0036 0.0069 0.0182
Echinococcus granulosus axis inhibition protein axin 0.0057 0.014 0.0131
Echinococcus multilocularis regulator of G protein signaling 7 0.0057 0.014 0.0131
Echinococcus granulosus Excitatory amino acid transporter 0.1081 0.3661 0.3655
Brugia malayi Glutamate receptor 2 precursor 0.0669 0.2243 0.2728
Schistosoma mansoni lamin 0.008 0.0218 0.025
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.014 0.0271
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1421 0.4829 0.4824
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0057 0.014 0.0161
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0164 0.0878
Loa Loa (eye worm) excitatory amino acid transporter 0.1081 0.3661 0.3661
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0142 0.2795
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0009
Loa Loa (eye worm) RGC/RGC protein kinase 0.037 0.1215 0.1214
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0015 0.004
Echinococcus granulosus glutamate receptor 2 0.1038 0.3514 0.3507
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.014 0.0131
Schistosoma mansoni glutamate receptor kainate 0.1051 0.3558 0.4076
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0069 0.0052
Toxoplasma gondii exonuclease III APE 0.0057 0.014 0.2758
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.001 0.024
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.0747 0.0738
Echinococcus granulosus glutamate NMDA receptor subunit 0.0622 0.2083 0.2075
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1081 0.3661 0.3655
Echinococcus granulosus intermediate filament protein 0.008 0.0218 0.0209
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0891 0.3007 0.3
Schistosoma mansoni glutamate receptor kainate 0.1051 0.3558 0.4076
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0036 0.0069 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0364 0.0417
Brugia malayi Cache domain containing protein 0.0394 0.13 0.158
Schistosoma mansoni hypothetical protein 0.0165 0.051 0.0585
Toxoplasma gondii microneme protein MIC2 0.0036 0.0069 0.0432
Brugia malayi hypothetical protein 0.0036 0.0069 0.0081
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0164 0.2362
Echinococcus multilocularis 6 phosphofructokinase 0.0213 0.0676 0.0667
Brugia malayi hypothetical protein 0.0101 0.0292 0.0353
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0094 0.0266
Brugia malayi 6-phosphofructokinase 0.0213 0.0676 0.0821
Loa Loa (eye worm) doublecortin family protein 0.0019 0.001 0.0009
Echinococcus granulosus regulator of G protein signaling 3 0.0057 0.014 0.0131
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0094 0.0084
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0365 0.1198 0.3267
Leishmania major ATP-dependent phosphofructokinase 0.0213 0.0676 0.5324
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0069 0.0052
Onchocerca volvulus 0.008 0.0218 0.059
Schistosoma mansoni hypothetical protein 0.0165 0.051 0.0585
Echinococcus multilocularis nmda type glutamate receptor 0.0679 0.2277 0.227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0349 0.04
Echinococcus granulosus glutamate receptor 1 0.0047 0.0104 0.0094
Entamoeba histolytica phosphofructokinase, putative 0.0213 0.0676 0.5302
Loa Loa (eye worm) hypothetical protein 0.037 0.1215 0.1214
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.014 0.0161
Echinococcus granulosus leukotriene A 4 hydrolase 0.0227 0.0723 0.0714
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0091 0.009
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.014 0.0168
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0015 0.0015
Echinococcus multilocularis axis inhibition protein axin 0.0057 0.014 0.0131
Echinococcus multilocularis Excitatory amino acid transporter 0.1081 0.3661 0.3655
Schistosoma mansoni survival motor neuron protein 0.0048 0.0107 0.0123
Loa Loa (eye worm) hypothetical protein 0.037 0.1215 0.1214
Loa Loa (eye worm) hypothetical protein 0.037 0.1215 0.1214
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.014 0.2005
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.037 0.1215 0.3314
Onchocerca volvulus 0.0936 0.316 0.863
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0094 0.022
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0094 0.0093
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0069 0.0052
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0164 0.0155
Brugia malayi hypothetical protein 0.0242 0.0776 0.0942
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0142 0.0636
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0069 0.0081
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0069 0.006
Echinococcus granulosus neutral amino acid transporter A 0.1081 0.3661 0.3655
Brugia malayi hypothetical protein 0.0104 0.0302 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.014 0.0437
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0069 0.006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0747 0.0746
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.014 0.067
Brugia malayi Cytochrome P450 family protein 0.007 0.0185 0.0223
Loa Loa (eye worm) hypothetical protein 0.2925 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0069
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0142 0.0441
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0069 0.0081
Brugia malayi 6-phosphofructokinase 0.0213 0.0676 0.0821
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Onchocerca volvulus 0.0101 0.0292 0.0792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.0168
Echinococcus granulosus bloom syndrome protein 0.0021 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0057 0.014 0.014
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0164 0.0878
Schistosoma mansoni regulator of G protein signaling 0.0057 0.014 0.0161
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.014 0.067
Echinococcus multilocularis receptor type guanylyl cyclase 0.037 0.1215 0.1206
Onchocerca volvulus 0.0019 0.001 0.002
Schistosoma mansoni tyrosine kinase 0.037 0.1215 0.1392
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.014 0.0437
Echinococcus granulosus 6 phosphofructokinase 0.0213 0.0676 0.0667
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0114 0.0334 0.0325
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0128 0.0119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0069 0.0081
Echinococcus multilocularis regulator of G protein signaling 7 0.0057 0.014 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0071
Echinococcus multilocularis Excitatory amino acid transporter 0.1081 0.3661 0.3655
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0015 0.004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.014 0.0378
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0128 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.014 0.0161
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0142 0.0441
Brugia malayi von Willebrand Factor 0.0036 0.0069 0.0081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0094 0.0112
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0738 0.2481 0.2474
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0036 0.0069 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0388 0.0445
Echinococcus granulosus regulator of G protein signaling 7 0.0057 0.014 0.0131
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0213 0.0676 1
Schistosoma mansoni protein kinase 0.037 0.1215 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0044 0.0133
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0213 0.0676 0.5324
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0253 0.029
Schistosoma mansoni 6-phosphofructokinase 0.0213 0.0676 0.0775
Onchocerca volvulus 0.0036 0.0069 0.0182
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1081 0.3661 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0142 0.389
Echinococcus granulosus Regulator of G protein signaling 20 0.0057 0.014 0.0131
Echinococcus multilocularis neutral amino acid transporter A 0.1081 0.3661 0.3655
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0735 0.2469 0.2468
Echinococcus multilocularis excitatory amino acid transporter 3 0.1081 0.3661 0.3655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0063 0.0193
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0036 0.0069 0.4613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0033 0.0099
Brugia malayi Pre-SET motif family protein 0.0118 0.0349 0.0422
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1421 0.4829 0.4824
Loa Loa (eye worm) hypothetical protein 0.0118 0.0349 0.0348
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0036 0.0069 0.1743
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0063 0.0854
Echinococcus granulosus histone lysine methyltransferase setb 0.0118 0.0349 0.034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0822 0.2769 0.2769
Entamoeba histolytica hypothetical protein 0.0057 0.014 0.0625
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0365 0.1198 0.1456
Onchocerca volvulus 0.008 0.0218 0.059
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0142 1
Plasmodium falciparum thrombospondin-related anonymous protein 0.0036 0.0069 0.4613
Echinococcus granulosus regulator of G protein signaling 7 0.0057 0.014 0.0131
Schistosoma mansoni regulator of G protein signaling 0.0057 0.014 0.0161
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0057 0.014 0.0168
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0479 0.1591 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0071
Loa Loa (eye worm) hypothetical protein 0.037 0.1215 0.1214
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0036 0.0069 0.021
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0057 0.014 0.014
Loa Loa (eye worm) CUTiclin-Like family member 0.0036 0.0069 0.0068
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0479 0.1591 0.1583
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1421 0.4829 0.4824
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0364 0.0355
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0107 0.0128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0118 0.0349 0.9519
Giardia lamblia GTOR 0.0044 0.0094 0.6578
Echinococcus multilocularis glutamate receptor 2 0.0729 0.2451 0.2444
Echinococcus granulosus voltage dependent calcium channel subunit 0.1959 0.6679 0.6676
Schistosoma mansoni glutamate receptor NMDA 0.0992 0.3354 0.3842
Trypanosoma cruzi extracellular receptor, putative 0.037 0.1215 1
Echinococcus multilocularis expressed protein 0.1114 0.3775 0.3769
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0057 0.014 0.0437
Entamoeba histolytica phosphofructokinase, putative 0.0213 0.0676 0.5302
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0094 0.0266
Echinococcus multilocularis NMDA receptor 0.0738 0.2481 0.2474
Echinococcus granulosus sodium:dicarboxylate symporter 0.1081 0.3661 0.3655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0063 0.0193
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0364 0.2981
Echinococcus multilocularis regulator of G protein signaling 0.0057 0.014 0.0131
Schistosoma mansoni glutamate receptor NMDA 0.0622 0.2083 0.2386
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.0253 0.0243
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0218 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0094 0.029
Brugia malayi PXA domain containing protein 0.0057 0.014 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0033 0.0096
Echinococcus granulosus voltage dependent calcium channel subunit 0.0891 0.3007 0.3
Brugia malayi phosphofructokinase 0.0213 0.0676 0.0821
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.014 0.9916
Echinococcus multilocularis lamin 0.008 0.0218 0.0209
Schistosoma mansoni hypothetical protein 0.0036 0.0069 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0033 0.0099
Echinococcus granulosus beta-adrenergic receptor kinase 0.0057 0.014 0.0131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Brugia malayi Doublecortin family protein 0.0019 0.001 0.0009
Schistosoma mansoni ap endonuclease 0.0057 0.014 0.0161
Echinococcus multilocularis excitatory amino acid transporter 2 0.1081 0.3661 0.3655
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1081 0.3661 0.4194
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0164 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0033 0.0099
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0094 0.1311
Schistosoma mansoni glutamate receptor AMPA 0.0622 0.2083 0.2386
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0094 0.0266
Echinococcus multilocularis metabotropic glutamate receptor 2 0.2041 0.6961 0.6958
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0069 0.1743
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0364 0.2981
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0142 0.0441
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0364 1
Echinococcus multilocularis tyrosine kinase 0.037 0.1215 0.1206
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0364 0.0988
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0118 0.0349 0.034
Brugia malayi hypothetical protein 0.0234 0.0747 0.0907
Echinococcus granulosus expressed protein 0.1114 0.3775 0.3769
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0094 0.0108
Loa Loa (eye worm) 6-phosphofructokinase 0.0213 0.0676 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0063 0.0193
Echinococcus granulosus receptor type guanylyl cyclase 0.037 0.1215 0.1206
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.2036 0.6944 0.8452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0063 0.0193
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0009
Brugia malayi Glutamate receptor 1 precursor 0.0669 0.2243 0.2728
Loa Loa (eye worm) hypothetical protein 0.0234 0.0747 0.0746
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0142 0.389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0071
Echinococcus multilocularis neutral amino acid transporter A 0.1081 0.3661 0.3655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.0168
Echinococcus multilocularis glutamate receptor 2 0.1038 0.3514 0.3507
Brugia malayi regulator of G-protein signaling egl-10 0.0057 0.014 0.0168
Loa Loa (eye worm) glutamate receptor 0.0884 0.2983 0.2983
Onchocerca volvulus 0.0048 0.0107 0.0287
Brugia malayi regulator of G-protein signaling rgs-7 0.0057 0.014 0.0168
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0622 0.2083 0.2075
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1421 0.4829 0.4824
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1108 0.3752 0.3746
Echinococcus multilocularis beta adrenergic receptor kinase 0.0057 0.014 0.0131
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1081 0.3661 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.014 0.3856
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0309 0.1006 0.0997
Brugia malayi Metabotropic glutamate receptor precursor. 0.2406 0.8215 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.014 0.0437
Schistosoma mansoni rab6-interacting 0.0019 0.001 0.0011
Brugia malayi hypothetical protein 0.0019 0.001 0.0009
Onchocerca volvulus 0.0036 0.0069 0.0182
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1081 0.3661 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0069 0.0081
Onchocerca volvulus 0.0036 0.0069 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0123
Echinococcus granulosus regulator of G protein signaling 3 0.0057 0.014 0.0131
Schistosoma mansoni axis inhibition protein axin 0.0057 0.014 0.0161
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0164 0.0188
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0036 0.0069 0.1743
Schistosoma mansoni metabotropic glutamate receptor 0.2041 0.6961 0.7974
Onchocerca volvulus 0.0036 0.0069 0.0182
Loa Loa (eye worm) hypothetical protein 0.0365 0.1198 0.1197
Entamoeba histolytica hypothetical protein 0.0057 0.014 0.0625
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0103
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1421 0.4829 0.4824
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0069 0.0943
Brugia malayi hypothetical protein 0.037 0.1215 0.1476
Echinococcus granulosus geminin 0.0165 0.051 0.0501
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.037 0.1215 0.1214
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0213 0.0676 0.1842
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0057 0.014 0.0161
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0015 0.0129
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0057 0.014 0.014
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0213 0.0676 0.2295
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0076
Brugia malayi hypothetical protein 0.0057 0.014 0.0168
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.014 0.9918
Onchocerca volvulus 0.0019 0.001 0.002
Echinococcus granulosus glutamate receptor 2 0.0729 0.2451 0.2444

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 59.2 % Analgesic activity against acetic acid-induced abdominal constriction in Swiss albino mouse at 15 mg/kg, po after 20 mins by writhing test ChEMBL. 18158248
Activity (functional) = 59.2 % Analgesic activity against acetic acid-induced abdominal constriction in Swiss albino mouse at 15 mg/kg, po after 20 mins by writhing test ChEMBL. 18158248
Activity (functional) = 114.51 % Analgesic activity against acetic acid-induced abdominal constriction in Swiss albino mouse at 15 mg/kg, po after 20 mins by writhing test relative to acetylsalicylic acid ChEMBL. 18158248
Activity (functional) = 114.51 % Analgesic activity against acetic acid-induced abdominal constriction in Swiss albino mouse at 15 mg/kg, po after 20 mins by writhing test relative to acetylsalicylic acid ChEMBL. 18158248
Inhibition (functional) = 0.1 % Antiinflammatory activity against carrageenin-induced paw edema in Sprague-Dawley rat at 15 mg/kg, po after 3 hrs ChEMBL. 18158248
Inhibition (functional) = 0.1 % Antiinflammatory activity against carrageenin-induced paw edema in Sprague-Dawley rat at 15 mg/kg, po relative to indomethacin after 3 hrs ChEMBL. 18158248
Inhibition (functional) = 0.8 % Antiinflammatory activity against carrageenin-induced paw edema in Sprague-Dawley rat at 15 mg/kg, po after 4 hrs ChEMBL. 18158248
Inhibition (functional) = 0.9 % Antiinflammatory activity against carrageenin-induced paw edema in Sprague-Dawley rat at 15 mg/kg, po after 2 hrs ChEMBL. 18158248
Inhibition (functional) = 1.5 % Antiinflammatory activity against carrageenin-induced paw edema in Sprague-Dawley rat at 15 mg/kg, po relative to indomethacin after 2 hrs ChEMBL. 18158248
Inhibition (functional) = 1.7 % Antiinflammatory activity against carrageenin-induced paw edema in Sprague-Dawley rat at 15 mg/kg, po relative to indomethacin after 4 hrs ChEMBL. 18158248
Inhibition (functional) = 10.5 % Antiinflammatory activity against carrageenin-induced paw edema in Sprague-Dawley rat at 15 mg/kg, po after 1 hr ChEMBL. 18158248
Inhibition (functional) = 14.5 % Antiinflammatory activity against carrageenin-induced paw edema in Sprague-Dawley rat at 15 mg/kg, po relative to indomethacin after 1 hr ChEMBL. 18158248
IZ (functional) = 9 mm Antimicrobial activity against Candida albicans at 50 ug/disk after 5 days ChEMBL. 18158248
IZ (functional) = 9 mm Antimicrobial activity against ChEMBL. 18158248
IZ (functional) = 9 mm Antimicrobial activity against Candida albicans at 50 ug/disk after 5 days ChEMBL. 18158248
IZ (functional) = 19 mm Antimicrobial activity against Escherichia coli at 50 ug/disk after 24 to 28 hrs ChEMBL. 18158248
IZ (functional) = 19 mm Antimicrobial activity against Escherichia coli at 50 ug/disk after 24 to 28 hrs ChEMBL. 18158248
IZ (functional) = 20 mm Antimicrobial activity against Klebsiella pneumoniae at 50 ug/disk after 24 to 28 hrs ChEMBL. 18158248
IZ (functional) = 21 mm Antimicrobial activity against Staphylococcus aureus at 50 ug/disk after 24 to 28 hrs ChEMBL. 18158248
IZ (functional) = 22 mm Antimicrobial activity against Pseudomonas aeruginosa at 50 ug/disk after 24 to 28 hrs ChEMBL. 18158248
MIC (functional) = 30 ug Antimicrobial activity against Escherichia coli ChEMBL. 18158248
MIC (functional) = 30 ug Antimicrobial activity against Klebsiella pneumoniae ChEMBL. 18158248
MIC (functional) = 30 ug Antimicrobial activity against Pseudomonas aeruginosa ChEMBL. 18158248
MIC (functional) = 30 ug Antimicrobial activity against Staphylococcus aureus ChEMBL. 18158248
MIC (functional) = 30 ug Antimicrobial activity against Escherichia coli ChEMBL. 18158248
Time (functional) = 8.93 s Analgesic activity in Swiss albino mouse assessed as reaction time at 15 mg/kg, po after 30 mins by hot plate test ChEMBL. 18158248
Time (functional) = 8.93 s Analgesic activity in Swiss albino mouse assessed as reaction time at 15 mg/kg, po after 30 mins by hot plate test ChEMBL. 18158248
Time (functional) = 10.15 s Analgesic activity in Swiss albino mouse assessed as reaction time at 15 mg/kg, po after 60 mins by hot plate test ChEMBL. 18158248
Time (functional) = 10.15 s Analgesic activity in Swiss albino mouse assessed as reaction time at 15 mg/kg, po after 60 mins by hot plate test ChEMBL. 18158248
Time (functional) = 11.5 s Analgesic activity in Swiss albino mouse assessed as reaction time at 15 mg/kg, po after 90 mins by hot plate test ChEMBL. 18158248
Time (functional) = 11.5 s Analgesic activity in Swiss albino mouse assessed as reaction time at 15 mg/kg, po after 90 mins by hot plate test ChEMBL. 18158248

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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