Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.1091 | 0.131 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.043 | 0.0441 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0015 | 0.042 | 0.3851 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0539 | 0.0552 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0077 | 0.2974 | 0.4036 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0186 | 0.1703 |
Schistosoma mansoni | DNA helicase recq5 | 0.0009 | 0.0186 | 0.0262 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.1044 | 0.1242 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2531 | 0.3568 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0186 | 0.1703 |
Brugia malayi | Uncoordinated protein 44 | 0.0015 | 0.0425 | 0.025 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.7095 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0216 | 0.8758 | 0.8966 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.7095 | 1 |
Echinococcus multilocularis | geminin | 0.0176 | 0.7095 | 1 |
Echinococcus granulosus | geminin | 0.0176 | 0.7095 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2531 | 0.3395 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.1091 | 0.0944 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0297 | 1 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0015 | 0.0425 | 0.0347 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2531 | 0.3568 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0297 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2531 | 0.3568 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2531 | 0.2448 |
Echinococcus granulosus | death domain containing protein | 0.0015 | 0.0425 | 0.0347 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.1091 | 0.1537 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.078 | 0.0798 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2531 | 0.2448 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.0613 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0246 | 0.9995 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0009 | 0.0186 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.1091 | 0.131 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2531 | 0.2591 |
Schistosoma mansoni | DNA helicase recq1 | 0.0009 | 0.0186 | 0.0262 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2531 | 0.2591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2531 | 0.3568 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0005 | 0.00000000015621 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0425 | 0.0599 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.1091 | 0.1537 |
Loa Loa (eye worm) | RecQ helicase | 0.0022 | 0.0725 | 0.0742 |
Brugia malayi | Death domain containing protein | 0.0015 | 0.0425 | 0.025 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0022 | 0.0725 | 0.0441 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0241 | 0.9768 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.1091 | 0.131 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0077 | 0.2974 | 0.4036 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0022 | 0.0725 | 0.0441 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0015 | 0.0425 | 0.0347 |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.043 | 0.0354 |
Brugia malayi | Pre-SET motif family protein | 0.0216 | 0.8758 | 0.8946 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0015 | 0.0425 | 0.0599 |
Echinococcus multilocularis | bloom syndrome protein | 0.0022 | 0.0725 | 0.078 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0015 | 0.0425 | 0.0347 |
Brugia malayi | follicle stimulating hormone receptor | 0.0241 | 0.9768 | 1 |
Schistosoma mansoni | netrin receptor unc5 | 0.0015 | 0.0425 | 0.0599 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.078 | 0.062 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.1091 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2531 | 0.2591 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.1091 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0022 | 0.0725 | 0.0562 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.043 | 0.0354 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0009 | 0.0186 | 0.019 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2531 | 0.2448 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0425 | 0.0435 |
Entamoeba histolytica | recQ family helicase, putative | 0.0012 | 0.0297 | 1 |
Onchocerca volvulus | 0.0031 | 0.1091 | 0.0695 | |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0297 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0018 | 0.0532 | 0.0749 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0015 | 0.0425 | 0.0435 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2531 | 0.3395 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.1091 | 0.1537 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0186 | 0.019 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0425 | 0.025 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.1091 | 0.1537 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.043 | 0.0607 |
Echinococcus granulosus | bloom syndrome protein | 0.0022 | 0.0725 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1091 | 0.1117 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.0425 | 0.025 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0015 | 0.0425 | 0.0347 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2531 | 0.3568 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Microsporum gypseum C115 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Trichophyton rubrum C113 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Trichophyton mentagrophytes ATCC9972 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC32264 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Aspergillus flavus ATCC9170 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Aspergillus niger ATCC9029 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC32264 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 200 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC9763 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 200 ug ml-1 | Antifungal activity against Aspergillus fumigatus ATCC26934 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | = 200 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC9763 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | > 250 ug ml-1 | Antifungal activity against Candida albicans ATCC10231 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | > 250 ug ml-1 | Antifungal activity against Candida tropicalis C131 by microbroth dilution method | ChEMBL. | 17981473 |
MIC (functional) | > 250 ug ml-1 | Antifungal activity against Candida albicans ATCC10231 by microbroth dilution method | ChEMBL. | 17981473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.