Detailed information for compound 514072

Basic information

Technical information
  • TDR Targets ID: 514072
  • Name: [(3R)-7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4 -benzodiazepin-3-yl] acetate
  • MW: 328.75 | Formula: C17H13ClN2O3
  • H donors: 1 H acceptors: 2 LogP: 3.06 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@H]1N=C(c2ccccc2)c2c(NC1=O)ccc(c2)Cl
  • InChi: 1S/C17H13ClN2O3/c1-10(21)23-17-16(22)19-14-8-7-12(18)9-13(14)15(20-17)11-5-3-2-4-6-11/h2-9,17H,1H3,(H,19,22)/t17-/m1/s1
  • InChiKey: FYRWUTOZBRWYCS-QGZVFWFLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • acetic acid [(3R)-7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl] ester
  • [(3R)-7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl] ethanoate
  • acetic acid [(3R)-7-chloro-2-keto-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein coupled receptor 0.0097 0.07 0.2174
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0145 0.0196
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1238 1 1
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0446 0.0679
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0001 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0003 0.0003
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0145 0.0196
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0003 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Echinococcus granulosus dro:myosuppressin receptor 0.0097 0.07 0.2174
Echinococcus granulosus biogenic amine 5HT receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Brugia malayi Dopamine receptor protein 2 0.0097 0.07 0.0947
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.07 0.1064
Onchocerca volvulus 0.0029 0.0145 0.0752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Onchocerca volvulus 0.0097 0.07 0.3635
Brugia malayi Cytochrome P450 family protein 0.0021 0.008 0.0107
Echinococcus granulosus allatostatin A receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0142 0.0191
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0097 0.07 0.0944
Echinococcus granulosus dnaJ subfamily B 0.0406 0.3219 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.073 0.0985
Echinococcus multilocularis dro:myosuppressin receptor 0.0097 0.07 0.1064
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Loa Loa (eye worm) hypothetical protein 0.0916 0.738 0.9965
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0003 0.0003
Echinococcus multilocularis neuropeptide receptor 0.0097 0.07 0.1064
Mycobacterium ulcerans short chain dehydrogenase 0.027 0.2114 0.2114
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0003 0.0003
Brugia malayi Cytochrome P450 family protein 0.0021 0.008 0.0107
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0889 0.7156 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Onchocerca volvulus 0.0097 0.07 0.3635
Schistosoma mansoni cpg binding protein 0.0029 0.0142 0.0442
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1238 1 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0097 0.07 0.2174
Loa Loa (eye worm) neuropeptide F receptor 0.0097 0.07 0.0944
Echinococcus granulosus acetylcholinesterase 0.0066 0.0446 0.1386
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Loa Loa (eye worm) hypothetical protein 0.0066 0.0446 0.0602
Schistosoma mansoni opsin-like receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0488 0.0657
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Schistosoma mansoni amine GPCR 0.0097 0.07 0.2174
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0097 0.07 0.1064
Schistosoma mansoni alpha-1 adrenergic receptor 0.0097 0.07 0.2174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0273 0.0369
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0003 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0111 1
Echinococcus multilocularis geminin 0.0168 0.1281 0.1948
Echinococcus granulosus neuropeptide Y receptor 0.0097 0.07 0.2174
Echinococcus granulosus hypothetical protein 0.0097 0.07 0.2174
Schistosoma mansoni neuropeptide receptor 0.0097 0.07 0.2174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.07 0.1064
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0145 0.0195
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0153 0.9924
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0097 0.07 0.2174
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.008 0.0104
Echinococcus granulosus neuropeptides capa receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0042 0.0053
Brugia malayi hypothetical protein 0.0155 0.1174 0.159
Brugia malayi Tachykinin-like peptides receptor 99D 0.0097 0.07 0.0947
Brugia malayi Serotonin receptor 0.0097 0.07 0.0947
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0097 0.07 0.0947
Onchocerca volvulus Dual oxidase homolog 0.0029 0.0145 0.0752
Loa Loa (eye worm) pax transcription factor protein 2 0.0247 0.1924 0.2597
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0002
Echinococcus granulosus neuroligin 0.0011 0.0001 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0097 0.07 0.0944
Schistosoma mansoni neuropeptide receptor 0.0097 0.07 0.2174
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0145 0.0196
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Brugia malayi Cytochrome P450 family protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Loa Loa (eye worm) hypothetical protein 0.0051 0.0324 0.0436
Echinococcus granulosus neuropeptide Y receptor 0.0097 0.07 0.2174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.07 0.1064
Schistosoma mansoni neuropeptide F-like receptor 0.0097 0.07 0.2174
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0064
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0097 0.07 0.1064
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0915 0.2842
Echinococcus granulosus g protein coupled receptor 0.0097 0.07 0.2174
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0273 0.0415
Onchocerca volvulus 0.0247 0.1924 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.07 0.1064
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0111 0.0391
Schistosoma mansoni adenoreceptor 0.0097 0.07 0.2174
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.07 0.2174
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0145 0.0195
Echinococcus multilocularis cpg binding protein 0.003 0.0156 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0097 0.07 0.3635
Schistosoma mansoni hypothetical protein 0.0406 0.3219 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.07 0.2174
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0042 0.0064
Echinococcus multilocularis serotonin receptor 0.0097 0.07 0.1064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Onchocerca volvulus 0.0097 0.07 0.3635
Onchocerca volvulus 0.0097 0.07 0.3635
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.073 0.0989
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0097 0.07 0.0947
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0916 0.738 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0111 0.0146
Echinococcus granulosus serotonin receptor 0.0097 0.07 0.2174
Onchocerca volvulus 0.0097 0.07 0.3635
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.07 0.1064
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0145 0.0195
Brugia malayi Serotonin receptor 0.0097 0.07 0.0947
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0003 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0097 0.07 0.2174
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0003 0.0003
Echinococcus granulosus fmrfamide receptor 0.0097 0.07 0.2174
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0097 0.07 0.2174
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0446 0.1386
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0097 0.07 0.2174
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0153 0.9924
Brugia malayi G-protein coupled receptor 0.0097 0.07 0.0947
Leishmania major hypothetical protein, conserved 0.0025 0.0111 0.0146
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0001 0.0001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0097 0.07 0.1064
Brugia malayi Carboxylesterase family protein 0.0066 0.0446 0.0604
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0527
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0446 0.1386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0488 0.0657
Echinococcus granulosus 7TM GPCR rhodopsin 0.0097 0.07 0.2174
Schistosoma mansoni biogenic amine receptor 0.0097 0.07 0.2174
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.07 0.2174
Echinococcus granulosus biogenic amine 5HT receptor 0.0097 0.07 0.2174
Brugia malayi larval opioid receptor 0.0097 0.07 0.0947
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni cpg binding protein 0.003 0.0156 0.0484
Brugia malayi TAR-binding protein 0.0123 0.0915 0.1239
Brugia malayi GnHR receptor homolog 0.0097 0.07 0.0947
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0097 0.07 0.2174
Onchocerca volvulus 0.0029 0.0145 0.0752
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Brugia malayi cytochrome P450 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Brugia malayi AKH receptor 0.0097 0.07 0.0947
Echinococcus multilocularis neuropeptide FF receptor 2 0.0097 0.07 0.1064
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0915 0.1239
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0145 0.0196
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.3219 0.4896
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0097 0.07 0.3635
Trypanosoma brucei cytochrome P450, putative 0.0021 0.008 0.0104
Echinococcus multilocularis allatostatin A receptor 0.0097 0.07 0.1064
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0889 0.7156 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0349 0.2755 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0111 0.0146
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0244 0.0372
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.017 0.0229
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0097 0.07 0.0947
Brugia malayi Dopamine receptor protein 1 0.0097 0.07 0.0947
Echinococcus granulosus neuropeptides capa receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0032 0.017 0.0228
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.07 0.2174
Brugia malayi putative neuropeptide receptor 0.0097 0.07 0.0947
Schistosoma mansoni peroxidasin 0.0029 0.0145 0.0452
Brugia malayi Carboxylesterase family protein 0.0066 0.0446 0.0604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0488 1
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0915 0.2842
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0527
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0244 0.0759
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.07 0.2174
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.003 0.0154 0.0547
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0403 0.1252
Loa Loa (eye worm) hypothetical protein 0.0069 0.0471 0.0635
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0003 0.0009
Loa Loa (eye worm) cytochrome P450 0.0011 0.0003 0.0003
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0915 0.1391
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni amine GPCR 0.0097 0.07 0.2174
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0042 0.0056
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0154 1
Brugia malayi Melatonin receptor type 1A 0.0097 0.07 0.0947
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Echinococcus multilocularis fmrfamide receptor 0.0097 0.07 0.1064
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0003 0.0002
Onchocerca volvulus 0.0097 0.07 0.3635
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.07 0.2174
Echinococcus multilocularis g protein coupled receptor 0.0097 0.07 0.1064
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.017 0.0258
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0064
Echinococcus granulosus g-protein coupled receptor 0.0097 0.07 0.2174
Echinococcus granulosus neuropeptide s receptor 0.0097 0.07 0.2174
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0273 0.0847
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Onchocerca volvulus 0.0029 0.0142 0.0737
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0097 0.07 0.2174
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0001 0.0002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0097 0.07 0.0944
Echinococcus multilocularis tumor protein p63 0.0347 0.2737 0.4164
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0097 0.07 0.1064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0003 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0488 0.0742
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0003 0.0003
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0145 0.0196
Brugia malayi Latrophilin receptor protein 2 0.0032 0.017 0.0229
Trichomonas vaginalis MYB, putative 0.003 0.0154 1
Loa Loa (eye worm) hypothetical protein 0.038 0.3004 0.4055
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.07 0.2174
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.017 0.0527
Loa Loa (eye worm) melatonin receptor type 1A 0.0097 0.07 0.0944
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0153 0.9924
Loa Loa (eye worm) RNA binding protein 0.0123 0.0915 0.1234
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1238 1 0.5
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0001 0.0002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0097 0.07 0.1064
Echinococcus granulosus neuropeptide receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0003 0.0002
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0001 0.0001
Trichomonas vaginalis MYB72, putative 0.003 0.0153 0.9924
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0042 0.0064
Echinococcus multilocularis peroxidasin 0.0029 0.0145 0.0221
Onchocerca volvulus Chorion peroxidase homolog 0.0029 0.0145 0.0752
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0097 0.07 0.0944
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0111 1
Schistosoma mansoni amine GPCR 0.0097 0.07 0.2174
Echinococcus granulosus peptide allatostatin:somatostatin 0.0097 0.07 0.2174
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.07 0.1064
Echinococcus multilocularis neuroligin 0.0011 0.0001 0.0001
Echinococcus granulosus neuropeptide receptor 0.0097 0.07 0.2174
Echinococcus granulosus tachykinin peptides receptor 99D 0.0097 0.07 0.2174
Schistosoma mansoni hypothetical protein 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.07 0.2174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.07 0.1064
Schistosoma mansoni opsin-like receptor 0.0097 0.07 0.2174
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0097 0.07 0.2174
Brugia malayi hypothetical protein 0.0025 0.0111 0.0149
Schistosoma mansoni biogenic amine (5HT) receptor 0.0097 0.07 0.2174
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0097 0.07 0.1064
Loa Loa (eye worm) CYP4Cod1 0.0021 0.008 0.0107
Echinococcus multilocularis fmrfamide receptor 0.0097 0.07 0.1064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Leishmania major C-8 sterol isomerase-like protein 0.0916 0.738 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.017 0.0229
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Trichomonas vaginalis C-MYB, putative 0.003 0.0153 0.9924
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.008 0.0104
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0042 0.0143
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0097 0.07 0.1064
Trichomonas vaginalis MYB3r3, putative 0.003 0.0153 0.9924
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Loa Loa (eye worm) TYRA-2 protein 0.0097 0.07 0.0944
Onchocerca volvulus 0.0097 0.07 0.3635
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.07 0.2174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.07 0.1064
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0097 0.07 0.1064
Echinococcus granulosus 7tm_1 domain containing protein 0.0097 0.07 0.2174
Schistosoma mansoni hypothetical protein 0.0168 0.1281 0.3979
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0273 0.0847
Schistosoma mansoni myosin xvIII 0.0097 0.07 0.2174
Echinococcus granulosus neuropeptide receptor A26 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0155 0.1174 0.1585
Echinococcus multilocularis g-protein coupled receptor 0.0097 0.07 0.1064
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0915 0.2842
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0273 0.0415
Schistosoma mansoni biogenic amine receptor 0.0097 0.07 0.2174
Onchocerca volvulus 0.0051 0.0324 0.1681
Echinococcus granulosus orexin receptor type 2 0.0097 0.07 0.2174
Brugia malayi G protein-coupled receptor 0.0097 0.07 0.0947
Onchocerca volvulus 0.0097 0.07 0.3635
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0446 0.0602
Echinococcus granulosus somatostatin receptor 0.0097 0.07 0.2174
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0148
Schistosoma mansoni hypothetical protein 0.0097 0.07 0.2174
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0053
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0488 0.066
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0145 0.0195
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0488 0.0657
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Echinococcus multilocularis g protein coupled receptor 0.0097 0.07 0.1064
Brugia malayi putative neuropeptide receptor NPR1 0.0097 0.07 0.0947
Brugia malayi Blistered cuticle protein 3 0.0029 0.0145 0.0196
Brugia malayi hypothetical protein 0.0029 0.0145 0.0196
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0097 0.07 0.2174
Echinococcus granulosus geminin 0.0168 0.1281 0.3979
Echinococcus multilocularis neuropeptides capa receptor 0.0097 0.07 0.1064
Giardia lamblia Myb 1-like protein 0.003 0.0154 0.5
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0349 0.2755 0.2754
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.07 0.1064
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Brugia malayi hypothetical protein 0.0016 0.0039 0.0053
Schistosoma mansoni cytochrome P450 0.0011 0.0003 0.0009
Schistosoma mansoni neuropeptide receptor 0.0097 0.07 0.2174
Schistosoma mansoni histamine h1 receptor 0.0097 0.07 0.2174
Echinococcus multilocularis serotonin receptor 0.0097 0.07 0.1064
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0003 0.0003
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0349 0.2755 0.3847
Echinococcus multilocularis neuropeptide receptor 0.0097 0.07 0.1064
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0145 0.0752
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.008 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0064
Onchocerca volvulus Peroxidase homolog 0.0029 0.0145 0.0752
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0003 0.0002
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.07 0.2174
Leishmania major cytochrome p450-like protein 0.0021 0.008 0.0104
Brugia malayi sulfakinin receptor protein 0.0097 0.07 0.0947
Echinococcus granulosus g protein coupled receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0003 0.0002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.008 0.0079
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0003 0.0002
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0488 0.1515
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0042 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0916 0.738 1
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0001 0.0002
Brugia malayi Peroxidasin 0.0029 0.0145 0.0196
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.017 0.0527
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0273 0.0847
Echinococcus multilocularis g protein coupled receptor 0.0097 0.07 0.1064
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0003 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.017 0.0258
Brugia malayi neuropeptide F receptor 0.0097 0.07 0.0947
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni peroxidasin 0.0029 0.0145 0.0452
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0097 0.07 0.2174
Schistosoma mansoni cpg binding protein 0.003 0.0156 0.0484
Onchocerca volvulus 0.0097 0.07 0.3635
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.035 0.1262
Schistosoma mansoni acetylcholinesterase 0.0011 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0009
Echinococcus multilocularis 0.0011 0.0003 0.0005
Echinococcus granulosus peroxidasin 0.0029 0.0145 0.0452
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0002
Echinococcus granulosus tumor protein p63 0.0347 0.2737 0.8504
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0003 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.0097 0.07 0.2174
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0446 0.0679
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0003 0.0003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0097 0.07 0.0947
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Echinococcus granulosus cpg binding protein 0.003 0.0156 0.0484
Echinococcus granulosus tar DNA binding protein 0.0123 0.0915 0.2842
Brugia malayi neuropeptide F receptor 0.0097 0.07 0.0947
Onchocerca volvulus Neuropeptide F receptor homolog 0.0097 0.07 0.3635
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0915 0.2842
Brugia malayi G protein-coupled receptor F59B2.13 0.0097 0.07 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0003 0.0003
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0153 0.9924
Onchocerca volvulus 0.0097 0.07 0.3635
Loa Loa (eye worm) G-protein coupled receptor 0.0097 0.07 0.0944
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0042 0.0143
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0097 0.07 0.3635
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0168 0.1281 0.3979
Brugia malayi CXXC zinc finger family protein 0.0029 0.0142 0.0192
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.073 0.0989
Brugia malayi isocitrate dehydrogenase 0.0016 0.0042 0.0056
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0097 0.07 0.2174
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0153 0.9924
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.092 0.7406 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0003 0.0002
Echinococcus granulosus GPCR family 2 0.0032 0.017 0.0527
Loa Loa (eye worm) G-protein coupled receptor 0.0097 0.07 0.0944
Schistosoma mansoni amine GPCR 0.0097 0.07 0.2174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0097 0.07 0.2174
Brugia malayi Dopamine receptor 0.0097 0.07 0.0947
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0097 0.07 0.0944
Echinococcus multilocularis sex peptide receptor 0.0097 0.07 0.1064
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0003 0.0002
Onchocerca volvulus 0.0097 0.07 0.3635
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0097 0.07 0.1064
Brugia malayi RNA binding protein 0.0123 0.0915 0.1239
Loa Loa (eye worm) hypothetical protein 0.092 0.7406 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0097 0.07 0.2174
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0153 0.9924
Schistosoma mansoni neuropeptide receptor 0.0097 0.07 0.2174
Echinococcus multilocularis somatostatin receptor 0.0097 0.07 0.1064
Echinococcus multilocularis neuropeptide Y receptor 0.0097 0.07 0.1064
Onchocerca volvulus 0.0155 0.1174 0.6103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0273 0.0847
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0042 0.0058
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Onchocerca volvulus 0.0097 0.07 0.3635
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Brugia malayi Cytochrome P450 family protein 0.0032 0.017 0.0229
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0111 0.0146
Brugia malayi Pax transcription factor protein 2 0.0247 0.1924 0.2606
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0097 0.07 0.1064
Echinococcus multilocularis GPCR, family 2 0.0032 0.017 0.0258
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0097 0.07 0.0944
Echinococcus multilocularis neuropeptides capa receptor 0.0097 0.07 0.1064
Schistosoma mansoni biogenic amine receptor 0.0097 0.07 0.2174
Schistosoma mansoni hypothetical protein 0.0097 0.07 0.2174
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.073 0.0985
Echinococcus granulosus neuropeptide FF receptor 2 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Brugia malayi G-protein coupled receptor 0.0097 0.07 0.0947
Echinococcus multilocularis neuropeptide receptor A26 0.0097 0.07 0.1064
Schistosoma mansoni hypothetical protein 0.0069 0.0471 0.1463
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0111 1
Echinococcus multilocularis G protein coupled receptor 139 0.0097 0.07 0.1064
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0097 0.07 0.1064
Schistosoma mansoni neuropeptide F-like receptor 0.0097 0.07 0.2174
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0153 0.9924
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.017 0.0228
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0471 0.0637
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0324 0.1006
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0488 0.0657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0097 0.07 0.2174
Echinococcus granulosus alpha 1A adrenergic receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) carboxylesterase 0.0066 0.0446 0.0602
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0915 0.1234
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0053
Echinococcus granulosus sex peptide receptor 0.0097 0.07 0.2174
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0003 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.008 0.0107
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0145 0.0752
Echinococcus multilocularis neuropeptide s receptor 0.0097 0.07 0.1064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.6574 1
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0446 0.0679
Brugia malayi follicle stimulating hormone receptor 0.0097 0.07 0.0947
Brugia malayi ORL1-like opioid receptor 0.0097 0.07 0.0947
Onchocerca volvulus 0.0097 0.07 0.3635
Brugia malayi RE15519p 0.0097 0.07 0.0947
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0154 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0273 0.0367
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.027 0.2114 0.2954
Schistosoma mansoni amine GPCR 0.0097 0.07 0.2174
Schistosoma mansoni neuropeptide f receptor 76f 0.0097 0.07 0.2174
Schistosoma mansoni opsin-like receptor 0.0097 0.07 0.2174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.07 0.1064
Echinococcus multilocularis orexin receptor type 2 0.0097 0.07 0.1064
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0003 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.07 0.1064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.07 0.2174
Trichomonas vaginalis C-MYB, putative 0.003 0.0153 0.9924
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0053
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0003 0.0002
Schistosoma mansoni gliotactin 0.0011 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0003 0.0002
Onchocerca volvulus 0.0029 0.0145 0.0752
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Onchocerca volvulus Peroxidase homolog 0.0029 0.0145 0.0752
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0195
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0527
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0153 0.9924
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Loa Loa (eye worm) hypothetical protein 0.0066 0.0446 0.0602
Echinococcus multilocularis G-protein coupled receptor, putative 0.0097 0.07 0.1064
Loa Loa (eye worm) blistered cuticle protein 3 0.0029 0.0145 0.0195
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.0944
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0488 0.0658
Echinococcus multilocularis neuropeptide Y receptor 0.0097 0.07 0.1064
Echinococcus granulosus acetylcholinesterase 0.0066 0.0446 0.1386
Onchocerca volvulus 0.0097 0.07 0.3635
Onchocerca volvulus 0.0097 0.07 0.3635
Trypanosoma brucei C-8 sterol isomerase, putative 0.0916 0.738 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0273 0.0847
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.07 0.2174
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0042 0.0131
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0488 0.1515
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0003 0.0002
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Brugia malayi hypothetical protein 0.0097 0.07 0.0947
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0915 0.1234
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0527
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0915 0.2842
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0097 0.07 0.2174
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.07 0.2174
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.07 0.2174
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0097 0.07 0.2174
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0097 0.07 0.0947

Activities

Activity type Activity value Assay description Source Reference
Ka (ADMET) = 1 10^4/M Binding affinity to human serum albumin on sepharose column by affinity chromatography ChEMBL. 18289858
Ka (ADMET) = 1 10^4/M Binding affinity to human serum albumin on sepharose column by affinity chromatography ChEMBL. 18289858

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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