Detailed information for compound 514151

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 619.753 | Formula: C37H41N5O4
  • H donors: 1 H acceptors: 3 LogP: 5.88 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCn1c2cc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)N1CCN(CC1)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C37H41N5O4/c1-3-19-41-32-25-31(38-34(32)36(44)42(20-4-2)37(41)45)27-15-17-30(18-16-27)46-26-33(43)39-21-23-40(24-22-39)35(28-11-7-5-8-12-28)29-13-9-6-10-14-29/h5-18,25,35,38H,3-4,19-24,26H2,1-2H3
  • InChiKey: WSKCJGRELCVAAA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References
Homo sapiens adenosine A2b receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0342 0.0394
Loa Loa (eye worm) hypothetical protein 0.0058 0.0765 0.0765
Trypanosoma brucei histidyl-tRNA synthetase 0.0018 0.0047 0.0046
Echinococcus multilocularis Developmentally regulated GTP binding protein 2 0.0017 0.0023 0.0027
Onchocerca volvulus 0.0245 0.4175 1
Plasmodium vivax heat shock protein 86, putative 0.0061 0.0815 0.1356
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0216 0.0216
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0087 0.1302 0.1302
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0028 0.0216 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0216 0.0447
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.0799 0.0799
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0596 0.0688
Giardia lamblia Metal-dependent hydrolase related to alanyl-tRNA synthetase 0.0018 0.0033 0.0028
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0837 0.2481
Brugia malayi hypothetical protein 0.0019 0.0053 0.0053
Echinococcus granulosus FK506 binding protein 2 0.0028 0.0216 0.0641
Brugia malayi Developmentally regulated GTP-binding protein 1, putative 0.0017 0.0023 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0245 0.4175 0.9606
Trypanosoma cruzi heat shock protein 85, putative 0.0061 0.0815 0.0814
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0216 0.0331
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0269 0.0311
Echinococcus granulosus histidyl tRNA synthetase 0.0018 0.0047 0.0139
Echinococcus granulosus glycyl tRNA synthetase 0.0031 0.0269 0.0798
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0028 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0028 0.0215 0.0638
Entamoeba histolytica hypothetical protein 0.0022 0.011 0.0258
Loa Loa (eye worm) heat shock protein 75 0.0048 0.0593 0.0593
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0173 0.2871 0.8507
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0031 0.0285 0.0284
Brugia malayi beta-lactamase family protein 0.0058 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0024 0.0159 0.0159
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Loa Loa (eye worm) hypothetical protein 0.0042 0.048 0.048
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0215 0.0215
Trypanosoma brucei glucosidase, putative 0.0039 0.0419 0.0418
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0028 0.0216 0.0641
Trypanosoma cruzi heat shock protein 90, putative 0.0061 0.0815 0.0814
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0028 0.0216 0.0216
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0269 0.0735
Onchocerca volvulus 0.0028 0.0216 0.0518
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0837 0.0966
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.2752 0.6592
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.035 0.0404
Trypanosoma cruzi Heat shock protein 83, putative 0.0061 0.0815 0.0814
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0051 0.0636 0.0636
Schistosoma mansoni bromodomain containing protein 0.0065 0.0905 0.2681
Trypanosoma cruzi alanyl-tRNA synthetase, putative 0.0018 0.0033 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0906 0.1045
Loa Loa (eye worm) inositol-1 0.0036 0.0371 0.0371
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0201 0.3375 0.3375
Loa Loa (eye worm) hypothetical protein 0.0044 0.0516 0.0516
Brugia malayi Bromodomain containing protein 0.0078 0.1125 0.1125
Trichomonas vaginalis penicillin-binding protein, putative 0.0058 0.0765 0.1715
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0201 0.3375 0.5741
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0201 0.3375 1
Brugia malayi RNA binding protein 0.0066 0.0906 0.0906
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0051 0.0636 0.0734
Brugia malayi Inositol-1 0.0036 0.0371 0.0371
Leishmania major threonyl-tRNA synthetase, putative 0.0144 0.2333 0.2333
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0371 0.1037
Toxoplasma gondii heat shock protein 90, putative 0.0061 0.0815 0.139
Mycobacterium tuberculosis Conserved protein 0.0058 0.0765 0.0882
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0419 0.0916
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0127 0.2023 0.5965
Loa Loa (eye worm) MH2 domain-containing protein 0.007 0.0993 0.0993
Plasmodium falciparum endoplasmin, putative 0.0048 0.0578 0.095
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0031 0.0269 0.0269
Loa Loa (eye worm) developmentally regulated GTP-binding protein 1 0.0017 0.0023 0.0023
Onchocerca volvulus 0.0028 0.0216 0.0518
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0419 0.1181
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.0269
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0419 0.0916
Entamoeba histolytica alanyl-tRNA synthetase, putative 0.0018 0.0033 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Echinococcus granulosus beta LACTamase domain containing family member 0.0058 0.0765 0.2266
Trichomonas vaginalis heat shock protein, putative 0.0061 0.083 0.1866
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0031 0.0285 0.0328
Echinococcus multilocularis beta LACTamase domain containing family member 0.0058 0.0765 0.0882
Toxoplasma gondii glycyl-tRNA synthetase 0.0031 0.0269 0.046
Echinococcus multilocularis fk506 binding protein 0.0201 0.3375 0.3893
Echinococcus granulosus 39S ribosomal protein L39 mitochondrial 0.0017 0.0023 0.0069
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0018 0.0047 0.0055
Echinococcus multilocularis heat shock protein 90 0.0061 0.0815 0.094
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0371 0.1099
Echinococcus granulosus geminin 0.01 0.1531 0.4536
Trichomonas vaginalis fk506 binding protein, putative 0.0028 0.0216 0.0447
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0031 0.0285 0.0448
Giardia lamblia Hypothetical protein 0.0028 0.0216 0.0577
Treponema pallidum exodeoxyribonuclease (exoA) 0.0031 0.0285 0.0754
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0765 0.0764
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.035 0.1038
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0201 0.3375 0.3893
Onchocerca volvulus 0.0058 0.0765 0.1831
Trypanosoma brucei heat shock protein, putative 0.0061 0.0815 0.0814
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0201 0.3375 0.3374
Mycobacterium tuberculosis Probable lipase LipE 0.0058 0.0765 0.0882
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0031 0.0285 0.078
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0028 0.0216 0.0216
Loa Loa (eye worm) heat shock protein 90 0.0061 0.0815 0.0815
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0028 0.0216 0.0216
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0028 0.0216 0.0369
Mycobacterium ulcerans heat shock protein 90 0.0061 0.083 0.2407
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0028 0.0216 0.055
Trypanosoma brucei heat shock protein, putative 0.0061 0.0815 0.0814
Brugia malayi hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0137 0.0407
Trichomonas vaginalis ap endonuclease, putative 0.0031 0.0285 0.0605
Trichomonas vaginalis fk506-binding protein, putative 0.0201 0.3375 0.7754
Mycobacterium ulcerans hypothetical protein 0.0028 0.0216 0.0577
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0201 0.3375 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0596 0.1767
Trypanosoma cruzi ribosome-interacting GTPase 2, putative 0.0017 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0022 0.011 0.0258
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0302 0.0472
Trypanosoma brucei C-8 sterol isomerase, putative 0.0565 1 1
Toxoplasma gondii cytosolic tRNA-Ala synthetase 0.0018 0.0033 0.0056
Schistosoma mansoni hypothetical protein 0.0028 0.0215 0.0638
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0275 0.0815
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.2897 0.8584
Plasmodium falciparum heat shock protein 90, putative 0.0338 0.5861 1
Onchocerca volvulus 0.0058 0.0765 0.1831
Schistosoma mansoni hypothetical protein 0.0028 0.0216 0.0641
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0269 0.0269
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0035 0.035 0.035
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0018 0.0047 0.0046
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0201 0.3375 1
Loa Loa (eye worm) alanyl-tRNA synthetase 0.0018 0.0033 0.0033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0371 0.0804
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0137 0.0158
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0159 0.0158
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Trichomonas vaginalis heat shock protein, putative 0.0054 0.069 0.1543
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.0342 0.095
Onchocerca volvulus 0.0031 0.0275 0.0658
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0061 0.083 0.0987
Treponema pallidum glycyl-tRNA synthetase 0.0018 0.0047 0.0043
Echinococcus granulosus zinc finger protein 0.002 0.0081 0.0241
Leishmania major hypothetical protein, conserved 0.0024 0.0159 0.0158
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0342 0.1012
Mycobacterium tuberculosis Conserved protein 0.0058 0.0765 0.0882
Schistosoma mansoni endoplasmin 0.0061 0.0815 0.2414
Echinococcus multilocularis 39S ribosomal protein L39, mitochondrial 0.0017 0.0023 0.0027
Trypanosoma cruzi heat shock protein 85, putative 0.0061 0.0815 0.0814
Schistosoma mansoni developmentally regulated GTP-binding protein 1 (drg 1) 0.0017 0.0023 0.0069
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0371 0.0804
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2916 0.6693
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0216 0.0447
Giardia lamblia Alanyl-tRNA synthetase 0.0018 0.0033 0.0028
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0028 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0028 0.0215 0.0638
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0101 0.0101
Echinococcus multilocularis glycyl tRNA synthetase 0.0031 0.0269 0.0311
Loa Loa (eye worm) hypothetical protein 0.0226 0.3824 0.3824
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0028 0.0216 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0906 0.2684
Mycobacterium tuberculosis Conserved protein 0.0058 0.0765 0.0882
Trypanosoma brucei ribosome-interacting GTPase 2, putative 0.0017 0.0023 0.0023
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0201 0.3375 0.3374
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0058 0.0765 0.2266
Loa Loa (eye worm) transcription factor SMAD2 0.007 0.0993 0.0993
Brugia malayi exodeoxyribonuclease III family protein 0.0031 0.0285 0.0285
Giardia lamblia Heat shock protein HSP 90-alpha 0.0054 0.069 0.1989
Echinococcus multilocularis zinc finger protein 0.002 0.0081 0.0094
Echinococcus multilocularis heat shock protein 0.0061 0.0815 0.094
Brugia malayi Hypothetical GTP-binding protein C02F5.3 in chromosome III 0.0017 0.0023 0.0023
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0419 0.0916
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0045 0.0045
Loa Loa (eye worm) alanyl-tRNA synthetase 0.0018 0.0033 0.0033
Echinococcus granulosus Developmentally regulated GTP binding protein 2 0.0017 0.0023 0.0069
Echinococcus granulosus heat shock protein 0.0061 0.0815 0.2414
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0031 0.0285 0.078
Echinococcus granulosus endoplasmin 0.0061 0.083 0.2459
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.0342 0.095
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0269 0.057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0058 0.0765 0.0765
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0419 0.0418
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0018 0.0047 0.0072
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0371 0.037
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0419 0.0418
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0048 0.0593 0.0684
Onchocerca volvulus 0.0101 0.1554 0.3723
Trichomonas vaginalis penicillin-binding protein, putative 0.0058 0.0765 0.1715
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2916 0.6693
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0342 0.0737
Leishmania major heat shock protein, putative 0.0048 0.0593 0.0593
Echinococcus multilocularis alanyl tRNA synthetase, mitochondrial 0.0018 0.0033 0.0038
Leishmania major glycyl tRNA synthetase, putative 0.0018 0.0047 0.0046
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0051 0.0636 0.1886
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Mycobacterium ulcerans alanyl-tRNA synthetase 0.0018 0.0033 0.0028
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0074 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0596 0.1767
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.2897 0.3341
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0765 0.0764
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0906 0.2684
Trypanosoma cruzi histidyl-tRNA synthetase 0.0018 0.0047 0.0046
Schistosoma mansoni fk506 binding protein 0.0028 0.0216 0.0641
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0028 0.0216 0.0798
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0492 0.867 1
Leishmania major cathepsin L-like protease 0.006 0.0798 0.0797
Plasmodium vivax endoplasmin, putative 0.0061 0.0815 0.1356
Schistosoma mansoni developmentally regulated GTP-binding protein 2 (drg 2) 0.0017 0.0023 0.0069
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0201 0.3375 0.7754
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0275 0.0317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Plasmodium falciparum heat shock protein 90, putative 0.0041 0.0453 0.0737
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0034 0.01
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Trypanosoma cruzi heat shock protein 85, putative 0.0061 0.0815 0.0814
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0201 0.3375 0.3375
Schistosoma mansoni mitochondrial 39S ribosomal protein L39 0.0017 0.0023 0.0069
Schistosoma mansoni inositol monophosphatase 0.0036 0.0371 0.1099
Mycobacterium ulcerans lipase LipD 0.0058 0.0765 0.2212
Echinococcus multilocularis GPCR, family 2 0.0028 0.0215 0.0248
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Loa Loa (eye worm) endoplasmin 0.0061 0.0815 0.0815
Schistosoma mansoni zinc finger protein 0.002 0.0081 0.0241
Chlamydia trachomatis histidine--tRNA ligase 0.0018 0.0047 0.0062
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0798 0.0797
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0201 0.3375 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.0342 0.0342
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0061 0.083 0.4006
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0201 0.3375 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0031 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0035 0.0342 0.0342
Plasmodium vivax alanine--tRNA ligase, putative 0.0018 0.0033 0.0016
Loa Loa (eye worm) hypothetical protein 0.0087 0.1302 0.1302
Brugia malayi hypothetical protein 0.0024 0.0159 0.0159
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0022 0.011 0.0326
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.2897 0.3341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0275 0.0815
Toxoplasma gondii exonuclease III APE 0.0031 0.0285 0.0486
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0058 0.0765 0.0882
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0269 0.0798
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0035 0.035 0.035
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0018 0.0047 0.0047
Plasmodium falciparum alanine--tRNA ligase 0.0018 0.0033 0.0016
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.0269
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0419 0.0916
Echinococcus multilocularis geminin 0.01 0.1531 0.1766
Toxoplasma gondii heat shock protein HSP90 0.0061 0.0815 0.139
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0061 0.083 0.0829
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0419 0.0419
Schistosoma mansoni glycyl-tRNA synthetase 0.0031 0.0269 0.0798
Schistosoma mansoni heat shock protein 0.0061 0.0815 0.2414
Trypanosoma brucei heat shock protein, putative 0.0061 0.0815 0.0814
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0061 0.083 0.3396
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0389 0.0449
Treponema pallidum threonyl-tRNA synthetase 0.0127 0.2023 0.5954
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0371 0.1037
Toxoplasma gondii Hsp90 domain-containing protein 0.0338 0.5861 1
Schistosoma mansoni hypothetical protein 0.0021 0.0101 0.03
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0419 0.0916
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0215 0.0248
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0159 0.0232
Echinococcus multilocularis heat shock protein 90 0.0054 0.069 0.0796
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0054 0.0704 0.0703
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0201 0.3375 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0201 0.3375 0.7754
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.0765 0.1715
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0342 0.0341
Echinococcus multilocularis adam 17 protease 0.0107 0.1669 0.1925
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0144 0.2333 0.2333
Leishmania major hypothetical protein, conserved 0.0058 0.0765 0.0764
Loa Loa (eye worm) hypothetical protein 0.0058 0.0765 0.0765
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0419 0.1242
Loa Loa (eye worm) FKBP5 protein 0.0201 0.3375 0.3375
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0216 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0033 0.0022
Trypanosoma cruzi major cysteine proteinase, putative 0.0047 0.0566 0.0565
Brugia malayi Calcitonin receptor-like protein seb-1 0.0087 0.1302 0.1302
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0028 0.0216 0.0216
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0028 0.0216 0.0216
Echinococcus multilocularis alanyl tRNA synthetase, cytoplasmic 0.0018 0.0033 0.0038
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0048 0.0593 0.1758
Toxoplasma gondii GTP-binding protein 0.0017 0.0023 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.4346 1
Trypanosoma brucei heat shock protein, putative 0.0061 0.0815 0.0814
Plasmodium vivax SET domain protein, putative 0.0031 0.0275 0.0431
Mycobacterium ulcerans beta-lactamase 0.0058 0.0765 0.2212
Trichomonas vaginalis heat shock protein, putative 0.0061 0.0815 0.1831
Echinococcus granulosus heat shock protein 90 0.0054 0.069 0.2044
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0371 0.037
Loa Loa (eye worm) hypothetical protein 0.006 0.0799 0.0799
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0371 0.0633
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0031 0.0285 0.078
Schistosoma mansoni immunophilin 0.0201 0.3375 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0028 0.0216 0.0577
Mycobacterium ulcerans esterase/lipase LipP 0.0058 0.0765 0.2212
Mycobacterium tuberculosis Probable esterase LipL 0.0058 0.0765 0.0882
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0453 0.0995
Trypanosoma brucei heat shock protein 90, putative 0.0061 0.0815 0.0814
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0018 0.0047 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Trypanosoma brucei heat shock protein, putative 0.0061 0.0815 0.0814
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0028 0.0216 0.0369
Schistosoma mansoni ap endonuclease 0.0031 0.0285 0.0843
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.2897 0.2897
Trichomonas vaginalis esterase, putative 0.0058 0.0765 0.1715
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0034 0.01
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.0342 0.1012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0215 0.0248
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0031 0.0285 0.0843
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0058 0.0765 0.0882
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0034 0.0039
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0419 0.0916
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0906 0.0906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Loa Loa (eye worm) hypothetical protein 0.0565 1 1
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0419 0.0418
Onchocerca volvulus 0.0058 0.0765 0.1831
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0018 0.0047 0.0071
Trichomonas vaginalis endoplasmin, putative 0.0048 0.0578 0.1283
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0419 0.0916
Brugia malayi heat shock protein 90 0.0061 0.0815 0.0815
Toxoplasma gondii heat shock protein 75, putative 0.0048 0.0593 0.1012
Mycobacterium ulcerans hypothetical protein 0.0058 0.0765 0.2212
Trypanosoma brucei heat shock protein, putative 0.0061 0.0815 0.0814
Mycobacterium leprae Probable lipase LipE 0.0058 0.0765 0.3035
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0371 0.037
Schistosoma mansoni immunophilin 0.0201 0.3375 1
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0028 0.0216 0.0923
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0269 0.0798
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0906 0.2684
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0087 0.1302 0.1302
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0048 0.0593 0.17
Giardia lamblia Heat shock protein HSP 90-alpha 0.0061 0.0815 0.2361
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2752 0.6314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.035 0.1038
Schistosoma mansoni histidyl-tRNA synthetase 0.0018 0.0047 0.0139
Loa Loa (eye worm) hypothetical protein 0.0073 0.1045 0.1045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0031 0.0285 0.011
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0067 0.094 0.1084
Echinococcus multilocularis adam 0.0019 0.0053 0.0061
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0028 0.0216 0.025
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0201 0.3375 0.3374
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.0765 0.1715
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0058 0.0765 0.0882
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0028 0.0216 0.0216
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0028 0.0216 0.0216
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0269 0.0735
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0058 0.0765 0.2212
Leishmania major fk506-binding protein 1-like protein 0.0201 0.3375 0.3374
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Plasmodium falciparum threonine--tRNA ligase 0.0127 0.2023 0.3425
Echinococcus granulosus developmentally regulated gtp binding protein 1 0.0017 0.0023 0.0069
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0269 0.0294
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0216 0.0331
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0389 0.1154
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0565 1 1
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0215 0.0638
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0028 0.0216 0.0369
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Trichomonas vaginalis ap endonuclease, putative 0.0031 0.0285 0.0605
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Brugia malayi Hsp90 protein 0.0048 0.0593 0.0593
Entamoeba histolytica hypothetical protein 0.0022 0.011 0.0258
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0173 0.2871 0.3311
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.069 0.0689
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0144 0.2333 0.2333
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0144 0.2333 0.2333
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0906 0.0906
Mycobacterium tuberculosis Probable lipase LipD 0.0058 0.0765 0.0882
Schistosoma mansoni ap endonuclease 0.0031 0.0285 0.0843
Trypanosoma cruzi tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative 0.0018 0.0033 0.0032
Brugia malayi Alanyl-tRNA synthetase 0.0018 0.0033 0.0033
Trypanosoma brucei heat shock protein, putative 0.0061 0.0815 0.0814
Loa Loa (eye worm) hypothetical protein 0.0028 0.0215 0.0215
Schistosoma mansoni threonyl-tRNA synthetase 0.0115 0.18 0.5334
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0031 0.0285 0.0284
Plasmodium falciparum heat shock protein 90 0.0061 0.0815 0.1356
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.4346 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0201 0.3375 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0369 0.6434 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2752 0.6314
Brugia malayi Endoplasmin precursor 0.0061 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0028 0.0216 0.0216
Schistosoma mansoni heat shock protein 0.0061 0.0815 0.2414
Trichomonas vaginalis fk506-binding protein, putative 0.0028 0.0216 0.0447
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.3634 0.3634
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0028 0.0216 0.0216
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.4346 1
Giardia lamblia Grp94/Hsp90 0.0061 0.083 0.2407
Schistosoma mansoni alpha-glucosidase 0.015 0.2453 0.727
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0127 0.2023 1
Entamoeba histolytica heat shock protein 90, putative 0.0061 0.0815 0.2361
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.0798 0.0797
Leishmania major GTP-binding protein, putative 0.0017 0.0023 0.0023
Trichomonas vaginalis fk506-binding protein, putative 0.0028 0.0216 0.0447
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0031 0.0269 0.0269
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0765 0.127
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0127 0.2023 0.2905
Schistosoma mansoni heat shock protein 0.0048 0.0593 0.1758
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0028 0.0216 0.0577
Loa Loa (eye worm) hypothetical protein 0.0049 0.0596 0.0596
Echinococcus granulosus GPCR family 2 0.0028 0.0215 0.0638
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0419 0.0916
Schistosoma mansoni immunophilin 0.0173 0.2871 0.8507
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0144 0.2333 0.2691
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0031 0.0269 0.0735
Leishmania major alanyl-tRNA synthetase, putative 0.0018 0.0033 0.0032
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0031 0.0285 0.0448
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0018 0.0047 0.008
Toxoplasma gondii ABC1 family protein 0.0058 0.0765 0.1305
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0159 0.0158
Schistosoma mansoni developmentally regulated GTP-binding protein 1 (drg 1) 0.0017 0.0023 0.0069
Toxoplasma gondii GTP-binding protein, putative 0.0017 0.0023 0.004
Loa Loa (eye worm) RNA binding protein 0.0066 0.0906 0.0906
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0342 0.1012
Schistosoma mansoni alpha glucosidase 0.0039 0.0419 0.1242
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0419 0.0419
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0031 0.0285 0.1266
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0275 0.0469
Plasmodium vivax proline--tRNA ligase, putative 0.0031 0.0269 0.0422
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0765 0.0764
Leishmania major developmentally regulated GTP-binding protein 1, putative 0.0017 0.0023 0.0023
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0419 0.1181
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0127 0.2023 0.3451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Loa Loa (eye worm) beta-lactamase 0.0058 0.0765 0.0765
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0144 0.2333 0.2333
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0201 0.3375 0.3375
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.0342 0.1012
Loa Loa (eye worm) hypothetical protein 0.0173 0.2871 0.2871
Echinococcus granulosus adam 17 protease 0.0118 0.1864 0.5524
Brugia malayi beta-lactamase family protein 0.0058 0.0765 0.0765
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Echinococcus granulosus alanyl tRNA synthetase mitochondrial 0.0018 0.0033 0.0097
Chlamydia trachomatis proline--tRNA ligase 0.0031 0.0269 0.1029
Schistosoma mansoni alpha-glucosidase 0.015 0.2453 0.727
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0022 0.011 0.0127
Plasmodium vivax histidine--tRNA ligase, putative 0.0018 0.0047 0.0041
Trypanosoma brucei Heat shock protein 83, putative 0.0061 0.0815 0.0814
Schistosoma mansoni inositol monophosphatase 0.0036 0.0371 0.1099
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0144 0.2333 0.2333
Trypanosoma brucei tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative 0.0018 0.0033 0.0032
Echinococcus granulosus heat shock protein 90 0.0061 0.0815 0.2414
Leishmania major cathepsin L-like protease 0.006 0.0798 0.0797
Toxoplasma gondii anticodon binding domain-containing protein 0.0018 0.0047 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0058 0.0765 0.0765
Trichomonas vaginalis immunophilin, putative 0.0201 0.3375 0.7754
Echinococcus granulosus tar DNA binding protein 0.0066 0.0906 0.2684
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0371 0.0428
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0201 0.3375 0.3374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Giardia lamblia Threonyl-tRNA synthetase 0.0127 0.2023 0.5965
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0269 0.0798
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0031 0.0269 0.0269
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.069 0.0689
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0216 0.0577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.035 0.1038
Schistosoma mansoni zinc finger protein 0.0016 0.0001 0.0002
Trichomonas vaginalis heat shock protein, putative 0.0061 0.083 0.1866
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0107 0.1669 0.4946
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0215 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.4346 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Trypanosoma brucei heat shock protein 90, putative 0.0061 0.0815 0.0814
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0048 0.0593 0.1421
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0201 0.3375 1
Entamoeba histolytica heat shock protein 90, putative 0.0061 0.0815 0.2361
Trypanosoma brucei developmentally regulated GTP-binding protein, putative 0.0017 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0054 0.069 0.2044
Plasmodium vivax heat shock protein, putative 0.0338 0.5861 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0031 0.0269 0.0269
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0419 0.0483
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0201 0.3375 0.3374
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0028 0.0216 0.0577
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.0342 0.1012
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0342 0.0394
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0906 0.2684
Plasmodium falciparum histidine--tRNA ligase, putative 0.0018 0.0047 0.0041
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0031 0.0269 0.0269
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0371 0.0804
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0419 0.0715
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0216 0.0216
Echinococcus multilocularis developmentally regulated gtp binding protein 1 0.0017 0.0023 0.0027
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0028 0.0216 0.0577
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0201 0.3375 0.3374
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.0765 0.1715
Trichomonas vaginalis alanyl-tRNA synthetase, putative 0.0018 0.0033 0.0022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0216 0.0216
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0302 0.0137
Loa Loa (eye worm) hypothetical protein 0.0058 0.0765 0.0765
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.2897 0.2897
Echinococcus granulosus adam 0.0019 0.0053 0.0156
Plasmodium falciparum glycine--tRNA ligase 0.0018 0.0047 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0159 0.0158
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0067 0.094 0.2786
Schistosoma mansoni endoplasmin 0.0061 0.0815 0.2414
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.035 0.0404
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0216 0.0216
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0578 0.1283
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0159 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2752 0.6314
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0127 0.2023 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0371 0.037
Schistosoma mansoni hypothetical protein 0.0028 0.0215 0.0638
Schistosoma mansoni hypothetical protein 0.01 0.1531 0.4536
Plasmodium vivax glycine--tRNA ligase, putative 0.0031 0.0269 0.0422
Onchocerca volvulus 0.0017 0.0023 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0215 0.0638
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2752 0.6314
Treponema pallidum heat shock protein 90 0.0061 0.083 0.2385
Loa Loa (eye worm) hypothetical protein 0.0058 0.0765 0.0765
Schistosoma mansoni threonyl-tRNA synthetase-related 0.0017 0.0023 0.0069
Leishmania major peptidylprolyl isomerase-like protein 0.0201 0.3375 0.3374
Brugia malayi Pre-SET motif family protein 0.0031 0.0275 0.0275
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0018 0.0047 0.0055
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.4346 0.4346
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Trypanosoma brucei heat shock protein, putative 0.0061 0.0815 0.0814
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0254 0.0753
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0798 0.0797
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.4346 1
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0019 0.0053 0.0156
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.4346 0.4346
Treponema pallidum prolyl-tRNA synthetase 0.0031 0.0269 0.0708
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0371 0.1699
Entamoeba histolytica hypothetical protein 0.0022 0.011 0.0258
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0034 0.01
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0342 0.0341
Mycobacterium leprae conserved hypothetical protein 0.0058 0.0765 0.3035
Brugia malayi beta-lactamase 0.0058 0.0765 0.0765
Leishmania major histidyl-tRNA synthetase, putative 0.0018 0.0047 0.0046
Brugia malayi Bromodomain containing protein 0.004 0.0434 0.0434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.035 0.1038
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0127 0.2023 0.4626
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0031 0.0269 0.0269
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0058 0.0765 0.0765
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0058 0.0765 0.2266
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0419 0.0916
Leishmania major heat shock protein 83-1 0.0061 0.0815 0.0814
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0201 0.3375 1
Trypanosoma cruzi heat shock protein, putative 0.0048 0.0593 0.0593
Chlamydia trachomatis threonine--tRNA ligase 0.0144 0.2333 1
Brugia malayi PHD-finger family protein 0.0026 0.0182 0.0182
Plasmodium falciparum proline--tRNA ligase 0.0031 0.0269 0.0422
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0906 0.0906
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0159 0.0271
Brugia malayi MH2 domain containing protein 0.007 0.0993 0.0993
Plasmodium vivax threonine--tRNA ligase, putative 0.0127 0.2023 0.3425
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0031 0.0269 0.0269
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0051 0.0636 0.1886
Leishmania major cathepsin L-like protease 0.006 0.0798 0.0797
Echinococcus multilocularis histidyl tRNA synthetase 0.0018 0.0047 0.0054
Schistosoma mansoni hypothetical protein 0.01 0.1531 0.4536
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0906 0.2684
Trypanosoma cruzi developmentally regulated GTP-binding protein, putative 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0058 0.0765 0.0765
Schistosoma mansoni histidyl-tRNA synthetase 0.0018 0.0047 0.0139
Trypanosoma brucei heat shock protein 84, putative 0.0048 0.0593 0.0593
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0031 0.0269 0.0735
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0596 0.1767
Echinococcus multilocularis endoplasmin 0.0061 0.083 0.0957
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0028 0.0216 0.0369
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0798 0.0797
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0031 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0289 0.4971 0.4971
Trypanosoma cruzi alanyl-tRNA synthetase, putative 0.0018 0.0033 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2752 0.6314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.035 0.1038
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0018 0.0047 0.0071
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0031 0.0269 0.0735
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2752 0.6314
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0269 0.0269
Plasmodium vivax heat shock protein 90, putative 0.0048 0.0593 0.0976
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0137 0.0407
Brugia malayi Pre-SET motif family protein 0.0215 0.3634 0.3634
Brugia malayi TAR-binding protein 0.0066 0.0906 0.0906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.0798 0.0797
Brugia malayi hypothetical protein 0.0022 0.011 0.011
Brugia malayi glycyl-tRNA synthetase 0.0031 0.0269 0.0269
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0031 0.0269 0.119
Mycobacterium tuberculosis Probable hydrolase 0.0058 0.0765 0.0882
Loa Loa (eye worm) hypothetical protein 0.004 0.0435 0.0435
Schistosoma mansoni alanyl-tRNA synthetase 0.0018 0.0033 0.0097
Trypanosoma cruzi tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative 0.0018 0.0033 0.0032
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0031 0.0285 0.0285
Trypanosoma brucei alanyl-tRNA synthetase, putative 0.0018 0.0033 0.0032
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0159 0.0232
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0342 0.0341
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0342 0.0737
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.4346 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0342 0.0737
Echinococcus granulosus Threonyl tRNA synthetase C 0.0144 0.2333 0.6914
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0201 0.3375 0.5741
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2752 0.6314
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.0342 0.0394
Brugia malayi alanyl-tRNA synthetase family protein 0.0018 0.0033 0.0033
Leishmania major C-8 sterol isomerase-like protein 0.0565 1 1
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0127 0.2023 0.5965
Schistosoma mansoni hypothetical protein 0.006 0.0799 0.2368
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0028 0.0216 0.0923
Schistosoma mansoni transcription factor LCR-F1 0.0022 0.011 0.0326
Giardia lamblia Glycyl-tRNA synthetase 0.0031 0.0269 0.0735
Echinococcus granulosus alanyl tRNA synthetase cytoplasmic 0.0018 0.0033 0.0097
Echinococcus multilocularis 0.0028 0.0216 0.025
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0035 0.0342 0.0341
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0022 0.011 0.0326
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0031 0.0269 0.046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0031 0.0285 0.0284

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -7.29 Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells ChEMBL. 18226909
Ki (binding) = -5.8 Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) 0 Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) 0 Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) = 5.8 Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) = 7.29 Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells ChEMBL. 18226909
Ratio (binding) = 30.9 Selectivity index, ratio for human adenosine A2A receptor to human adenosine A2B receptor ChEMBL. 18226909

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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