Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0096 | 0.1796 | 1 |
Plasmodium vivax | heat shock protein, putative | 0.0365 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0082 | 0.1371 | 0.7635 |
Giardia lamblia | Grp94/Hsp90 | 0.009 | 0.1616 | 0.5748 |
Brugia malayi | heat shock protein 90 | 0.0096 | 0.1796 | 0.615 |
Schistosoma mansoni | endoplasmin | 0.0096 | 0.1796 | 0.615 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.004 | 0.0087 | 0.0483 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Schistosoma mansoni | heat shock protein | 0.0096 | 0.1796 | 0.615 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0096 | 0.1796 | 0.1796 |
Plasmodium falciparum | heat shock protein 90 | 0.0096 | 0.1796 | 0.1305 |
Leishmania major | heat shock protein, putative | 0.0064 | 0.0809 | 0.4505 |
Plasmodium falciparum | endoplasmin, putative | 0.007 | 0.099 | 0.045 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0309 | 0.106 |
Trypanosoma brucei | heat shock protein 84, putative | 0.0064 | 0.0809 | 0.4505 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0309 | 0.106 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0309 | 0.106 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.009 | 0.1616 | 0.5 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0064 | 0.0809 | 0.0809 |
Plasmodium vivax | heat shock protein 86, putative | 0.0096 | 0.1796 | 0.1796 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0096 | 0.1796 | 0.615 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0309 | 0.106 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.2921 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2921 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2921 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.2921 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.2921 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0309 | 0.106 |
Schistosoma mansoni | heat shock protein | 0.0096 | 0.1796 | 0.615 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0309 | 0.106 |
Trichomonas vaginalis | heat shock protein, putative | 0.009 | 0.1616 | 0.8994 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0064 | 0.0809 | 0.277 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.2921 | 1 |
Trypanosoma cruzi | heat shock protein, putative | 0.0064 | 0.0809 | 0.4505 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0082 | 0.1371 | 0.7635 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.009 | 0.1616 | 0.262 |
Trichomonas vaginalis | heat shock protein, putative | 0.009 | 0.1616 | 0.8994 |
Plasmodium vivax | heat shock protein 90, putative | 0.0064 | 0.0809 | 0.0809 |
Mycobacterium ulcerans | heat shock protein 90 | 0.009 | 0.1616 | 1 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.0064 | 0.0809 | 0.277 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0096 | 0.1796 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.007 | 0.099 | 0.5511 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0309 | 0.106 |
Trypanosoma brucei | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0096 | 0.1796 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.007 | 0.099 | 0.5511 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2921 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0082 | 0.1371 | 0.4695 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0096 | 0.1796 | 1 |
Brugia malayi | Hsp90 protein | 0.0064 | 0.0809 | 0.277 |
Plasmodium vivax | endoplasmin, putative | 0.0096 | 0.1796 | 0.1796 |
Treponema pallidum | heat shock protein 90 | 0.009 | 0.1616 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Echinococcus multilocularis | endoplasmin | 0.009 | 0.1616 | 0.5531 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0096 | 0.1796 | 0.615 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0096 | 0.1796 | 1 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0096 | 0.1796 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0096 | 0.1796 | 0.615 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0096 | 0.1796 | 0.1796 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Echinococcus granulosus | heat shock protein | 0.0096 | 0.1796 | 0.615 |
Brugia malayi | TAR-binding protein | 0.0133 | 0.2921 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0096 | 0.1796 | 1 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0064 | 0.0809 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Echinococcus granulosus | endoplasmin | 0.009 | 0.1616 | 0.5531 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0096 | 0.1796 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0309 | 0.106 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.0064 | 0.0809 | 0.277 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0365 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0309 | 0.106 |
Trypanosoma brucei | heat shock protein, putative | 0.0096 | 0.1796 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2921 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0082 | 0.1371 | 0.7635 |
Leishmania major | heat shock protein 83-1 | 0.0096 | 0.1796 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0056 | 0.0565 | 0.3146 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0096 | 0.1796 | 1 |
Brugia malayi | Endoplasmin precursor | 0.0096 | 0.1796 | 0.615 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0096 | 0.1796 | 1 |
Echinococcus multilocularis | heat shock protein | 0.0096 | 0.1796 | 0.615 |
Echinococcus granulosus | heat shock protein 90 | 0.0082 | 0.1371 | 0.4695 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.024 | 0.6167 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0082 | 0.1371 | 0.4695 |
Echinococcus multilocularis | heat shock protein 90 | 0.0096 | 0.1796 | 0.615 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.2921 | 1 |
Schistosoma mansoni | heat shock protein | 0.0064 | 0.0809 | 0.277 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.2921 | 1 |
Schistosoma mansoni | endoplasmin | 0.0096 | 0.1796 | 0.615 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.009 | 0.1616 | 0.8994 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2921 | 1 |
Brugia malayi | RNA binding protein | 0.0133 | 0.2921 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.009 | 0.1616 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0096 | 0.1796 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pTD50 (functional) | = 1.457 | Anticarcinogenic activity in rat assessed as induction of tumors per day | ChEMBL. | 18295489 |
TD50 (functional) | = 28.63 umol/Kg | Anticarcinogenic activity in rat assessed as induction of tumors per day | ChEMBL. | 18295489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.