TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 332.358 | Formula: C13H8N4O3S2
H donors: 1 H acceptors: 4 LogP: 3.23 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1N/C(=N\c2nccs2)/S/C/1=C\c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C13H8N4O3S2/c18-11-10(7-8-1-3-9(4-2-8)17(19)20)22-13(15-11)16-12-14-5-6-21-12/h1-7H,(H,14,15,16,18)/b10-7-
InChiKey: MINTVBBMBYDMCN-YFHOEESVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	beta-lactamase family protein	0.0038	0.0957	0.0957
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0199	0.016
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0199	0.0199
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0957	0.0953
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0047	0.0135
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0047	0.0047
Brugia malayi	beta-lactamase	0.0038	0.0957	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0074	0.2503	0.2503
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0957	0.0953
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0199	0.5
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0957	0.4013
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0957	0.0957
Toxoplasma gondii	ABC1 family protein	0.0038	0.0957	0.4461
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0006	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0019	0.0149	0.0149
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0957	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0112	0.0112
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0199	0.1791
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0957	0.0957
Brugia malayi	photoreceptor-specific nuclear receptor	0.0019	0.0149	0.0149
Echinococcus multilocularis	ecdysone induced protein 78C	0.0019	0.0149	0.0149
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0957	0.0953
Onchocerca volvulus	Protein ultraspiracle homolog	0.0019	0.0149	0.0978
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0957	0.0957
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0149	0.0219
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0047	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0149
Schistosoma mansoni	survival motor neuron protein	0.0051	0.1524	0.2243
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.014	0.014
Onchocerca volvulus		0.0038	0.0957	0.6276
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0957	0.1408
Onchocerca volvulus		0.0019	0.0149	0.0978
Brugia malayi	Steroid receptor seven-up type 2	0.0019	0.0149	0.0149
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0112	0.0112
Brugia malayi	nuclear hormone receptor	0.0019	0.0149	0.0149
Schistosoma mansoni	hypothetical protein	0.0174	0.6796	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0019	0.0149	0.0219
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0199	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0957	0.0957
Brugia malayi	Uncoordinated protein 44	0.0015	0.000000037533	0.000000037533
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0149	0.0149
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0957	0.1408
Schistosoma mansoni	hypothetical protein	0.0022	0.0272	0.04
Brugia malayi	Protein kinase domain containing protein	0.0015	0.000000037533	0.000000037533
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.2087	0.2135
Schistosoma mansoni	ap endonuclease	0.002	0.0199	0.0293
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0019	0.0149	0.0149
Toxoplasma gondii	exonuclease III APE	0.002	0.0199	0.0749
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1168	0.1168
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0957	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0019	0.0149	0.0149
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0019	0.0149	0.0219
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0047	0.0135
Schistosoma mansoni	hypothetical protein	0.0051	0.1524	0.2243
Brugia malayi	PHD-finger family protein	0.0026	0.0463	0.0463
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0149	0.0149
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0019	0.0149	0.0149
Mycobacterium ulcerans	lipase LipD	0.0038	0.0957	0.4013
Brugia malayi	ecdysteroid receptor	0.0019	0.0149	0.0149
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0019	0.0149	0.0149
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0149	0.0149
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0149	0.0149
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0112	0.0165
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0149	0.0219
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0019	0.0149	0.0149
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0047	0.0047
Echinococcus granulosus	Ankyrin	0.0015	0.0006	0.0006
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0346	0.0346
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.2012	0.2012
Schistosoma mansoni	hypothetical protein	0.0174	0.6796	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0957	0.0957
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0112	0.0165
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0357	0.0525
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0199	0.1791
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0149	0.0149
Brugia malayi	steroid hormone receptor	0.0019	0.0149	0.0149
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0199	0.1791
Echinococcus granulosus	zinc finger protein	0.002	0.0225	0.0225
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.000000037533	0.000000055226
Loa Loa (eye worm)	hypothetical protein	0.004	0.1062	0.1062
Echinococcus granulosus	FTZ F1 alpha	0.0019	0.0149	0.0149
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0357	0.0357
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.000000037533	0.000000037533
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0957	1
Onchocerca volvulus		0.0051	0.1524	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0957	0.4013
Loa Loa (eye worm)	hypothetical protein	0.0249	1	1
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0078	0.2668	0.2668
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0199	0.5
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0199	0.0199
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0019	0.0149	0.0149
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0019	0.0149	0.0219
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0957	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0112	0.0165
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0957	0.0957
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0957	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0019	0.0149	0.0149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0019	0.0149	0.0149
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0149	0.0149
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0957	1
Brugia malayi	nuclear receptor NHR-88	0.0019	0.0149	0.0149
Brugia malayi	beta-lactamase family protein	0.0038	0.0957	0.0957
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0149	0.0219
Echinococcus multilocularis	FTZ F1 alpha	0.0019	0.0149	0.0149
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.2087	0.307
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0019	0.0149	0.0149
Brugia malayi	Death domain containing protein	0.0015	0.000000037533	0.000000037533
Echinococcus multilocularis	survival motor neuron protein 1	0.0249	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0149
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0149
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0957	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0199	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0229	0.9145	0.9145
Brugia malayi	Bromodomain containing protein	0.004	0.1059	0.1059
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0019	0.0149	0.0149
Echinococcus multilocularis	Ankyrin	0.0015	0.0006	0.0006
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0199	0.5
Leishmania major	hypothetical protein, conserved	0.0038	0.0957	0.4495
Onchocerca volvulus	Bile acid receptor homolog	0.0019	0.0149	0.0978
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0957	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0047	0.0047
Schistosoma mansoni	coup transcription factor	0.0019	0.0149	0.0219
Brugia malayi	Bromodomain containing protein	0.0078	0.2694	0.2694
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0112	0.0112
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0199	0.0805
Echinococcus multilocularis	zinc finger protein	0.002	0.0225	0.0225
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0019	0.0149	0.0149
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0019	0.0149	0.0219
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0019	0.0149	0.0978
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.2087	1
Trichomonas vaginalis	esterase, putative	0.0038	0.0957	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0357	0.0357
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0957	0.0957
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0957	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0149
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0957	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0957	0.0957
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0149	0.0149
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0019	0.0149	0.0219
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.2087	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.2087	0.2087
Echinococcus granulosus	survival motor neuron protein 1	0.0249	1	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0047	0.0135
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0149	0.0149
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0078	0.2668	0.2668
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.2087	0.307
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0047	0.0047
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0047	0.0047
Schistosoma mansoni	bromodomain containing protein	0.0066	0.2172	0.3196
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0019	0.0149	0.0219
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0149	0.0219
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0957	0.0953
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0019	0.0149	0.0149
Echinococcus multilocularis	geminin	0.0174	0.6796	0.6796
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0957	0.0953
Schistosoma mansoni	zinc finger protein	0.002	0.0225	0.0331
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0957	0.4013
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0112	0.0112
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0954	0.0954
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0019	0.0149	0.0149
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0272	0.0272
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.2087	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0954	0.0954
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.2087	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0019	0.0149	0.0149
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0957	0.0953
Schistosoma mansoni	ap endonuclease	0.002	0.0199	0.0293
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0149	0.0149
Echinococcus granulosus	geminin	0.0174	0.6796	0.6796
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0149
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.2087	0.2087
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0112	0.0165
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0019	0.0149	0.0149
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.1524	0.1524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0149
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0957	0.4013
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0047	0.0047
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0199	0.1679
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0199	0.0199
Schistosoma mansoni	hypothetical protein	0.0016	0.0034	0.005
Onchocerca volvulus		0.0038	0.0957	0.6276
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0047	0.0135
Onchocerca volvulus		0.0038	0.0957	0.6276
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0047	0.0047
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0047	0.0047
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0149	0.0149
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0019	0.0149	0.0219
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0112	0.0112
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0957	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0957	0.0957
Schistosoma mansoni	RAR-like nuclear receptor	0.0019	0.0149	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0957	0.0957
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0019	0.0149	0.0149
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0047	0.0047
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0346	0.0346
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0047	0.0061
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0019	0.0149	0.0149
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0957	0.0953
Brugia malayi	follicle stimulating hormone receptor	0.0229	0.9145	0.9145
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1253	0.1253
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0019	0.0149	0.0149
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.000000037533	0.000000037533
Schistosoma mansoni	zinc finger protein	0.0016	0.0034	0.005
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0019	0.0149	0.0149
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0957	0.5
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.9601	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.2012	0.2012
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0957	0.0953
Loa Loa (eye worm)	steroid hormone receptor	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0957	0.0957
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0149
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0199	0.0199
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0957	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.2087	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 upto 100 ug/ml by broth dilution technique	ChEMBL.	18299196
Activity (functional)		Antimicrobial activity against Escherichia coli SPA27 upto 100 ug/ml by broth dilution technique	ChEMBL.	18299196
Activity (functional)	0	Antimicrobial activity against Escherichia coli SPA27 upto 100 ug/ml by broth dilution technique	ChEMBL.	18299196
Activity (functional)	0	Antimicrobial activity against Candida tropicalis ATCC 1369 upto 100 ug/ml by broth dilution technique	ChEMBL.	18299196
Activity (functional)	0	Antimicrobial activity against Aspergillus niger ATCC 6275 upto 100 ug/ml by broth dilution technique	ChEMBL.	18299196
Activity (functional)	0	Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 upto 100 ug/ml by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 0.3 ug ml-1	Antimicrobial activity against Haemophilus influenzae by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 0.7 ug ml-1	Antimicrobial activity against Bacillus megaterium by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 1.5 ug ml-1	Antimicrobial activity against Bacillus subtilis ATCC 6633 by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 1.5 ug ml-1	Antimicrobial activity against penicillin-resistant Staphylococcus aureus by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 1.5 ug ml-1	Antimicrobial activity against Streptococcus agalactiae by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 1.5 ug ml-1	Antimicrobial activity against Bacillus thuringiensis var. kurstaki BGSC 4D1 by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 3 ug ml-1	Antimicrobial activity against Sarcina lutea by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 3 ug ml-1	Antimicrobial activity against Staphylococcus aureus ATCC 25923 by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 6 ug ml-1	Antimicrobial activity against penicillin-resistant Staphylococcus epidermidis ATCC 12228 by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 6 ug ml-1	Antimicrobial activity against penicillin-resistant Staphylococcus epidermidis by broth dilution technique	ChEMBL.	18299196
MIC (functional)	= 6 ug ml-1	Antimicrobial activity against Staphylococcus haemolyticus by broth dilution technique	ChEMBL.	18299196
MIC (functional)	> 100 ug ml-1	Antimicrobial activity against Streptococcus faecalis by broth dilution technique	ChEMBL.	18299196
MIC (functional)	> 100 ug ml-1	Antimicrobial activity against Streptococcus faecium by broth dilution technique	ChEMBL.	18299196
MIC (functional)	> 100 ug ml-1	Antimicrobial activity against Streptococcus pyogenes by broth dilution technique	ChEMBL.	18299196

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL260884

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 514264