Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.1561 | 0.1561 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0095 | 1 | 1 | |
Echinococcus granulosus | peroxidasin | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0095 | 1 | 1 | |
Onchocerca volvulus | 0.0095 | 1 | 1 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0095 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.1561 | 0.1561 |
Echinococcus multilocularis | peroxidasin | 0.0095 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0095 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.4648 | 0.3658 |
Schistosoma mansoni | peroxidasin | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0095 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0095 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.15 | 0.15 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1561 | 0.1561 |
Onchocerca volvulus | Peroxidase homolog | 0.0095 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 3 % | Nitric oxide release in PBS at pH 7.4 in 37 degC after 1.5 hrs | ChEMBL. | 18096394 |
Activity (functional) | = 8.5 % | Nitric oxide release in PBS in presence of 5 mM L-cysteine at pH 7.4 in 37 degC after 1.5 hrs | ChEMBL. | 18096394 |
IC50 (binding) | = 0.18 uM | Inhibition of ovine COX2 by enzyme immunoassay | ChEMBL. | 18096394 |
IC50 (binding) | = 0.18 uM | Inhibition of ovine COX2 by enzyme immunoassay | ChEMBL. | 18096394 |
IC50 (binding) | = 6.2 uM | Inhibition of ovine COX1 by enzyme immunoassay | ChEMBL. | 18096394 |
IC50 (binding) | = 6.2 uM | Inhibition of ovine COX1 by enzyme immunoassay | ChEMBL. | 18096394 |
Ratio IC50 (binding) | = 34.4 | Selectivity index, ratio of IC50 for ovine COX1 to IC50 for ovine COX2 | ChEMBL. | 18096394 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.