Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | adenosine deaminase-related growth factor | Adenosine deaminase | 363 aa | 299 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1068 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0104 | 1 | 1 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0034 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | AMP deaminase | 0.0034 | 0.1068 | 0.1068 |
Plasmodium falciparum | plasmepsin VI | 0.0071 | 0.5855 | 0.5855 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1068 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0071 | 0.5855 | 0.5855 |
Plasmodium vivax | adenosine deaminase, putative | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0071 | 0.5855 | 0.5855 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0034 | 0.1068 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0071 | 0.5855 | 0.536 |
Leishmania major | adenine aminohydrolase | 0.0104 | 1 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0071 | 0.5855 | 0.5855 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1068 | 0.1068 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0034 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.5855 | 0.5855 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0034 | 0.1068 | 0.1068 |
Plasmodium falciparum | plasmepsin I | 0.0071 | 0.5855 | 0.5855 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0104 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1068 | 1 |
Toxoplasma gondii | AMP deaminase | 0.0034 | 0.1068 | 0.1068 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 1 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0071 | 0.5855 | 0.5855 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0071 | 0.5855 | 0.5855 |
Brugia malayi | adenosine monophosphate deaminase | 0.0034 | 0.1068 | 0.1068 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.1068 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1068 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0071 | 0.5855 | 0.536 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0071 | 0.5855 | 0.536 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0071 | 0.5855 | 0.536 |
Schistosoma mansoni | adenosine deaminase | 0.0104 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5685 | 0.5685 |
Plasmodium falciparum | plasmepsin II | 0.0071 | 0.5855 | 0.5855 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.1068 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 1 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0071 | 0.5855 | 0.5855 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0034 | 0.1068 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0104 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0034 | 0.1068 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0034 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5685 | 0.5685 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0104 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0104 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5685 | 0.5685 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0034 | 0.1068 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0104 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative | 0.0034 | 0.1068 | 0.1068 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5685 | 0.5685 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1068 | 1 |
Plasmodium falciparum | AMP deaminase, putative | 0.0034 | 0.1068 | 0.1068 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0071 | 0.5855 | 0.536 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.1068 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.16 uM | Inhibitory activity against calf intestinal Adenosine deaminase (ADA) | ChEMBL. | 10780907 |
Ki (binding) | = 0.16 uM | Inhibitory activity against calf intestinal Adenosine deaminase (ADA) | ChEMBL. | 10780907 |
Ki (binding) | = 24.3 uM | Inhibitory activity against porcine heart Adenylate deaminase (AMPDA) | ChEMBL. | 10780907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.