Detailed information for compound 514422

Basic information

Technical information
  • TDR Targets ID: 514422
  • Name: 1-benzylpyrrole
  • MW: 157.212 | Formula: C11H11N
  • H donors: 0 H acceptors: 0 LogP: 2.26 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)Cn1cccc1
  • InChi: 1S/C11H11N/c1-2-6-11(7-3-1)10-12-8-4-5-9-12/h1-9H,10H2
  • InChiKey: FNEQHKCQXDKYEO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(phenylmethyl)pyrrole
  • 1-(benzyl)pyrrole
  • 2051-97-0
  • 1H-Pyrrole, 1-(phenylmethyl)-
  • N-Benzylpyrrole
  • NSC4024
  • Pyrrole, 1-benzyl-
  • 566322_ALDRICH
  • 1-benzyl-1H-pyrrole
  • Pyrrole, 1-benzyl- (8CI)
  • NSC 4024
  • NSC116806
  • InChI=1/C11H11N/c1-2-6-11(7-3-1)10-12-8-4-5-9-12/h1-9H,10H
  • EINECS 218-137-1
  • NSC 116806

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0051 0.0007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0319 0.0424
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.009 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0051 0.0015
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0319 0.1056
Brugia malayi G-protein coupled receptor 0.0033 0.0319 0.1056
Schistosoma mansoni phosphoglucomutase 0.0068 0.098 0.094
Mycobacterium tuberculosis Hypothetical protein 0.0074 0.11 0.4065
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0094 0.0077
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0051 0.0007
Brugia malayi ORL1-like opioid receptor 0.0033 0.0319 0.1056
Trypanosoma brucei rac serine-threonine kinase, putative 0.0032 0.0309 0.0266
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis serotonin receptor 0.0033 0.0319 0.0424
Brugia malayi RNase H family protein 0.0068 0.098 0.3603
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0024 0.0162 0.0262
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0319 0.1056
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0319 0.0276
Entamoeba histolytica protein kinase, putative 0.0031 0.0293 0.0648
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0319 0.0424
Brugia malayi Melatonin receptor type 1A 0.0033 0.0319 0.1056
Brugia malayi G-protein coupled receptor 0.0033 0.0319 0.1056
Brugia malayi PXA domain containing protein 0.0019 0.0051 0.0025
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0051 0.001
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0024 0.0162 0.0118
Plasmodium vivax DNA polymerase alpha, putative 0.0045 0.0557 0.1972
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Brugia malayi hypothetical protein 0.0019 0.0051 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0319 0.1056
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0319 0.0424
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0319 0.0424
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0309 0.0592
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0319 0.0424
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0094 0.0077
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0051 0.001
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.009 0.0071
Schistosoma mansoni neuropeptide receptor 0.0033 0.0319 0.0276
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0156 0.2642 0.5
Echinococcus granulosus g protein coupled receptor 0.0033 0.0319 0.0424
Echinococcus multilocularis ribonuclease H1 0.0068 0.098 0.1447
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0051 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0319 0.0424
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0319 0.0276
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.0319 0.0424
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0319 0.1056
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0051 0.0007
Brugia malayi RNase H family protein 0.0068 0.098 0.3603
Echinococcus granulosus hypothetical protein 0.0033 0.0319 0.0424
Brugia malayi G protein-coupled receptor 0.0033 0.0319 0.1056
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0051 0.001
Entamoeba histolytica protein kinase 2, putative 0.0021 0.0094 0.0209
Entamoeba histolytica protein kinase, putative 0.0032 0.0309 0.0685
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0319 0.0276
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0319 0.0424
Giardia lamblia Ribonuclease H 0.0068 0.098 0.2093
Trypanosoma brucei thymidine kinase 0.0256 0.4517 0.4493
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0319 0.0424
Giardia lamblia Thymidine kinase 0.0256 0.4517 1
Onchocerca volvulus 0.0156 0.2642 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0056 0.0756 0.11
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0319 0.0276
Schistosoma mansoni adenoreceptor 0.0033 0.0319 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus fmrfamide receptor 0.0033 0.0319 0.0424
Echinococcus multilocularis nervana 2 0.0021 0.009 0.0071
Trypanosoma brucei unspecified product 0.008 0.1214 0.1175
Schistosoma mansoni amine GPCR 0.0033 0.0319 0.0276
Brugia malayi Serotonin receptor 0.0033 0.0319 0.1056
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0051 0.001
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0051 0.001
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0111 0.0149
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0319 0.0424
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0319 0.1056
Echinococcus multilocularis thymidylate synthase 0.0156 0.2642 0.4016
Brugia malayi AKH receptor 0.0033 0.0319 0.1056
Trypanosoma cruzi ribonuclease H1, putative 0.0068 0.098 0.2093
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0055 0.0017
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.0319 0.0424
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0051 0.001
Brugia malayi Protein kinase domain containing protein 0.0032 0.0309 0.102
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0051 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0319 0.0424
Schistosoma mansoni neuropeptide receptor 0.0033 0.0319 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0056 0.0756 0.11
Trypanosoma brucei ribonuclease H1 0.0068 0.098 0.094
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0319 0.1056
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0319 0.0424
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0137 0.0093
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0051 0.0025
Echinococcus granulosus allatostatin A receptor 0.0033 0.0319 0.0424
Schistosoma mansoni amine GPCR 0.0033 0.0319 0.0276
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0319 0.1056
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0051 0.0025
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0319 0.0424
Echinococcus granulosus neuropeptide s receptor 0.0033 0.0319 0.0424
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis somatostatin receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0293 0.0956
Schistosoma mansoni biogenic amine receptor 0.0033 0.0319 0.0276
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0111 0.0246
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus nervana 2 0.0021 0.009 0.0071
Trichomonas vaginalis thymidine kinase, putative 0.0256 0.4517 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0319 0.0424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Echinococcus granulosus sex peptide receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0319 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0309 0.0592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0051 0.0007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0319 0.1056
Brugia malayi Dopamine receptor protein 2 0.0033 0.0319 0.1056
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0055 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0055 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0319 0.0424
Toxoplasma gondii ribonuclease HI protein 0.0068 0.098 0.3603
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0319 0.0424
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0319 0.0424
Trichomonas vaginalis ribonuclease H1, putative 0.0068 0.098 0.2093
Trypanosoma cruzi thymidine kinase, putative 0.0256 0.4517 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0319 0.0276
Entamoeba histolytica hypothetical protein 0.0019 0.0051 0.0113
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.2642 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0319 0.0276
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0319 0.0424
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0319 0.1056
Schistosoma mansoni opsin-like receptor 0.0033 0.0319 0.0276
Brugia malayi thymidylate synthase 0.0156 0.2642 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0051 0.0015
Trypanosoma cruzi Protein kinase B 0.0022 0.0111 0.0149
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.11 0.2361
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0156 0.2642 0.261
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0025
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0319 0.1056
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0055 0.0011
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0051 0.0025
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.009 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0309 0.0592
Schistosoma mansoni hypothetical protein 0.0033 0.0319 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0051 0.0015
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.009 0.0071
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni histamine h1 receptor 0.0033 0.0319 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0319 0.0424
Entamoeba histolytica hypothetical protein 0.0019 0.0051 0.0113
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0319 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0319 0.0424
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0055 0.0042
Entamoeba histolytica hypothetical protein 0.0019 0.0051 0.0113
Schistosoma mansoni phosphoglucomutase 0.0068 0.098 0.094
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0319 0.0424
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0051 0.001
Entamoeba histolytica protein kinase, putative 0.0032 0.0309 0.0685
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0051 0.0007
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.2642 0.261
Brugia malayi Dopamine receptor 0.0033 0.0319 0.1056
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0051 0.0007
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0051 0.0025
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0051 0.0007
Schistosoma mansoni biogenic amine receptor 0.0033 0.0319 0.0276
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0319 0.0424
Echinococcus granulosus expressed protein 0.0362 0.6513 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0056 0.0756 0.0715
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Brugia malayi neuropeptide F receptor 0.0033 0.0319 0.1056
Schistosoma mansoni amine GPCR 0.0033 0.0319 0.0276
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0319 0.0424
Schistosoma mansoni biogenic amine receptor 0.0033 0.0319 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0319 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0309 0.0592
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Trichomonas vaginalis DNA polymerase II, putative 0.0024 0.0162 0.0262
Echinococcus granulosus thymidylate synthase 0.0156 0.2642 0.4016
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0051 0.001
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0051 0.0007
Schistosoma mansoni hypothetical protein 0.0033 0.0319 0.0276
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Trypanosoma brucei RNA helicase, putative 0.0547 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0111 0.0246
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0319 0.0424
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0319 0.1056
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.2642 1
Echinococcus multilocularis sex peptide receptor 0.0033 0.0319 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0051 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0025
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0319 0.1056
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.008 0.1214 0.1175
Echinococcus granulosus g protein coupled receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0021 0.0094 0.0357
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0319 0.0424
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0319 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0309 0.0592
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0319 0.0424
Schistosoma mansoni neuropeptide receptor 0.0033 0.0319 0.0276
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0319 0.0424
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0025
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0051 0.001
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.0319 0.0424
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0319 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0051 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0319 0.0424
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0156 0.2642 0.5808
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0319 0.0424
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0319 0.0424
Schistosoma mansoni amine GPCR 0.0033 0.0319 0.0276
Brugia malayi putative neuropeptide receptor 0.0033 0.0319 0.1056
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0309 0.0592
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0077 0.1151 0.3582
Echinococcus granulosus somatostatin receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0051 0.0025
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0319 0.1056
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0319 0.0424
Schistosoma mansoni hypothetical protein 0.0033 0.0319 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0319 0.0276
Echinococcus multilocularis expressed protein 0.0362 0.6513 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0111 0.0103
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0051 0.001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0025
Echinococcus granulosus nervana 2 0.0021 0.009 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.0319 0.0424
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0021 0.0094 0.0192
Brugia malayi GnHR receptor homolog 0.0033 0.0319 0.1056
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0044 0.0168
Brugia malayi follicle stimulating hormone receptor 0.0033 0.0319 0.1056
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0077 0.1151 0.426
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0074 0.11 0.2361
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Trypanosoma brucei ingi protein (ORF1) 0.008 0.1214 0.1175
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0309 0.0592
Echinococcus multilocularis nervana 2 0.0021 0.009 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0319 0.0424
Schistosoma mansoni opsin-like receptor 0.0033 0.0319 0.0276
Brugia malayi DNA polymerase alpha catalytic subunit 0.0045 0.0557 0.1972
Echinococcus granulosus neuropeptide receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0319 0.0424
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0162 0.0262
Echinococcus granulosus neuropeptide receptor 0.0033 0.0319 0.0424
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0319 0.0424
Echinococcus granulosus serotonin receptor 0.0033 0.0319 0.0424
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0319 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Entamoeba histolytica thymidine kinase, putative 0.0256 0.4517 1
Trypanosoma brucei hypothetical protein, conserved 0.008 0.1214 0.1175
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0319 0.1056
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0055 0.0042
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) thymidylate synthase 0.0156 0.2642 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0319 0.0276
Trypanosoma cruzi ribonuclease H1, putative 0.0068 0.098 0.2093
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Brugia malayi Serotonin receptor 0.0033 0.0319 0.1056
Trypanosoma cruzi thymidine kinase, putative 0.0256 0.4517 1
Brugia malayi neuropeptide F receptor 0.0033 0.0319 0.1056
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0051 0.0025
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0293 0.0956
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0319 0.0276
Toxoplasma gondii AGC kinase 0.0031 0.0293 0.0956
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0156 0.2642 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0051 0.0015
Brugia malayi RE15519p 0.0033 0.0319 0.1056
Brugia malayi hypothetical protein 0.0074 0.11 0.4065
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0319 0.0424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0051 0.001
Brugia malayi larval opioid receptor 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus ribonuclease H1 0.0068 0.098 0.1447
Brugia malayi hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0319 0.0276
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0319 0.0424
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0319 0.0424
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0111 0.0067
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0319 0.1056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0051 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0045 0.0557 0.1972
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0111 0.0103
Schistosoma mansoni hypothetical protein 0.0033 0.0319 0.0276
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0319 0.0424
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0051 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0162 0.0262
Leishmania major ribonuclease H1, putative 0.0068 0.098 0.2093
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0319 0.0424
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0051 0.001
Trypanosoma brucei ingi protein (ORF1) 0.008 0.1214 0.1175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0051 0.0007
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0111 0.0067
Schistosoma mansoni amine GPCR 0.0033 0.0319 0.0276
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0319 0.0424
Treponema pallidum ribonuclease H (rnhA) 0.0068 0.098 1
Brugia malayi PXA domain containing protein 0.0019 0.0051 0.0025
Echinococcus granulosus g protein coupled receptor 0.0033 0.0319 0.0424
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0319 0.0424
Schistosoma mansoni opsin-like receptor 0.0033 0.0319 0.0276
Brugia malayi hypothetical protein 0.0019 0.0051 0.0025
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0309 0.102
Brugia malayi sulfakinin receptor protein 0.0033 0.0319 0.1056
Trichomonas vaginalis thymidine kinase, putative 0.0256 0.4517 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0319 0.0424
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0044 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0055 0.0042
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0319 0.0424
Giardia lamblia Kinase, AGC PKA 0.0021 0.0094 0.0112
Echinococcus multilocularis serotonin receptor 0.0033 0.0319 0.0424
Leishmania major thymidine kinase, putative 0.0256 0.4517 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Schistosoma mansoni neuropeptide receptor 0.0033 0.0319 0.0276
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0319 0.0276
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0051 0.0015
Giardia lamblia DNA polymerase alpha subunit A 0.0047 0.0594 0.1229
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0051 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0319 0.0424
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0156 0.2642 0.5808
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0094 0.0077
Schistosoma mansoni myosin xvIII 0.0033 0.0319 0.0276
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0319 0.0424
Schistosoma mansoni phosphoglucomutase 0.0068 0.098 0.094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.0096 0.0052
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0055 0.0017
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0068 0.098 1
Brugia malayi Dopamine receptor protein 1 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0319 0.0424
Mycobacterium ulcerans thymidylate synthase 0.0156 0.2642 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0319 0.0276
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0319 0.1056
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0051 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0051 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0319 0.0424
Echinococcus granulosus orexin receptor type 2 0.0033 0.0319 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0051 0.0015
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0319 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.1056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0025
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0051 0.001
Trichomonas vaginalis thymidine kinase, putative 0.0256 0.4517 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0156 0.2642 1
Onchocerca volvulus Ribonuclease H1 homolog 0.0068 0.098 0.2847
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0319 0.0276
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0319 0.0424
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0319 0.1056
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0319 0.0424
Brugia malayi RNase H family protein 0.0068 0.098 0.3603
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0319 0.0276
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0021 0.0094 0.0112

Activities

Activity type Activity value Assay description Source Reference
Log EC50 (binding) = 3.89 Inhibition of HIV1 gp41 ChEMBL. 18226912

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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