Detailed information for compound 514452

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 509.654 | Formula: C34H36FNO2
  • H donors: 0 H acceptors: 3 LogP: 5.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1CCC2=C3[C@H](C[C@]4([C@H]([C@@H]3CCC2=C1)C[C@H]([C@@H]4C(=O)C1CC1)C)C)c1ccc(cc1)c1ccc(nc1)F
  • InChi: 1S/C34H36FNO2/c1-19-15-29-27-12-9-23-16-25(37)11-13-26(23)31(27)28(17-34(29,2)32(19)33(38)22-7-8-22)21-5-3-20(4-6-21)24-10-14-30(35)36-18-24/h3-6,10,14,16,18-19,22,27-29,32H,7-9,11-13,15,17H2,1-2H3/t19-,27+,28-,29+,32-,34+/m1/s1
  • InChiKey: WIAJUDCSRLGLND-YYYGECPPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens progesterone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cytochrome c oxidase subunit I 0.0031 0.0055 0.046
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.001 0.0079
Schistosoma mansoni coup transcription factor 0.0019 0.001 0.0079
Mycobacterium tuberculosis Conserved protein 0.0043 0.0099 0.0099
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.003 0.0027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0154 0.1281
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0044 0.0364
Schistosoma mansoni intermediate filament proteins 0.0028 0.0044 0.0364
Mycobacterium tuberculosis Conserved protein 0.0043 0.0099 0.0099
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0024 0.003 0.071
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.265 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0024
Onchocerca volvulus 0.0043 0.0099 0.1141
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.001 0.011
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0083 0.0688
Schistosoma mansoni cytochrome oxidase subunit 0.0076 0.0225 0.1868
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0039 0.0084 0.1997
Brugia malayi cytochrome c oxidase subunit I 0.0031 0.0055 0.046
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0104 0.0579
Brugia malayi Pre-SET motif family protein 0.0216 0.0758 0.6291
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0099 0.0764
Giardia lamblia Cysteinyl-tRNA synthetase 0.0039 0.0084 0.3415
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0025 0.0613
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0104 0.0796
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0003 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.001 0.0028
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0095 0.0727
Mycobacterium ulcerans monoamine oxidase 0.0095 0.0299 0.0296
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.001 0.0079
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.001 0.0079
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0022
Brugia malayi exodeoxyribonuclease III family protein 0.0081 0.0247 0.2049
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0083 0.0688
Onchocerca volvulus 0.0038 0.0083 0.0952
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.001 0.0079
Plasmodium vivax cysteine--tRNA ligase, putative 0.0039 0.0084 0.0648
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.003 0.0249
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.007 0.0583
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0024 0.003 0.003
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0024 0.003 0.0027
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.016 0.1327
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0104 0.0711
Echinococcus granulosus peroxidasin 0.0038 0.0083 0.0569
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0207
Loa Loa (eye worm) dihydrofolate reductase 0.0334 0.1205 1
Onchocerca volvulus 0.0023 0.0025 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.001 0.0079
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0024 0.003 0.0027
Echinococcus multilocularis lamin dm0 0.0028 0.0044 0.0127
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.001 0.0079
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0407 1
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.0495
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0022 0.0522
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0024 0.003 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0099 0.2355
Onchocerca volvulus Peroxidase homolog 0.0038 0.0083 0.0952
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.007 0.0204
Mycobacterium ulcerans glutaminase 0.0284 0.1015 0.1013
Loa Loa (eye worm) cytochrome c oxidase subunit III 0.0027 0.004 0.0332
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0154 0.0449
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0104 0.0301
Brugia malayi jmjC domain containing protein 0.0057 0.0154 0.1281
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0024 0.003 0.0005
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0095 0.0299 0.2482
Mycobacterium tuberculosis Probable cytochrome C oxidase (subunit III) CtaE 0.0069 0.0201 0.0201
Plasmodium falciparum cysteine--tRNA ligase 0.0039 0.0084 0.0648
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0142 0.1176
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0039 0.0084 0.0245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Schistosoma mansoni cytochrome c oxidase subunit III 0.0027 0.004 0.0332
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0081 0.0247 0.6061
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0082 0.0627
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0055 0.016
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.0706 0.485
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0039 0.0084 0.07
Schistosoma mansoni hypothetical protein 0.0165 0.0562 0.4666
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.0591
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0081 0.0247 0.5848
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0022 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0099 0.2355
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0334 0.1205 0.1205
Trichomonas vaginalis esterase, putative 0.0043 0.0099 0.0764
Echinococcus granulosus tumor protein p63 0.04 0.1457 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Loa Loa (eye worm) blistered cuticle protein 3 0.0038 0.0083 0.0688
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0099 0.0764
Loa Loa (eye worm) glutaminase 0.0284 0.1015 0.8425
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.0407 0.9648
Brugia malayi amine oxidase, flavin-containing family protein 0.0095 0.0299 0.2482
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0142 0.0973
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0117 0.1341
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0024 0.003 0.0027
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.0706 0.2053
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.001 0.011
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0472 0.1371
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.0825
Brugia malayi dihydrofolate reductase family protein 0.0334 0.1205 1
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0407 0.3128
Onchocerca volvulus 0.0076 0.0225 0.2583
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0207
Onchocerca volvulus 0.0043 0.0099 0.1141
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0364
Schistosoma mansoni thyroid hormone receptor 0.0019 0.001 0.0079
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0024 0.003 0.0087
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0081 0.0247 0.0244
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0032 0.006 0.0058
Brugia malayi Peroxidasin 0.0038 0.0083 0.0688
Brugia malayi Cytochrome P450 family protein 0.0022 0.0022 0.0183
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0024
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0154 0.106
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.0495
Schistosoma mansoni inositol monophosphatase 0.0044 0.0104 0.086
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0154 0.106
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0024
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.0407 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.001 0.0079
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0142 0.0412
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0099 0.0099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0055 0.016
Loa Loa (eye worm) hypothetical protein 0.0059 0.016 0.1327
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0025 0.0613
Onchocerca volvulus Dual oxidase homolog 0.0038 0.0083 0.0952
Leishmania major oxidoreductase-like protein 0.0032 0.006 0.1431
Schistosoma mansoni cytochrome oxidase subunit 0.0076 0.0225 0.1868
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.001 0.0079
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0095 0.0299 0.2297
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0083 0.0688
Plasmodium vivax cytochrome c oxidase subunit 3 0.0069 0.0201 0.1547
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0064 0.1583
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.001 0.0066
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0104 0.0796
Mycobacterium tuberculosis Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1) 0.0076 0.0225 0.0225
Brugia malayi Pre-SET motif family protein 0.0031 0.0055 0.0458
Onchocerca volvulus 0.0043 0.0099 0.1141
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0064 0.0495
Loa Loa (eye worm) acetyltransferase 0.0141 0.0472 0.3916
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0064 0.2611
Brugia malayi SWIRM domain containing protein 0.0095 0.0299 0.2482
Brugia malayi hypothetical protein 0.0035 0.007 0.0583
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0079
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0081 0.0247 0.0717
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0095 0.0299 0.2297
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0064 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.001 0.0079
Plasmodium falciparum enoyl-acyl carrier reductase 0.0359 0.1302 1
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0039 0.0084 0.0648
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0407 0.9648
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0064 0.0495
Mycobacterium ulcerans hypothetical protein 0.0023 0.0025 0.0022
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0064 0.0495
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0099 0.0764
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0246 0.0871 0.6693
Brugia malayi Dihydrofolate reductase 0.0334 0.1205 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0082 0.2004
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0024 0.003 0.0249
Leishmania major cytochrome p450-like protein 0.0022 0.0022 0.0522
Loa Loa (eye worm) hypothetical protein 0.0047 0.0117 0.097
Plasmodium vivax cytochrome c oxidase subunit I 0.0076 0.0225 0.1729
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0117 0.0802
Trypanosoma cruzi UDP-galactopyranose mutase 0.0095 0.0299 0.7083
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0079
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0117 0.0802
Brugia malayi beta-lactamase family protein 0.0043 0.0099 0.0825
Onchocerca volvulus 0.0047 0.0117 0.1341
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0003 0.0022
Onchocerca volvulus 0.0024 0.003 0.0344
Mycobacterium ulcerans iron-dependent repressor and activator IdeR 0.1805 0.679 0.6789
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.001 0.0079
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0022 0.0183
Schistosoma mansoni dihydropteridine reductase 0.0024 0.003 0.0249
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1352 0.507 0.5068
Loa Loa (eye worm) hypothetical protein 0.0095 0.0299 0.2482
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0024 0.003 0.0249
Echinococcus granulosus Cytochrome c oxidase subunit III 0.0069 0.0201 0.1383
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.001 0.0028
Leishmania major pteridine reductase 1 0.0032 0.006 0.1431
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0359 0.1302 0.1302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.001 0.0079
Onchocerca volvulus Chorion peroxidase homolog 0.0038 0.0083 0.0952
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0064 0.0135
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0128 0.0422 0.3242
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Echinococcus granulosus geminin 0.0165 0.0562 0.386
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.003 0.0027
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0359 0.1302 0.128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0025 0.0025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0099 0.0099
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 1 0.0076 0.0225 0.1534
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0407 0.3128
Mycobacterium leprae IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER 0.1805 0.679 0.6782
Trypanosoma brucei pteridine reductase 1 0.0024 0.003 0.071
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0081 0.0247 1
Schistosoma mansoni peroxidasin 0.0038 0.0083 0.0688
Echinococcus granulosus dihydrofolate reductase 0.0334 0.1205 0.8272
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0095 0.0727
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.001 0.0066
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0359 0.1302 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0079
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0614 0.2267 0.2267
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0407 0.3128
Onchocerca volvulus Peroxidasin homolog 0.0038 0.0083 0.0952
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0024 0.003 0.023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.003 0.0249
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Schistosoma mansoni glutaminase 0.0284 0.1015 0.8425
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0025 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0022 0.0522
Brugia malayi hypothetical protein 0.0038 0.0083 0.0688
Mycobacterium leprae PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE 0.0069 0.0201 0.0177
Schistosoma mansoni amine oxidase 0.0095 0.0299 0.2482
Mycobacterium tuberculosis Possible oxidoreductase 0.0024 0.003 0.003
Mycobacterium tuberculosis Possible oxidoreductase 0.0095 0.0299 0.0299
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0142 0.0412
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.001 0.0079
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0614 0.2267 0.2265
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0064 0.0495
Schistosoma mansoni nuclear hormone receptor 0.0019 0.001 0.0079
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0022 0.0183
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Brugia malayi cytochrome c oxidase subunit III 0.0027 0.004 0.0332
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0247 0.1896
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0249
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1352 0.507 0.5068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0099 0.0825
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Loa Loa (eye worm) phosphofructokinase 0.0124 0.0407 0.338
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.001 0.0079
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0025 0.0022
Onchocerca volvulus Peroxidase homolog 0.0038 0.0083 0.0952
Onchocerca volvulus 0.0038 0.0083 0.0952
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.006 0.0499
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0079
Mycobacterium ulcerans cytochrome C oxidase (subunit III) CtaE 0.0069 0.0201 0.0199
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0017 0.0004 0.0084
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.001 0.0066
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0039 0.0084 0.0648
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0022
Brugia malayi mbt repeat family protein 0.0047 0.0117 0.097
Echinococcus granulosus lamin dm0 0.0028 0.0044 0.0301
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0117 0.097
Chlamydia trachomatis metal ABC transporter permease 0.0369 0.1338 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.003 0.003
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0024 0.003 0.0206
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0024 0.003 0.0027
Trichomonas vaginalis hypothetical protein 0.0359 0.1302 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0407 0.338
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0334 0.1205 0.1183
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0099 0.0825
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0099 0.0075
Mycobacterium tuberculosis Conserved protein 0.0043 0.0099 0.0099
Treponema pallidum exodeoxyribonuclease (exoA) 0.0081 0.0247 0.0516
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0083 0.0688
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0128 0.0422 1
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0024 0.003 0.003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0104 0.2455
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.003 0.003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.001 0.0066
Onchocerca volvulus 0.0095 0.0299 0.3432
Loa Loa (eye worm) hypothetical protein 0.0095 0.0299 0.2482
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.001 0.0028
Entamoeba histolytica hypothetical protein 0.0035 0.007 0.1724
Echinococcus granulosus intermediate filament protein 0.0028 0.0044 0.0301
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.001 0.0028
Onchocerca volvulus 0.0032 0.006 0.0693
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0104 0.0796
Entamoeba histolytica hypothetical protein 0.0035 0.007 0.1724
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.001 0.0079
Brugia malayi mbt repeat family protein 0.0047 0.0117 0.097
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0923 0.3441 1
Schistosoma mansoni amine oxidase 0.0095 0.0299 0.2482
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.001 0.0028
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Chlamydia trachomatis cysteine--tRNA ligase 0.0039 0.0084 0.061
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0472 0.3916
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.001 0.0079
Treponema pallidum cation-activated repressor protein (troR) 0.1277 0.4787 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.0407 0.0404
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.0407 0.0383
Loa Loa (eye worm) glutaminase 2 0.0284 0.1015 0.8425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.001 0.0079
Mycobacterium ulcerans short chain dehydrogenase 0.0032 0.006 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0154 0.1281
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0359 0.1302 0.1299
Toxoplasma gondii hypothetical protein 0.0042 0.0099 0.076
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.001 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.001 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.001 0.0079
Trypanosoma cruzi UDP-galactopyranose mutase 0.0095 0.0299 0.7083
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Mycobacterium ulcerans beta-lactamase 0.0043 0.0099 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.0495
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0104 0.2455
Brugia malayi phosphofructokinase 0.0124 0.0407 0.338
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0039 0.0084 0.1997
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0117 0.034
Loa Loa (eye worm) oxidoreductase 0.0024 0.003 0.0249
Leishmania major pantothenate kinase subunit, putative 0.0017 0.0004 0.0084
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0083 0.0688
Mycobacterium tuberculosis Possible oxidoreductase 0.0024 0.003 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.0825
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0083 0.0688
Brugia malayi jmjC domain containing protein 0.0057 0.0154 0.1281
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0457 0.3137
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.006 0.006
Brugia malayi nuclear hormone receptor 0.0019 0.001 0.0079
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0024 0.003 0.071
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.0407 0.2796
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 0.006 0.0058
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Brugia malayi nuclear receptor NHR-88 0.0019 0.001 0.0079
Treponema pallidum cysteinyl-tRNA synthetase 0.0039 0.0084 0.0176
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0334 0.1205 0.1202
Mycobacterium ulcerans lipase LipD 0.0043 0.0099 0.0097
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0086 0.0061
Brugia malayi 6-phosphofructokinase 0.0124 0.0407 0.338
Brugia malayi 6-phosphofructokinase 0.0124 0.0407 0.338
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0083 0.0688
Chlamydia trachomatis protoporphyrinogen oxidase 0.0095 0.0299 0.2217
Mycobacterium ulcerans cytochrome C oxidase polypeptide I CtaD 0.0076 0.0225 0.0222
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0055 0.0379
Schistosoma mansoni lamin 0.0028 0.0044 0.0364
Echinococcus granulosus leucyl tRNA synthetase 0.0039 0.0084 0.0579
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0099 0.0099
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0095 0.0727
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1256 0.4708 0.4708
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0154 0.0449
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0022 0.0522
Mycobacterium ulcerans cytochrome C oxidase polypeptide I CtaD 0.0076 0.0225 0.0222
Mycobacterium tuberculosis Conserved hypothetical protein 0.0095 0.0299 0.0299
Plasmodium falciparum protoporphyrinogen oxidase 0.0095 0.0299 0.2297
Schistosoma mansoni cytochrome oxidase subunit 0.0076 0.0225 0.1868
Toxoplasma gondii cytochrome c oxidase subunit iii subfamily protein 0.0069 0.0201 0.1547
Schistosoma mansoni ap endonuclease 0.0081 0.0247 0.2049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.001 0.0028
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0039 0.0084 0.07
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0117 0.097
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.001 0.0079
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0024 0.003 0.023
Schistosoma mansoni cytochrome-c oxidase 0.0069 0.0201 0.1672
Brugia malayi beta-lactamase 0.0043 0.0099 0.0825
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0099 0.0825
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.003 0.003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0272 0.0972 0.0972
Brugia malayi beta-lactamase family protein 0.0043 0.0099 0.0825
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0299 0.2297
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0024 0.003 0.0027
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0104 0.2544
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0081 0.0247 0.1695
Schistosoma mansoni cytochrome oxidase subunit 0.0076 0.0225 0.1868
Mycobacterium ulcerans transcriptional repressor SirR 0.1805 0.679 0.6789
Loa Loa (eye worm) hypothetical protein 0.0095 0.0299 0.2482
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0099 0.0825
Schistosoma mansoni hypothetical protein 0.0165 0.0562 0.4666
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0064 0.0495
Mycobacterium tuberculosis Iron-dependent repressor and activator IdeR 0.1805 0.679 0.679
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.001 0.0079
Trichomonas vaginalis glutaminase, putative 0.0284 0.1015 0.7797
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0025 0.0022
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0247 0.1896
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0407 0.338
Trypanosoma brucei oxidoreductase-like protein 0.0032 0.006 0.1431
Schistosoma mansoni thyroid hormone receptor 0.0019 0.001 0.0079
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.001 0.0079
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.0495
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.001 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.007 0.0482
Onchocerca volvulus Cytochrome c oxidase subunit 1 homolog 0.0076 0.0225 0.2583
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0055 0.0458
Plasmodium vivax unspecified product 0.0069 0.0201 0.1547
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0117 0.097
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.001 0.0028
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.0407 0.1183
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0095 0.0299 0.2482
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0095 0.0299 0.2297
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0095 0.0299 0.0869
Loa Loa (eye worm) cytochrome c oxidase subunit I 0.0031 0.0055 0.046
Loa Loa (eye worm) hypothetical protein 0.0095 0.0299 0.2482
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Brugia malayi ecdysteroid receptor 0.0019 0.001 0.0079
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0024 0.003 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0025 0.0613
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0095 0.0727
Leishmania major hypothetical protein, conserved 0.0043 0.0099 0.2355
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0022 0.0019
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0104 0.0796
Schistosoma mansoni lamin 0.0028 0.0044 0.0364
Echinococcus multilocularis lamin 0.0028 0.0044 0.0127
Mycobacterium ulcerans oxidoreductase 0.0095 0.0299 0.0296
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0081 0.0247 0.5848
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0039 0.0084 0.207
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0081 0.0247 0.0247
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 0.006 0.0058
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0024 0.003 0.071
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0024 0.003 0.0027
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0081 0.0247 0.2049
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0099 0.0764
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0099 0.0764
Echinococcus granulosus cysteinyl tRNA synthetase 0.0039 0.0084 0.0579
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0299 0.2297
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0039 0.0084 0.0427
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0099 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0207
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0099 0.2355
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0099 0.0764
Schistosoma mansoni ap endonuclease 0.0081 0.0247 0.2049
Loa Loa (eye worm) hypothetical protein 0.0095 0.0299 0.2482
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0024 0.003 0.071
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.003 0.0027
Brugia malayi glutaminase DH11.1 0.0284 0.1015 0.8425
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0099 0.0099
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.001 0.0079
Toxoplasma gondii hypothetical protein 0.0042 0.0099 0.076
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0024 0.003 0.023
Echinococcus granulosus cytochrome c oxidase subunit 1 0.0076 0.0225 0.1545
Leishmania major cysteinyl-tRNA synthetase, putative 0.0039 0.0084 0.1997
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0247 0.1896
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.001 0.0066
Onchocerca volvulus 0.0246 0.0871 1
Brugia malayi intermediate filament protein 0.0028 0.0044 0.0364
Brugia malayi steroid hormone receptor 0.0019 0.001 0.0079
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.001 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.001 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0207
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0064 0.0495
Echinococcus granulosus lamin 0.0028 0.0044 0.0301
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0207
Echinococcus multilocularis musashi 0.0028 0.0044 0.0127
Brugia malayi Inositol-1 0.0044 0.0104 0.086
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0128 0.0422 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.0591
Onchocerca volvulus 0.0028 0.0044 0.0503
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0142 0.1176
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0359 0.1302 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0128 0.0422 0.3242
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0024 0.003 0.023
Plasmodium falciparum cysteine--tRNA ligase 0.0039 0.0084 0.0648
Brugia malayi Cytochrome P450 family protein 0.0022 0.0022 0.0183
Loa Loa (eye worm) MBCTL1 0.0054 0.0142 0.1176
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0024 0.003 0.0736
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0044 0.0364
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0095 0.0299 0.0296
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0099 0.0099
Mycobacterium leprae Probable lipase LipE 0.0043 0.0099 0.0075
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0083 0.0688
Chlamydia trachomatis dihydrofolate reductase 0.0334 0.1205 0.8999
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.003 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.0758 0.6291
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0128 0.0422 0.3242
Echinococcus multilocularis geminin 0.0165 0.0562 0.1634
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.0407 0.0851
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0064 0.0495
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.0591
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0099 0.0097
Toxoplasma gondii exonuclease III APE 0.0081 0.0247 0.1896
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0039 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.0825
Echinococcus multilocularis dihydrofolate reductase 0.0334 0.1205 0.3501
Mycobacterium ulcerans oxidoreductase 0.0024 0.003 0.0027
Chlamydia trachomatis oxoacy-ACP reductase 0.0024 0.003 0.0203
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0117 0.034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.001 0.0079
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0025 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.001 0.0079
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0095 0.0299 0.0275
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.001 0.0066
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0086 0.0086
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0099 0.0683
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0154 0.1281
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0117 0.097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.001 0.0079
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.0495
Mycobacterium ulcerans hypothetical protein 0.0043 0.0099 0.0097
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0104 0.2455
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0099 0.0097
Schistosoma mansoni dihydrofolate reductase 0.0334 0.1205 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0472 0.3916
Schistosoma mansoni peroxidasin 0.0038 0.0083 0.0688
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0407 1
Loa Loa (eye worm) retinol dehydrogenase 12 0.0024 0.003 0.0249
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0024 0.003 0.071
Mycobacterium leprae PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) 0.0076 0.0225 0.0201
Onchocerca volvulus Peroxidasin homolog 0.0038 0.0083 0.0952
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0051 0.0349
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.001 0.0079
Loa Loa (eye worm) beta-lactamase 0.0043 0.0099 0.0825
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0024 0.003 0.0005
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0039 0.0084 0.07
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0083 0.0688
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.001 0.0079
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0039 0.0084 0.1997
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.003 0.0027
Onchocerca volvulus 0.0019 0.001 0.011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0099 0.0289
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0407 0.3128
Brugia malayi Blistered cuticle protein 3 0.0038 0.0083 0.0688
Echinococcus multilocularis 0.0095 0.0299 0.0869
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.001 0.0066
Onchocerca volvulus 0.0028 0.0044 0.0503
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0128 0.0422 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0407 0.338
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0044 0.0364
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.265 1 1
Toxoplasma gondii histone lysine-specific demethylase 0.0095 0.0299 0.2297
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0407 0.338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.001 0.0066
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0095 0.0299 0.2297
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0081 0.0247 0.5848
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.0495
Toxoplasma gondii ABC1 family protein 0.0043 0.0099 0.0764
Onchocerca volvulus 0.0039 0.0084 0.0968
Echinococcus granulosus lysine specific histone demethylase 1A 0.0095 0.0299 0.2053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0458
Echinococcus granulosus lysine specific histone demethylase 1A 0.0095 0.0299 0.2053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0458
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0039 0.0084 0.07
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0688
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0359 0.1302 0.9726
Echinococcus granulosus FTZ F1 alpha 0.0019 0.001 0.0066
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0081 0.0247 0.5848
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0079
Loa Loa (eye worm) inositol-1 0.0044 0.0104 0.086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0348
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0064 0.0461
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0024 0.003 0.071
Brugia malayi Cytochrome P450 family protein 0.0032 0.006 0.0499
Echinococcus multilocularis peroxidasin 0.0038 0.0083 0.0241
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0104 0.2455
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.001 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.07
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0154 0.1281
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0104 0.0101
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0032 0.006 0.0464
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0142 0.0973
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 3 0.0069 0.0201 0.1348
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0207
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0032 0.006 0.1431
Echinococcus multilocularis protoporphyrinogen oxidase 0.0095 0.0299 0.0869
Brugia malayi hypothetical protein 0.0095 0.0299 0.2482
Onchocerca volvulus 0.0031 0.0055 0.0634
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0081 0.0247 0.1705
Mycobacterium ulcerans dehydrogenase 0.0095 0.0299 0.0296
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.003 0.0027
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0095 0.0299 0.2297
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.003 0.0027
Echinococcus multilocularis tumor protein p63 0.04 0.1457 0.4233
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0025 0.0025
Mycobacterium tuberculosis Probable transcriptional repressor SirR 0.1805 0.679 0.679
Schistosoma mansoni inositol monophosphatase 0.0044 0.0104 0.086
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0095 0.0727
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0064 0.0461
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.001 0.0079
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0099 0.0099
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.001 0.0079
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0095 0.065
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0407 0.9648
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0247 0.1896
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0055 0.0424
Leishmania major UDP-galactopyranose mutase 0.0095 0.0299 0.7083
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0082 0.3306
Loa Loa (eye worm) hypothetical protein 0.0095 0.0299 0.2482
Plasmodium vivax SET domain protein, putative 0.0031 0.0055 0.0424
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.0825
Onchocerca volvulus 0.0038 0.0083 0.0952
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0359 0.1302 1
Entamoeba histolytica hypothetical protein 0.0035 0.007 0.1724
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.001 0.0079
Onchocerca volvulus Cytochrome c oxidase subunit 3 0.0069 0.0201 0.2312
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.0825
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0407 1
Entamoeba histolytica hypothetical protein 0.0035 0.007 0.1724
Onchocerca volvulus 0.0059 0.016 0.1835
Schistosoma mansoni hypothetical protein 0.0035 0.007 0.0583
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.0825
Schistosoma mansoni hypothetical protein 0.0303 0.109 0.9046
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0003 0.0022
Plasmodium falciparum cytochrome c oxidase subunit 1 0.0076 0.0225 0.1729
Loa Loa (eye worm) hypothetical protein 0.0054 0.0142 0.1176
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.001 0.0079

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.49 nM Agonist activity at human PRB expressed in CHO cells ChEMBL. 18243712
EC50 (functional) = 0.49 nM Agonist activity at human PRB expressed in CHO cells ChEMBL. 18243712
Efficacy (functional) = 50 % Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation relative to Org 31710 ChEMBL. 18243712
Efficacy (functional) = 50 % Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation relative to Org 31710 ChEMBL. 18243712
Efficacy (functional) = 51 % Agonist activity at human PRB expressed in CHO cells relative to Org 2058 ChEMBL. 18243712
Efficacy (functional) = 51 % Agonist activity at human PRB expressed in CHO cells relative to Org 2058 ChEMBL. 18243712
IC50 (functional) = 8.48 nM Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation ChEMBL. 18243712
IC50 (functional) = 8.48 nM Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation ChEMBL. 18243712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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