Detailed information for compound 514453

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 884.968 | Formula: C49H50F2N8O6
  • H donors: 4 H acceptors: 6 LogP: 6.7 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)c1cn(Cc2c(F)cccc2F)c2n(c1=O)c(CN(Cc1ccccc1)CC(=O)N[C@H](C(=O)NCC#Cc1ccccc1)C(C)C)c(n2)c1ccc(cc1)NC(=O)NCC
  • InChi: 1S/C49H50F2N8O6/c1-5-52-48(64)54-36-24-22-35(23-25-36)44-41(59-46(62)38(47(63)65-6-2)29-58(49(59)56-44)28-37-39(50)20-13-21-40(37)51)30-57(27-34-17-11-8-12-18-34)31-42(60)55-43(32(3)4)45(61)53-26-14-19-33-15-9-7-10-16-33/h7-13,15-18,20-25,29,32,43H,5-6,26-28,30-31H2,1-4H3,(H,53,61)(H,55,60)(H2,52,54,64)/t43-/m0/s1
  • InChiKey: APSPIRFRZVFKQV-QLKFWGTOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Putative organic anion transporter 0.0044 0.02 0.0647
Onchocerca volvulus 0.0146 0.1209 0.5187
Brugia malayi hypoxia-induced factor 1 0.0158 0.1323 0.1638
Brugia malayi RNA binding protein 0.0062 0.0379 0.0469
Brugia malayi photoreceptor-specific nuclear receptor 0.0105 0.0801 0.0991
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0146 0.1209 0.1795
Onchocerca volvulus 0.0146 0.1209 0.5187
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.0798 0.0988
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0115 1
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0255 0.0255
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0314 0.0388
Echinococcus granulosus g protein coupled receptor 0.0146 0.1209 0.1209
Brugia malayi neuropeptide F receptor 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.0801 0.1188
Onchocerca volvulus 0.0146 0.1209 0.5187
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0365 0.3365 0.4994
Schistosoma mansoni single-minded 0.0051 0.027 0.0401
Loa Loa (eye worm) hypothetical protein 0.0105 0.0801 0.0991
Echinococcus granulosus FTZ F1 alpha 0.0105 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1209 0.1795
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0115 0.0179
Brugia malayi TAR-binding protein 0.0062 0.0379 0.0469
Echinococcus granulosus geminin 0.0334 0.3067 0.3067
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0105 0.0801 0.0991
Echinococcus multilocularis neuropeptide receptor A26 0.0617 0.5856 0.8691
Brugia malayi bZIP transcription factor family protein 0.0084 0.0593 0.0735
Echinococcus granulosus peptide allatostatin:somatostatin 0.0146 0.1209 0.1209
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0124 0.0028
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0356 0.0742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0146 0.1209 0.1497
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0044 0.02 0.0297
Schistosoma mansoni patched 1 0.0041 0.0176 0.0261
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0124 0.0153
Onchocerca volvulus Bile acid receptor homolog 0.0255 0.2279 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Brugia malayi Melatonin receptor type 1A 0.0146 0.1209 0.1497
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0146 0.1209 0.1795
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1212 0.3374
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0255 0.2279 0.2822
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0146 0.1209 0.5187
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0105 0.0801 0.0991
Echinococcus granulosus neuropeptide Y receptor 0.0146 0.1209 0.1209
Schistosoma mansoni biogenic amine receptor 0.0146 0.1209 0.1795
Brugia malayi larval opioid receptor 0.0146 0.1209 0.1497
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0593 0.0881
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0255 0.0379
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0126 0.1016 0.4891
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0379 0.0562
Schistosoma mansoni inositol monophosphatase 0.0036 0.0124 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0049 0.0255 0.0379
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0687 0.6541 0.8099
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0105 0.0801 0.1188
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis FTZ F1 alpha 0.0105 0.0801 0.1188
Schistosoma mansoni coup transcription factor 0.0105 0.0801 0.1188
Toxoplasma gondii transporter, major facilitator family protein 0.0044 0.02 0.0435
Echinococcus multilocularis neuropeptide FF receptor 2 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0082 0.0579 0.0717
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0135 0.0062
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0146 0.1209 0.1209
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0105 0.0801 0.0991
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Onchocerca volvulus 0.0044 0.02 0.0647
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0105 0.0801 0.1188
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.1375 0.678
Schistosoma mansoni lamin 0.0082 0.0579 0.0859
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0379 0.0562
Brugia malayi nuclear receptor NHR-88 0.0049 0.0255 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0143
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0579 0.0717
Schistosoma mansoni nuclear hormone receptor 0.0105 0.0801 0.1188
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0146 0.1209 0.1497
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.0255 0.0255
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0249 0.0308
Brugia malayi hypothetical protein 0.0171 0.1453 0.1799
Toxoplasma gondii ABC1 family protein 0.0035 0.0115 0.0179
Schistosoma mansoni neuropeptide receptor 0.0146 0.1209 0.1795
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0124 0.0028
Schistosoma mansoni neuropeptide F-like receptor 0.0146 0.1209 0.1795
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.0801 0.0991
Schistosoma mansoni nuclear receptor 0.0049 0.0255 0.0379
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0365 0.3365 1
Echinococcus multilocularis lamin dm0 0.0082 0.0579 0.0859
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0176 0.0176
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0365 0.3365 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0135 1
Brugia malayi ORL1-like opioid receptor 0.0146 0.1209 0.1497
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0146 0.1209 0.1795
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0146 0.1209 0.1209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Brugia malayi Dopamine receptor 0.0146 0.1209 0.1497
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0105 0.0801 0.1188
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0202 0.0251
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.0314 0.0388
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0146 0.1209 0.1209
Loa Loa (eye worm) G-protein coupled receptor 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.1323 0.1638
Brugia malayi Pre-SET motif family protein 0.0029 0.0056 0.0069
Echinococcus multilocularis serotonin receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0105 0.0801 0.0801
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0146 0.1209 0.1795
Echinococcus multilocularis microtubule associated protein 2 0.0707 0.6738 1
Echinococcus multilocularis g protein coupled receptor 0.0146 0.1209 0.1795
Echinococcus granulosus single minded 2 0.0038 0.014 0.014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.2818 0.8318
Schistosoma mansoni amine GPCR 0.0146 0.1209 0.1795
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.0255 0.0316
Echinococcus multilocularis fmrfamide receptor 0.0146 0.1209 0.1795
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0135 0.0062
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0115 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0056 0.0083
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0105 0.0801 0.1188
Mycobacterium ulcerans hypothetical protein 0.0163 0.1375 0.3876
Onchocerca volvulus 0.0044 0.02 0.0647
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0255 0.0379
Brugia malayi Serotonin receptor 0.0146 0.1209 0.1497
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.0255 0.0316
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0176 0.0217
Trypanosoma cruzi MFS transporter, putative 0.0044 0.02 0.026
Brugia malayi hypothetical protein 0.0035 0.0115 0.0142
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0105 0.0801 0.1188
Loa Loa (eye worm) melatonin receptor type 1A 0.0146 0.1209 0.1497
Onchocerca volvulus 0.0146 0.1209 0.5187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0056 0.0083
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0135 0.0135
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0146 0.1209 0.1497
Echinococcus granulosus tachykinin peptides receptor 99D 0.0146 0.1209 0.1209
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.1209 0.1209
Schistosoma mansoni intermediate filament proteins 0.0082 0.0579 0.0859
Schistosoma mansoni hypothetical protein 0.004 0.0161 0.0239
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0124 0.0028
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0105 0.0801 0.1188
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0044 0.02 0.02
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0105 0.0801 0.1188
Onchocerca volvulus 0.0146 0.1209 0.5187
Schistosoma mansoni steroid hormone receptor ad4bp 0.0105 0.0801 0.1188
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0255 0.0379
Brugia malayi Tachykinin-like peptides receptor 99D 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0247
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0105 0.0801 0.0801
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0146 0.1209 0.1497
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0197 0.0251
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0069
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0115 0.0149
Onchocerca volvulus 0.0146 0.1209 0.5187
Echinococcus granulosus neuropeptide FF receptor 2 0.0146 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0096 0.0718 0.0888
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0146 0.1209 0.1795
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0238 0.2117 0.616
Onchocerca volvulus 0.0146 0.1209 0.5187
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0197 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0105 0.0801 0.0991
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0365 0.3365 0.4994
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0314 0.0465
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.0798 0.2242
Loa Loa (eye worm) hypothetical protein 0.0055 0.0314 0.0388
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Loa Loa (eye worm) hypothetical protein 0.0171 0.1453 0.1799
Brugia malayi ecdysone receptor 0.0049 0.0255 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0379 0.0562
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Onchocerca volvulus 0.0049 0.0255 0.0896
Onchocerca volvulus Putative organic anion transporter 0.0044 0.02 0.0647
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.0798 0.21
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0146 0.1209 0.1795
Echinococcus multilocularis protein patched 0.0041 0.0176 0.0261
Schistosoma mansoni amine GPCR 0.0146 0.1209 0.1795
Mycobacterium tuberculosis Conserved protein 0.0035 0.0115 0.0149
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0124 0.0028
Schistosoma mansoni hypothetical protein 0.004 0.0161 0.0239
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1209 0.1209
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0105 0.0801 0.0991
Echinococcus multilocularis g-protein coupled receptor 0.0146 0.1209 0.1795
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0202 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0105 0.0801 0.0991
Schistosoma mansoni hypothetical protein 0.0033 0.0097 0.0144
Brugia malayi Pre-SET motif family protein 0.0203 0.1775 0.2198
Brugia malayi nuclear hormone receptor 0.0105 0.0801 0.0991
Echinococcus granulosus Solute carrier organic anion transporter family 0.0044 0.02 0.02
Brugia malayi AKH receptor 0.0146 0.1209 0.1497
Brugia malayi nuclear receptor NHR-88 0.0105 0.0801 0.0991
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0115 0.0171
Brugia malayi nuclear receptor NHR-67 0.0049 0.0255 0.0316
Brugia malayi hypothetical protein 0.0049 0.0255 0.0316
Schistosoma mansoni opsin-like receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0143
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0687 0.6541 0.8099
Schistosoma mansoni neuropeptide F-like receptor 0.0146 0.1209 0.1795
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0593 0.0593
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.0798 0.21
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.0314 0.0465
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0115 0.0171
Echinococcus multilocularis orexin receptor type 2 0.0146 0.1209 0.1795
Schistosoma mansoni microtubule-associated protein tau 0.0707 0.6738 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0255 0.0255
Brugia malayi Nuclear hormone receptor-like 1 0.0105 0.0801 0.0991
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0159 0.0237
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0071 0.0088
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0255 0.0316
Brugia malayi sodium-independent organic anion transporter family protein 0.0044 0.02 0.0247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0255 0.0255
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0115 0.0149
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0135 0.0201
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0056 0.0083
Brugia malayi putative neuropeptide receptor NPR1 0.0146 0.1209 0.1497
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0115 0.0143
Onchocerca volvulus 0.0232 0.2054 0.8984
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.0798 0.2051
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0365 0.3365 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0379 0.0562
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1209 0.1209
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0146 0.1209 0.1795
Onchocerca volvulus 0.0035 0.0115 0.0267
Echinococcus granulosus tar DNA binding protein 0.0062 0.0379 0.0379
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0115 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.0801 0.0801
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0146 0.1209 0.1795
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1209 0.1209
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0124 0.0184
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0274 0.049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0579 0.0717
Echinococcus multilocularis neuropeptide receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0055 0.0314 0.0388
Echinococcus granulosus jun protein 0.0084 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0105 0.0801 0.0991
Mycobacterium tuberculosis Conserved protein 0.0035 0.0115 0.0149
Loa Loa (eye worm) hypothetical protein 0.0051 0.0267 0.0331
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0365 0.3365 1
Echinococcus granulosus dro:myosuppressin receptor 0.0146 0.1209 0.1209
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.2818 0.8318
Echinococcus multilocularis neuropeptide Y receptor 0.0146 0.1209 0.1795
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0105 0.0801 0.0801
Onchocerca volvulus 0.0146 0.1209 0.5187
Echinococcus granulosus fmrfamide receptor 0.0146 0.1209 0.1209
Echinococcus granulosus orexin receptor type 2 0.0146 0.1209 0.1209
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0121 0.096 0.2599
Brugia malayi prostaglandin transporter 0.0044 0.02 0.0247
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1125 0.1125
Trypanosoma brucei protein kinase, putative 0.0104 0.0798 0.21
Brugia malayi G-protein coupled receptor 0.0146 0.1209 0.1497
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0365 0.3365 0.5
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0247
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0159 0.0159
Onchocerca volvulus 0.0146 0.1209 0.5187
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0579 0.0717
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.0798 0.1184
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Leishmania major cathepsin L-like protease 0.0065 0.0412 0.0914
Brugia malayi CHE-14 protein 0.0041 0.0176 0.0217
Echinococcus granulosus lamin dm0 0.0082 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Schistosoma mansoni hypothetical protein 0.0146 0.1209 0.1795
Echinococcus multilocularis ecdysone induced protein 78C 0.0105 0.0801 0.1188
Loa Loa (eye worm) steroid hormone receptor 0.0105 0.0801 0.0991
Echinococcus granulosus expressed protein 0.0365 0.3368 0.3368
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.1209 0.1795
Echinococcus granulosus g protein coupled receptor 0.0146 0.1209 0.1209
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0146 0.1209 0.1209
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0124 0.0206
Onchocerca volvulus Putative organic anion transporter 0.0044 0.02 0.0647
Loa Loa (eye worm) neuropeptide F receptor 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0105 0.0801 0.0991
Schistosoma mansoni hypothetical protein 0.0334 0.3067 0.4553
Echinococcus granulosus neuropeptides capa receptor 0.0146 0.1209 0.1209
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0365 0.3365 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0146 0.1209 0.1795
Onchocerca volvulus 0.0146 0.1209 0.5187
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0146 0.1209 0.1795
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0146 0.1209 0.1795
Schistosoma mansoni thyroid hormone receptor 0.0105 0.0801 0.1188
Echinococcus granulosus 7TM GPCR rhodopsin 0.0146 0.1209 0.1209
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0115 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Schistosoma mansoni jun-related protein 0.0068 0.0439 0.0651
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1209 0.1209
Echinococcus multilocularis G protein coupled receptor 139 0.0146 0.1209 0.1795
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0412 0.0914
Echinococcus multilocularis g protein coupled receptor 0.0146 0.1209 0.1795
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Brugia malayi tailless protein 0.0049 0.0255 0.0316
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0146 0.1209 0.1795
Schistosoma mansoni amine GPCR 0.0146 0.1209 0.1795
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0115 0.0149
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0115 0.0149
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0255 0.0896
Leishmania major cathepsin L-like protease 0.0065 0.0412 0.0914
Onchocerca volvulus 0.0049 0.0255 0.0896
Echinococcus granulosus neuropeptide Y receptor 0.0146 0.1209 0.1209
Echinococcus multilocularis allatostatin A receptor 0.0146 0.1209 0.1795
Onchocerca volvulus 0.0146 0.1209 0.5187
Brugia malayi hypothetical protein 0.0066 0.0416 0.0515
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.0798 0.21
Schistosoma mansoni organic anion transporter 0.0044 0.02 0.0297
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0718 0.0718
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0379 0.0469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Mycobacterium tuberculosis Conserved protein 0.0035 0.0115 0.0149
Mycobacterium ulcerans putative regulatory protein 0.0038 0.014 0.0075
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0146 0.1209 0.1497
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0365 0.3365 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.012
Brugia malayi hypothetical protein 0.0055 0.0314 0.0388
Echinococcus granulosus neuropeptide receptor 0.0146 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0115 0.0143
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0365 0.3365 1
Onchocerca volvulus 0.0038 0.014 0.0377
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1212 0.3374
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0105 0.0801 0.1188
Brugia malayi hypothetical protein 0.0055 0.0314 0.0388
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0412 0.0914
Schistosoma mansoni myosin xvIII 0.0146 0.1209 0.1795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Echinococcus granulosus serotonin receptor 0.0146 0.1209 0.1209
Echinococcus multilocularis neuropeptide Y receptor 0.0146 0.1209 0.1795
Schistosoma mansoni alpha-1 adrenergic receptor 0.0146 0.1209 0.1795
Brugia malayi nuclear receptor RXR 0.0055 0.0314 0.0388
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0842 0.8076 1
Brugia malayi intermediate filament protein 0.0082 0.0579 0.0717
Schistosoma mansoni lamin 0.0082 0.0579 0.0859
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.0801 0.0991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Brugia malayi nuclear receptor RXR 0.0049 0.0255 0.0316
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0049 0.0255 0.0379
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0197 0.0251
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.0798 0.21
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0105 0.0801 0.0991
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0124 0.0028
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0146 0.1209 0.1795
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0105 0.0801 0.1188
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0365 0.3365 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0044 0.02 0.0247
Brugia malayi Inositol-1 0.0036 0.0124 0.0154
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0238 0.2117 0.6229
Schistosoma mansoni RAR-like nuclear receptor 0.0105 0.0801 0.1188
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0247
Brugia malayi neuropeptide F receptor 0.0146 0.1209 0.1497
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.0798 0.0798
Onchocerca volvulus 0.0146 0.1209 0.5187
Brugia malayi conserved hypotetical protein 0.0049 0.0255 0.0316
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0097 0.012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0115 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0798 0.21
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0105 0.0801 0.1188
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.0798 0.1184
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.0255 0.0316
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.0255 0.0379
Brugia malayi hypothetical protein 0.0049 0.0255 0.0316
Echinococcus multilocularis fmrfamide receptor 0.0146 0.1209 0.1795
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0718 0.0888
Schistosoma mansoni biogenic amine receptor 0.0146 0.1209 0.1795
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0143
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0365 0.3365 0.3365
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0143
Echinococcus granulosus sex peptide receptor 0.0146 0.1209 0.1209
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.0255 0.0316
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0687 0.6541 0.9708
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0732 0.1087
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0105 0.0801 0.0991
Echinococcus multilocularis protein dispatched 1 0.0047 0.0233 0.0346
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Schistosoma mansoni retinoic acid receptor RXR 0.0105 0.0801 0.1188
Brugia malayi Serotonin receptor 0.0146 0.1209 0.1497
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0146 0.1209 0.1497
Schistosoma mansoni hypothetical protein 0.0035 0.0115 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0056 0.0083
Loa Loa (eye worm) hypothetical protein 0.0081 0.0571 0.0707
Brugia malayi Dopamine receptor protein 2 0.0146 0.1209 0.1497
Brugia malayi G protein-coupled receptor F59B2.13 0.0146 0.1209 0.1497
Leishmania major cathepsin L-like protease 0.0065 0.0412 0.0914
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0135 0.0255
Echinococcus granulosus lamin 0.0082 0.0579 0.0579
Onchocerca volvulus 0.0035 0.0115 0.0267
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0143
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1209 0.1795
Echinococcus granulosus g-protein coupled receptor 0.0146 0.1209 0.1209
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0176 0.0261
Echinococcus multilocularis g protein coupled receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0044 0.02 0.0297
Schistosoma mansoni inositol monophosphatase 0.0036 0.0124 0.0184
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1775 0.2198
Schistosoma mansoni opsin-like receptor 0.0146 0.1209 0.1795
Echinococcus granulosus neuropeptides capa receptor 0.0146 0.1209 0.1209
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0478 0.0478
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.0798 0.0798
Schistosoma mansoni ap endonuclease 0.0037 0.0135 0.0201
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1209 0.1795
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0135 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.0801 0.0991
Brugia malayi beta-lactamase family protein 0.0035 0.0115 0.0143
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.1209 0.1795
Onchocerca volvulus 0.0146 0.1209 0.5187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0105 0.0801 0.0991
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0115 0.0149
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.0255 0.0316
Schistosoma mansoni thyroid hormone receptor 0.0105 0.0801 0.1188
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0249 0.0308
Brugia malayi Dopamine receptor protein 1 0.0146 0.1209 0.1497
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0255 0.0379
Onchocerca volvulus Neuropeptide F receptor homolog 0.0146 0.1209 0.5187
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0115 0.0171
Onchocerca volvulus 0.0066 0.0416 0.162
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0135 0.0062
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0146 0.1209 0.1209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0105 0.0801 0.0991
Onchocerca volvulus 0.0082 0.0579 0.2352
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0365 0.3365 0.4167
Schistosoma mansoni nuclear receptor 0.0049 0.0255 0.0379
Echinococcus granulosus neuropeptide s receptor 0.0617 0.5856 0.5856
Brugia malayi RE15519p 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1209 0.1795
Schistosoma mansoni hypothetical protein 0.004 0.0161 0.0239
Loa Loa (eye worm) G-protein coupled receptor 0.0146 0.1209 0.1497
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.0255 0.0379
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0124 0.0028
Schistosoma mansoni biogenic amine receptor 0.0146 0.1209 0.1795
Onchocerca volvulus 0.0082 0.0579 0.2352
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0197 0.0251
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0135 0.0168
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0365 0.3365 1
Schistosoma mansoni hypothetical protein 0.0146 0.1209 0.1795
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0798 0.21
Onchocerca volvulus 0.0044 0.02 0.0647
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.2818 0.8318
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0146 0.1209 0.1795
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0105 0.0801 0.0991
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0379 0.0469
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0115 0.0149
Loa Loa (eye worm) DR-78 0.0049 0.0255 0.0316
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.0801 0.1188
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Brugia malayi nuclear hormone receptor 0.0049 0.0255 0.0316
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.1209 0.1795
Onchocerca volvulus 0.0044 0.02 0.0647
Echinococcus multilocularis neuropeptides capa receptor 0.0146 0.1209 0.1795
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0115 0.0115
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0146 0.1209 0.1497
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0255 0.0379
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1209 0.1795
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.0801 0.0991
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0412 0.0914
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0146 0.1209 0.1795
Echinococcus granulosus allatostatin A receptor 0.0146 0.1209 0.1209
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Brugia malayi PAS domain containing protein 0.0051 0.027 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0379 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0176 0.0185
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0117 0.0925 0.2493
Onchocerca volvulus 0.0146 0.1209 0.5187
Brugia malayi hypothetical protein 0.0044 0.02 0.0247
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.1209 0.1795
Schistosoma mansoni hypothetical protein 0.0334 0.3067 0.4553
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.027 0.0401
Loa Loa (eye worm) hypothetical protein 0.0105 0.0801 0.0991
Brugia malayi Steroid receptor seven-up type 2 0.0105 0.0801 0.0991
Echinococcus multilocularis geminin 0.0334 0.3067 0.4553
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0105 0.0801 0.0991
Brugia malayi steroid hormone receptor 0.0105 0.0801 0.0991
Brugia malayi Cytochrome P450 family protein 0.0031 0.0071 0.0088
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.0255 0.0379
Echinococcus granulosus somatostatin receptor 0.0146 0.1209 0.1209
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2052 0.5961
Echinococcus granulosus hypothetical protein 0.0146 0.1209 0.1209
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis dro:myosuppressin receptor 0.0146 0.1209 0.1795
Toxoplasma gondii exonuclease III APE 0.0037 0.0135 0.024
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0687 0.6541 0.6541
Echinococcus multilocularis lamin 0.0082 0.0579 0.0859
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0038 0.0145 0.0179
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.014 0.0207
Schistosoma mansoni neuropeptide receptor 0.0146 0.1209 0.1795
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0718 0.1065
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0478 0.071
Brugia malayi G-protein coupled receptor 0.0146 0.1209 0.1497
Echinococcus granulosus neuropeptide receptor A26 0.0617 0.5856 0.5856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0135 0.0062
Brugia malayi bHLH-PAS transcription factor 0.0038 0.014 0.0173
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.1209 0.1209
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.0801 0.0991
Loa Loa (eye worm) hypothetical protein 0.0055 0.0314 0.0388
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus g protein coupled receptor 0.0146 0.1209 0.1209
Brugia malayi ecdysteroid receptor 0.0255 0.2279 0.2822
Echinococcus multilocularis neuropeptide receptor 0.0146 0.1209 0.1795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Echinococcus multilocularis serotonin receptor 0.0146 0.1209 0.1795
Brugia malayi sodium-independent organic anion transporter family protein 0.0044 0.02 0.0247
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0365 0.3365 1
Brugia malayi beta-lactamase family protein 0.0035 0.0115 0.0143
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0124 0.0028
Loa Loa (eye worm) hypothetical protein 0.0105 0.0801 0.0991
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0143
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.0255 0.0379
Echinococcus multilocularis somatostatin receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0146 0.1209 0.1497
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0249 0.0308
Brugia malayi hypothetical protein 0.0044 0.02 0.0247
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0798 0.21
Brugia malayi putative neuropeptide receptor 0.0146 0.1209 0.1497
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0255 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0135 0.024
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis thyroid hormone receptor alpha 0.0105 0.0801 0.1188
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Onchocerca volvulus 0.0146 0.1209 0.5187
Schistosoma mansoni hypothetical protein 0.004 0.0161 0.0239
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0146 0.1209 0.1497
Echinococcus multilocularis jun protein 0.0084 0.0593 0.0881
Echinococcus granulosus expressed conserved protein 0.009 0.066 0.066
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus ecdysone induced protein 78C 0.0105 0.0801 0.0801
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.2818 0.8318
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Brugia malayi G protein-coupled receptor 0.0146 0.1209 0.1497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Brugia malayi beta-lactamase 0.0035 0.0115 0.0143
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.0255 0.0316
Loa Loa (eye worm) hypothetical protein 0.0081 0.0564 0.0698
Schistosoma mansoni organic anion transporter 0.0044 0.02 0.0297
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0798 0.1184
Onchocerca volvulus 0.0105 0.0801 0.3349
Onchocerca volvulus Protein ultraspiracle homolog 0.0105 0.0801 0.3349
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0105 0.0801 0.0991
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0038 0.0145 0.0179
Echinococcus granulosus neuropeptide receptor 0.0146 0.1209 0.1209
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0105 0.0801 0.3349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Toxoplasma gondii hypothetical protein 0.005 0.026 0.0617
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.0255 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.0801 0.0991
Onchocerca volvulus 0.0035 0.0115 0.0267
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.1209 0.1795
Schistosoma mansoni hypothetical protein 0.0146 0.1209 0.1795
Schistosoma mansoni opsin-like receptor 0.0146 0.1209 0.1795
Schistosoma mansoni hypothetical protein 0.0053 0.029 0.0431
Schistosoma mansoni amine GPCR 0.0146 0.1209 0.1795
Loa Loa (eye worm) neuropeptide F receptor 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Onchocerca volvulus 0.0146 0.1209 0.5187
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0718 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0159 0.0197
Brugia malayi GnHR receptor homolog 0.0702 0.669 0.8283
Schistosoma mansoni neuropeptide receptor 0.0146 0.1209 0.1795
Echinococcus multilocularis G-protein coupled receptor, putative 0.0146 0.1209 0.1795
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1986 1
Echinococcus multilocularis neuropeptide s receptor 0.0617 0.5856 0.8691
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1209 0.1795
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0412 0.0914
Mycobacterium leprae Probable lipase LipE 0.0035 0.0115 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0687 0.6541 0.9708
Echinococcus multilocularis expressed protein 0.0365 0.3368 0.4998
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0291 0.054
Loa Loa (eye worm) hypothetical protein 0.0055 0.0314 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0412 0.0914
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0146 0.1209 0.1795
Schistosoma mansoni ap endonuclease 0.0037 0.0135 0.0201
Echinococcus granulosus intermediate filament protein 0.0082 0.0579 0.0579
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0056 0.0083
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0135 0.0168
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.1209 0.1209
Loa Loa (eye worm) beta-lactamase 0.0035 0.0115 0.0143
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Schistosoma mansoni amine GPCR 0.0146 0.1209 0.1795
Schistosoma mansoni hypothetical protein 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0247
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0316
Echinococcus multilocularis neuropeptides capa receptor 0.0146 0.1209 0.1795
Echinococcus multilocularis expressed conserved protein 0.009 0.066 0.0979
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.0314 0.0314
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0314 0.0388
Schistosoma mansoni histamine h1 receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) hypothetical protein 0.0105 0.0801 0.0991
Loa Loa (eye worm) hypothetical protein 0.0055 0.0314 0.0388
Echinococcus granulosus microtubule associated protein 2 0.0707 0.6738 0.6738
Echinococcus granulosus alpha 1A adrenergic receptor 0.0146 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0041 0.0176 0.0217
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0798 0.21
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0146 0.1209 0.1795
Schistosoma mansoni adenoreceptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) TYRA-2 protein 0.0146 0.1209 0.1497
Schistosoma mansoni zinc finger protein 0.0049 0.0255 0.0379
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0798 0.21
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0379 0.0562
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0365 0.3365 1
Echinococcus granulosus G protein coupled receptor 139 0.0146 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.0308
Loa Loa (eye worm) inositol-1 0.0036 0.0124 0.0154
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1209 0.1209
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.1209 0.1795
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0379 0.0469
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.0314 0.0465
Brugia malayi glucose-6-phosphate dehydrogenase 0.0365 0.3365 0.4167
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0798 0.21
Onchocerca volvulus 0.0146 0.1209 0.5187
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0105 0.0801 0.0801
Brugia malayi MAP kinase sur-1 0.0104 0.0798 0.0988
Schistosoma mansoni neuropeptide receptor 0.0146 0.1209 0.1795
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0124 0.0028
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0146 0.1209 0.1209
Schistosoma mansoni hypothetical protein 0.0068 0.0439 0.0651
Schistosoma mansoni neuropeptide f receptor 76f 0.0146 0.1209 0.1795
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0044 0.02 0.0247
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0105 0.0801 0.0801
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0135 0.0062
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0146 0.1209 0.1795
Brugia malayi sulfakinin receptor protein 0.0146 0.1209 0.1497
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0135 0.0062
Echinococcus granulosus 7tm_1 domain containing protein 0.0146 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0146 0.1209 0.1497
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0135 0.0062
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0365 0.3365 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0379 0.0469
Echinococcus multilocularis musashi 0.0082 0.0579 0.0859
Onchocerca volvulus 0.0044 0.02 0.0647
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0105 0.0801 0.0991
Echinococcus multilocularis sex peptide receptor 0.0146 0.1209 0.1795
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1212 0.3374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0105 0.0801 0.0991
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0255 0.0896
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1209 0.1209
Brugia malayi follicle stimulating hormone receptor 0.0842 0.8076 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0146 0.1209 0.1795
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.0798 0.21
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.1209 0.1209
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0146 0.1209 0.1795
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0056 0.0083
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1125 0.167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1209 0.1795
Brugia malayi hypothetical protein 0.0146 0.1209 0.1497
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0056 0.0056

Activities

Activity type Activity value Assay description Source Reference
Efficacy (functional) = 60 % Antagonist activity at human recombinant GnRHR expressed in CHOK1 cells assessed as reduction in luminescence signal at 10 uM by luciferase reporter gene assay ChEMBL. 18282756
Efficacy (functional) = 60 % Antagonist activity at human recombinant GnRHR expressed in CHOK1 cells assessed as reduction in luminescence signal at 10 uM by luciferase reporter gene assay ChEMBL. 18282756
Efficacy (functional) = 64 % Antagonist activity at human recombinant GnRHR expressed in CHOK1 cells assessed as reduction in luminescence signal at 3 uM by luciferase reporter gene assay ChEMBL. 18282756
Efficacy (functional) = 64 % Antagonist activity at human recombinant GnRHR expressed in CHOK1 cells assessed as reduction in luminescence signal at 3 uM by luciferase reporter gene assay ChEMBL. 18282756
IC50 (functional) = 0.52 uM Antagonist activity at human recombinant GnRHR expressed in CHOK1 cells assessed as reduction in luminescence signal by luciferase reporter gene assay ChEMBL. 18282756
IC50 (functional) = 0.52 uM Antagonist activity at human recombinant GnRHR expressed in CHOK1 cells assessed as reduction in luminescence signal by luciferase reporter gene assay ChEMBL. 18282756
Ki (binding) = 0.77 uM Displacement of [125I]triptorelin from human GnRHR expressed in CHO cells ChEMBL. 18282756
Ki (binding) = 0.77 uM Displacement of [125I]triptorelin from human GnRHR expressed in CHO cells ChEMBL. 18282756

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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