Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0219066 | 0.403467 | 0.5 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0105241 | 0.109466 | 0.118545 |
Trichomonas vaginalis | hypothetical protein | 0.0219066 | 0.403467 | 1 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0105241 | 0.109466 | 0.302214 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0105241 | 0.109466 | 0.109466 |
Echinococcus granulosus | proliferating cell nuclear antigen | 0.00900683 | 0.0702764 | 0.194019 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0219066 | 0.403467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.041681 | 0.914226 | 0.990053 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0203094 | 0.362213 | 0.690486 |
Trypanosoma brucei | proliferative cell nuclear antigen (PCNA), putative | 0.00900683 | 0.0702764 | 0.5 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0105241 | 0.109466 | 0.208675 |
Loa Loa (eye worm) | hypothetical protein | 0.0105241 | 0.109466 | 0.118545 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0105241 | 0.109466 | 0.109466 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0219066 | 0.403467 | 1 |
Leishmania major | proliferative cell nuclear antigen (PCNA), putative | 0.00900683 | 0.0702764 | 0.5 |
Schistosoma mansoni | organic anion transporter | 0.0105241 | 0.109466 | 0.208675 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0420365 | 0.923411 | 0.923411 |
Trypanosoma cruzi | proliferative cell nuclear antigen (PCNA), putative | 0.00900683 | 0.0702764 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0265954 | 0.524577 | 1 |
Entamoeba histolytica | proliferating cell nuclear antigen, putative | 0.00900683 | 0.0702764 | 0.5 |
Onchocerca volvulus | 0.0105241 | 0.109466 | 1 | |
Loa Loa (eye worm) | proliferating cell nuclear antigen | 0.00900683 | 0.0702764 | 0.0761053 |
Trypanosoma cruzi | proliferative cell nuclear antigen (PCNA), putative | 0.00900683 | 0.0702764 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0420365 | 0.923411 | 1 |
Onchocerca volvulus | 0.0105241 | 0.109466 | 1 | |
Echinococcus multilocularis | proliferating cell nuclear antigen | 0.00900683 | 0.0702764 | 0.133968 |
Schistosoma mansoni | thyroid hormone receptor | 0.0265954 | 0.524577 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0420365 | 0.923411 | 0.923411 |
Schistosoma mansoni | hypothetical protein | 0.0203094 | 0.362213 | 0.690486 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0450018 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0265954 | 0.524577 | 1 |
Giardia lamblia | PcnA | 0.00900683 | 0.0702764 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0219066 | 0.403467 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0219066 | 0.403467 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0203094 | 0.362213 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0219066 | 0.403467 | 1 |
Brugia malayi | proliferating cell nuclear antigen (PCNA) | 0.00900683 | 0.0702764 | 0.0702764 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.00900683 | 0.0702764 | 0.133968 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.00900683 | 0.0702764 | 0.133968 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0219066 | 0.403467 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0219066 | 0.403467 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 5.6 uM | Antimalarial activity against Plasmodium falciparum 3D7 [3H]hypoxanthine uptake method | ChEMBL. | 17567585 |
EC50 (functional) | = 5.6 uM | Antimalarial activity against Plasmodium falciparum 3D7 [3H]hypoxanthine uptake method | ChEMBL. | 17567585 |
EC50 (functional) | = 11 uM | Antimalarial activity against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake method | ChEMBL. | 17567585 |
EC50 (functional) | = 11 uM | Antimalarial activity against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake method | ChEMBL. | 17567585 |
IC50 (binding) | = 76 nM | Inhibition of Plasmodium falciparum ENR | ChEMBL. | 17567585 |
IC50 (binding) | = 76 nM | Inhibition of Plasmodium falciparum ENR | ChEMBL. | 17567585 |
IC50 (binding) | = 76 nM | Inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase | ChEMBL. | 19217192 |
IC50 (functional) | = 0.021 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 days | ChEMBL. | 20727773 |
MIC (functional) | = 52 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 days | ChEMBL. | 20727773 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mycobacterium tuberculosis | 20727773 | ||
Plasmodium falciparum | ChEMBL23 | 17567585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.