Detailed information for compound 514644

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 507.662 | Formula: C34H37NO3
  • H donors: 0 H acceptors: 3 LogP: 5.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cn1)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@H]([C@H]3C1=C1CCC(=O)C=C1CC3)CC[C@@H]2C(=O)C1CC1
  • InChi: 1S/C34H37NO3/c1-34-18-28(21-5-3-20(4-6-21)24-10-16-31(38-2)35-19-24)32-26-13-11-25(36)17-23(26)9-12-27(32)29(34)14-15-30(34)33(37)22-7-8-22/h3-6,10,16-17,19,22,27-30H,7-9,11-15,18H2,1-2H3/t27-,28+,29-,30+,34-/m0/s1
  • InChiKey: CBAXMWATMDOQLY-MIPTWNPFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens progesterone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.0015 0.0173 0.0173
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0174 0.0174
Schistosoma mansoni DNA helicase recq1 0.0018 0.0272 0.0272
Brugia malayi hypothetical protein 0.0024 0.0491 0.0634
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.7741 0.7741
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0272 0.077
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0662 0.3823
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0272 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0319 0.0319
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1677 0.1677
Brugia malayi polk-prov protein 0.0036 0.089 0.115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0319 0.0413
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.1673 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0174 0.0174
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.145 0.145
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0648 0.3746
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0067 0.1982 0.1982
Brugia malayi MH2 domain containing protein 0.0115 0.3659 0.4728
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0319 0.0319
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0272 0.0272
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0391 0.2177
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0174 0.0855
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0457 0.2022
Trypanosoma brucei protein kinase, putative 0.0052 0.145 0.8636
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0173 0.0173
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.1234 0.5728
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0319 0.0319
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.2079 0.2079
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0319 0.0413
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.145 1
Loa Loa (eye worm) fli-1 protein 0.0213 0.704 0.704
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0057 0.1636 0.1636
Entamoeba histolytica hypothetical protein 0.0071 0.2129 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0429 0.2411
Schistosoma mansoni gabp alpha 0.007 0.2079 0.2079
Trypanosoma cruzi DNA polymerase eta, putative 0.0057 0.1636 0.9771
Schistosoma mansoni tsg101-related 0.0056 0.1591 0.1591
Schistosoma mansoni importin beta-1 0.0028 0.0613 0.0613
Brugia malayi Fli-1 protein 0.0213 0.704 0.9095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0319 0.0319
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0319 0.0413
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0174 0.0174
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1677 0.2167
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0174 0.0855
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0457 0.2584
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.132 0.132
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0319 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0319 0.0319
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0217 0.0338
Loa Loa (eye worm) hypothetical protein 0.0048 0.132 0.132
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.1677 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.145 0.8487
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0391 0.2177
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0779 0.0779
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0319 0.0319
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0174 0.0855
Leishmania major DNA polymerase eta, putative 0.0057 0.1636 0.9725
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.145 0.145
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0491 0.2786
Brugia malayi Ets-domain containing protein 0.007 0.2079 0.2686
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.1452 0.8646
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0133 0.4281 0.4281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0613 0.0613
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.1673 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0983 1
Schistosoma mansoni hypothetical protein 0.0015 0.0173 0.0173
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0173
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0319 0.0319
Trichomonas vaginalis hypothetical protein 0.0033 0.0782 0.4564
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0272 0.0352
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0319 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.089 0.5221
Echinococcus multilocularis snurportin 1 0.0298 1 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0173 0.0224
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0319 0.0319
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0779 0.3555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0319 0.0319
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0613 0.0613
Schistosoma mansoni coup transcription factor 0.0019 0.0319 0.0319
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.2129 0.2129
Loa Loa (eye worm) hypothetical protein 0.006 0.1726 0.1726
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0173 0.0173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0319 0.0319
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0319 0.0319
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.145 0.8636
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0491 0.2481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0319 0.0319
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0613 0.353
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1677 0.1677
Echinococcus multilocularis bloom syndrome protein 0.0044 0.1168 0.1168
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0319 0.0413
Brugia malayi Ets-domain containing protein 0.007 0.2079 0.2686
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0023 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0319 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0319 0.0413
Trypanosoma brucei unspecified product 0.0023 0.0426 0.2392
Entamoeba histolytica hypothetical protein 0.0071 0.2129 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.132 0.1705
Leishmania major hypothetical protein, conserved 0.0022 0.0391 0.1441
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0491 0.2786
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0319 0.0413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0319 0.0319
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1677 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0272 0.0272
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0173 0.0173
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0613 0.353
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.145 0.8636
Brugia malayi isocitrate dehydrogenase 0.0015 0.0174 0.0225
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.145 0.8636
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.145 0.8636
Schistosoma mansoni hypothetical protein 0.0033 0.0789 0.0789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0319 0.0319
Brugia malayi RNA, U transporter 1 0.0079 0.2401 0.3102
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.154 0.154
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0319 0.0319
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0174 0.0855
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0272 0.1214
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0174 0.0174
Trypanosoma brucei DNA polymerase eta, putative 0.0057 0.1636 0.9771
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.145 0.8636
Echinococcus granulosus GA binding protein alpha chain 0.007 0.2079 0.2079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.1673 1
Schistosoma mansoni DNA polymerase eta 0.0057 0.1636 0.1636
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Schistosoma mansoni hypothetical protein 0.0173 0.5653 0.5653
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.1001 0.55
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.089 0.5221
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0319 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0319 0.0413
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0272 0.0352
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0319 0.0413
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0319 0.0319
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0429 0.2411
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.145 0.8636
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0779 0.0779
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.1673 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1982 0.1982
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.145 0.145
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0319 0.0319
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0319 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0429 0.2411
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0319 0.0413
Brugia malayi nuclear receptor NHR-88 0.0019 0.0319 0.0413
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0319 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0319 0.0413
Trypanosoma brucei unspecified product 0.0052 0.1452 0.8646
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.1168 0.6918
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.1168 0.1509
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0779 0.1006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0319 0.0319
Echinococcus granulosus importin subunit beta 1 0.0028 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0018 0.0272 0.0272
Trypanosoma brucei unspecified product 0.0023 0.0426 0.2392
Giardia lamblia DINP protein human, muc B family 0.0039 0.1001 0.6187
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.132 0.1705
Brugia malayi hypothetical protein 0.0071 0.2129 0.2751
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.145 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0674 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0071 0.2129 0.2129
Schistosoma mansoni DNA helicase recq5 0.0018 0.0272 0.0272
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.2129 0.2129
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0457 0.2584
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0847 0.0847
Echinococcus multilocularis dna polymerase eta 0.0057 0.1636 0.1636
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0779 0.0779
Echinococcus granulosus dna polymerase kappa 0.0058 0.1673 0.1673
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.1673 1
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0067 0.1982 0.1982
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0852 0.4991
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0491 0.3913
Schistosoma mansoni tsg101-related 0.0056 0.1591 0.1591
Onchocerca volvulus 0.0233 0.7741 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0491 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0319 0.0413
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0319 0.0319
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0319 0.0319
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.1673 1
Schistosoma mansoni hypothetical protein 0.0015 0.0173 0.0173
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.1636 0.2113
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0429 0.2411
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0319 0.0319
Plasmodium vivax importin-beta 2, putative 0.0028 0.0613 0.8772
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0319 0.0319
Echinococcus multilocularis geminin 0.0173 0.5653 0.5653
Brugia malayi hypothetical protein 0.0067 0.1982 0.2561
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0789 0.1019
Echinococcus multilocularis dna polymerase kappa 0.0058 0.1673 0.1673
Brugia malayi Importin beta-1 subunit 0.0028 0.0613 0.0791
Entamoeba histolytica hypothetical protein 0.0071 0.2129 1
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.1673 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0852 0.5316
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.145 0.145
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.1673 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Schistosoma mansoni tsg101-related 0.0046 0.1234 0.1234
Leishmania major DNA polymerase eta, putative 0.0035 0.0852 0.4512
Brugia malayi hypothetical protein 0.0016 0.019 0.0245
Echinococcus multilocularis GPCR, family 2 0.0015 0.0173 0.0173
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0319 0.0319
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0319 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0648 0.3746
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0033 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0036 0.089 0.089
Schistosoma mansoni hypothetical protein 0.0298 1 1
Brugia malayi ecdysteroid receptor 0.0019 0.0319 0.0413
Brugia malayi MAP kinase sur-1 0.0052 0.145 0.1873
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.145 0.8636
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0457 0.2584
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.1677 1
Echinococcus granulosus bloom syndrome protein 0.0044 0.1168 0.1168
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.145 0.145
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0173 0.0173
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.3659 0.3659
Schistosoma mansoni ets-related 0.0213 0.704 0.704
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0779 0.0779
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1673 1
Schistosoma mansoni hypothetical protein 0.0173 0.5653 0.5653
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0319 0.0319
Entamoeba histolytica hypothetical protein 0.0071 0.2129 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0613 0.3438
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0319 0.0319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0319 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0319 0.0413
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0779 0.0779
Loa Loa (eye worm) hypothetical protein 0.0019 0.0319 0.0319
Brugia malayi nuclear hormone receptor 0.0019 0.0319 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0648 0.3746
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0319 0.0319
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.145 0.8636
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.145 0.8487
Loa Loa (eye worm) RecQ helicase 0.0044 0.1168 0.1168
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 1 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0429 0.1697
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.2129 0.2129
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0174 0.0225
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.1168 0.6918
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.1001 0.55
Plasmodium falciparum importin beta, putative 0.0028 0.0613 0.5423
Echinococcus granulosus GPCR family 2 0.0015 0.0173 0.0173
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0491 0.3913
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1677 1
Brugia malayi steroid hormone receptor 0.0019 0.0319 0.0413
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0319 0.0319
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0272 0.077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0319 0.0319
Echinococcus granulosus geminin 0.0173 0.5653 0.5653
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.3659 0.3659
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0319 0.0319
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0319 0.0413
Echinococcus granulosus dna polymerase eta 0.0057 0.1636 0.1636
Leishmania major DNA polymerase kappa, putative 0.0039 0.1001 0.55
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0491 0.2786
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0319 0.0413
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0779 0.4023
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.145 0.145
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0319 0.0319
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0319 0.0319
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0173 0.0224
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.1677 0.1677
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0457 0.1886
Brugia malayi Pax transcription factor protein 2 0.0233 0.7741 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0319 0.0413
Entamoeba histolytica hypothetical protein 0.0023 0.0429 0.1887
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1001 0.5897
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.2079 0.2079
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0491 0.633
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.145 0.8636
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0015 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0319 0.0319
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0174 0.0174
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0319 0.0319
Leishmania major hypothetical protein, conserved 0.0024 0.0491 0.2106
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0319 0.0319

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.51 nM Agonist activity at human PRB expressed in CHO cells ChEMBL. 18243712
EC50 (functional) = 0.51 nM Agonist activity at human PRB expressed in CHO cells ChEMBL. 18243712
Efficacy (functional) = 28 % Agonist activity at human PRB expressed in CHO cells relative to Org 2058 ChEMBL. 18243712
Efficacy (functional) = 28 % Agonist activity at human PRB expressed in CHO cells relative to Org 2058 ChEMBL. 18243712
Efficacy (functional) = 57 % Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation relative to Org 31710 ChEMBL. 18243712
Efficacy (functional) = 57 % Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation relative to Org 31710 ChEMBL. 18243712
IC50 (functional) = 0.43 nM Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation ChEMBL. 18243712
IC50 (functional) = 0.43 nM Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation ChEMBL. 18243712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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