Detailed information for compound 515007

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 479.975 | Formula: C26H22ClNO4S
  • H donors: 0 H acceptors: 4 LogP: 4.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)c1c(c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C26H22ClNO4S/c1-3-23(29)25-24(18-7-5-4-6-8-18)22-15-19(27)11-14-21(22)26(30)28(25)16-17-9-12-20(13-10-17)33(2,31)32/h4-15H,3,16H2,1-2H3
  • InChiKey: NOLFLBFMEJTECS-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis c Jun NH2 terminal kinase Get druggable targets OG5_129677 All targets in OG5_129677
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma japonicum ko:K04440 c-Jun N-terminal kinase, putative Get druggable targets OG5_129677 All targets in OG5_129677
Echinococcus granulosus c-Jun N-terminal kinases Get druggable targets OG5_129677 All targets in OG5_129677
Brugia malayi Stress-activated protein kinase jnk-1 Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma japonicum IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing Get druggable targets OG5_129677 All targets in OG5_129677

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0013 0.0057
Brugia malayi Cytochrome P450 family protein 0.0024 0.0106 0.0537
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0043 0.0451
Brugia malayi Protein cec-1. 0.0012 0.0022 0.0113
Plasmodium falciparum importin beta, putative 0.003 0.0153 0.5038
Brugia malayi Protein kinase domain containing protein 0.0016 0.005 0.0255
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0013 0.0057
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0061 0.0221
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0013 0.0057
Onchocerca volvulus 0.0021 0.0083 0.0355
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0326 0.3999
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0161 0.0704
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0114 0.0053
Echinococcus multilocularis geminin 0.0178 0.1229 0.5372
Schistosoma mansoni lipoxygenase 0.0021 0.0083 0.0365
Echinococcus multilocularis Chromo domain 0.0012 0.0022 0.0097
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0304 0.133
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0022 0.0014
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0022 0.0097
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0022 0.0097
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0061 0.0268
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0163 0.0832
Brugia malayi 6-phosphofructokinase 0.0117 0.0787 0.4
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0095 0.0415
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0022 0.0097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0298
Leishmania major trypanothione reductase 0.0051 0.0304 0.3708
Leishmania major hypothetical protein, conserved 0.0076 0.0483 0.6047
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0013 0.0057
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0083 0.2744
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.1742 0.7614
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0068 0.001
Brugia malayi follicle stimulating hormone receptor 0.0243 0.1704 0.8667
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0095 0.098
Onchocerca volvulus 0.0012 0.0022 0.000000092503
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0022 0.0031
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0095 0.0415
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0061 0.0849
Loa Loa (eye worm) hypothetical protein 0.0076 0.0483 0.2114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0022 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0483 0.0595
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0304 0.6112
Echinococcus multilocularis musashi 0.0028 0.0139 0.0607
Onchocerca volvulus 0.0076 0.0483 0.2676
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0022 0.0097
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0114 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0061 0.0542
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0186
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.048 0.2098
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0061 0.0542
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Toxoplasma gondii thioredoxin reductase 0.0051 0.0304 0.1098
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.078 0.1013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0298
Schistosoma mansoni lamin 0.0028 0.0139 0.0607
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0083 0.0365
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0083 0.0365
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0163 0.0103
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0787 0.3439
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0787 1
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0013 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0591
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0787 0.3439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0161 0.0704
Schistosoma mansoni chromobox protein 0.0075 0.048 0.2098
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0326 0.3999
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0022 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Trypanosoma brucei trypanothione reductase 0.0051 0.0304 0.3708
Echinococcus granulosus protein C ets 2 0.0011 0.0013 0.0057
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0111 0.0531
Loa Loa (eye worm) RecQ helicase 0.0022 0.0096 0.0419
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0114 0.0053
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0061 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0483 0.6047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0153 0.0667
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0298
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0389 0.2771 0.2726
Schistosoma mansoni survival motor neuron protein 0.0051 0.0302 0.1318
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0076 0.0483 0.2114
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0043 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0365
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0326 0.1427
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0787 0.3439
Brugia malayi hypothetical protein 0.0248 0.1742 0.8856
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0483 0.2688
Echinococcus granulosus c-Jun N-terminal kinases 0.0279 0.1967 0.8597
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0083 0.1328
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0326 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0095 0.0415
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0061 0.0001
Schistosoma mansoni gabp alpha 0.0076 0.0487 0.2127
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0787 0.4445
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0487 0.2127
Schistosoma mansoni ets 0.0011 0.0013 0.0057
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0483 0.0595
Plasmodium falciparum glutathione reductase 0.0051 0.0304 1
Onchocerca volvulus 0.0076 0.0483 0.2676
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0141
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0095 0.3123
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0787 0.4445
Brugia malayi Ets-domain containing protein 0.0076 0.0487 0.2474
Echinococcus granulosus Chromo domain 0.0012 0.0022 0.0097
Plasmodium falciparum glutathione reductase 0.0018 0.0061 0.2017
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0013 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0022 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0111 0.0531
Schistosoma mansoni rab6-interacting 0.0021 0.0083 0.0365
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0022 0.0113
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0043 0.0186
Brugia malayi beta-lactamase 0.0076 0.0483 0.2459
Brugia malayi Thioredoxin reductase 0.0051 0.0304 0.1546
Schistosoma mansoni hypothetical protein 0.0178 0.1229 0.5372
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0163 0.0832
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0022 0.008
Mycobacterium ulcerans hypothetical protein 0.0025 0.0114 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.0704
Schistosoma mansoni rab6-interacting 0.0021 0.0083 0.0365
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0022 0.0113
Echinococcus multilocularis chromobox protein 2 0.0012 0.0022 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0022 0.0014
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.138 1 1
Schistosoma mansoni hypothetical protein 0.0012 0.0022 0.0097
Brugia malayi hypothetical protein 0.0021 0.0083 0.0424
Toxoplasma gondii ABC1 family protein 0.0076 0.0483 0.1745
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0013 0.0057
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0013 0.0057
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0875 0.1079
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0095 0.0343
Entamoeba histolytica hypothetical protein 0.0025 0.0111 0.1195
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0153 0.0553
Loa Loa (eye worm) glutathione reductase 0.0051 0.0304 0.133
Brugia malayi Stress-activated protein kinase jnk-1 0.0279 0.1967 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0163 0.0832
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0787 0.1022
Echinococcus granulosus chromobox protein 2 0.0012 0.0022 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0326 0.1778
Schistosoma mansoni importin beta-1 0.003 0.0153 0.067
Schistosoma mansoni ets-related 0.0011 0.0013 0.0057
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0483 0.0425
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0279 0.1967 0.8597
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0326 0.3999
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0607
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0787 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0095 0.2909
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0022 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0153 0.1739
Schistosoma mansoni lamin 0.0028 0.0139 0.0607
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.2288 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0057
Schistosoma mansoni hypothetical protein 0.0051 0.0302 0.1318
Onchocerca volvulus 0.0249 0.1746 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0483 0.2459
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0022 0.0097
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0022 0.0014
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0061 0.0312
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1525 0.6666
Trichomonas vaginalis chromobox protein, putative 0.0075 0.048 0.2668
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0095 0.1577
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0114 0.1228
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0163 0.0832
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0787 0.3439
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0875 0.1146
Schistosoma mansoni netrin receptor unc5 0.0015 0.0043 0.0186
Mycobacterium ulcerans lipase LipD 0.0076 0.0483 0.0425
Onchocerca volvulus 0.0021 0.0083 0.0355
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0483 0.2114
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0239 0.1273
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0022 0.0097
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0043 0.0186
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0013 0.0057
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0096 0.0441
Schistosoma mansoni hypothetical protein 0.0323 0.2288 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0161 0.0819
Mycobacterium tuberculosis Conserved protein 0.0076 0.0483 0.0595
Brugia malayi beta-lactamase family protein 0.0076 0.0483 0.2459
Echinococcus multilocularis ets variant gene 4 0.0011 0.0013 0.0057
Brugia malayi phosphofructokinase 0.0117 0.0787 0.4
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0061 0.0849
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0061 0.0241
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.1742 0.7614
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0027 0.0138
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0022 0.0014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0061 0.0268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.0704
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0263 0.1408
Echinococcus multilocularis lamin dm0 0.0028 0.0139 0.0607
Plasmodium vivax importin-beta 2, putative 0.003 0.0153 0.284
Mycobacterium ulcerans beta-lactamase 0.0076 0.0483 0.0425
Onchocerca volvulus 0.0025 0.0114 0.0533
Loa Loa (eye worm) hypothetical protein 0.0065 0.0406 0.1776
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0013 0.0057
Schistosoma mansoni ran 0.0022 0.0095 0.0415
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0163 0.306
Mycobacterium tuberculosis Conserved protein 0.0076 0.0483 0.0595
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0163 0.5371
Schistosoma mansoni loxhd1 0.0021 0.0083 0.0365
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0991 0.7162 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.0704
Mycobacterium tuberculosis Conserved protein 0.0076 0.0483 0.0595
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0114 0.058
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0061 0.0542
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0326 0.3999
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0022 0.0014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.078 0.1013
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0027 0.0138
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0068 0.0996
Schistosoma mansoni chromobox protein 0.0012 0.0022 0.0097
Schistosoma mansoni ets-related 0.0231 0.1615 0.7058
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0787 0.073
Schistosoma mansoni hypothetical protein 0.0054 0.0328 0.1435
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0061 0.2017
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0043 0.0118
Mycobacterium tuberculosis Probable reductase 0.0116 0.078 0.1013
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0022 0.0031
Echinococcus multilocularis snurportin 1 0.0323 0.2288 1
Brugia malayi MAP kinase sur-1 0.0054 0.0326 0.166
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0022 0.0113
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0062 0.0269
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0061 0.0542
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0326 0.1427
Brugia malayi SET domain containing protein 0.0013 0.0031 0.0156
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0787 0.0954
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0496 0.2168
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0083 0.0365
Schistosoma mansoni polycystin 1-related 0.0021 0.0083 0.0365
Schistosoma mansoni chromobox protein 0.0075 0.048 0.2098
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0114 0.1228
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0304 0.133
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0076 0.25
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0013 0.0057
Mycobacterium ulcerans hypothetical protein 0.0076 0.0483 0.0425
Leishmania major GTP-binding protein, putative 0.0022 0.0095 0.098
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0061 0.0542
Schistosoma mansoni chromobox protein 0.0012 0.0022 0.0097
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0022 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0298
Echinococcus multilocularis protein C ets 2 0.0011 0.0013 0.0057
Brugia malayi Ets-domain containing protein 0.0076 0.0487 0.2474
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0163 0.5371
Brugia malayi Death domain containing protein 0.0015 0.0043 0.0217
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0061 0.0542
Echinococcus granulosus chromobox protein 1 0.0075 0.048 0.2098
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0096 0.0487
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0163 0.5003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0304 0.0343
Onchocerca volvulus 0.0028 0.0139 0.0677
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0114 0.1228
Loa Loa (eye worm) hypothetical protein 0.0076 0.0483 0.2114
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0496 0.2168
Brugia malayi hypothetical protein 0.0021 0.0083 0.0424
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0326 0.1778
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0326 0.3999
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0013 0.0057
Schistosoma mansoni hypothetical protein 0.0178 0.1229 0.5372
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0163 0.1872
Brugia malayi Doublecortin family protein 0.0021 0.0083 0.0424
Trichomonas vaginalis esterase, putative 0.0076 0.0483 0.2688
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0326 0.1427
Entamoeba histolytica Ran family GTPase 0.0022 0.0095 0.098
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0061 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0326 0.1778
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0061 0.0221
Brugia malayi Importin beta-1 subunit 0.003 0.0153 0.0779
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0483 0.2114
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0389 0.2771 0.2726
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0173 0.0757
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0483 0.0595
Trichomonas vaginalis set domain proteins, putative 0.0248 0.1745 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0787 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0114 0.1228
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0483 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0114 0.058
Onchocerca volvulus 0.0051 0.0302 0.1621
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0114 0.0053
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0061 0.0542
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.078 0.1013
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0096 0.0419
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0013 0.0057
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0355 0.1552
Echinococcus granulosus Chromobox protein 3 0.0012 0.0022 0.0097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0097
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0013 0.0057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0186
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0061 0.2017
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0111 0.1195
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0114 0.0053
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0304 0.3708
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0161 0.0704
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0153 0.1739
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0326 0.1778
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0068 0.0007
Plasmodium falciparum thioredoxin reductase 0.0051 0.0304 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0326 0.3999
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0061 0.0542
Loa Loa (eye worm) helicase 0.0012 0.0022 0.0097
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0163 0.059
Echinococcus granulosus importin subunit beta 1 0.003 0.0153 0.067
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0483 0.2688
Echinococcus granulosus geminin 0.0178 0.1229 0.5372
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0022 0.0014
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0083 0.0365
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0263 0.1408
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0263 0.1396
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0095 0.098
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0279 0.1967 0.8597
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0483 0.6047
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0083 0.0365
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0483 0.0595
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0389 0.2771 0.377
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0139 0.0607
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0304 0.133
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0083 0.0365
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0032 0.0141
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0114 0.1228
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0061 0.0542
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0787 0.3439
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0096 0.0441
Trichomonas vaginalis ran, putative 0.0022 0.0095 0.0436
Brugia malayi Heterochromatin protein 1 0.0075 0.048 0.2441
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.078 0.1013
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0061 0.0542
Schistosoma mansoni ran 0.0022 0.0095 0.0415
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0161 0.0581
Brugia malayi CHD4 protein 0.0012 0.0022 0.0113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0114 0.0075
Loa Loa (eye worm) beta-lactamase 0.0076 0.0483 0.2114
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0163 0.059
Onchocerca volvulus 0.0028 0.0139 0.0677
Loa Loa (eye worm) hypothetical protein 0.0076 0.0483 0.2114
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0787 0.3439
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0163 0.0832
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0061 0.0542
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0114 0.058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0365
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0043 0.0186
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0483 0.2114
Trichomonas vaginalis conserved hypothetical protein 0.003 0.015 0.0754
Brugia malayi transcription factor E74 isoform 0.0011 0.0013 0.0066
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0095 0.0483
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.1047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.1704 0.7451
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0013 0.0057
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.078 0.0945
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0114 0.0075
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0114 0.0053
Plasmodium falciparum thioredoxin reductase 0.0018 0.0061 0.2017
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0991 0.7162 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0483 0.2114
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.078 0.1013
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0022 0.073
Echinococcus granulosus RUN 0.0021 0.0083 0.0365
Onchocerca volvulus 0.0033 0.0173 0.0876
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0787 0.3439
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0032 0.0141
Schistosoma mansoni hypothetical protein 0.0021 0.0083 0.0365
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0022 0.0113
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0875 0.1146
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0022 0.00000000060236
Echinococcus multilocularis chromobox protein 1 0.0075 0.048 0.2098
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0483 0.0595
Echinococcus granulosus Ankyrin 0.0015 0.0044 0.019
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0326 0.3999
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0498
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0043 0.0219
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0787 0.4445
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0022 0.0014
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.138 1 1
Trichomonas vaginalis hypothetical protein 0.0012 0.0022 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0483 0.0425
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0061 0.0542
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.1967 0.8597
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0124
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0139 0.0706
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0022 0.0097
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0022 0.073
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0022 0.0014
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0022 0.0097
Entamoeba histolytica hypothetical protein 0.0012 0.0022 0.0031
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0483 0.0595
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0498
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0013 0.0057
Brugia malayi hypothetical protein 0.0012 0.0023 0.0118
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.3452 0.4776
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0043 0.0186
Echinococcus granulosus lamin dm0 0.0028 0.0139 0.0607
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0068 0.224
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0239 0.1273
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0302 0.1534
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0101
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0487 0.2127
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0326 0.1178
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0057
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0355 0.1552
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0044 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0483 0.2114
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0068 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0106 0.0462
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0061 0.0542
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0487 0.2127
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0124
Trichomonas vaginalis chromobox protein, putative 0.0075 0.048 0.2668
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0483 0.2688
Echinococcus multilocularis RUN 0.0021 0.0083 0.0365
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0114 0.0053
Echinococcus granulosus intermediate filament protein 0.0028 0.0139 0.0607
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0083 0.0365
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0483 0.2688
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0022 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0251 0.1095
Loa Loa (eye worm) hypothetical protein 0.003 0.0153 0.067
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0163 0.0832
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0787 0.4445
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0057
Plasmodium vivax SET domain protein, putative 0.0031 0.0161 0.3008
Trypanosoma brucei protein kinase, putative 0.0054 0.0326 0.3999
Loa Loa (eye worm) hypothetical protein 0.0248 0.1742 0.7614
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0326 0.1427
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0787 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0163 0.0103
Echinococcus granulosus lamin 0.0028 0.0139 0.0607
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0061 0.0542
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0483 0.2114
Onchocerca volvulus 0.0076 0.0483 0.2676
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0163 0.059
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0042 0.015
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0013 0.0057
Brugia malayi beta-lactamase family protein 0.0076 0.0483 0.2459
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0163 0.0832
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0787 1
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0326 0.1427
Onchocerca volvulus 0.0044 0.0251 0.1325
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0013 0.0057
Entamoeba histolytica hypothetical protein 0.0012 0.0022 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0114 0.1228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0275
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.138 1 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0061 0.1879
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0483 0.6047
Echinococcus multilocularis lamin 0.0028 0.0139 0.0607
Plasmodium vivax glutathione reductase, putative 0.0051 0.0304 0.6112
Trichomonas vaginalis conserved hypothetical protein 0.003 0.015 0.0754
Brugia malayi RNA, U transporter 1 0.0086 0.056 0.2847
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0483 0.0524
Brugia malayi Pre-SET motif family protein 0.0218 0.1525 0.7753
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0787 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0061 0.0542
Echinococcus multilocularis importin subunit beta 1 0.003 0.0153 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.0014
Echinococcus granulosus death domain containing protein 0.0015 0.0043 0.0186
Brugia malayi Fli-1 protein 0.0231 0.1615 0.821
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0043 0.0186
Brugia malayi Uncoordinated protein 44 0.0015 0.0043 0.0217
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0239 0.1261
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0326 0.1427
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0043 0.0217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0298
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0787 0.073
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0389 0.2771 1
Brugia malayi intermediate filament protein 0.0028 0.0139 0.0706
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0022 0.008
Mycobacterium leprae Probable lipase LipE 0.0076 0.0483 0.0524
Echinococcus granulosus bloom syndrome protein 0.0022 0.0096 0.0419
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0022 0.0014
Leishmania major importin beta-1 subunit, putative 0.0025 0.0111 0.1195
Schistosoma mansoni intermediate filament proteins 0.0028 0.0139 0.0607
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0097
Brugia malayi Ets-domain containing protein 0.0011 0.0013 0.0066
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0139 0.0607
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.00000000003069 0.00000000011076
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0095 0.098
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0163 0.306
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0483 0.2688
Echinococcus granulosus chromobox protein 1 0.0075 0.048 0.2098
Schistosoma mansoni lipoxygenase 0.0058 0.0355 0.1552
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0111 0.0531
Brugia malayi chromobox protein homolog 3 0.0042 0.0239 0.1218
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0875 0.1146
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0061 0.0268
Echinococcus multilocularis chromobox protein 1 0.0075 0.048 0.2098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0022 0.0014
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0483 0.0595
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0022 0.0014
Schistosoma mansoni elf1 0.0011 0.0013 0.0057
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0498
Brugia malayi 6-phosphofructokinase 0.0117 0.0787 0.4
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0161 0.0704
Entamoeba histolytica hypothetical protein 0.0012 0.0022 0.0031
Loa Loa (eye worm) hypothetical protein 0.0076 0.0483 0.2114
Brugia malayi glutathione reductase 0.0051 0.0304 0.1546
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0061 0.0542
Loa Loa (eye worm) fli-1 protein 0.0231 0.1615 0.7058
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0043 0.0186
Echinococcus granulosus snurportin 1 0.0323 0.2288 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0057
Echinococcus multilocularis Ankyrin 0.0015 0.0044 0.019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0163 0.0103
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0022 0.073

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of JNK1 in rat H9c2 cells assessed as inhibition of anisomycin-induced cJun phosphorylation after 30 mins ChEMBL. 18313930
IC50 (binding) 0 Inhibition of JNK1 in rat H9c2 cells assessed as inhibition of anisomycin-induced cJun phosphorylation after 30 mins ChEMBL. 18313930
IC50 (binding) = 28 nM Inhibition of human JNK1 by radiometric assay ChEMBL. 18313930
IC50 (binding) = 28 nM Inhibition of human JNK1 by radiometric assay ChEMBL. 18313930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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