Detailed information for compound 515063

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.464 | Formula: C26H22N2O4
  • H donors: 1 H acceptors: 3 LogP: 4.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@@H]1C#C/C=C\C#CC[C@@H]2[C@@H]1N(C2=O)C(=O)NCCc1cccc2c1cccc2
  • InChi: 1S/C26H22N2O4/c1-18(29)32-23-15-6-4-2-3-5-14-22-24(23)28(25(22)30)26(31)27-17-16-20-12-9-11-19-10-7-8-13-21(19)20/h2,4,7-13,22-24H,14,16-17H2,1H3,(H,27,31)/b4-2-/t22-,23-,24+/m1/s1
  • InChiKey: DQDVUNAZQPWFOT-KKPWMFGWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor RXR 0.0014 0.0167 0.0342
Loa Loa (eye worm) hypothetical protein 0.0012 0.012 0.042
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0494 0.0494
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0167 0.0582
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.152 0.6522
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0167 0.0342
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0766 0.2673
Echinococcus multilocularis tar DNA binding protein 0.007 0.1364 0.1319
Schistosoma mansoni cpg binding protein 0.0033 0.0586 0.0586
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0494 0.0445
Schistosoma mansoni hypothetical protein 0.0077 0.152 0.152
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0494 0.0494
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0192 0.2142
Echinococcus granulosus geminin 0.0155 0.3182 0.3147
Echinococcus multilocularis dnaJ subfamily B 0.0475 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0766 0.2673
Brugia malayi nuclear receptor NHR-67 0.0014 0.0167 0.0342
Echinococcus multilocularis GPCR, family 2 0.0036 0.0636 0.0588
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0202 0.0151
Loa Loa (eye worm) hypothetical protein 0.014 0.2866 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0167 0.0582
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0766 0.0718
Brugia malayi hypothetical protein 0.0015 0.0202 0.0502
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0494 0.5457
Loa Loa (eye worm) RecQ helicase 0.0028 0.0469 0.1637
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0042 0.0766 0.2673
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0494 0.0445
Brugia malayi beta-lactamase family protein 0.0042 0.0766 0.308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000013852
Echinococcus granulosus cpg binding protein 0.0035 0.0626 0.0578
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0494 0.5457
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0167 0.0116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0636 0.0588
Loa Loa (eye worm) hypothetical protein 0.0029 0.0494 0.1723
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0494 0.1836
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0766 1
Onchocerca volvulus 0.0042 0.0766 1
Treponema pallidum ATP-dependent DNA helicase 0.0006 0.00000000010115 0.5
Entamoeba histolytica hypothetical protein 0.0042 0.0766 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0494 0.1723
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0984
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0984
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0926 0.126
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.3413 0.4643
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0766 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0926 0.126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0167 0.0116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0766 0.0718
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0636 0.222
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0167 0.0342
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0167 0.0167
Echinococcus multilocularis bloom syndrome protein 0.0028 0.0469 0.042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0272 0.2226
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000013852
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0494 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0494 0.1836
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0494 0.0494
Mycobacterium ulcerans hypothetical protein 0.0185 0.3813 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0636 0.0588
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0202 0.0202
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.012 0.0069
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0766 0.0802
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0029 0.0494 0.1723
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0202 0.0151
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.3413 0.4499
Loa Loa (eye worm) hypothetical protein 0.0015 0.0202 0.0705
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0926 0.126
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0494 0.1836
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.2281 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0351 0.7351 1
Brugia malayi nuclear receptor NHR-88 0.0014 0.0167 0.0342
Toxoplasma gondii ABC1 family protein 0.0042 0.0766 0.6271
Schistosoma mansoni cpg binding protein 0.0035 0.0626 0.0626
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0766 1
Schistosoma mansoni nuclear receptor 0.0014 0.0167 0.0167
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0494 0.0494
Toxoplasma gondii hypothetical protein 0.0057 0.1081 0.8846
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0000000013852
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0494 0.0445
Schistosoma mansoni hypothetical protein 0.0155 0.3182 0.3182
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000013852
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0494 0.0494
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0766 0.308
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0167 0.0342
Onchocerca volvulus 0.0042 0.0766 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0202 0.0705
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1383 0.1383
Schistosoma mansoni cpg binding protein 0.0035 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0192 0.2514
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0192 0.0262
Brugia malayi RNA recognition motif domain containing protein 0.007 0.1364 0.5812
Brugia malayi hypothetical protein 0.0014 0.0167 0.0342
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.012 0.0069
Schistosoma mansoni DNA helicase recq5 0.0012 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0494 0.1836
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.012 0.042
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0494 0.0445
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1222 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0494 0.1836
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0167 0.0116
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0494 0.0445
Schistosoma mansoni tar DNA-binding protein 0.007 0.1364 0.1364
Loa Loa (eye worm) DR-78 0.0014 0.0167 0.0582
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0494 0.0445
Brugia malayi nuclear hormone receptor 0.0014 0.0167 0.0342
Onchocerca volvulus 0.0042 0.0766 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0494 0.0445
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0636 0.2486
Entamoeba histolytica hypothetical protein 0.0042 0.0766 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0167 0.0116
Loa Loa (eye worm) hypothetical protein 0.0036 0.0636 0.222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0494 0.1723
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0167 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0494 0.1723
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0766 0.1042
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Brugia malayi hypothetical protein 0.0014 0.0167 0.0342
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0494 0.1836
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0494 0.0445
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0202 0.0502
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0766 0.0718
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0167 0.0116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0202 0.0705
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0494 0.0445
Loa Loa (eye worm) beta-lactamase 0.0042 0.0766 0.2673
Brugia malayi tailless protein 0.0014 0.0167 0.0342
Brugia malayi ecdysteroid receptor 0.0029 0.0494 0.1836
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.1364 0.4759
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.012 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Leishmania major hypothetical protein, conserved 0.0042 0.0766 0.0802
Mycobacterium tuberculosis Conserved hypothetical protein 0.0185 0.3813 0.6343
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0766 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0028 0.0469 0.5932
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0167 0.0167
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0766 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0494 0.1836
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0202 0.0502
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000013852
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0494 0.0494
Brugia malayi nuclear hormone receptor 0.0029 0.0494 0.1836
Mycobacterium leprae Probable lipase LipE 0.0042 0.0766 0.5
Schistosoma mansoni hypothetical protein 0.0042 0.0766 0.0766
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0129
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.5569 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.2281 0.7958
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0494 0.1836
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0167 0.0342
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0095 0.0044
Schistosoma mansoni hypothetical protein 0.0036 0.0636 0.0636
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0167 0.0167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0494 0.1836
Loa Loa (eye worm) hypothetical protein 0.0029 0.0494 0.1723
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0636 0.2486
Echinococcus granulosus bloom syndrome protein 0.0028 0.0469 0.042
Echinococcus multilocularis geminin 0.0155 0.3182 0.3147
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0167 0.0167
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000013852
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0494 0.1836
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0494 0.0445
Entamoeba histolytica hypothetical protein 0.0042 0.0766 1
Brugia malayi steroid hormone receptor 0.0029 0.0494 0.1836
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0766 0.1042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0494 0.0494
Brugia malayi beta-lactamase 0.0042 0.0766 0.308
Echinococcus multilocularis cpg binding protein 0.0035 0.0626 0.0578
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0494 0.0494
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0167 0.0582
Loa Loa (eye worm) hypothetical protein 0.0015 0.0202 0.0705
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.1156 0.1573
Loa Loa (eye worm) hypothetical protein 0.0029 0.0494 0.1723
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0167 0.0167
Brugia malayi ecdysone receptor 0.0014 0.0167 0.0342
Schistosoma mansoni tar DNA-binding protein 0.007 0.1364 0.1364
Schistosoma mansoni hypothetical protein 0.0036 0.0636 0.0636
Schistosoma mansoni hypothetical protein 0.0036 0.0636 0.0636
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0167 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0351 0.7351 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0167 0.0342
Loa Loa (eye worm) hypothetical protein 0.0042 0.0766 0.2673
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Loa Loa (eye worm) hypothetical protein 0.0042 0.0766 0.2673
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0926 0.1025
Schistosoma mansoni DNA helicase recq1 0.0012 0.012 0.012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0636 0.0588
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Schistosoma mansoni tar DNA-binding protein 0.007 0.1364 0.1364
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0494 0.5457
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0766 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000013852
Loa Loa (eye worm) hypothetical protein 0.0042 0.0766 0.2673
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0766 0.0766
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0129
Trichomonas vaginalis esterase, putative 0.0042 0.0766 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0494 0.1723
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0095 0.0044
Onchocerca volvulus 0.0029 0.0494 0.5457
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0494 0.1723
Schistosoma mansoni tar DNA-binding protein 0.007 0.1364 0.1364
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0167 0.0116
Brugia malayi CXXC zinc finger family protein 0.0033 0.0586 0.2256
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0494 0.0445
Brugia malayi RNA binding protein 0.007 0.1364 0.5812
Echinococcus granulosus tar DNA binding protein 0.007 0.1364 0.1319
Loa Loa (eye worm) histone methyltransferase 0.001 0.0095 0.0331
Brugia malayi hypothetical protein 0.0042 0.0766 0.3077
Schistosoma mansoni hypothetical protein 0.0036 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0029 0.0494 0.1723
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0351 0.7351 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0494 0.1836
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0494 0.0445
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0494 0.1836
Loa Loa (eye worm) hypothetical protein 0.0042 0.0766 0.2673
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0397 1
Schistosoma mansoni coup transcription factor 0.0029 0.0494 0.0494
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0494 0.1836
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0494 0.0445
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0344 0.0344
Schistosoma mansoni hypothetical protein 0.0155 0.3182 0.3182
Loa Loa (eye worm) hypothetical protein 0.0015 0.0202 0.0705
Brugia malayi beta-lactamase family protein 0.0042 0.0766 0.308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0494 0.1723
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0202 0.0202
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0766 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0167 0.0342
Leishmania major mitochondrial DNA polymerase beta 0.0351 0.7351 1
Brugia malayi conserved hypotetical protein 0.0014 0.0167 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0494 0.1836
Loa Loa (eye worm) hypothetical protein 0.0077 0.152 0.5302
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.3413 0.4499
Schistosoma mansoni tar DNA-binding protein 0.007 0.1364 0.1364
Loa Loa (eye worm) hypothetical protein 0.0015 0.0202 0.0705
Entamoeba histolytica hypothetical protein 0.0042 0.0766 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0494 0.0494
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.012 0.5
Brugia malayi nuclear receptor NHR-88 0.0029 0.0494 0.1836
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0494 0.0494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0494 0.0445
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0636 0.0588
Echinococcus granulosus GPCR family 2 0.0036 0.0636 0.0588
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0167 0.0116
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0000000013852
Loa Loa (eye worm) hypothetical protein 0.0029 0.0494 0.1723
Brugia malayi TAR-binding protein 0.007 0.1364 0.5812
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0586 0.2044
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0494 0.0445
Loa Loa (eye worm) hypothetical protein 0.0113 0.2281 0.7958
Brugia malayi hypothetical protein 0.0015 0.0202 0.0502
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Schistosoma mansoni hypothetical protein 0.0475 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0494 0.0445
Brugia malayi nuclear receptor RXR 0.0015 0.0202 0.0502
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0582
Schistosoma mansoni nuclear receptor 0.0014 0.0167 0.0167
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.2281 1
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0494 0.1723
Brugia malayi Bloom's syndrome protein homolog 0.0028 0.0469 0.1723
Onchocerca volvulus 0.0033 0.0586 0.6991
Schistosoma mansoni zinc finger protein 0.0014 0.0167 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0494 0.1723
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0494 0.0445
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0494 0.0494
Loa Loa (eye worm) TAR-binding protein 0.007 0.1364 0.4759
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.012 0.0069
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0167 0.0116
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0469 0.5932
Loa Loa (eye worm) RNA binding protein 0.007 0.1364 0.4759
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0167 0.0116
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0494 0.1836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0494 0.1723
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0766 0.0718
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0766 0.0766
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0167 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0494 0.1723
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0494 0.1836

Activities

Activity type Activity value Assay description Source Reference
CS50 (binding) = 40 uM Induction of plasmid pBR322 DNA cleavage assessed as concentration required to cleave 50% of DNA after 24 hrs by gel electrophoresis ChEMBL. 18304820

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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