Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Importin beta-1 subunit | 0.0027 | 0.0342 | 0.0341 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0018 | 0.0067 | 0.0079 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0892 | 0.1062 |
Echinococcus granulosus | snurportin 1 | 0.0284 | 0.8398 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0027 | 0.0342 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0892 | 0.0892 |
Plasmodium vivax | importin-beta 2, putative | 0.0027 | 0.0342 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.012 | 0.3253 | 0.3874 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0019 | 0.0103 | 0.0103 |
Echinococcus multilocularis | zinc finger protein | 0.0018 | 0.0073 | 0.0086 |
Brugia malayi | TAR-binding protein | 0.012 | 0.3253 | 0.3252 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0018 | 0.0067 | 0.5 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0271 | 0.027 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.3253 | 0.3874 |
Schistosoma mansoni | smad1 5 8 and | 0.0023 | 0.0224 | 0.0267 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0027 | 0.0342 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.0949 | 0.0948 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.4402 | 0.5242 |
Schistosoma mansoni | smad1 5 8 and | 0.0023 | 0.0224 | 0.0267 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0055 | 0.1227 | 0.1461 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0284 | 0.8398 | 0.8398 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0033 | 0.0543 | 0.0647 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0271 | 0.6779 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0271 | 0.7428 |
Schistosoma mansoni | smad | 0.0023 | 0.0224 | 0.0267 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0055 | 0.1227 | 0.1461 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0023 | 0.0224 | 0.0224 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.002 | 0.0122 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.012 | 0.3253 | 0.3253 |
Plasmodium falciparum | importin beta, putative | 0.0027 | 0.0342 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0892 | 0.0891 |
Schistosoma mansoni | bromodomain containing protein | 0.0058 | 0.133 | 0.1584 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0271 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.012 | 0.3253 | 0.3253 |
Echinococcus granulosus | zinc finger protein | 0.0018 | 0.0073 | 0.0086 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0023 | 0.0224 | 0.0224 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.0224 | 0.0223 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0892 | 0.1062 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0493 | 0.0587 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.3253 | 0.3874 |
Leishmania major | GTP-binding protein, putative | 0.002 | 0.0122 | 0.2715 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0067 | 0.0067 |
Schistosoma mansoni | DNA polymerase eta | 0.0018 | 0.0067 | 0.0079 |
Brugia malayi | MH2 domain containing protein | 0.0023 | 0.0224 | 0.0223 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.0224 | 0.0223 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.002 | 0.0122 | 0.2017 |
Echinococcus multilocularis | geminin | 0.0156 | 0.4402 | 0.5242 |
Echinococcus multilocularis | snurportin 1 | 0.0284 | 0.8398 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0284 | 0.8398 | 1 |
Echinococcus granulosus | geminin | 0.0156 | 0.4402 | 0.5242 |
Brugia malayi | PHD-finger family protein | 0.0023 | 0.0226 | 0.0225 |
Brugia malayi | MH2 domain containing protein | 0.0023 | 0.0224 | 0.0223 |
Brugia malayi | RNA binding protein | 0.012 | 0.3253 | 0.3252 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0271 | 0.0271 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0021 | 0.0158 | 0.0188 |
Echinococcus granulosus | smad | 0.0023 | 0.0224 | 0.0267 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0023 | 0.0224 | 0.0267 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.002 | 0.0122 | 0.0145 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0271 | 0.6779 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.3253 | 0.3874 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0018 | 0.0067 | 0.0065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0892 | 0.1062 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.3253 | 0.3874 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0018 | 0.0067 | 0.0065 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0046 | 0.0949 | 0.0949 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0018 | 0.0067 | 0.0079 |
Brugia malayi | RNA, U transporter 1 | 0.0076 | 0.1877 | 0.1876 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0271 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.002 | 0.0122 | 0.2715 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0023 | 0.0224 | 0.0267 |
Schistosoma mansoni | ran | 0.002 | 0.0122 | 0.0145 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0023 | 0.0224 | 0.0267 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0271 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0335 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.0184 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.002 | 0.0122 | 0.2715 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0018 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0613 | 0.0613 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0027 | 0.0342 | 0.0407 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0018 | 0.0067 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0023 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1544 | 0.1544 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0023 | 0.0224 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0682 | 0.0682 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0021 | 0.0158 | 0.0188 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0022 | 0.0184 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0022 | 0.0184 | 0.5763 |
Brugia malayi | Bromodomain containing protein | 0.0069 | 0.1667 | 0.1667 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0073 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0342 | 0.0342 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0892 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0493 | 0.0493 |
Echinococcus granulosus | dna polymerase kappa | 0.0018 | 0.0067 | 0.0079 |
Schistosoma mansoni | smad1 5 8 and | 0.0023 | 0.0224 | 0.0267 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0103 | 0.0123 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0018 | 0.0067 | 0.5 |
Echinococcus granulosus | importin subunit beta 1 | 0.0027 | 0.0342 | 0.0407 |
Echinococcus multilocularis | dna polymerase kappa | 0.0018 | 0.0067 | 0.0079 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.012 | 0.3253 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0949 | 0.0949 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0892 | 0.1062 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0031 | 0.0493 | 0.0492 |
Brugia malayi | RNA recognition motif domain containing protein | 0.012 | 0.3253 | 0.3252 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0018 | 0.0067 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0892 | 0.1062 |
Schistosoma mansoni | importin beta-1 | 0.0027 | 0.0342 | 0.0407 |
Trichomonas vaginalis | ran, putative | 0.002 | 0.0122 | 0.471 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.4402 | 0.5242 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0018 | 0.0067 | 0.0079 |
Schistosoma mansoni | ran | 0.002 | 0.0122 | 0.0145 |
Echinococcus multilocularis | dna polymerase eta | 0.0018 | 0.0067 | 0.0079 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.002 | 0.0122 | 0.0145 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0023 | 0.0224 | 0.0267 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0016 | 0.0018 | 0.0018 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.0949 | 0.0948 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0033 | 0.0543 | 0.0647 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0027 | 0.0342 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0022 | 0.0184 | 1 |
Schistosoma mansoni | Smad4 | 0.0023 | 0.0224 | 0.0267 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0271 | 0.6779 |
Echinococcus multilocularis | tar DNA binding protein | 0.012 | 0.3253 | 0.3874 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0271 | 0.6779 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.3253 | 0.3874 |
Brugia malayi | Bromodomain containing protein | 0.0035 | 0.0611 | 0.061 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0018 | 0.0067 | 0.0079 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0892 | 0.1062 |
Echinococcus multilocularis | smad | 0.0023 | 0.0224 | 0.0267 |
Echinococcus granulosus | dna polymerase eta | 0.0018 | 0.0067 | 0.0079 |
Echinococcus granulosus | Smad4 | 0.0023 | 0.0224 | 0.0267 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0335 | 1 | 1 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.002 | 0.0122 | 0.0121 |
Entamoeba histolytica | Ran family GTPase | 0.002 | 0.0122 | 0.471 |
Brugia malayi | Smad1 | 0.0023 | 0.0224 | 0.0223 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.002 | 0.0122 | 0.0122 |
Echinococcus multilocularis | Smad4 | 0.0023 | 0.0224 | 0.0267 |
Trichomonas vaginalis | importin beta-1, putative | 0.0022 | 0.0184 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0022 | 0.0184 | 0.5763 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0021 | 0.0158 | 0.0188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Cryptococcus neoformans | ChEMBL. | 17976995 | |
Activity (functional) | Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by Alamar blue assay | ChEMBL. | 17976995 | |
Activity (functional) | Antifungal activity against Candida albicans | ChEMBL. | 17976995 | |
Activity (functional) | 0 | Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by Alamar blue assay | ChEMBL. | 17976995 |
Activity (functional) | 0 | Cytotoxicity against human SKMEL cells by neutral red assay up to 25 ug/mL | ChEMBL. | 17976995 |
Activity (functional) | 0 | Cytotoxicity against human KB cells by neutral red assay up to 25 ug/mL | ChEMBL. | 17976995 |
Activity (functional) | 0 | Cytotoxicity against human SK-OV3 cells by neutral red assay up to 25 ug/mL | ChEMBL. | 17976995 |
Activity (ADMET) | 0 | Cytotoxicity against african green monkey Vero cells by neutral red assay up to 25 ug/mL | ChEMBL. | 17976995 |
Activity (ADMET) | 0 | Cytotoxicity against pig LLC-PK11 cells by neutral red assay up to 25 ug/mL | ChEMBL. | 17976995 |
Activity (functional) | 0 | Antifungal activity against Candida albicans | ChEMBL. | 17976995 |
Activity (functional) | 0 | Antifungal activity against Cryptococcus neoformans | ChEMBL. | 17976995 |
Activity (functional) | 0 | Antifungal activity against Aspergillus fumigatus | ChEMBL. | 17976995 |
IC50 (functional) | > 25 ug ml-1 | Cytotoxicity against human BT549 cells by neutral red assay | ChEMBL. | 17976995 |
IC50 (functional) | > 25 ug ml-1 | Cytotoxicity against human BT549 cells by neutral red assay | ChEMBL. | 17976995 |
IC50 (functional) | > 40 ug ml-1 | Antileishmanial activity against Leishmania donovani promastigotes | ChEMBL. | 21665468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.