Detailed information for compound 515296

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 519.635 | Formula: C29H37N5O4
  • H donors: 2 H acceptors: 4 LogP: 4.57 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNc1cccc(c1)NC(=O)Cn1c(=O)n(CC(=O)C(C)(C)C)c2c(n(c1=O)C1CCCCC1)cccc2
  • InChi: 1S/C29H37N5O4/c1-29(2,3)25(35)18-32-23-15-8-9-16-24(23)34(22-13-6-5-7-14-22)28(38)33(27(32)37)19-26(36)31-21-12-10-11-20(17-21)30-4/h8-12,15-17,22,30H,5-7,13-14,18-19H2,1-4H3,(H,31,36)
  • InChiKey: GKODGPCMRMTNFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholecystokinin B receptor Starlite/ChEMBL References
Homo sapiens cholecystokinin A receptor Starlite/ChEMBL References
Rattus norvegicus Cholecystokinin B receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Brugia malayi sulfakinin receptor protein Get druggable targets OG5_132882 All targets in OG5_132882
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Cholecystokinin B receptor   452 aa 389 aa 31.4 %
Echinococcus granulosus rhodopsin orphan GPCR cholecystokinin A receptor 428 aa 373 aa 19.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0209 0.015 0.016
Loa Loa (eye worm) hypothetical protein 0.011 0.0071 0.0075
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0082 0.0048 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0279 0.0206 0.0221
Schistosoma mansoni hypothetical protein 0.0244 0.0178 0.019
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0082 0.0048 0.0039
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0072 0.0075
Schistosoma mansoni hypothetical protein 0.0222 0.016 0.0171
Schistosoma mansoni hypothetical protein 0.0113 0.0073 0.0077
Schistosoma mansoni acetyl-CoA synthetase 0.0082 0.0048 0.0051
Onchocerca volvulus 0.0032 0.0009 0.0003
Echinococcus granulosus peptidase Clp S14 family 0.0049 0.0022 0.0022
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0082 0.0048 0.0043
Echinococcus granulosus histone acetyltransferase KAT2B 0.0133 0.0089 0.0094
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.2116 0.1676 0.1802
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0008 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0072 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0018 0.0018
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0049 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0357 0.0268 0.0287
Brugia malayi MH2 domain containing protein 0.0145 0.0099 0.0105
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0029 0.0029
Schistosoma mansoni patched 1 0.023 0.0167 0.0178
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0018 0.0018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0018 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0111 0.0236
Loa Loa (eye worm) STAT protein 0.0145 0.0099 0.0105
Schistosoma mansoni jumonji/arid domain-containing protein 0.0139 0.0094 0.01
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0075 0.0043 0.004
Brugia malayi Dihydrofolate reductase 0.2116 0.1676 0.1803
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0082 0.0048 0.005
Echinococcus multilocularis sterol regulatory element binding protein 0.023 0.0167 0.0178
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Entamoeba histolytica hypothetical protein 0.0236 0.0171 0.4043
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0082 0.0048 0.0051
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0082 0.0048 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0279 0.0206 0.0221
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0082 0.0048 0.005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0075 0.0043 0.0033
Echinococcus multilocularis survival motor neuron protein 1 0.1287 0.1013 0.1089
Loa Loa (eye worm) hypothetical protein 0.1287 0.1013 0.1089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0236 0.0171 0.0183
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0244 0.0178 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0072 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0048 0.005
Brugia malayi RNA binding protein 0.0397 0.0301 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0000076559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.0019
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0037 0.0012 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0018 0.0018
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0037 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0111 0.0236
Leishmania major acetyl-CoA synthetase, putative 0.0082 0.0048 0.0043
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0072 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0018 0.0018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0018 0.0018
Echinococcus granulosus lysine specific demethylase 5A 0.0139 0.0094 0.01
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0016 0.0176
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0048 0.0039
Mycobacterium tuberculosis Hypothetical protein 0.5624 0.4484 0.4824
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Brugia malayi hypothetical protein 0.0032 0.0009 0.0008
Onchocerca volvulus 0.0112 0.0072 0.0071
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0029 0.0025
Schistosoma mansoni inositol monophosphatase 0.0041 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0018 0.0018
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0263 0.0193 0.0206
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0018 0.0018
Echinococcus granulosus sterol regulatory element binding protein 0.023 0.0167 0.0178
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0048 0.005
Loa Loa (eye worm) hypothetical protein 0.0112 0.0072 0.0076
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0018 0.0013
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0049 0.0022 0.002
Onchocerca volvulus 0.0032 0.0009 0.0003
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0017 0.0014
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0018 0.0018
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0005 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0007
Echinococcus granulosus microtubule associated protein 2 0.2258 0.1789 0.1925
Echinococcus multilocularis lysine specific demethylase 5A 0.0137 0.0092 0.0098
Echinococcus granulosus jumonji domain containing 1A 0.0037 0.0012 0.0011
Schistosoma mansoni inositol monophosphatase 0.0041 0.0016 0.0016
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.023 0.0167 0.0361
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0037 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.0019
Plasmodium falciparum lipid/sterol:H+ symporter 0.0032 0.0009 0.0005
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0049 0.0022 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0111 0.0236
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0094 0.01
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0005 0.0001
Loa Loa (eye worm) patched family protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0209 0.015 0.016
Onchocerca volvulus 0.0112 0.0072 0.0071
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0024 0.0025
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0082 0.0048 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.2258 0.1789 0.1925
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.0016 0.0011
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0037 0.0012 0.0008
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0024 0.0397
Echinococcus multilocularis ubiquitin specific protease 41 0.0032 0.0008 0.0008
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0016 0.0015
Brugia malayi TAR-binding protein 0.0397 0.0301 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.0019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0017 0.0017
Mycobacterium ulcerans thymidylate synthase 1.1632 0.9292 1
Loa Loa (eye worm) TAR-binding protein 0.0397 0.0301 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Brugia malayi Inositol-1 0.0041 0.0016 0.0015
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0072 0.0075
Brugia malayi Probable ClpP-like protease 0.0075 0.0043 0.0045
Onchocerca volvulus 0.0032 0.0009 0.0003
Echinococcus granulosus expressed conserved protein 0.0503 0.0385 0.0413
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0039 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0048 0.0039
Schistosoma mansoni bromodomain containing protein 0.0074 0.0042 0.0044
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0003 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0037 0.0012 0.0012
Brugia malayi jmjC domain containing protein 0.0037 0.0012 0.0011
Onchocerca volvulus Glucosylceramidase homolog 0.016 0.0111 0.0113
Mycobacterium tuberculosis Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) 0.0037 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0000076559
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0082 0.0048 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0018 0.0018
Echinococcus granulosus Niemann Pick C1 protein 0.0536 0.0411 0.0441
Loa Loa (eye worm) hypothetical protein 0.0051 0.0023 0.0024
Echinococcus granulosus dihydrofolate reductase 0.2116 0.1676 0.1803
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 1.2518 1 1
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) 0.0037 0.0012 0.001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0014 0.001
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0018 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0072 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0016 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0018 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0048 0.0039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0264 0.0194 0.0207
Loa Loa (eye worm) inositol-1 0.0041 0.0016 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0005 0.0001
Brugia malayi hypothetical protein 0.1287 0.1013 0.1089
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0072 0.0064
Schistosoma mansoni hypothetical protein 0.0222 0.016 0.0171
Echinococcus granulosus Niemann Pick C1 protein 0.0766 0.0596 0.064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0029 0.0018
Brugia malayi nuclear hormone receptor 0.0044 0.0018 0.0018
Brugia malayi steroid hormone receptor 0.0044 0.0018 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0111 0.0236
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT 0.0168 0.0117 0.0122
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0024 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0005 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0000076559
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0112 0.0072 0.0076
Loa Loa (eye worm) fli-1 protein 0.0212 0.0152 0.0163
Brugia malayi hypothetical protein 0.0032 0.0009 0.0008
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0016 0.0308
Brugia malayi STAT protein, DNA binding domain containing protein 0.0145 0.0099 0.0105
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Brugia malayi dihydrofolate reductase family protein 0.2116 0.1676 0.1803
Loa Loa (eye worm) patched family protein 0.0032 0.0009 0.0008
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0137 0.0092 0.0098
Brugia malayi jmjC domain containing protein 0.0137 0.0092 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0018 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0111 0.0236
Loa Loa (eye worm) hypothetical protein 0.0098 0.0061 0.0065
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0075 0.0043 0.004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0038 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0072 0.0149
Echinococcus multilocularis lysine specific demethylase 6a 0.0037 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0301 0.0322
Schistosoma mansoni zinc finger protein 0.0025 0.0003 0.0002
Plasmodium vivax acyl-CoA synthetase, putative 0.0209 0.015 0.0146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0263 0.0193 0.0206
Brugia malayi Ets-domain containing protein 0.007 0.0039 0.004
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0037 0.0012 0.0007
Echinococcus granulosus GPCR family 2 0.0113 0.0073 0.0077
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.2116 0.1676 0.1801
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0018 0.0018
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0082 0.0048 0.005
Toxoplasma gondii patched family protein 0.0032 0.0009 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0397 0.0301 0.0322
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0039 0.004
Brugia malayi Patched related family protein 4 0.0032 0.0009 0.0008
Plasmodium falciparum histone acetyltransferase GCN5 0.0037 0.0012 0.0009
Trichomonas vaginalis antibiotic synthetase, putative 0.0082 0.0048 0.0096
Echinococcus multilocularis jumonji domain containing 1A 0.0037 0.0012 0.0011
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0048 0.005
Loa Loa (eye worm) patched family protein 0.0032 0.0009 0.0008
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Echinococcus granulosus zinc finger protein 0.0025 0.0003 0.0001
Brugia malayi protein C24B5.3 0.0032 0.0009 0.0008
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0016 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0236 0.0171 0.0183
Loa Loa (eye worm) hypothetical protein 0.0098 0.0061 0.0065
Echinococcus multilocularis tar DNA binding protein 0.0397 0.0301 0.0322
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0082 0.0048 0.0043
Giardia lamblia Histone acetyltransferase GCN5 0.0037 0.0012 0.2363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0024 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0072 0.0076
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 1.2518 1 1
Schistosoma mansoni hypothetical protein 0.0113 0.0073 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0118 0.0251
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0544 0.0418 0.0449
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0014 0.0013
Echinococcus multilocularis protein patched 0.023 0.0167 0.0178
Echinococcus granulosus Protein patched homolog 1 0.023 0.0167 0.0178
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0048 0.0039
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Brugia malayi Ets-domain containing protein 0.007 0.0039 0.004
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0024 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0072 0.0076
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0048
Brugia malayi hypothetical protein 0.0266 0.0195 0.0209
Mycobacterium tuberculosis Conserved protein 0.0112 0.0072 0.0075
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0082 0.0048 0.005
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0032 0.0008 0.0008
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0082 0.0048 0.0043
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0072 0.0064
Entamoeba histolytica hypothetical protein 0.0236 0.0171 0.4043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0018 0.0018
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0244 0.0178 0.019
Loa Loa (eye worm) hypothetical protein 0.0536 0.0411 0.0442
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0072 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Onchocerca volvulus 0.0091 0.0055 0.0053
Echinococcus granulosus JmjC domain containing protein 4 0.0037 0.0012 0.0011
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Brugia malayi hypothetical protein 0.0032 0.0009 0.0008
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0082 0.0048 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0197 0.0141 0.0149
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0082 0.0048 0.0048
Loa Loa (eye worm) beta-lactamase 0.0112 0.0072 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0139 0.0094 0.01
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0002 0.0002
Onchocerca volvulus 0.0037 0.0012 0.0006
Schistosoma mansoni ets-related 0.0212 0.0152 0.0163
Schistosoma mansoni hypothetical protein 0.0113 0.0073 0.0077
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0016 0.0003
Onchocerca volvulus 0.0032 0.0009 0.0003
Echinococcus granulosus tar DNA binding protein 0.0397 0.0301 0.0322
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0072 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0018 0.0018
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0029 0.0028
Onchocerca volvulus 0.0032 0.0009 0.0003
Onchocerca volvulus 0.0082 0.0048 0.0045
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0018 0.0018
Echinococcus multilocularis zinc finger protein 0.0025 0.0003 0.0001
Echinococcus granulosus tumor protein p63 0.1085 0.0851 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0008 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0082 0.0048 0.0039
Echinococcus multilocularis thymidylate synthase 1.1632 0.9292 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.023 0.0167 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0007 0.0005
Brugia malayi ecdysteroid receptor 0.0044 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0016 0.0024
Onchocerca volvulus 0.0032 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0082 0.0048 0.0051
Onchocerca volvulus 0.0263 0.0193 0.0201
Loa Loa (eye worm) hypothetical protein 0.0112 0.0072 0.0076
Loa Loa (eye worm) hypothetical protein 0.0112 0.0072 0.0076
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0082 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0209 0.015 0.016
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0048 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0072 0.0067
Schistosoma mansoni dihydrofolate reductase 0.2116 0.1676 0.1803
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0075 0.0043 0.0045
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0024 0.0024
Brugia malayi Fli-1 protein 0.0212 0.0152 0.0162
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0094 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0048 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0048 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0018 0.0018
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0279 0.0206 0.0221
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 1.1632 0.9292 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0075 0.0043 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0209 0.015 0.016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0209 0.015 0.0159
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Echinococcus granulosus geminin 0.0536 0.0411 0.0441
Brugia malayi hypothetical protein 0.0098 0.0061 0.0064
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0082 0.0048 0.0051
Mycobacterium ulcerans beta-lactamase 0.0112 0.0072 0.0064
Leishmania major hypothetical protein, conserved 0.0112 0.0072 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0279 0.0206 0.4909
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0279 0.0206 0.0209
Brugia malayi Niemann-Pick C1 protein precursor 0.0536 0.0411 0.0441
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.006 0.003 0.0032
Loa Loa (eye worm) RNA binding protein 0.0397 0.0301 0.0322
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.0019
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0017 0.0026
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0003 0.0001
Onchocerca volvulus 0.0044 0.0018 0.0013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0038 0.004
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Mycobacterium ulcerans lipase LipD 0.0112 0.0072 0.0064
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0222 0.016 0.0171
Echinococcus granulosus ubiquitin specific protease 41 0.0032 0.0008 0.0008
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0082 0.0048 0.0039
Brugia malayi sulfakinin receptor protein 0.0266 0.0195 0.0209
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0024 0.0025
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase 0.0168 0.0117 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0018 0.0018
Plasmodium vivax patched family protein, putative 0.0032 0.0009 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0279 0.0206 0.0221
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 1.1632 0.9292 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.0208 0.0223
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0137 0.0092 0.0098
Schistosoma mansoni hypothetical protein 0.0536 0.0411 0.0442
Onchocerca volvulus 1.1632 0.9292 1
Brugia malayi jmjC domain containing protein 0.0139 0.0094 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0118 0.0251
Entamoeba histolytica acyl-CoA synthetase, putative 0.0279 0.0206 0.4909
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0018 0.0018
Echinococcus granulosus thymidylate synthase 1.1632 0.9292 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0003 0.0002
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.2116 0.1676 0.1793
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0016 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0197 0.0141 0.0149
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0016 0.0024
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0016 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0111 0.0236
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0082 0.0048 0.0048
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0016 0.0016
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 1.2518 1 1
Schistosoma mansoni cellular tumor antigen P53 0.0159 0.011 0.0117
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0018 0.0029
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0279 0.0206 0.0209
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0082 0.0048 0.005
Loa Loa (eye worm) transcription factor SMAD2 0.0145 0.0099 0.0105
Echinococcus multilocularis phd:f box containing protein 0.0037 0.0012 0.0011
Echinococcus multilocularis peptidase Clp (S14 family) 0.0049 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0236 0.0171 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0301 0.0322
Loa Loa (eye worm) hypothetical protein 0.0279 0.0206 0.0221
Loa Loa (eye worm) hypothetical protein 0.0082 0.0048 0.0051
Mycobacterium ulcerans hypothetical protein 0.0279 0.0206 0.0209
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0008 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0012 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0072 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0018 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0029 0.0024
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0307 0.0228 0.0244
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.023 0.0167 0.0178
Loa Loa (eye worm) patched family protein 0.0032 0.0009 0.0008
Brugia malayi nuclear receptor NHR-88 0.0044 0.0018 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.0178 0.0386
Brugia malayi Patched protein homolog 1 0.0032 0.0009 0.0008
Echinococcus granulosus survival motor neuron protein 1 0.1287 0.1013 0.1089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0159 0.011 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.0178 0.0386
Brugia malayi jmjC domain containing protein 0.0037 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0145 0.0099 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0016 0.0024
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0017 0.0014
Brugia malayi beta-lactamase 0.0112 0.0072 0.0076
Loa Loa (eye worm) dihydrofolate reductase 0.2116 0.1676 0.1803
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0024 0.0025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0072 0.0075
Schistosoma mansoni eyes absent homolog 0.0098 0.0061 0.0065
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0032 0.0008 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0048 0.0039
Trichomonas vaginalis esterase, putative 0.0112 0.0072 0.0149
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0048 0.0051
Mycobacterium tuberculosis Conserved protein 0.0112 0.0072 0.0075
Brugia malayi latrophilin 2 splice variant baaae 0.0244 0.0178 0.019
Loa Loa (eye worm) hypothetical protein 0.0113 0.0073 0.0077
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 1.2518 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0018 0.0013
Schistosoma mansoni hypothetical protein 0.0222 0.016 0.0171
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0082 0.0048 0.099
Toxoplasma gondii ABC1 family protein 0.0112 0.0072 0.0069
Leishmania major acetyl-CoA synthetase, putative 0.0082 0.0048 0.0043
Schistosoma mansoni jumonji/arid domain-containing protein 0.0139 0.0094 0.01
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0082 0.0048 0.005
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0075 0.0043 0.004
Loa Loa (eye worm) patched family protein 0.0032 0.0009 0.0008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0072 0.0076
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0082 0.0048 0.0051
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0032 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0244 0.0178 0.019
Echinococcus multilocularis protein dispatched 1 0.0262 0.0193 0.0206
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Echinococcus multilocularis dihydrofolate reductase 0.2116 0.1676 0.1803
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0018 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0017 0.0026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0018 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0279 0.0206 0.0209
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0018 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0048 0.0051
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0072 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0018 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.6081 0.4849 0.5218
Loa Loa (eye worm) hypothetical protein 0.0266 0.0195 0.0209
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Brugia malayi CHE-14 protein 0.023 0.0167 0.0178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0029 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0016 0.0024
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0536 0.0411 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0209 0.015 0.0654
Mycobacterium ulcerans phosphoribosylamine--glycine ligase 0.0168 0.0117 0.0113
Onchocerca volvulus 0.0082 0.0048 0.0045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0113 0.0073 0.0077
Toxoplasma gondii hypothetical protein 0.0032 0.0009 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0018 0.0018
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 1.1632 0.9292 1
Brugia malayi Bromodomain containing protein 0.0087 0.0052 0.0055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0094 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0012
Entamoeba histolytica acetyltransferase, GNAT family 0.0037 0.0012 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0279 0.0206 0.022
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0008 0.0008
Giardia lamblia GTOR 0.0052 0.0024 1
Mycobacterium ulcerans hypothetical protein 0.0112 0.0072 0.0064
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0008 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0197 0.0141 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.0279 0.0206 0.0209
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Toxoplasma gondii propionate-CoA ligase 0.0082 0.0048 0.0045
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.0071 0.155
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.0178 0.0386
Echinococcus multilocularis geminin 0.0536 0.0411 0.0441
Echinococcus multilocularis GPCR, family 2 0.0113 0.0073 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0072 0.0076
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Chlamydia trachomatis dihydrofolate reductase 0.2116 0.1676 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0007 0.0005
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0075 0.0043 0.004
Schistosoma mansoni protein phosphatase 2C 0.0037 0.0012 0.0012
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0018 0.0018
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.0071 0.155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0018 0.0018
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0082 0.0048 0.0045
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0082 0.0048 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0029 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0236 0.0171 0.4043
Onchocerca volvulus 0.0112 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Brugia malayi beta-lactamase family protein 0.0112 0.0072 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0279 0.0206 0.0209
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0082 0.0048 0.0039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0018 0.0018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0279 0.0206 0.0218
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.0071 0.155
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0024 0.0025
Echinococcus multilocularis Niemann Pick C1 protein 0.0536 0.0411 0.0441
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0301 0.0322
Onchocerca volvulus Heat shock factor protein 2 homolog 0.011 0.0071 0.007
Onchocerca volvulus 0.0279 0.0206 0.0215
Brugia malayi Cytochrome P450 family protein 0.0025 0.0002 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0113 0.0073 0.0077
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0209 0.015 0.0148
Leishmania major 4-coumarate:coa ligase-like protein 0.0279 0.0206 0.0201
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0279 0.0206 0.0218
Onchocerca volvulus 0.0082 0.0048 0.0045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0016 0.0023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0015 0.0014
Mycobacterium tuberculosis Conserved protein 0.0112 0.0072 0.0075
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0082 0.0048 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0301 0.0322
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0016 0.0023
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0082 0.0048 0.005
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0024 0.0025
Echinococcus granulosus lysine specific demethylase 6a 0.0037 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0000076559
Entamoeba histolytica acyl-coA synthetase, putative 0.0279 0.0206 0.4909
Brugia malayi Myosin head containing protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0039 0.004
Plasmodium falciparum JmjC domain-containing protein, putative 0.0037 0.0012 0.0008
Brugia malayi HSF-type DNA-binding domain containing protein 0.011 0.0071 0.0075
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0012 0.0011
Brugia malayi beta-lactamase family protein 0.0112 0.0072 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Toxoplasma gondii patched family protein 0.0032 0.0009 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0072 0.0067
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0279 0.0206 0.0209
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0008 0.0008
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0075 0.0043 0.0033
Plasmodium vivax acetyl-CoA synthetase, putative 0.0082 0.0048 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0072 0.0149
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0082 0.0048 0.0043
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0005 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0197 0.0141 0.0149
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0072 0.0069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0357 0.0268 0.0287
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0015 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0008 0.0005
Schistosoma mansoni survival motor neuron protein 0.0263 0.0193 0.0206
Brugia malayi protein C24B5.3 0.0032 0.0009 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.5624 0.4484 0.4481
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0111 0.0236
Onchocerca volvulus Protein patched homolog 0.0032 0.0009 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0018 0.0018
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0713 0.0553 0.0593
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0018 0.0018
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0209 0.015 0.016
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0075 0.0043 0.2936
Schistosoma mansoni coup transcription factor 0.0044 0.0018 0.0018
Echinococcus granulosus phd:f box containing protein 0.0037 0.0012 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.5624 0.4484 1
Brugia malayi thymidylate synthase 1.1632 0.9292 1
Brugia malayi Latrophilin receptor protein 2 0.0113 0.0073 0.0077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0113 0.0073 0.0077
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0008 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0301 0.0322
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0037 0.0012 0.0007
Mycobacterium leprae Probable lipase LipE 0.0112 0.0072 0.0074
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0024 0.0397
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0018 0.0018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0113 0.0073 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.0178 0.0386
Plasmodium falciparum acyl-CoA synthetase 0.0209 0.015 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.0019
Loa Loa (eye worm) oxidoreductase 0.0082 0.0048 0.0051
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0039 0.004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0018 0.0018
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0014 0.0013
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0075 0.0043 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.0307 0.0228 0.0244
Leishmania major 4-coumarate:coa ligase-like protein 0.0279 0.0206 0.0201
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0016 0.0011
Schistosoma mansoni gabp alpha 0.007 0.0039 0.004
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0075 0.0043 1
Echinococcus multilocularis tumor protein p63 0.1085 0.0851 0.0914
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0048 0.0048
Mycobacterium ulcerans acetyl-CoA synthetase 0.0082 0.0048 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0024 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0011 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.0178 0.0386
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0008 0.0008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0016 0.0023
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0017 0.0014
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0082 0.0048 0.0045
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0072 0.0075
Onchocerca volvulus 0.0032 0.0009 0.0003
Echinococcus multilocularis Niemann Pick C1 protein 0.0766 0.0596 0.064
Loa Loa (eye worm) acetyltransferase 0.014 0.0094 0.01
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0075 0.0043 0.0043
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0279 0.0206 0.022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0029 0.0029
Brugia malayi hypothetical protein 0.5624 0.4484 0.4825
Brugia malayi Patched related family protein 10 0.0032 0.0009 0.0008
Toxoplasma gondii patched family protein 0.0032 0.0009 0.0005
Schistosoma mansoni hypothetical protein 0.0536 0.0411 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0024 0.0043
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0397 0.0301 0.0322
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0113 0.0073 0.0077
Leishmania major 4-coumarate:coa ligase-like protein 0.0279 0.0206 0.0201
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.0016 0.0011
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 1.2518 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0018 0.0018
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0018 0.0013
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0029 0.003
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0018 0.0018
Schistosoma mansoni phosphatidylserine receptor 0.0037 0.0012 0.0012
Echinococcus multilocularis JmjC domain containing protein 4 0.0037 0.0012 0.0011
Brugia malayi Bromodomain containing protein 0.0046 0.0019 0.0019
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0008 0.0003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0082 0.0048 0.0051
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0018 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0357 0.0268 0.0287
Schistosoma mansoni hypothetical protein 0.0113 0.0073 0.0077
Schistosoma mansoni microtubule-associated protein tau 0.2258 0.1789 0.1925
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0002 0.0002
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0001 0.0000047597
Brugia malayi hypothetical protein 0.0236 0.0171 0.0183
Brugia malayi jmjC domain containing protein 0.0037 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0082 0.0048 0.0043
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0072 0.0076
Brugia malayi jmjC domain containing protein 0.0037 0.0012 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0018 0.0018
Brugia malayi hypothetical protein 0.0028 0.0005 0.0004
Schistosoma mansoni peptidase Clp (S14 family) 0.0075 0.0043 0.0045
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0032 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0022 0.0022
Leishmania major hypothetical protein, conserved 0.0037 0.0012 0.0007
Plasmodium vivax JmjC domain containing protein 0.0037 0.0012 0.0008
Trichomonas vaginalis antibiotic synthetase, putative 0.0082 0.0048 0.0096
Schistosoma mansoni jumonji domain containing protein 0.0137 0.0092 0.0098
Brugia malayi PHD-finger family protein 0.0031 0.0007 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0018 0.0018
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.0048 0.0051
Loa Loa (eye worm) latrophilin receptor protein 2 0.0113 0.0073 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0018 0.0018
Toxoplasma gondii patched family protein 0.0032 0.0009 0.0005
Loa Loa (eye worm) thymidylate synthase 1.1632 0.9292 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0012 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0018 0.0018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0024 0.0019
Brugia malayi Patched related family protein 12 0.0032 0.0009 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0357 0.0268 0.0287
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0029 0.003
Brugia malayi hypothetical protein 0.0032 0.0009 0.0008
Echinococcus multilocularis expressed conserved protein 0.0503 0.0385 0.0413
Onchocerca volvulus 0.0159 0.011 0.0111
Schistosoma mansoni phd/f-box containing protein 0.0037 0.0012 0.0012
Schistosoma mansoni transcription factor LCR-F1 0.0236 0.0171 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0279 0.0206 0.0221
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0048 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0018 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0279 0.0206 0.0209
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.0178 0.0386
Brugia malayi Patched family protein 0.0032 0.0009 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0072 0.0149
Entamoeba histolytica hypothetical protein 0.0236 0.0171 0.4043
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0072 0.0072
Brugia malayi follicle stimulating hormone receptor 0.0264 0.0194 0.0207
Onchocerca volvulus Protein patched homolog 0.0032 0.0009 0.0003

Activities

Activity type Activity value Assay description Source Reference
Kd (functional) = 7.71 Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion ChEMBL. 18289857
Ki (binding) = -8.02 Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells ChEMBL. 18289857
Ki (binding) = -5.63 Displacement of [3H]L364718 from human recombinant CCK1 receptor expressed in CHO-K1 cells ChEMBL. 18289857
Log Ki (binding) = 5.63 Displacement of [3H]L364718 from human recombinant CCK1 receptor expressed in CHO-K1 cells ChEMBL. 18289857
Log Ki (binding) = 8.02 Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells ChEMBL. 18289857
pA2 (functional) = 7.71 Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion ChEMBL. 18289857

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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