Detailed information for compound 515425

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 905.04 | Formula: C45H78O14P2
  • H donors: 0 H acceptors: 6 LogP: 11.89 Rotable bonds: 32
    Rule of 5 violations (Lipinski): 2
  • SMILES: C/C(=C/CC(P(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)(P(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C/C=C(\CCC=C(C)C)/C)/CCC=C(C)C
  • InChi: 1S/C45H78O14P2/c1-33(2)21-19-23-35(5)25-27-45(28-26-36(6)24-20-22-34(3)4,60(50,56-29-52-37(46)41(7,8)9)57-30-53-38(47)42(10,11)12)61(51,58-31-54-39(48)43(13,14)15)59-32-55-40(49)44(16,17)18/h21-22,25-26H,19-20,23-24,27-32H2,1-18H3/b35-25-,36-26-
  • InChiKey: PCSFTZHNYWJSHB-SDURLSCFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax SET domain protein, putative 0.0034 0.0289 0.1233
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0066 0.0016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.1084 0.5396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0561 0.0561
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0316 0.0348
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0055 0.062 0.0753
Onchocerca volvulus 0.0034 0.0289 0.0721
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0625 0.0625
Entamoeba histolytica Thymidylate kinase, putative 0.0141 0.1962 0.254
Echinococcus multilocularis smad 0.0035 0.0307 0.0307
Trypanosoma brucei thymidylate kinase, putative 0.0141 0.1962 0.254
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0059
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.15 0.1901
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.1433 0.1433
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0289 0.0289
Schistosoma mansoni ap endonuclease 0.0019 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.1084 0.4983
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.2625 0.654
Brugia malayi MH2 domain containing protein 0.0035 0.0307 0.0389
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.1084 0.5396
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0054 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.0016
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0712 0.0712
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2992 0.2992
Loa Loa (eye worm) hypothetical protein 0.0034 0.0289 0.0289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0531 0.0531
Trichomonas vaginalis ran, putative 0.0045 0.0459 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2992 0.2992
Schistosoma mansoni smad1 5 8 and 0.0035 0.0307 0.0307
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0066 0.0066
Echinococcus multilocularis ribonuclease H1 0.0022 0.0093 0.0093
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0181 0.0181
Brugia malayi RNase H family protein 0.0022 0.0093 0.0118
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0181 0.0169
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0531 0.0634
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0459 0.2121
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0316 0.0316
Trypanosoma brucei RNA helicase, putative 0.0218 0.3163 0.4138
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0316 0.1372
Echinococcus multilocularis transfer RNA-Ile 0.0249 0.3661 0.3661
Echinococcus granulosus glycogen phosphorylase 0.0107 0.1433 0.1433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0289 0.0289
Echinococcus granulosus dna polymerase kappa 0.002 0.0066 0.0066
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0066 0.0016
Schistosoma mansoni hypothetical protein 0.0052 0.0561 0.0561
Schistosoma mansoni smad1 5 8 and 0.0035 0.0307 0.0307
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.2309 0.2309
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1773 0.1773
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0211 0.0822
Echinococcus granulosus tar DNA binding protein 0.0207 0.2992 0.2992
Giardia lamblia Deoxynucleoside kinase 0.04 0.6027 0.7951
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0093 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0531 0.0531
Treponema pallidum ribonuclease H (rnhA) 0.0022 0.0093 0.0205
Loa Loa (eye worm) glycogen phosphorylase 0.0107 0.1433 0.1433
Schistosoma mansoni thymidylate kinase 0.0141 0.1962 0.1962
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0141 0.1962 1
Trichomonas vaginalis importin beta-1, putative 0.005 0.0531 0.0634
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.027 0.027
Brugia malayi Inositol-1 0.0036 0.0316 0.04
Echinococcus multilocularis geminin 0.036 0.5393 0.5393
Loa Loa (eye worm) transcription factor SMAD2 0.0519 0.7891 0.7891
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2992 0.2992
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0316 0.0348
Entamoeba histolytica hypothetical protein 0.005 0.0531 0.0634
Trypanosoma brucei thymidine kinase 0.0499 0.7566 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0307 0.0307
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0066 0.0084
Brugia malayi hypothetical protein 0.0027 0.0181 0.023
Toxoplasma gondii thymidylate kinase 0.0141 0.1962 1
Brugia malayi Importin beta-1 subunit 0.0061 0.0712 0.0902
Schistosoma mansoni hypothetical protein 0.0052 0.0561 0.0561
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0531 0.0634
Schistosoma mansoni hypothetical protein 0.0052 0.0561 0.0561
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0066 0.0063
Schistosoma mansoni glycogen phosphorylase 0.0107 0.1433 0.1433
Trypanosoma cruzi thymidine kinase, putative 0.0499 0.7566 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Schistosoma mansoni inositol monophosphatase 0.0036 0.0316 0.0316
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0066 0.0084
Trypanosoma brucei unspecified product 0.002 0.0066 0.0016
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0459 0.2121
Loa Loa (eye worm) hypothetical protein 0.0052 0.0561 0.0561
Leishmania major ribonuclease H1, putative 0.0022 0.0093 0.0052
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0459 0.2121
Echinococcus granulosus smad 0.0035 0.0307 0.0307
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2992 0.2992
Mycobacterium ulcerans thymidylate kinase 0.0141 0.1962 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.1433 0.1836
Plasmodium falciparum thymidylate kinase 0.0141 0.1962 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0307 0.0307
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0257 0.1062
Schistosoma mansoni phosphoglucomutase 0.0022 0.0093 0.0093
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0093 0.0205
Trypanosoma cruzi thymidine kinase, putative 0.0499 0.7566 1
Loa Loa (eye worm) RNA binding protein 0.0207 0.2992 0.2992
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0141 0.1962 1
Echinococcus granulosus dna polymerase eta 0.002 0.0066 0.0066
Echinococcus granulosus importin subunit beta 1 0.0061 0.0712 0.0712
Giardia lamblia CDC8 0.0141 0.1962 0.254
Schistosoma mansoni glycogen phosphorylase 0.0046 0.0479 0.0479
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.2309 0.2926
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0307 0.0307
Echinococcus granulosus Glycosyl transferase family 35 0.0107 0.1433 0.1433
Loa Loa (eye worm) hypothetical protein 0.0061 0.0712 0.0712
Echinococcus multilocularis dna polymerase kappa 0.002 0.0066 0.0066
Echinococcus multilocularis Glycosyl transferase, family 35 0.0107 0.1433 0.1433
Echinococcus granulosus Smad4 0.0035 0.0307 0.0307
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0055 0.062 0.0753
Trypanosoma brucei unspecified product 0.0027 0.017 0.0155
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.1084 0.5396
Loa Loa (eye worm) hypothetical protein 0.0112 0.15 0.15
Echinococcus granulosus ribonuclease H1 0.0022 0.0093 0.0093
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0459 0.0459
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0561 0.0561
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0316 0.1372
Brugia malayi N-terminal motif family protein 0.0183 0.2625 0.3327
Leishmania major thymidylate kinase-like protein 0.0141 0.1962 0.254
Echinococcus granulosus geminin 0.036 0.5393 0.5393
Brugia malayi Pre-SET motif family protein 0.0034 0.0289 0.0367
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0141 0.1962 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0066 0.0066
Brugia malayi thymidylate kinase 0.0141 0.1962 0.2486
Schistosoma mansoni smad 0.0035 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0654 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0316 0.0348
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.1433 0.1433
Schistosoma mansoni glycogen phosphorylase 0.0107 0.1433 0.1433
Trichomonas vaginalis set domain proteins, putative 0.0272 0.4014 0.5272
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.1084 0.1084
Brugia malayi MH1 domain containing protein 0.002 0.0059 0.0075
Trichomonas vaginalis thymidine kinase, putative 0.0499 0.7566 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0316 0.0348
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0625 0.2992
Chlamydia trachomatis thymidylate kinase 0.0141 0.1962 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0066 0.0066
Echinococcus multilocularis tar DNA binding protein 0.0207 0.2992 0.2992
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Brugia malayi MH1 domain containing protein 0.002 0.0059 0.0075
Brugia malayi hypothetical protein 0.0018 0.0029 0.0037
Echinococcus multilocularis thymidine kinase 0.0249 0.3661 0.3661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0289 0.0289
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0561 0.0561
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.017 0.0155
Schistosoma mansoni phosphoglucomutase 0.0022 0.0093 0.0093
Schistosoma mansoni smad1 5 8 and 0.0035 0.0307 0.0307
Loa Loa (eye worm) nuclear factor I 0.002 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0066
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0307 0.0307
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0181 0.0169
Loa Loa (eye worm) hypothetical protein 0.0085 0.1084 0.1084
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0479 0.0566
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0625 0.0625
Trypanosoma brucei thymidylate kinase, putative 0.0141 0.1962 0.254
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0066 0.0016
Treponema pallidum thymidylate kinase (tmk) 0.0141 0.1962 1
Brugia malayi MH1 domain containing protein 0.0035 0.0307 0.0389
Trypanosoma brucei ribonuclease H1 0.0022 0.0093 0.0052
Leishmania major DNA polymerase eta, putative 0.002 0.0066 0.0016
Schistosoma mansoni thymidine kinase 0.0249 0.3661 0.3661
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0459 0.0539
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.017 0.0155
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0459 0.0539
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.1084 0.5396
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.2992 0.3792
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0046 0.0479 0.2227
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0625 0.2364
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0066 0.0066
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.1084 0.5396
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0066 0.0016
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0459 0.0581
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0066 0.0016
Toxoplasma gondii hypothetical protein 0.0029 0.0211 0.0822
Schistosoma mansoni hypothetical protein 0.0053 0.0582 0.0582
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.0016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0289 0.0289
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0181 0.0667
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.1084 0.5396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0654 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0316 0.0348
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0257 0.0262
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0066 0.0016
Schistosoma mansoni hypothetical protein 0.036 0.5393 0.5393
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0625 0.2992
Brugia malayi Pre-SET motif family protein 0.0239 0.3497 0.4431
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.1084 0.1084
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.1084 0.1084
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.036 0.5393 0.5393
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0289 0.0289
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0307 0.0307
Brugia malayi RNase H family protein 0.0022 0.0093 0.0118
Echinococcus multilocularis dna polymerase eta 0.002 0.0066 0.0066
Giardia lamblia Glycogen phosphorylase 0.0107 0.1433 0.1836
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.1084 0.5396
Brugia malayi carbohydrate phosphorylase 0.0107 0.1433 0.1816
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0066 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0531 0.0531
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0561 0.0711
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0181 0.0169
Brugia malayi MH2 domain containing protein 0.0035 0.0307 0.0389
Echinococcus granulosus thymidine kinase 0.0249 0.3661 0.3661
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0531 0.0531
Echinococcus granulosus thymidine kinase 0.0249 0.3661 0.3661
Entamoeba histolytica thymidine kinase, putative 0.0499 0.7566 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0531 0.0634
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0316 0.0348
Onchocerca volvulus Putative thymidylate kinase 0.0141 0.1962 0.4888
Schistosoma mansoni ran 0.0045 0.0459 0.0459
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.0016
Trichomonas vaginalis thymidine kinase, putative 0.0499 0.7566 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0066 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.2309 0.2926
Loa Loa (eye worm) inositol-1 0.0036 0.0316 0.0316
Trypanosoma cruzi thymidylate kinase, putative 0.0141 0.1962 0.254
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0307 0.0307
Brugia malayi MH2 domain containing protein 0.0519 0.7891 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0316 0.1372
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0561 0.0711
Schistosoma mansoni ran 0.0045 0.0459 0.0459
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0459 0.0539
Entamoeba histolytica Ran family GTPase 0.0045 0.0459 0.0539
Leishmania major importin beta-1 subunit, putative 0.005 0.0531 0.0634
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.1433 0.1836
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0066 0.0063
Echinococcus multilocularis snurportin 1 0.0654 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0712 0.3449
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0046 0.0479 0.2227
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0459 0.0459
Trypanosoma cruzi thymidylate kinase, putative 0.0141 0.1962 0.254
Entamoeba histolytica glycogenphosphorylase, putative 0.0046 0.0479 0.0566
Brugia malayi Probable ClpP-like protease 0.0085 0.1084 0.1373
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0307 0.0307
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0289 0.0289
Brugia malayi RNA binding protein 0.0207 0.2992 0.3792
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0712 0.0876
Schistosoma mansoni hypothetical protein 0.0218 0.3163 0.3163
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.0093 0.0205
Schistosoma mansoni ap endonuclease 0.0019 0.0054 0.0054
Trichomonas vaginalis thymidylate kinase, putative 0.0141 0.1962 0.254
Echinococcus multilocularis thyroid hormone receptor alpha 0.0139 0.1935 0.1935
Giardia lamblia Ribonuclease H 0.0022 0.0093 0.0052
Plasmodium vivax thymidylate kinase, putative 0.0141 0.1962 1
Schistosoma mansoni thyroid hormone receptor 0.0139 0.1935 0.1935
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0093 0.0052
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0712 0.0876
Plasmodium vivax importin-beta 2, putative 0.0061 0.0712 0.3449
Schistosoma mansoni importin beta-1 0.0061 0.0712 0.0712
Echinococcus multilocularis thymidine kinase 0.0249 0.3661 0.3661
Schistosoma mansoni DNA polymerase eta 0.002 0.0066 0.0066
Plasmodium falciparum importin beta, putative 0.0061 0.0712 0.3449
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.3497 0.3497
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0066 0.0066
Brugia malayi RNA, U transporter 1 0.0174 0.2482 0.3145
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0066 0.0063
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.017 0.0155
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0181 0.0667
Schistosoma mansoni hypothetical protein 0.0129 0.1773 0.1773
Brugia malayi TAR-binding protein 0.0207 0.2992 0.3792
Trichomonas vaginalis thymidylate kinase, putative 0.0141 0.1962 0.254
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.1433 0.1836
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0181 0.0667
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0289 0.1233
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.0016
Schistosoma mansoni hypothetical protein 0.0112 0.15 0.15
Loa Loa (eye worm) Smad1 0.0035 0.0307 0.0307
Loa Loa (eye worm) MH2 domain-containing protein 0.0519 0.7891 0.7891
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2992 0.2992
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0211 0.0822
Schistosoma mansoni hypothetical protein 0.0052 0.0561 0.0561
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.2992 0.2992
Brugia malayi MH1 domain containing protein 0.0035 0.0307 0.0389
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.0016
Chlamydia trachomatis glycogen phosphorylase 0.0107 0.1433 0.3981
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1773 0.1773
Echinococcus granulosus glycogen phosphorylase 0.0107 0.1433 0.1433
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0561 0.0561
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0316 0.0348
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0181 0.0667
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0459 0.0539
Loa Loa (eye worm) thymidylate kinase 0.0141 0.1962 0.1962
Echinococcus multilocularis GPCR, family 2 0.0052 0.0561 0.0561
Leishmania major hypothetical protein, conserved 0.0027 0.0181 0.0169
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0531 0.0531
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.0093 0.0232
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0479 0.0566
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0016
Schistosoma mansoni thymidylate kinase 0.0141 0.1962 0.1962
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0289 0.0289
Echinococcus granulosus GPCR family 2 0.0052 0.0561 0.0561
Leishmania major hypothetical protein, conserved 0.0055 0.062 0.0753
Onchocerca volvulus Glycogen phosphorylase homolog 0.0107 0.1433 0.357
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0459 0.0459
Giardia lamblia Thymidine kinase 0.0499 0.7566 1
Echinococcus multilocularis Smad4 0.0035 0.0307 0.0307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0531 0.0673
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.1433 0.1836
Brugia malayi RNase H family protein 0.0022 0.0093 0.0118
Echinococcus granulosus thymidylate kinase 0.0141 0.1962 0.1962
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0093 0.0052
Onchocerca volvulus 0.0272 0.4014 1
Leishmania major thymidine kinase, putative 0.0499 0.7566 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0316 0.0348
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0054 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0531 0.0531
Giardia lamblia DINP protein human, muc B family 0.002 0.0066 0.0016
Loa Loa (eye worm) hypothetical protein 0.0183 0.2625 0.2625
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0561 0.0561
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0054 0.0054
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0211 0.0822
Schistosoma mansoni thyroid hormone receptor 0.0139 0.1935 0.1935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0531 0.0531
Schistosoma mansoni Smad4 0.0035 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0141 0.1962 0.1962
Echinococcus multilocularis thymidylate kinase 0.0141 0.1962 0.1962
Trichomonas vaginalis thymidine kinase, putative 0.0499 0.7566 1
Leishmania major GTP-binding protein, putative 0.0045 0.0459 0.0539
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0531 0.0531
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0249 0.3661 0.3661
Schistosoma mansoni phosphoglucomutase 0.0022 0.0093 0.0093
Brugia malayi Smad1 0.0035 0.0307 0.0389
Loa Loa (eye worm) hypothetical protein 0.0163 0.2309 0.2309
Schistosoma mansoni inositol monophosphatase 0.0036 0.0316 0.0316
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0027 0.017 0.0155
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.1084 0.5396
Loa Loa (eye worm) TAR-binding protein 0.0207 0.2992 0.2992

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 10 uM Inhibition of Rap1a protein modification in human K562 cells by Western blot relative to lovastatin ChEMBL. 18308574
Activity (functional) = 10 uM Inhibition of Rap1a protein modification in human K562 cells by Western blot relative to lovastatin ChEMBL. 18308574
GI50 (functional) > 100 uM Growth inhibition of human K562 cells after 24 hrs ChEMBL. 18308574
GI50 (functional) > 100 uM Growth inhibition of human K562 cells after 24 hrs ChEMBL. 18308574

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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