Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | adenosine deaminase-related growth factor | Adenosine deaminase | 363 aa | 299 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Niemann Pick C1 protein | 0.018 | 0.2293 | 0.2293 |
Trichomonas vaginalis | conserved hypothetical protein | 0.018 | 0.2293 | 0.7529 |
Treponema pallidum | adenosine deaminase | 0.0104 | 0 | 0.5 |
Echinococcus multilocularis | protein patched | 0.018 | 0.2293 | 0.2293 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0104 | 0 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0438 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0438 | 1 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.018 | 0.2293 | 0.2293 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0104 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0206 | 0.3046 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0206 | 0.3046 | 1 |
Schistosoma mansoni | patched 1 | 0.018 | 0.2293 | 0.2293 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.018 | 0.2293 | 0.2293 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.018 | 0.2293 | 0.2293 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.018 | 0.2293 | 0.2293 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0438 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0104 | 0 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0206 | 0.3046 | 0.5 |
Brugia malayi | CHE-14 protein | 0.018 | 0.2293 | 0.2293 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2293 | 0.2293 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0438 | 1 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.018 | 0.2293 | 0.2293 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0206 | 0.3046 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 0 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0104 | 0 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.018 | 0.2293 | 0.2293 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0438 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.018 | 0.2293 | 0.2293 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0438 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0438 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0438 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.96 uM | Evaluated for the inhibition of calf intestinal Adenosine deaminase (ADA) | ChEMBL. | 10780906 |
Ki (binding) | = 0.96 uM | Evaluated for the inhibition of calf intestinal Adenosine deaminase (ADA) | ChEMBL. | 10780906 |
Ki (binding) | = 55 uM | Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA) | ChEMBL. | 10780906 |
Ki (binding) | = 55 uM | Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA) | ChEMBL. | 10780906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.