Detailed information for compound 515487

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.43 | Formula: C23H22F2N2O
  • H donors: 1 H acceptors: 1 LogP: 4.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)NC1CCN(CC1)Cc1ccc2c(c1)ccc(c2)F
  • InChi: 1S/C23H22F2N2O/c24-20-6-3-17(4-7-20)23(28)26-22-9-11-27(12-10-22)15-16-1-2-19-14-21(25)8-5-18(19)13-16/h1-8,13-14,22H,9-12,15H2,(H,26,28)
  • InChiKey: GVYDSNDGNRGVMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neurogenic locus notch protein 4 0.0561 0.1902 0.3373
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Loa Loa (eye worm) PAN domain-containing protein 0.0502 0.1699 0.1694
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Onchocerca volvulus 0.2309 0.7907 0.7905
Brugia malayi EGF-like domain containing protein 0.0561 0.1902 0.1898
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.1093 0.3729 0.3726
Schistosoma mansoni cpg binding protein 0.0031 0.008 0.0071
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1676 0.5732 1
Schistosoma mansoni cpg binding protein 0.0031 0.008 0.0071
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0028 0.0092
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.001 0.001 0.0008
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1676 0.5732 1
Plasmodium falciparum cysteine repeat modular protein 1 0.1618 0.5534 0.9655
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0502 0.1699 0.1694
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.0008
Plasmodium vivax cysteine repeat modular protein 1, putative 0.1618 0.5534 0.9655
Echinococcus multilocularis slit 2 protein 0.0561 0.1902 0.3373
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.001 0.0005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0028 0.0018
Brugia malayi Dihydrofolate reductase 0.0485 0.1642 0.1638
Brugia malayi notch-like transmembrane receptor 0.0561 0.1902 0.1898
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0011 0.0001
Echinococcus multilocularis fibropellin Ia 0.0561 0.1902 0.3373
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.001 0.001 0.0008
Leishmania major protein kinase, putative 0.001 0.0011 0.0001
Trypanosoma brucei Flagellar Member 6 0.001 0.001 0.0018
Giardia lamblia CDC8 0.007 0.0217 0.1091
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0609 0.2068 0.3667
Loa Loa (eye worm) Notch2 0.0562 0.1907 0.1902
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0609 0.2068 0.3667
Entamoeba histolytica protein kinase, putative 0.0029 0.0075 0.1129
Echinococcus multilocularis tissue type plasminogen activator 0.1618 0.5534 0.9833
Entamoeba histolytica Thymidylate kinase, putative 0.007 0.0217 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0057 0.0082
Schistosoma mansoni laminin gamma-3 chain 0.0561 0.1902 0.1894
Echinococcus granulosus fibropellin Ia 0.0561 0.1902 0.3373
Chlamydia trachomatis thymidylate kinase 0.007 0.0217 0.1265
Giardia lamblia High cysteine protein 0.0561 0.1902 1
Loa Loa (eye worm) trypsin family protein 0.0609 0.2068 0.2063
Loa Loa (eye worm) hypothetical protein 0.0609 0.2068 0.2063
Brugia malayi Calcium binding EGF domain containing protein 0.1093 0.3729 0.3726
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.0243 0.0422
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0057 0.0052
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0057 0.0116
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0225 0.1127
Echinococcus granulosus neurogenic locus notch protein 0.0561 0.1902 0.3373
Echinococcus granulosus tissue type plasminogen activator 0.1618 0.5534 0.9833
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1191 0.4064 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0015 0.0028 0.0023
Toxoplasma gondii hypothetical protein 0.0502 0.1699 0.2539
Brugia malayi hypothetical protein 0.0566 0.192 0.1916
Loa Loa (eye worm) hypothetical protein 0.0502 0.1699 0.1694
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.001 0.0004
Onchocerca volvulus 0.0561 0.1902 0.1894
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0036 0.0161
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.001 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Echinococcus multilocularis neurogenic locus protein delta 0.0561 0.1902 0.3373
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Loa Loa (eye worm) hypothetical protein 0.2919 1 1
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0561 0.1902 0.1894
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0075 0.0069
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.001 0.001 0.0008
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0028 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.001 0.0005
Onchocerca volvulus 0.0609 0.2068 0.206
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.001 0.0008
Brugia malayi Calcium binding EGF domain containing protein 0.0561 0.1902 0.1898
Schistosoma mansoni hypothetical protein 0.007 0.0217 0.0207
Echinococcus multilocularis fat cadherin tumor suppressor 0.0561 0.1902 0.3373
Brugia malayi EGF-like domain containing protein 0.0561 0.1902 0.1898
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0015 0.0028 0.0039
Loa Loa (eye worm) notch protein 0.0561 0.1902 0.1897
Brugia malayi Muscle positioning protein 4 0.0561 0.1902 0.1898
Loa Loa (eye worm) steroid hormone receptor 0.001 0.001 0.0004
Leishmania major hypothetical protein, conserved 0.1618 0.5534 0.9655
Echinococcus granulosus neurogenic locus notch protein 0.0561 0.1902 0.3373
Echinococcus multilocularis neurogenic locus notch protein 0.0561 0.1902 0.3373
Echinococcus granulosus cyclic nucleotide gated cation channel 0.001 0.001 0.0008
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0561 0.1902 0.1898
Schistosoma mansoni dihydrofolate reductase 0.0485 0.1642 0.1634
Toxoplasma gondii kringle domain-containing protein 0.1618 0.5534 0.8306
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.002
Loa Loa (eye worm) AGC/PKG protein kinase 0.001 0.0011 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.001 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0093 0.0088
Echinococcus granulosus dnaJ subfamily B 0.0414 0.1398 0.2477
Toxoplasma gondii microneme protein, putative 0.0502 0.1699 0.2539
Toxoplasma gondii calcium binding egf domain-containing protein 0.1093 0.3729 0.5592
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0036 0.0065
Loa Loa (eye worm) thymidylate kinase 0.007 0.0217 0.0211
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0609 0.2068 0.206
Echinococcus granulosus GPCR family 2 0.0016 0.003 0.0043
Schistosoma mansoni notch 0.0561 0.1902 0.1894
Brugia malayi Egg laying defective protein 4 0.001 0.0011 0.0006
Echinococcus granulosus cGMP dependent protein kinase 1 0.001 0.0011 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.001 0.0008
Brugia malayi thymidylate kinase 0.007 0.0217 0.0211
Onchocerca volvulus 0.0561 0.1902 0.1894
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0566 0.192 0.3338
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Leishmania major protein kinase, putative 0.001 0.0011 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0057 0.0082
Schistosoma mansoni thymidylate kinase 0.007 0.0217 0.0207
Onchocerca volvulus 0.0502 0.1699 0.169
Toxoplasma gondii PAN domain-containing protein 0.0502 0.1699 0.2539
Mycobacterium ulcerans thymidylate kinase 0.007 0.0217 0.0509
Brugia malayi ecdysteroid receptor 0.001 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0005
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0028 0.0018
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0028 0.0039
Echinococcus multilocularis enteropeptidase 0.1646 0.5628 1
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.001 0.001 0.0008
Mycobacterium tuberculosis Hypothetical protein 0.0566 0.192 0.4711
Schistosoma mansoni notch 0.0561 0.1902 0.1894
Brugia malayi Steroid receptor seven-up type 2 0.001 0.001 0.0005
Trypanosoma brucei protein kinase A regulatory subunit 0.001 0.001 0.0018
Onchocerca volvulus 0.1618 0.5534 0.553
Echinococcus granulosus protein jagged 2 0.0561 0.1902 0.3373
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1646 0.5628 0.5624
Brugia malayi CXXC zinc finger family protein 0.0029 0.0075 0.0069
Toxoplasma gondii microneme protein MIC17C 0.0502 0.1699 0.2539
Brugia malayi Cadherin domain containing protein 0.0561 0.1902 0.1898
Schistosoma mansoni cell polarity protein 0.0561 0.1902 0.1894
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2919 1 1
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0502 0.1699 0.2539
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0075 0.0065
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0028 0.0039
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0036 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0004
Echinococcus granulosus neurogenic locus protein delta 0.0561 0.1902 0.3373
Echinococcus granulosus cGMP dependent protein kinase 1 0.001 0.0011 0.0009
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Trypanosoma cruzi thymidylate kinase, putative 0.007 0.0217 0.0361
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Schistosoma mansoni hypothetical protein 0.0035 0.0093 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0566 0.192 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.001 0.0005
Trypanosoma brucei thymidylate kinase, putative 0.007 0.0217 0.0378
Schistosoma mansoni notch 0.0561 0.1902 0.1894
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Loa Loa (eye worm) hypothetical protein 0.1093 0.3729 0.3725
Leishmania major thymidylate kinase-like protein 0.007 0.0217 0.0361
Brugia malayi Cadherin domain containing protein 0.0561 0.1902 0.1898
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0052
Brugia malayi EGF-like domain containing protein 0.0561 0.1902 0.1898
Trypanosoma brucei cAMP binding protein, putative 0.001 0.001 0.0018
Toxoplasma gondii PAN domain-containing protein 0.1946 0.6661 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0004
Echinococcus granulosus Mastin 0.1646 0.5628 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0268 0.0258
Brugia malayi steroid hormone receptor 0.001 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0004
Onchocerca volvulus Arrow homolog 0.1093 0.3729 0.3723
Echinococcus granulosus FTZ F1 alpha 0.001 0.001 0.0008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0225 0.1127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0022
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0609 0.2068 0.3667
Onchocerca volvulus 0.0561 0.1902 0.1894
Onchocerca volvulus 0.0502 0.1699 0.169
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.0043
Brugia malayi Calcium binding EGF domain containing protein 0.0561 0.1902 0.1898
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0004
Echinococcus granulosus enteropeptidase 0.1646 0.5628 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Schistosoma mansoni notch 0.0561 0.1902 0.1894
Schistosoma mansoni hypothetical protein 0.0561 0.1902 0.1894
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.001 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0031
Toxoplasma gondii PAN domain-containing protein 0.0502 0.1699 0.2539
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0031
Brugia malayi Fibulin-1 precursor 0.1093 0.3729 0.3726
Schistosoma mansoni notch 0.0561 0.1902 0.1894
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0057 0.0116
Brugia malayi dihydrofolate reductase family protein 0.0485 0.1642 0.1638
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.001 0.001 0.0005
Toxoplasma gondii hypothetical protein 0.0502 0.1699 0.2539
Loa Loa (eye worm) hypothetical protein 0.0502 0.1699 0.1694
Loa Loa (eye worm) bone morphogenetic protein 1b 0.1093 0.3729 0.3725
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0052 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0057 0.0116
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.0243 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.1618 0.5534 0.9655
Onchocerca volvulus 0.0024 0.0057 0.0047
Onchocerca volvulus 0.0561 0.1902 0.1894
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1676 0.5732 1
Loa Loa (eye worm) hypothetical protein 0.0609 0.2068 0.2063
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.1093 0.3729 0.3725
Echinococcus multilocularis GPCR, family 2 0.0016 0.003 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0017 0.0007
Onchocerca volvulus 0.0502 0.1699 0.169
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0028 0.0039
Brugia malayi nuclear hormone receptor 0.001 0.001 0.0005
Echinococcus multilocularis protein jagged 1 0.0561 0.1902 0.3373
Onchocerca volvulus 0.0609 0.2068 0.206
Toxoplasma gondii microneme protein MIC17A 0.0502 0.1699 0.2539
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0052
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2919 1 1
Loa Loa (eye worm) PAN domain-containing protein 0.0502 0.1699 0.1694
Brugia malayi Trypsin family protein 0.0609 0.2068 0.2063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0143
Toxoplasma gondii PAN/Apple domain-containing protein 0.0502 0.1699 0.2539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.0008
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0015 0.0028 0.0039
Chlamydia trachomatis dihydrofolate reductase 0.0485 0.1642 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0609 0.2068 0.3667
Brugia malayi hypothetical protein 0.0609 0.2068 0.2063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0033 0.0056
Onchocerca volvulus 0.1191 0.4064 0.4058
Brugia malayi Trypsin family protein 0.0609 0.2068 0.2063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0005
Echinococcus granulosus dihydrofolate reductase 0.0485 0.1642 0.2911
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0485 0.1642 0.4026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.001 0.0008
Schistosoma mansoni thymidylate kinase 0.007 0.0217 0.0207
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0028 0.0018
Echinococcus multilocularis Tolloid protein 1 0.1093 0.3729 0.6622
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0029 0.0075 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.001 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0052 0.0083
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0029 0.0075 0.0124
Schistosoma mansoni hypothetical protein 0.1618 0.5534 0.553
Echinococcus granulosus protein jagged 1 0.0561 0.1902 0.3373
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.002
Loa Loa (eye worm) hypothetical protein 0.1093 0.3729 0.3725
Brugia malayi Ribonuclease 2-5A family protein 0.0029 0.0075 0.007
Onchocerca volvulus Neurogenic locus notch homolog 0.0561 0.1902 0.1894
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0011 0.0001
Plasmodium falciparum cGMP-dependent protein kinase 0.001 0.0011 0.0001
Echinococcus multilocularis patatin phospholipase domain containing protein 0.001 0.001 0.0008
Plasmodium vivax thymidylate kinase, putative 0.007 0.0217 0.0361
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.003 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0005
Brugia malayi GCC2 and GCC3 family protein 0.0561 0.1902 0.1898
Loa Loa (eye worm) dihydrofolate reductase 0.0485 0.1642 0.1638
Echinococcus granulosus neural cadherin 0.0561 0.1902 0.3373
Brugia malayi Latrophilin receptor protein 2 0.0016 0.003 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.001 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Echinococcus multilocularis neurogenic locus notch protein 4 0.0561 0.1902 0.3373
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0011 0.0001
Schistosoma mansoni 60S ribosomal protein L21 0.0012 0.0017 0.0007
Echinococcus multilocularis protein jagged 1 0.0561 0.1902 0.3373
Schistosoma mansoni hypothetical protein 0.0609 0.2068 0.206
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0028 0.007 0.0104
Loa Loa (eye worm) hypothetical protein 0.0609 0.2068 0.2063
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.007 0.0217 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0502 0.1699 0.1694
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0028 0.0022
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.001 0.001 0.0008
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1191 0.4064 0.4058
Echinococcus granulosus thymidylate synthase 0.1191 0.4064 0.7218
Echinococcus granulosus protein jagged 1 0.0561 0.1902 0.3373
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0057 0.0052
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0028 0.0018
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Schistosoma mansoni egf-like domain protein 0.1093 0.3729 0.3723
Loa Loa (eye worm) hypothetical protein 0.0502 0.1699 0.1694
Echinococcus multilocularis neural cadherin 0.0561 0.1902 0.3373
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0057 0.0116
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0164 0.0231
Loa Loa (eye worm) IRE protein kinase 0.0029 0.0075 0.007
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Echinococcus multilocularis transmembrane protease serine 3 0.0609 0.2068 0.3667
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0057 0.0116
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.001 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Brugia malayi Kringle domain containing protein 0.1618 0.5534 0.5532
Loa Loa (eye worm) TK/ROR protein kinase 0.1618 0.5534 0.5532
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0052 0.0043
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.001 0.0004
Onchocerca volvulus Slit protein homolog 0.0561 0.1902 0.1894
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.1398 0.2477
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0485 0.1642 0.4026
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0057 0.0052
Echinococcus granulosus patatin phospholipase domain containing protein 0.001 0.001 0.0008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Schistosoma mansoni hypothetical protein 0.0561 0.1902 0.1894
Echinococcus granulosus Tolloid protein 1 0.1093 0.3729 0.6622
Echinococcus multilocularis dihydrofolate reductase 0.0485 0.1642 0.2911
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0057 0.0116
Loa Loa (eye worm) hypothetical protein 0.0068 0.0208 0.0202
Onchocerca volvulus 0.0502 0.1699 0.169
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.001 0.001 0.0018
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.002
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1676 0.5732 1
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Loa Loa (eye worm) thymidylate synthase 0.1191 0.4064 0.4061
Loa Loa (eye worm) hypothetical protein 0.2919 1 1
Echinococcus granulosus glycoprotein Antigen 5 0.1646 0.5628 1
Brugia malayi Calcium binding EGF domain containing protein 0.0561 0.1902 0.1898
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0004
Toxoplasma gondii PAN domain-containing protein 0.0502 0.1699 0.2539
Toxoplasma gondii thymidylate kinase 0.007 0.0217 0.031
Brugia malayi Delta serrate ligand family protein 0.0561 0.1902 0.1898
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.001 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.001 0.001 0.0008
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0052 0.0083
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.1093 0.3729 0.3725
Brugia malayi Trypsin-like protease protein 5 0.0609 0.2068 0.2063
Trichomonas vaginalis thymidylate kinase, putative 0.007 0.0217 0.1081
Onchocerca volvulus 0.0561 0.1902 0.1894
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.007 0.0217 0.0509
Echinococcus multilocularis Mastin 0.1646 0.5628 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0028 0.0039
Brugia malayi thymidylate synthase 0.1191 0.4064 0.4061
Treponema pallidum thymidylate kinase (tmk) 0.007 0.0217 1
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.001 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0052
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0057 0.0116
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.001 0.0008
Onchocerca volvulus 0.0609 0.2068 0.206
Trypanosoma cruzi thymidylate kinase, putative 0.007 0.0217 0.0361
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0057 0.0116
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0609 0.2068 0.206
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0088
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0609 0.2068 0.206
Loa Loa (eye worm) PAN domain-containing protein 0.0502 0.1699 0.1694
Echinococcus multilocularis laminin 0.1093 0.3729 0.6622
Trypanosoma brucei cAMP response protein 1, putative 0.001 0.001 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0033 0.0056
Schistosoma mansoni notch 0.0561 0.1902 0.1894
Toxoplasma gondii subtilisin SUB12 0.0502 0.1699 0.2539
Schistosoma mansoni hypothetical protein 0.0561 0.1902 0.1894
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Onchocerca volvulus Putative cubilin 0.0561 0.1902 0.1894
Echinococcus granulosus notch 0.0561 0.1902 0.3373
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0075 0.0337
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.0043
Toxoplasma gondii microneme protein MIC17B 0.0502 0.1699 0.2539
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0052 0.0047
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0004
Echinococcus multilocularis cpg binding protein 0.0031 0.008 0.0133
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0268 0.0258
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0029 0.0075 0.0337
Loa Loa (eye worm) hypothetical protein 0.0502 0.1699 0.1694
Brugia malayi EGF-like domain containing protein 0.0561 0.1902 0.1898
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1191 0.4064 1
Brugia malayi EGF-like domain containing protein 0.0561 0.1902 0.1898
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0057 0.0116
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0052 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.001 0.0005
Onchocerca volvulus 0.0502 0.1699 0.169
Echinococcus multilocularis thymidylate synthase 0.1191 0.4064 0.7218
Echinococcus granulosus slit 2 protein 0.0561 0.1902 0.3373
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0148 0.0143
Leishmania major hypothetical protein, conserved 0.0028 0.007 0.0104
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0015 0.0028 0.0039
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.003 0.0024
Schistosoma mansoni hypothetical protein 0.0561 0.1902 0.1894
Onchocerca volvulus 0.0502 0.1699 0.169
Echinococcus multilocularis fibrillin 1 0.1093 0.3729 0.6622
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0561 0.1902 0.1894
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0609 0.2068 0.2063
Onchocerca volvulus 0.2919 1 1
Loa Loa (eye worm) hypothetical protein 0.0502 0.1699 0.1694
Toxoplasma gondii calcium binding egf domain-containing protein 0.1093 0.3729 0.5592
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0031
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.001 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0031
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0028 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0187 0.0177
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0609 0.2068 0.206
Mycobacterium ulcerans hypothetical protein 0.0024 0.0057 0.0116
Toxoplasma gondii PAN domain-containing protein 0.0502 0.1699 0.2539
Echinococcus multilocularis glycoprotein Antigen 5 0.1646 0.5628 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0036 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0033 0.0056
Schistosoma mansoni hypothetical protein 0.0609 0.2068 0.206
Loa Loa (eye worm) hypothetical protein 0.1093 0.3729 0.3725
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0028 0.0039
Schistosoma mansoni hypothetical protein 0.0561 0.1902 0.1894
Brugia malayi EGF-like domain containing protein 0.0561 0.1902 0.1898
Brugia malayi nuclear receptor NHR-88 0.001 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Onchocerca volvulus 0.0502 0.1699 0.169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0148 0.0143
Onchocerca volvulus 0.0502 0.1699 0.169
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0028 0.007 0.0104
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0028 0.0039
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0485 0.1642 0.4026
Echinococcus multilocularis neurogenic locus protein delta 0.0561 0.1902 0.3373
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.0243 0.0238
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0028 0.0039
Onchocerca volvulus 0.0502 0.1699 0.169
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0057 0.0116
Echinococcus multilocularis cGMP dependent protein kinase 1 0.001 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.1618 0.5534 0.5532
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0015 0.0028 0.0039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0057 0.0082
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.007 0.0217 0.0509
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0028 0.0022
Onchocerca volvulus Putative thymidylate kinase 0.007 0.0217 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.001 0.0004
Mycobacterium ulcerans thymidylate synthase 0.1191 0.4064 1
Schistosoma mansoni cpg binding protein 0.0029 0.0075 0.0065
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Schistosoma mansoni septate junction protein 0.0561 0.1902 0.1894
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.001 0.0005
Brugia malayi EGF-like domain containing protein 0.0561 0.1902 0.1898
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1676 0.5732 1
Plasmodium falciparum thymidylate kinase 0.007 0.0217 0.0361
Schistosoma mansoni hypothetical protein 0.0561 0.1902 0.1894
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0005
Brugia malayi Protein kinase domain containing protein 0.1618 0.5534 0.5532
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.001 0.0008
Brugia malayi Trypsin family protein 0.0609 0.2068 0.2063
Loa Loa (eye worm) hypothetical protein 0.1093 0.3729 0.3725
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1676 0.5732 0.8603
Schistosoma mansoni hypothetical protein 0.0414 0.1398 0.139
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0028 0.0092
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.0243 0.0238
Toxoplasma gondii microneme protein MIC4 0.0502 0.1699 0.2539
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.002
Onchocerca volvulus 0.0502 0.1699 0.169
Schistosoma mansoni cercarial elastase (S01 family) 0.0609 0.2068 0.206
Onchocerca volvulus 0.0609 0.2068 0.206
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0036 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0052 0.0047
Loa Loa (eye worm) hypothetical protein 0.0609 0.2068 0.2063
Loa Loa (eye worm) PAN domain-containing protein 0.0502 0.1699 0.1694
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.1093 0.3729 0.3723
Echinococcus multilocularis thymidylate kinase 0.007 0.0217 0.0375
Toxoplasma gondii EGF family domain-containing protein 0.0561 0.1902 0.2845
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Echinococcus multilocularis expressed conserved protein 0.001 0.0011 0.0009
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.001 0.001 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Trypanosoma brucei thymidylate kinase, putative 0.007 0.0217 0.0378
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0561 0.1902 0.1897
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.001 0.001 0.0005
Echinococcus granulosus cGMP dependent protein kinase 0.001 0.0011 0.0009
Echinococcus granulosus cpg binding protein 0.0031 0.008 0.0133
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0057 0.0116
Toxoplasma gondii PAN domain-containing protein 0.1946 0.6661 1
Onchocerca volvulus 0.0609 0.2068 0.206
Onchocerca volvulus 0.0029 0.0075 0.0065
Echinococcus multilocularis protein jagged 2 0.0561 0.1902 0.3373
Echinococcus multilocularis notch 0.0561 0.1902 0.3373
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.001 0.001 0.0008
Trichomonas vaginalis thymidylate kinase, putative 0.007 0.0217 0.1081
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0052 0.0083
Echinococcus granulosus transmembrane protease serine 3 0.0609 0.2068 0.3667
Schistosoma mansoni slit 0.0561 0.1902 0.1894
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.001 0.001 0.0005
Brugia malayi PAN domain containing protein 0.0502 0.1699 0.1694
Schistosoma mansoni hypothetical protein 0.0561 0.1902 0.1894
Onchocerca volvulus 0.0502 0.1699 0.169
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0609 0.2068 0.206
Entamoeba histolytica protein kinase, putative 0.0029 0.0075 0.1129
Echinococcus granulosus protein jagged 2 0.0561 0.1902 0.3373
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0024
Mycobacterium ulcerans hypothetical protein 0.0609 0.2068 0.5075
Loa Loa (eye worm) PAN domain-containing protein 0.0502 0.1699 0.1694
Echinococcus granulosus laminin 0.1093 0.3729 0.6622
Echinococcus multilocularis neurogenic locus notch protein 0.0561 0.1902 0.3373
Echinococcus multilocularis cGMP dependent protein kinase 1 0.001 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.1093 0.3729 0.3725
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.001 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0005
Echinococcus granulosus delta-like protein 1 0.0561 0.1902 0.3373
Brugia malayi N-terminal motif family protein 0.001 0.001 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.001 0.0008
Echinococcus granulosus thymidylate kinase 0.007 0.0217 0.0375
Loa Loa (eye worm) hypothetical protein 0.0609 0.2068 0.2063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.001 0.0004

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 640 nM Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux ChEMBL. 19620010
IC50 (functional) = 0.64 uM Antagonist activity at CCR3 (unknown origin) expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx ChEMBL. 17951061
IC50 (functional) = 0.64 uM Antagonist activity at CCR3 (unknown origin) expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx ChEMBL. 17951061

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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