Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0107 | 0.1433 | 0.1433 |
Brugia malayi | TAR-binding protein | 0.0207 | 0.2992 | 0.3792 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0022 | 0.0093 | 0.0052 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0141 | 0.1962 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0046 | 0.0479 | 0.2227 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0066 | 0.0016 |
Plasmodium falciparum | thymidylate kinase | 0.0141 | 0.1962 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0046 | 0.0479 | 0.0479 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0066 | 0.0066 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0045 | 0.0459 | 0.2121 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0045 | 0.0459 | 0.0581 |
Schistosoma mansoni | hypothetical protein | 0.0654 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0207 | 0.2992 | 0.2992 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0035 | 0.0307 | 0.0307 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0061 | 0.0712 | 0.0876 |
Leishmania major | thymidylate kinase-like protein | 0.0141 | 0.1962 | 0.254 |
Schistosoma mansoni | thyroid hormone receptor | 0.0139 | 0.1935 | 0.1935 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0066 | 0.0063 |
Schistosoma mansoni | glycogen phosphorylase | 0.0107 | 0.1433 | 0.1433 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0531 | 0.0531 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0061 | 0.0712 | 0.0876 |
Loa Loa (eye worm) | nuclear factor I | 0.002 | 0.0059 | 0.0059 |
Brugia malayi | MH1 domain containing protein | 0.002 | 0.0059 | 0.0075 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0066 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0561 | 0.0561 |
Brugia malayi | Pre-SET motif family protein | 0.0239 | 0.3497 | 0.4431 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0316 | 0.1372 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.0066 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0181 | 0.0181 |
Trichomonas vaginalis | importin beta-1, putative | 0.005 | 0.0531 | 0.0634 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0066 | 0.0016 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.062 | 0.0753 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0207 | 0.2992 | 0.2992 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0066 | 0.0066 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0054 | 0.0054 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.15 | 0.15 |
Brugia malayi | N-terminal motif family protein | 0.0183 | 0.2625 | 0.3327 |
Brugia malayi | RNase H family protein | 0.0022 | 0.0093 | 0.0118 |
Brugia malayi | MH1 domain containing protein | 0.0035 | 0.0307 | 0.0389 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0257 | 0.1062 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.0561 | 0.0561 |
Leishmania major | ribonuclease H1, putative | 0.0022 | 0.0093 | 0.0052 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.0055 | 0.062 | 0.0753 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.1084 | 0.5396 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0046 | 0.0479 | 0.0566 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0582 | 0.0582 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0211 | 0.0822 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0054 | 0.0054 |
Brugia malayi | Importin beta-1 subunit | 0.0061 | 0.0712 | 0.0902 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0499 | 0.7566 | 1 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0046 | 0.0479 | 0.0566 |
Schistosoma mansoni | thymidylate kinase | 0.0141 | 0.1962 | 0.1962 |
Echinococcus granulosus | ribonuclease H1 | 0.0022 | 0.0093 | 0.0093 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0066 | 0.0066 |
Schistosoma mansoni | Smad4 | 0.0035 | 0.0307 | 0.0307 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0022 | 0.0093 | 0.0205 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.2992 | 0.2992 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0561 | 0.0561 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0316 | 0.0348 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0066 | 0.0016 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0107 | 0.1433 | 0.357 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0107 | 0.1433 | 0.1433 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0066 | 0.0016 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0022 | 0.0093 | 0.0052 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0112 | 0.15 | 0.1901 |
Schistosoma mansoni | glycogen phosphorylase | 0.0107 | 0.1433 | 0.1433 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.1084 | 0.5396 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.005 | 0.0531 | 0.0634 |
Schistosoma mansoni | thyroid hormone receptor | 0.0139 | 0.1935 | 0.1935 |
Trypanosoma brucei | ribonuclease H1 | 0.0022 | 0.0093 | 0.0052 |
Trypanosoma brucei | unspecified product | 0.0027 | 0.017 | 0.0155 |
Echinococcus multilocularis | geminin | 0.036 | 0.5393 | 0.5393 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0093 | 0.0093 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0531 | 0.0531 |
Brugia malayi | RNase H family protein | 0.0022 | 0.0093 | 0.0118 |
Echinococcus granulosus | geminin | 0.036 | 0.5393 | 0.5393 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0499 | 0.7566 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0654 | 1 | 1 |
Echinococcus granulosus | thymidine kinase | 0.0249 | 0.3661 | 0.3661 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0129 | 0.1773 | 0.1773 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0129 | 0.1773 | 0.1773 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0289 | 0.0289 |
Mycobacterium ulcerans | thymidylate kinase | 0.0141 | 0.1962 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0061 | 0.0712 | 0.3449 |
Giardia lamblia | Deoxynucleoside kinase | 0.04 | 0.6027 | 0.7951 |
Trypanosoma brucei | thymidine kinase | 0.0499 | 0.7566 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0066 | 0.0063 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0499 | 0.7566 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0519 | 0.7891 | 0.7891 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.2309 | 0.2309 |
Echinococcus granulosus | tar DNA binding protein | 0.0207 | 0.2992 | 0.2992 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0035 | 0.0307 | 0.0307 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0066 | 0.0084 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0141 | 0.1962 | 0.4888 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.2992 | 0.2992 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0531 | 0.0531 |
Leishmania major | importin beta-1 subunit, putative | 0.005 | 0.0531 | 0.0634 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0029 | 0.0211 | 0.0822 |
Echinococcus multilocularis | Smad4 | 0.0035 | 0.0307 | 0.0307 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0307 | 0.0307 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0499 | 0.7566 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0141 | 0.1962 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0316 | 0.1372 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0059 | 0.0059 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0066 | 0.0066 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0289 | 0.0289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.2992 | 0.2992 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0066 | 0.0066 |
Echinococcus multilocularis | thymidine kinase | 0.0249 | 0.3661 | 0.3661 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.1084 | 0.5396 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0183 | 0.2625 | 0.654 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0289 | 0.0289 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.1773 | 0.1773 |
Chlamydia trachomatis | thymidylate kinase | 0.0141 | 0.1962 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0107 | 0.1433 | 0.1433 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0181 | 0.0169 |
Loa Loa (eye worm) | thymidylate kinase | 0.0141 | 0.1962 | 0.1962 |
Entamoeba histolytica | thymidine kinase, putative | 0.0499 | 0.7566 | 1 |
Leishmania major | GTP-binding protein, putative | 0.0045 | 0.0459 | 0.0539 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0181 | 0.0169 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0052 | 0.0561 | 0.0711 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0066 | 0.0066 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0107 | 0.1433 | 0.1836 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0027 | 0.017 | 0.0155 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0141 | 0.1962 | 0.254 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0181 | 0.0667 |
Leishmania major | thymidine kinase, putative | 0.0499 | 0.7566 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0499 | 0.7566 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0054 | 0.0054 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0316 | 0.0316 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0316 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1084 | 0.1084 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0289 | 0.0289 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0141 | 0.1962 | 0.254 |
Trichomonas vaginalis | ran, putative | 0.0045 | 0.0459 | 0.0539 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0054 | 0.0068 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0056 | 0.0625 | 0.0625 |
Schistosoma mansoni | hypothetical protein | 0.036 | 0.5393 | 0.5393 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0316 | 0.1372 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0139 | 0.1935 | 0.1935 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0085 | 0.1084 | 0.1084 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0027 | 0.017 | 0.0155 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0052 | 0.0561 | 0.0561 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0035 | 0.0307 | 0.0307 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0141 | 0.1962 | 0.254 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0239 | 0.3497 | 0.3497 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0531 | 0.0531 |
Echinococcus multilocularis | thymidine kinase | 0.0249 | 0.3661 | 0.3661 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.0055 | 0.062 | 0.0753 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0029 | 0.0211 | 0.0822 |
Giardia lamblia | Ribonuclease H | 0.0022 | 0.0093 | 0.0052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.2992 | 0.2992 |
Onchocerca volvulus | 0.0272 | 0.4014 | 1 | |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0066 | 0.0066 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0289 | 0.1233 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0066 | 0.0016 |
Echinococcus granulosus | glycogen phosphorylase | 0.0107 | 0.1433 | 0.1433 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.2992 | 0.2992 |
Schistosoma mansoni | smad | 0.0035 | 0.0307 | 0.0307 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0029 | 0.0037 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0066 | 0.0066 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0181 | 0.0169 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0249 | 0.3661 | 0.3661 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0056 | 0.0625 | 0.0625 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0066 | 0.0016 |
Entamoeba histolytica | Ran family GTPase | 0.0045 | 0.0459 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0289 | 0.0289 |
Giardia lamblia | Glycogen phosphorylase | 0.0107 | 0.1433 | 0.1836 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0141 | 0.1962 | 0.254 |
Echinococcus granulosus | glycogen phosphorylase | 0.0107 | 0.1433 | 0.1433 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.0066 | 0.0016 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0066 | 0.0063 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0045 | 0.0459 | 0.0539 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0316 | 0.0348 |
Brugia malayi | RNase H family protein | 0.0022 | 0.0093 | 0.0118 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0035 | 0.0307 | 0.0307 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0561 | 0.0561 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0066 | 0.0084 |
Echinococcus granulosus | thymidine kinase | 0.0249 | 0.3661 | 0.3661 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0066 | 0.0016 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0531 | 0.0531 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0027 | 0.017 | 0.0155 |
Brugia malayi | RNA, U transporter 1 | 0.0174 | 0.2482 | 0.3145 |
Echinococcus granulosus | smad | 0.0035 | 0.0307 | 0.0307 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0207 | 0.2992 | 0.3792 |
Echinococcus multilocularis | GPCR, family 2 | 0.0052 | 0.0561 | 0.0561 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0289 | 0.0289 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0316 | 0.0316 |
Giardia lamblia | Thymidine kinase | 0.0499 | 0.7566 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0316 | 0.0316 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0289 | 0.0289 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0066 | 0.0016 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0085 | 0.1084 | 0.4983 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0056 | 0.0625 | 0.2992 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0056 | 0.0625 | 0.2992 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0316 | 0.0348 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.15 | 0.15 |
Toxoplasma gondii | thymidylate kinase | 0.0141 | 0.1962 | 1 |
Brugia malayi | thymidylate kinase | 0.0141 | 0.1962 | 0.2486 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0163 | 0.2309 | 0.2926 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0054 | 0.0054 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0289 | 0.0289 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0249 | 0.3661 | 0.3661 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0316 | 0.0348 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0107 | 0.1433 | 0.1836 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0316 | 0.0316 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0029 | 0.0211 | 0.0822 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0107 | 0.1433 | 0.1836 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0066 | 0.0066 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0163 | 0.2309 | 0.2309 |
Trypanosoma brucei | RNA helicase, putative | 0.0218 | 0.3163 | 0.4138 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0107 | 0.1433 | 0.1433 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.1084 | 0.5396 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Brugia malayi | MH1 domain containing protein | 0.002 | 0.0059 | 0.0075 |
Loa Loa (eye worm) | Smad1 | 0.0035 | 0.0307 | 0.0307 |
Echinococcus granulosus | Smad4 | 0.0035 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0531 | 0.0531 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.1084 | 0.5396 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Schistosoma mansoni | ran | 0.0045 | 0.0459 | 0.0459 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0316 | 0.0348 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0046 | 0.0479 | 0.0566 |
Schistosoma mansoni | ran | 0.0045 | 0.0459 | 0.0459 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0045 | 0.0459 | 0.0459 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.027 | 0.027 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.1084 | 0.5396 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0107 | 0.1433 | 0.3981 |
Brugia malayi | MH1 domain containing protein | 0.0035 | 0.0307 | 0.0389 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0107 | 0.1433 | 0.1433 |
Brugia malayi | Smad1 | 0.0035 | 0.0307 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0561 | 0.0561 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0045 | 0.0459 | 0.2121 |
Echinococcus multilocularis | thymidylate kinase | 0.0141 | 0.1962 | 0.1962 |
Plasmodium vivax | importin-beta 2, putative | 0.0061 | 0.0712 | 0.3449 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0654 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0056 | 0.0625 | 0.2364 |
Loa Loa (eye worm) | TAR-binding protein | 0.0207 | 0.2992 | 0.2992 |
Onchocerca volvulus | 0.0034 | 0.0289 | 0.0721 | |
Brugia malayi | RNA binding protein | 0.0207 | 0.2992 | 0.3792 |
Echinococcus granulosus | GPCR family 2 | 0.0052 | 0.0561 | 0.0561 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0141 | 0.1962 | 0.254 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0141 | 0.1962 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0045 | 0.0459 | 0.0539 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0561 | 0.0561 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.3163 | 0.3163 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.1962 | 0.1962 |
Brugia malayi | MH2 domain containing protein | 0.0035 | 0.0307 | 0.0389 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.0561 | 0.0561 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0257 | 0.0262 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0061 | 0.0712 | 0.0712 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0085 | 0.1084 | 0.5396 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0022 | 0.0093 | 0.0232 |
Echinococcus multilocularis | tar DNA binding protein | 0.0207 | 0.2992 | 0.2992 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0022 | 0.0093 | 0.0052 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0027 | 0.017 | 0.0155 |
Echinococcus granulosus | thymidylate kinase | 0.0141 | 0.1962 | 0.1962 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0066 | 0.0066 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.005 | 0.0531 | 0.0634 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0163 | 0.2309 | 0.2926 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0093 | 0.0093 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0181 | 0.0667 |
Brugia malayi | MH2 domain containing protein | 0.0035 | 0.0307 | 0.0389 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.005 | 0.0531 | 0.0634 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0045 | 0.0459 | 0.2121 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.2625 | 0.2625 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0061 | 0.0712 | 0.3449 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.0561 | 0.0561 |
Brugia malayi | carbohydrate phosphorylase | 0.0107 | 0.1433 | 0.1816 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0531 | 0.0531 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0035 | 0.0307 | 0.0307 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0289 | 0.1233 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0531 | 0.0531 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0046 | 0.0479 | 0.2227 |
Schistosoma mansoni | thymidine kinase | 0.0249 | 0.3661 | 0.3661 |
Giardia lamblia | CDC8 | 0.0141 | 0.1962 | 0.254 |
Schistosoma mansoni | hypothetical protein | 0.036 | 0.5393 | 0.5393 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0045 | 0.0459 | 0.0539 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0141 | 0.1962 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0141 | 0.1962 | 0.254 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0045 | 0.0459 | 0.0459 |
Toxoplasma gondii | ribonuclease HI protein | 0.0022 | 0.0093 | 0.0205 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0289 | 0.0367 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0066 | 0.0016 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0141 | 0.1962 | 0.254 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0035 | 0.0307 | 0.0307 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0181 | 0.0667 |
Plasmodium vivax | thymidylate kinase, putative | 0.0141 | 0.1962 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0066 | 0.0016 |
Entamoeba histolytica | hypothetical protein | 0.005 | 0.0531 | 0.0634 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0045 | 0.0459 | 0.0539 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0519 | 0.7891 | 0.7891 |
Brugia malayi | MH2 domain containing protein | 0.0519 | 0.7891 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0307 | 0.0307 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0107 | 0.1433 | 0.1836 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0181 | 0.023 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0093 | 0.0093 |
Echinococcus granulosus | importin subunit beta 1 | 0.0061 | 0.0712 | 0.0712 |
Brugia malayi | Probable ClpP-like protease | 0.0085 | 0.1084 | 0.1373 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0316 | 0.0348 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0045 | 0.0459 | 0.0459 |
Echinococcus multilocularis | smad | 0.0035 | 0.0307 | 0.0307 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0531 | 0.0673 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0066 | 0.0063 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0316 | 0.0316 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0035 | 0.0307 | 0.0307 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0066 | 0.0016 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0316 | 0.04 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0181 | 0.0169 |
Schistosoma mansoni | importin beta-1 | 0.0061 | 0.0712 | 0.0712 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0022 | 0.0093 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0712 | 0.0712 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0316 | 0.0348 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0054 | 0.0054 |
Trichomonas vaginalis | set domain proteins, putative | 0.0272 | 0.4014 | 0.5272 |
Echinococcus multilocularis | ribonuclease H1 | 0.0022 | 0.0093 | 0.0093 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0181 | 0.0667 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0052 | 0.0561 | 0.0711 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.0561 | 0.0561 |
Schistosoma mansoni | thymidylate kinase | 0.0141 | 0.1962 | 0.1962 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.1084 | 0.5396 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 96 % | Inhibition of human recombinant GGDPS expressed in BL21 gold bacteria at 10 uM relative to control | ChEMBL. | 18308574 |
Activity (binding) | = 96 % | Inhibition of human recombinant GGDPS expressed in BL21 gold bacteria at 10 uM relative to control | ChEMBL. | 18308574 |
Activity (functional) | = 10 uM | Inhibition of Rap1a protein modification in human K562 cells by Western blot relative to lovastatin | ChEMBL. | 18308574 |
Activity (functional) | = 10 uM | Inhibition of Rap1a protein modification in human K562 cells by Western blot relative to lovastatin | ChEMBL. | 18308574 |
GI50 (functional) | = 58 uM | Growth inhibition of human K562 cells after 24 hrs | ChEMBL. | 18308574 |
GI50 (functional) | = 58 uM | Growth inhibition of human K562 cells after 24 hrs | ChEMBL. | 18308574 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.