Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0121 | 0.0121 |
Echinococcus granulosus | smad | 0.0015 | 0.003 | 0.003 |
Echinococcus multilocularis | Smad4 | 0.0015 | 0.003 | 0.003 |
Echinococcus multilocularis | dna polymerase kappa | 0.0018 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0015 | 0.003 | 0.003 |
Echinococcus granulosus | dna polymerase eta | 0.0018 | 0.0121 | 0.0121 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0018 | 0.0121 | 0.0121 |
Schistosoma mansoni | smad1 5 8 and | 0.0015 | 0.003 | 0.003 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0015 | 0.003 | 0.003 |
Entamoeba histolytica | Ran family GTPase | 0.0019 | 0.0187 | 0.471 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0015 | 0.003 | 0.003 |
Brugia malayi | RNA, U transporter 1 | 0.0075 | 0.2268 | 0.2897 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1099 | 0.1099 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0283 | 1 | 1 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0019 | 0.0187 | 0.0238 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0018 | 0.0121 | 0.0154 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1099 | 0.1099 |
Brugia malayi | RNA binding protein | 0.0119 | 0.3899 | 0.4982 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0026 | 0.0447 | 0.0447 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0031 | 0.0627 | 0.0801 |
Schistosoma mansoni | tar DNA-binding protein | 0.0119 | 0.3899 | 0.3899 |
Echinococcus granulosus | tar DNA binding protein | 0.0119 | 0.3899 | 0.3899 |
Leishmania major | importin beta-1 subunit, putative | 0.0021 | 0.0261 | 0.5763 |
Loa Loa (eye worm) | TAR-binding protein | 0.0119 | 0.3899 | 0.3899 |
Brugia malayi | MH1 domain containing protein | 0.0015 | 0.003 | 0.0038 |
Trichomonas vaginalis | importin beta-1, putative | 0.0021 | 0.0261 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0019 | 0.0187 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0019 | 0.0187 | 0.2715 |
Schistosoma mansoni | ran | 0.0019 | 0.0187 | 0.0187 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0015 | 0.003 | 0.003 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0018 | 0.0121 | 0.0121 |
Echinococcus granulosus | Smad4 | 0.0015 | 0.003 | 0.003 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0363 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0021 | 0.0261 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0119 | 0.3899 | 0.4982 |
Brugia malayi | Importin beta-1 subunit | 0.0026 | 0.0447 | 0.0571 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0018 | 0.0121 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0015 | 0.003 | 0.0038 |
Schistosoma mansoni | DNA polymerase eta | 0.0018 | 0.0121 | 0.0121 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1099 | 0.1099 |
Schistosoma mansoni | smad | 0.0015 | 0.003 | 0.003 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0018 | 0.0121 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.5262 | 0.5262 |
Brugia malayi | MH1 domain containing protein | 0.0015 | 0.003 | 0.0038 |
Echinococcus granulosus | geminin | 0.0156 | 0.5262 | 0.5262 |
Echinococcus multilocularis | geminin | 0.0156 | 0.5262 | 0.5262 |
Brugia malayi | MH2 domain containing protein | 0.0224 | 0.7826 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0224 | 0.7826 | 0.7826 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0363 | 0.6779 |
Schistosoma mansoni | ran | 0.0019 | 0.0187 | 0.0187 |
Schistosoma mansoni | Smad4 | 0.0015 | 0.003 | 0.003 |
Echinococcus granulosus | dna polymerase kappa | 0.0018 | 0.0121 | 0.0121 |
Schistosoma mansoni | smad1 5 8 and | 0.0015 | 0.003 | 0.003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0119 | 0.3899 | 0.3899 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1099 | 0.1099 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0026 | 0.0447 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0119 | 0.3899 | 0.3899 |
Plasmodium vivax | importin-beta 2, putative | 0.0026 | 0.0447 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0018 | 0.0121 | 0.0121 |
Echinococcus granulosus | importin subunit beta 1 | 0.0026 | 0.0447 | 0.0447 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0019 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0119 | 0.3899 | 0.3899 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1099 | 0.1405 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1099 | 0.1099 |
Loa Loa (eye worm) | RNA binding protein | 0.0119 | 0.3899 | 0.3899 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0363 | 0.0363 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.1167 | 0.1491 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0627 | 0.0627 |
Echinococcus multilocularis | dna polymerase eta | 0.0018 | 0.0121 | 0.0121 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0015 | 0.003 | 0.003 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0363 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1099 | 0.1099 |
Schistosoma mansoni | smad1 5 8 and | 0.0015 | 0.003 | 0.003 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0363 | 0.6779 |
Leishmania major | GTP-binding protein, putative | 0.0019 | 0.0187 | 0.2715 |
Schistosoma mansoni | tar DNA-binding protein | 0.0119 | 0.3899 | 0.3899 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1099 | 0.1099 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0018 | 0.0121 | 0.0121 |
Trichomonas vaginalis | ran, putative | 0.0019 | 0.0187 | 0.471 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0018 | 0.0121 | 0.0154 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0026 | 0.0447 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0019 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0046 | 0.1167 | 0.1167 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0018 | 0.0121 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0283 | 1 | 1 |
Brugia malayi | Smad1 | 0.0015 | 0.003 | 0.0038 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.5262 | 0.5262 |
Plasmodium falciparum | importin beta, putative | 0.0026 | 0.0447 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0363 | 0.0464 |
Echinococcus multilocularis | smad | 0.0015 | 0.003 | 0.003 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1099 | 0.1099 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0018 | 0.0121 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0447 | 0.0447 |
Brugia malayi | TAR-binding protein | 0.0119 | 0.3899 | 0.4982 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0019 | 0.0187 | 0.0187 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0019 | 0.0187 | 0.2017 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0019 | 0.0187 | 0.2715 |
Brugia malayi | MH2 domain containing protein | 0.0015 | 0.003 | 0.0038 |
Schistosoma mansoni | tar DNA-binding protein | 0.0119 | 0.3899 | 0.3899 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.1167 | 0.1491 |
Schistosoma mansoni | tar DNA-binding protein | 0.0119 | 0.3899 | 0.3899 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0363 | 0.7428 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0627 | 0.0627 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0015 | 0.003 | 0.003 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0363 | 0.6779 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0026 | 0.0447 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0021 | 0.0261 | 0.5763 |
Echinococcus multilocularis | snurportin 1 | 0.0283 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0043 | 0.0055 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0224 | 0.7826 | 0.7826 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0018 | 0.0121 | 0.5 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0021 | 0.0261 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0015 | 0.003 | 0.003 |
Schistosoma mansoni | importin beta-1 | 0.0026 | 0.0447 | 0.0447 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0363 | 0.6779 |
Loa Loa (eye worm) | Smad1 | 0.0015 | 0.003 | 0.003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 25.71 % | Antifungal activity against Cytospora mandshurica at 50 ug/ml by poison plate technique | ChEMBL. | 18329885 |
Inhibition (functional) | = 30.5 % | Antifungal activity against Fusarium oxysporum at 50 ug/ml by poison plate technique | ChEMBL. | 18329885 |
Inhibition (functional) | = 37.69 % | Antifungal activity against Gibberella zeae at 50 ug/ml by poison plate technique | ChEMBL. | 18329885 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.