Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.1469 | 0.1469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1469 | 0.1469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.4752 | 0.4752 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.4752 | 0.4752 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.1469 | 0.1469 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.758 | 0.758 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1469 | 0.1469 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.758 | 0.758 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.1469 | 0.1469 |
Brugia malayi | TAR-binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1469 | 0.1469 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.1469 | 0.1469 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.758 | 0.758 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.4752 | 0.4752 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.1469 | 0.1469 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.1469 | 0.1469 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1469 | 0.1469 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.758 | 0.758 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.1469 | 0.1469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1469 | 0.1469 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.1469 | 0.1469 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.1469 | 0.1469 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 390 nM | Inhibition of human cSrc-vSrc fusion protein expressed in rat fibroblast cells by ELISA | ChEMBL. | 17905586 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.