Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | serotonin transporter b | 0.0097 | 0.0625 | 0.1042 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0368 | 0.4286 | 0.6429 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0076 | 0.0332 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.535 | 0.8917 |
Echinococcus multilocularis | acetylcholinesterase | 0.0447 | 0.535 | 0.5746 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.0332 | 0.0497 |
Echinococcus multilocularis | neuroligin | 0.0076 | 0.0332 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0625 | 0.1042 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0332 | 0.0553 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0332 | 0.0497 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0076 | 0.0332 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 0.6 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0447 | 0.535 | 0.535 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.0332 | 0.0497 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0447 | 0.535 | 0.8917 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0455 | 0.5455 | 0.5455 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0097 | 0.0625 | 0.1042 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0447 | 0.535 | 0.5746 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0625 | 0.1042 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0951 | 0.1585 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0368 | 0.4286 | 0.7857 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1765 | 0.2941 |
Loa Loa (eye worm) | carboxylesterase | 0.0076 | 0.0332 | 0.0553 |
Loa Loa (eye worm) | carboxylesterase | 0.0076 | 0.0332 | 0.0553 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0076 | 0.0332 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0076 | 0.0332 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0076 | 0.0332 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0332 | 0.0553 |
Echinococcus multilocularis | serotonin receptor | 0.0182 | 0.1765 | 0.1895 |
Echinococcus granulosus | serotonin transporter | 0.0097 | 0.0625 | 0.0625 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0625 | 0.1042 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0076 | 0.0332 | 0.0608 |
Echinococcus granulosus | acetylcholinesterase | 0.0447 | 0.535 | 0.535 |
Loa Loa (eye worm) | carboxylesterase | 0.0447 | 0.535 | 0.8917 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0951 | 0.1585 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0332 | 0.0553 |
Onchocerca volvulus | 0.0076 | 0.0332 | 0.5304 | |
Schistosoma mansoni | amine GPCR | 0.0229 | 0.24 | 0.44 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.4286 | 0.7143 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1765 | 0.2941 |
Brugia malayi | Carboxylesterase family protein | 0.0447 | 0.535 | 0.8026 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.4286 | 0.7143 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0455 | 0.5455 | 0.5858 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0076 | 0.0332 | 0.0608 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0447 | 0.535 | 0.9809 |
Onchocerca volvulus | 0.0076 | 0.0332 | 0.5304 | |
Brugia malayi | Serotonin receptor | 0.0545 | 0.6667 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0076 | 0.0332 | 0.0356 |
Onchocerca volvulus | 0.0076 | 0.0332 | 0.5304 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0455 | 0.5455 | 1 |
Onchocerca volvulus | 0.0076 | 0.0332 | 0.5304 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0076 | 0.0332 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0076 | 0.0332 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0332 | 0.0553 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0076 | 0.0332 | 0.0356 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0097 | 0.0625 | 0.1042 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0097 | 0.0625 | 0.1146 |
Echinococcus granulosus | neuroligin | 0.0076 | 0.0332 | 0.0332 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0741 | 0.9311 | 1 |
Onchocerca volvulus | 0.0097 | 0.0625 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0076 | 0.0332 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0076 | 0.0332 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.535 | 0.8917 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0182 | 0.1765 | 0.3235 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0097 | 0.0625 | 0.0938 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0332 | 0.0553 |
Brugia malayi | Carboxylesterase family protein | 0.0447 | 0.535 | 0.8026 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0076 | 0.0332 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0076 | 0.0332 | 0.0608 |
Echinococcus multilocularis | serotonin receptor | 0.0182 | 0.1765 | 0.1895 |
Echinococcus granulosus | acetylcholinesterase | 0.0447 | 0.535 | 0.535 |
Onchocerca volvulus | 0.0076 | 0.0332 | 0.5304 | |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0332 | 0.0553 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.0332 | 0.0497 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0076 | 0.0332 | 0.0608 |
Echinococcus multilocularis | serotonin transporter | 0.0097 | 0.0625 | 0.0671 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.0332 | 0.0497 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0076 | 0.0332 | 0.0608 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0076 | 0.0332 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0332 | 0.0553 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0097 | 0.0625 | 0.1146 |
Schistosoma mansoni | gliotactin | 0.0076 | 0.0332 | 0.0608 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0182 | 0.1765 | 0.1765 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0951 | 0.1427 |
Echinococcus multilocularis | acetylcholinesterase | 0.0447 | 0.535 | 0.5746 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0097 | 0.0625 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 0.6 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of rabbit recombinant GSK3beta | ChEMBL. | 17919914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.