Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma japonicum | ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma mansoni | retinoic acid receptor RXR | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.0308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.0308 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.0308 | 0.0308 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.0308 | 0.0308 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0128 | 0.9213 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.0308 | 0.0335 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0308 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0308 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.0308 | 0.0335 |
Onchocerca volvulus | 0.0018 | 0.0308 | 1 | |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.0308 | 0.0335 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.0308 | 0.0308 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.0308 | 0.0308 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.0308 | 0.0308 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.0308 | 0.0335 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.0308 | 0.0308 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.0308 | 0.0308 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.0308 | 0.0335 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.0308 | 0.0335 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.0308 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.0308 | 0.0308 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0308 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.0308 | 0.0308 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.0308 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.0308 | 0.0308 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.0308 | 0.0308 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.0308 | 0.0308 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.0308 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0308 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0308 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.0308 | 0.0335 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.0308 | 0.0308 |
Brugia malayi | ecdysteroid receptor | 0.0018 | 0.0308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.0308 | 0.0308 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.0308 | 0.0308 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.0308 | 0.0308 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0308 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.0308 | 0.0335 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.0308 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.0308 | 0.0335 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.0308 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.0308 | 0.0308 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.0308 | 0.0308 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0308 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.0308 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2.61 | Plasma lipid-lowering activity at a dosage of 0.001% in the diet in KKAy mice | ChEMBL. | 11906293 |
Activity (functional) | = 15 | Plasma glucose-lowering activity at a dosage of 0.001% in the diet in KKAy mice | ChEMBL. | 11906293 |
Activity (functional) | = 17 | Plasma lipid-lowering activity at a dosage of 0.005% in the diet in KKA(y) mice. | ChEMBL. | 11906293 |
Activity (functional) | = 43 | Plasma glucose-lowering activity at a dosage of 0.005% in the diet in KKA(y) mice. | ChEMBL. | 11906293 |
Activity (functional) | = 58 | Plasma lipid-lowering activity at a dosage of 0.01% in the diet in KKAy mice | ChEMBL. | 11906293 |
EC50 (functional) | = 269 nM | Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha | ChEMBL. | 11906293 |
EC50 (functional) | = 269 nM | Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha | ChEMBL. | 11906293 |
EC50 (functional) | = 813 nM | Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha | ChEMBL. | 11906293 |
EC50 (functional) | = 813 nM | Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha | ChEMBL. | 11906293 |
EC50 (functional) | > 1000 nM | Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha | ChEMBL. | 11906293 |
EC50 (functional) | > 1000 nM | Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha | ChEMBL. | 11906293 |
ED25 (functional) | = 0.23 mg kg-1 day-1 | Effective dose for 25% reduction in glucose-lowering activity in Wistar fatty rats | ChEMBL. | 11906293 |
ED25 (functional) | = 0.5 mg kg-1 day-1 | Effective dose for 25% reduction in plasma glucose-lowering activity in Wistar fatty rats | ChEMBL. | 11906293 |
ED25 (functional) | = 1.44 mg kg-1 day-1 | Effective dose for 25% reduction in plasma glucose-lowering activity in KKAy mice | ChEMBL. | 11906293 |
ED25 (functional) | = 1.44 mg kg-1 day-1 | Effective dose for 25% reduction in plasma glucose-lowering activity in KKAy mice | ChEMBL. | 11906293 |
ED25 (functional) | = 3 mg kg-1 day-1 | Effective dose for 25% reduction in glucose-lowering activity in Wistar fatty rats | ChEMBL. | 11906293 |
ND (functional) | 0 | Effective dose for 25% reduction in plasma glucose-lowering activity in KKAy mice;ND denotes no data. | ChEMBL. | 11906293 |
ND (functional) | 0 | Effective dose for 25% reduction in plasma glucose-lowering activity of KKAy mice;ND denotes no-data. | ChEMBL. | 11906293 |
ND (functional) | 0 | Plasma glucose-lowering activity at a dosage of 0.01% in the diet in KKA(y) mice. | ChEMBL. | 11906293 |
ND (functional) | 0 | Effective dose for 25% reduction in plasma lipid-lowering activity of KKA(y) mice. | ChEMBL. | 11906293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.