TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 341.672 | Formula: C14H7ClF3N3O2
H donors: 2 H acceptors: 3 LogP: 3.37 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: ClC1=C(Nc2ccc(c(c2F)F)F)C(=O)c2c(C1=O)nc([nH]2)C
InChi: 1S/C14H7ClF3N3O2/c1-4-19-11-12(20-4)14(23)10(7(15)13(11)22)21-6-3-2-5(16)8(17)9(6)18/h2-3,21H,1H3,(H,19,20)
InChiKey: AURAGQKAOURERG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0324	0.2388	0.2388
Brugia malayi	PXA domain containing protein	0.0041	0.0168	0.0168
Brugia malayi	diacylglycerol kinase	0.004	0.0162	0.0162
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0534	0.4027	1
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0156	0.1071	0.266
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.1597	0.1597
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0168	0.0168
Brugia malayi	protein kinase C II.	0.0174	0.1206	0.1206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Schistosoma mansoni	diacylglycerol kinase theta	0.004	0.0162	0.0162
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0156	0.1071	0.1071
Brugia malayi	follicle stimulating hormone receptor	0.0033	0.0103	0.0103
Brugia malayi	GnHR receptor homolog	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0168	0.0168
Echinococcus granulosus	sex peptide receptor	0.0033	0.0103	0.0103
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.0367	0.0911
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0033	0.0103	0.0103
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.0103	0.0103
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0031	0.0093	0.0231
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0293	0.0293
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0031	0.0093	0.0231
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.004	0.0162	0.0162
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0031	0.0093	0.0231
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	RGS-3 protein	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0093	0.0093
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0156	0.1071	0.1071
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0168	0.0168
Mycobacterium ulcerans	amidase	0.0156	0.1071	0.266
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0057	0.0293	0.0293
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0341	0.2519	0.2519
Brugia malayi	Protein kinase c protein 2	0.0168	0.116	0.116
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	protein kinase C	0.0045	0.0203	0.0203
Schistosoma mansoni	tyrosinase precursor	0.01	0.0633	0.0633
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	protein kinase C mu	0.0042	0.0172	0.0172
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0057	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0156	0.1071	0.266
Echinococcus granulosus	unc 13 munc13	0.0045	0.0203	0.0203
Plasmodium vivax	PST-A protein	0.0031	0.0093	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0168	0.0416
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0031	0.0093	0.0231
Schistosoma mansoni	unc-13 (munc13)	0.0045	0.0203	0.0203
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0031	0.0093	0.0093
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0056	0.0284	0.0704
Schistosoma mansoni	axis inhibition protein axin	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0093	0.0093
Echinococcus multilocularis	somatostatin receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0293	0.0293
Echinococcus multilocularis	sex peptide receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.004	0.0162	0.0162
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0367	0.0911
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0103	0.0103
Brugia malayi	G protein-coupled receptor F59B2.13	0.0033	0.0103	0.0103
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0093	0.0231
Trypanosoma brucei	Serine peptidase, Clan SC, Family S09X	0.0031	0.0093	0.0231
Plasmodium falciparum	lysophospholipase, putative	0.0534	0.4027	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0041	0.0168	0.0168
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0033	0.0103	0.0103
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0057	0.0293	0.0293
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.0103	0.0103
Plasmodium vivax	unspecified product	0.0031	0.0093	0.0231
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0103	0.0103
Mycobacterium ulcerans	amidase	0.0156	0.1071	0.266
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0087	0.0525	0.0525
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0024	0.0037	0.0093
Brugia malayi	Serotonin receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0042	0.0172	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.0103	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0057	0.0293	0.0293
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0093	0.0231
Echinococcus multilocularis	protein kinase c eta type	0.004	0.0162	0.0162
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0033	0.0103	0.0103
Echinococcus granulosus	serine:threonine protein kinase N2	0.0057	0.0293	0.0293
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0041	0.0168	0.0168
Entamoeba histolytica	;Alias	0.0031	0.0093	0.0231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Brugia malayi	PXA domain containing protein	0.0041	0.0168	0.0168
Echinococcus granulosus	protein kinase c epsilon type	0.0174	0.1206	0.1206
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus granulosus	Rac GTPase activating protein 1	0.004	0.0162	0.0162
Echinococcus granulosus	orexin receptor type 2	0.0033	0.0103	0.0103
Brugia malayi	ORL1-like opioid receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0057	0.0293	0.0293
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1296	1	1
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0031	0.0093	0.0093
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus granulosus	G protein coupled receptor 139	0.0033	0.0103	0.0103
Echinococcus granulosus	axis inhibition protein axin	0.0041	0.0168	0.0168
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.0031	0.0093	0.0231
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0093	0.0231
Schistosoma mansoni	adenoreceptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Onchocerca volvulus		0.004	0.0162	0.0303
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0087	0.0525	0.0525
Schistosoma mansoni	peptidase	0.0031	0.0093	0.0093
Echinococcus granulosus	Diacylglycerol kinase theta	0.004	0.0162	0.0162
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.0103	0.0103
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0093	0.0093
Plasmodium falciparum	epoxide hydrolase 2	0.0031	0.0093	0.0231
Echinococcus granulosus	g-protein coupled receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	histamine h1 receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	regulator of G protein signaling 7	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Echinococcus multilocularis	regulator of G protein signaling 3	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0284	0.2072	0.2072
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0103	0.0103
Echinococcus granulosus	7TM GPCR rhodopsin	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Brugia malayi	Protein C20orf22	0.0031	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0041	0.0168	0.0168
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0103	0.0103
Entamoeba histolytica	protein kinase, putative	0.0057	0.0293	0.0728
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Toxoplasma gondii	hypothetical protein	0.0031	0.0093	0.3173
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0033	0.0103	0.0103
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0103	0.0103
Brugia malayi	Variant SH3 domain containing protein	0.004	0.0162	0.0162
Onchocerca volvulus		0.01	0.0633	0.2691
Echinococcus granulosus	NDR protein kinase	0.0057	0.0293	0.0293
Plasmodium vivax	PST-A protein	0.0031	0.0093	0.0231
Mycobacterium ulcerans	hydrolase	0.0031	0.0093	0.0231
Schistosoma mansoni	opsin-like receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	unc-13 (munc13)	0.0045	0.0203	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Echinococcus multilocularis	Diacylglycerol kinase theta	0.004	0.0162	0.0162
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Onchocerca volvulus		0.0284	0.2072	1
Entamoeba histolytica	protein kinase, putative	0.0057	0.0293	0.0728
Brugia malayi	regulator of G-protein signaling rgs-7	0.0041	0.0168	0.0168
Schistosoma mansoni	amine GPCR	0.0033	0.0103	0.0103
Echinococcus multilocularis	serotonin receptor	0.0033	0.0103	0.0103
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0093	0.0231
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0103	0.0103
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0103	0.0103
Echinococcus granulosus	regulator of G protein signaling 7	0.0041	0.0168	0.0168
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0033	0.0103	0.0103
Plasmodium vivax	alpha/beta hydrolase, putative	0.0031	0.0093	0.0231
Echinococcus granulosus	Phospholipase carboxylesterase	0.0031	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Schistosoma mansoni	neuropeptide f receptor 76f	0.0033	0.0103	0.0103
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0033	0.0103	0.0103
Brugia malayi	Amidase family protein	0.0156	0.1071	0.1071
Brugia malayi	putative amidase	0.0156	0.1071	0.1071
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0031	0.0093	0.0231
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.0103	0.0103
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0042	0.0172	0.0172
Echinococcus granulosus	regulator of G protein signaling 3	0.0041	0.0168	0.0168
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.0031	0.0093	0.0231
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0033	0.0103	0.0103
Echinococcus granulosus	regulator of G protein signaling 3	0.0041	0.0168	0.0168
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0057	0.0293	0.0293
Toxoplasma gondii	peptidase S15, putative	0.0031	0.0093	0.3173
Mycobacterium ulcerans	amidase	0.0156	0.1071	0.266
Trichomonas vaginalis	conserved hypothetical protein	0.0534	0.4027	1
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0168	0.0168
Plasmodium falciparum	lysophospholipase, putative	0.0534	0.4027	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0033	0.0103	0.0103
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0534	0.4027	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0024	0.0037	0.1272
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0042	0.0177	0.0177
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0042	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Echinococcus granulosus	dro:myosuppressin receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0103	0.0103
Leishmania major	hypothetical protein, conserved	0.0031	0.0093	0.0231
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.01	0.0633	0.0633
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0033	0.0103	0.0103
Brugia malayi	C1-like domain containing protein	0.0042	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0033	0.0103	0.0103
Mycobacterium ulcerans	hypothetical protein	0.0534	0.4027	1
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0042	0.0177	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Schistosoma mansoni	amine GPCR	0.0033	0.0103	0.0103
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.004	0.0162	0.0162
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.01	0.0633	0.0633
Plasmodium falciparum	prodrug activation and resistance esterase	0.0031	0.0093	0.0231
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus multilocularis	protein kinase c iota type	0.0097	0.0609	0.0609
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.0103	0.0103
Brugia malayi	neuropeptide F receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0103	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0072	0.0413	0.1025
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0031	0.0093	0.0231
Plasmodium falciparum	exported lipase 2	0.0031	0.0093	0.0231
Chlamydia trachomatis	acyltransferase family protein	0.0031	0.0093	0.0539
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.1597	0.1597
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0156	0.1071	0.266
Chlamydia trachomatis	hydrolase	0.0031	0.0093	0.0539
Mycobacterium ulcerans	hypothetical protein	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Leishmania major	monoglyceride lipase, putative	0.0534	0.4027	1
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0093	0.0231
Brugia malayi	p70 ribosomal S6 kinase beta	0.0057	0.0293	0.0293
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0156	0.1071	0.266
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0024	0.0037	0.0093
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0534	0.4027	1
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0156	0.1071	0.266
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0031	0.0093	0.0231
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Mycobacterium ulcerans	amidase	0.0156	0.1071	0.266
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0293	0.0293
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0031	0.0093	0.0093
Schistosoma mansoni	amine GPCR	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Entamoeba histolytica	hypothetical protein	0.004	0.0162	0.0403
Trypanosoma cruzi	amidase, putative	0.0156	0.1071	0.266
Toxoplasma gondii	protein c14orf29, putative	0.0031	0.0093	0.3173
Toxoplasma gondii	hypothetical protein	0.0031	0.0093	0.3173
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Schistosoma mansoni	z-protein (S1r protein)	0.0041	0.0168	0.0168
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	regulator of G protein signaling 3	0.0041	0.0168	0.0168
Plasmodium vivax	PST-A protein	0.0031	0.0093	0.0231
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0172	0.0172
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Schistosoma mansoni	amidase	0.1296	1	1
Toxoplasma gondii	phospholipase	0.0031	0.0093	0.3173
Plasmodium vivax	alpha/beta hydrolase, putative	0.0031	0.0093	0.0231
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0031	0.0093	0.0231
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0293	0.0293
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0177	0.0177
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0525	0.0525
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus granulosus	somatostatin receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	amine GPCR	0.0033	0.0103	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0168	0.0416
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0128	0.085	0.085
Echinococcus multilocularis	neuropeptide s receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0033	0.0103	0.0103
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0031	0.0093	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0174	0.1206	0.1206
Plasmodium vivax	PST-A protein	0.0534	0.4027	1
Loa Loa (eye worm)	RasGEF domain-containing protein	0.004	0.0162	0.0162
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0103	0.0103
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0534	0.4027	1
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0156	0.1071	0.266
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0293	0.0293
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0031	0.0093	0.0231
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0156	0.1071	0.1071
Schistosoma mansoni	amine GPCR	0.0033	0.0103	0.0103
Loa Loa (eye worm)	amidase	0.0156	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Onchocerca volvulus		0.01	0.0633	0.2691
Echinococcus granulosus	neuropeptide receptor	0.0033	0.0103	0.0103
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.0037	0.0093
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0031	0.0093	0.0093
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0031	0.0093	0.0093
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0534	0.4027	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Brugia malayi	Dopamine receptor protein 1	0.0033	0.0103	0.0103
Plasmodium vivax	lysophospholipase, putative	0.0031	0.0093	0.0231
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.0103	0.0103
Echinococcus multilocularis	expressed protein	0.0798	0.6097	0.6097
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0033	0.0103	0.0103
Echinococcus granulosus	fmrfamide receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0224	0.1597	0.1597
Brugia malayi	RE15519p	0.0033	0.0103	0.0103
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.0103	0.0103
Brugia malayi	G protein-coupled receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Brugia malayi	putative neuropeptide receptor	0.0033	0.0103	0.0103
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0037	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus granulosus	7tm_1 domain containing protein	0.0033	0.0103	0.0103
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0534	0.4027	1
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Trypanosoma brucei	monoglyceride lipase, putative	0.0534	0.4027	1
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0156	0.1071	0.266
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0057	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Mycobacterium tuberculosis	Possible lysophospholipase	0.0534	0.4027	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1296	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0093	0.0093
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.004	0.0162	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Echinococcus granulosus	abhydrolase domain containing 3	0.0031	0.0093	0.0093
Entamoeba histolytica	diacylglycerol kinase, putative	0.004	0.0162	0.0403
Brugia malayi	putative neuropeptide receptor NPR1	0.0033	0.0103	0.0103
Plasmodium vivax	unspecified product	0.0031	0.0093	0.0231
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0162	0.0162
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0033	0.0103	0.0103
Plasmodium falciparum	lysophospholipase, putative	0.0031	0.0093	0.0231
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0103	0.0103
Leishmania major	hypothetical protein, conserved	0.0156	0.1071	0.266
Plasmodium vivax	lysophospholipase, putative	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus multilocularis	g-protein coupled receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0024	0.0037	0.0348
Entamoeba histolytica	diacylglycerol kinase, putative	0.004	0.0162	0.0403
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0057	0.0293	0.0293
Brugia malayi	G-protein coupled receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Echinococcus granulosus	expressed protein	0.0798	0.6097	0.6097
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0033	0.0103	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0168	0.0416
Schistosoma mansoni	hypothetical protein	0.0033	0.0103	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Onchocerca volvulus		0.01	0.0633	0.2691
Trypanosoma cruzi	monoglyceride lipase, putative	0.0534	0.4027	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0203	0.0203
Plasmodium falciparum	esterase, putative	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Echinococcus granulosus	neuropeptide FF receptor 2	0.0033	0.0103	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0168	0.0416
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	axis inhibition protein axin	0.0041	0.0168	0.0168
Echinococcus multilocularis	abhydrolase domain containing 3	0.0031	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Loa Loa (eye worm)	ShTK domain-containing protein	0.01	0.0633	0.0633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Echinococcus granulosus	RNA directed DNA polymerase	0.0121	0.0794	0.0794
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	tyrosinase 1	0.01	0.0633	0.0633
Brugia malayi	protein kinase C3,putative	0.0042	0.0172	0.0172
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0057	0.0293	0.0728
Mycobacterium ulcerans	peptide amidase, GatA	0.0156	0.1071	0.266
Plasmodium falciparum	esterase, putative	0.0031	0.0093	0.0231
Brugia malayi	MGC83647 protein	0.0031	0.0093	0.0093
Schistosoma mansoni	vav2	0.004	0.0162	0.0162
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.004	0.0162	0.0162
Toxoplasma gondii	phospholipase/carboxylesterase	0.0031	0.0093	0.3173
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0057	0.0293	0.0293
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0033	0.0103	0.0103
Leishmania major	cathepsin L-like protease	0.0066	0.0367	0.0911
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.01	0.0633	0.0633
Entamoeba histolytica	hypothetical protein	0.0041	0.0168	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0168	0.0168
Schistosoma mansoni	protein kinase C mu	0.004	0.0162	0.0162
Brugia malayi	diacylglycerol kinase	0.004	0.0162	0.0162
Entamoeba histolytica	hypothetical protein	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0057	0.0293	0.0293
Brugia malayi	RhoGAP domain containing protein	0.004	0.0162	0.0162
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0057	0.0293	0.0293
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0103	0.0103
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0041	0.0168	0.0168
Echinococcus granulosus	Protein kinase C brain isozyme	0.0224	0.1597	0.1597
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.01	0.0633	0.0633
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0093	0.0231
Leishmania major	phosphopantetheinyl transferase-like protein	0.0024	0.0037	0.0093
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.0103	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Plasmodium vivax	lysophospholipase, putative	0.0031	0.0093	0.0231
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0031	0.0093	0.0231
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0041	0.0168	0.0416
Brugia malayi	Pleckstrin Homology Domain	0.004	0.0162	0.0162
Loa Loa (eye worm)	amidase	0.0156	0.1071	0.1071
Trypanosoma brucei	monoglyceride lipase, putative	0.0534	0.4027	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0045	0.0203	0.0203
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0031	0.0093	0.3173
Brugia malayi	hypothetical protein	0.0041	0.0168	0.0168
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0156	0.1071	1
Brugia malayi	neuropeptide F receptor	0.0033	0.0103	0.0103
Mycobacterium ulcerans	hypothetical protein	0.0031	0.0093	0.0231
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0033	0.0103	0.0103
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.0103	0.0103
Plasmodium vivax	PST-A protein	0.0031	0.0093	0.0231
Echinococcus granulosus	neuropeptide receptor A26	0.0033	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Echinococcus multilocularis	G protein coupled receptor 139	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Leishmania major	cathepsin L-like protease	0.0066	0.0367	0.0911
Schistosoma mansoni	myosin xvIII	0.0033	0.0103	0.0103
Echinococcus granulosus	N chimaerin	0.004	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0174	0.1206	0.1206
Brugia malayi	ShTK domain containing protein	0.01	0.0633	0.0633
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Echinococcus granulosus	raf serine:threonine protein kinase	0.004	0.0162	0.0162
Plasmodium vivax	PST-A protein	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0284	0.2072	0.2072
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0168	0.0416
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0031	0.0093	0.3173
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0156	0.1071	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.004	0.0162	0.0162
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0156	0.1071	0.1071
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	raf serine:threonine protein kinase	0.004	0.0162	0.0162
Echinococcus granulosus	allatostatin A receptor	0.0033	0.0103	0.0103
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0103	0.0103
Echinococcus multilocularis	orexin receptor type 2	0.0033	0.0103	0.0103
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0156	0.1071	0.1071
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Toxoplasma gondii	AGC kinase	0.0057	0.0293	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0057	0.0293	0.0293
Loa Loa (eye worm)	raf kinase	0.004	0.0162	0.0162
Mycobacterium ulcerans	lysophospholipase	0.0534	0.4027	1
Onchocerca volvulus		0.0045	0.0203	0.0508
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0033	0.0103	0.0103
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0033	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0168	0.0416
Echinococcus multilocularis	Rac GTPase activating protein 1	0.004	0.0162	0.0162
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0041	0.0168	0.0168
Echinococcus granulosus	neuropeptide receptor	0.0033	0.0103	0.0103
Brugia malayi	regulator of G-protein signaling egl-10	0.0041	0.0168	0.0168
Onchocerca volvulus		0.01	0.0633	0.2691
Echinococcus multilocularis	serine threonine protein kinase	0.0183	0.1281	0.1281
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0041	0.0168	0.0168
Echinococcus granulosus	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.0103	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Entamoeba histolytica	hypothetical protein	0.0024	0.0037	0.0093
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0177	0.0177
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0057	0.0293	0.0293
Echinococcus multilocularis	N chimaerin	0.004	0.0162	0.0162
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0093	0.0231
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.0103	0.0103
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0093	0.0231
Echinococcus multilocularis	allatostatin A receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0293	0.0293
Echinococcus granulosus	protein kinase C gamma type	0.0183	0.1281	0.1281
Plasmodium falciparum	exported lipase 1	0.0031	0.0093	0.0231
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0367	0.0911
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0103	0.0103
Plasmodium falciparum	BEM46-like protein, putative	0.0031	0.0093	0.0231
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0093	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0156	0.1071	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Brugia malayi	Melatonin receptor type 1A	0.0033	0.0103	0.0103
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.01	0.0633	0.0633
Brugia malayi	A-kinase anchor protein 10, precursor	0.0041	0.0168	0.0168
Mycobacterium ulcerans	amidase	0.0156	0.1071	0.266
Entamoeba histolytica	protein kinase, putative	0.0057	0.0293	0.0728
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1296	1	1
Schistosoma mansoni	fatty-acid amide hydrolase	0.1296	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0033	0.0103	0.0103
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0024	0.0037	0.1272
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0033	0.0103	0.0103
Entamoeba histolytica	hypothetical protein	0.0041	0.0168	0.0416
Schistosoma mansoni	serine/threonine kinase	0.0057	0.0293	0.0293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	dro:myosuppressin receptor	0.0033	0.0103	0.0103
Brugia malayi	sulfakinin receptor protein	0.0033	0.0103	0.0103
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0093	0.0231
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0033	0.0103	0.0103
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0033	0.0103	0.0103
Leishmania major	cathepsin L-like protease	0.0066	0.0367	0.0911
Trichomonas vaginalis	conserved hypothetical protein	0.0534	0.4027	1
Echinococcus multilocularis	myotubularin protein 13	0.004	0.0162	0.0162
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0042	0.0172	0.0172
Brugia malayi	MGC79044 protein	0.0031	0.0093	0.0093
Schistosoma mansoni	opsin-like receptor	0.0033	0.0103	0.0103
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0033	0.0103	0.0103
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	ShTK domain-containing protein	0.01	0.0633	0.0633
Schistosoma mansoni	hypothetical protein	0.004	0.0162	0.0162
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0024	0.0037	0.0093
Brugia malayi	RhoGAP domain containing protein	0.004	0.0162	0.0162
Schistosoma mansoni	tyrosinase precursor	0.01	0.0633	0.0633
Echinococcus granulosus	serine:threonine protein kinase N2	0.0072	0.0413	0.0413
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0033	0.0103	0.0103
Brugia malayi	Common central domain of tyrosinase family protein	0.01	0.0633	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Brugia malayi	Hr1 repeat family protein	0.0057	0.0293	0.0293
Schistosoma mansoni	atypical protein kinase C	0.0097	0.0609	0.0609
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0045	0.0203	0.0203
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0031	0.0093	0.3173
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0033	0.0103	0.0103
Echinococcus granulosus	L aminoadipate semialdehyde	0.0087	0.0525	0.0525
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.0103	0.0103
Echinococcus granulosus	myotubularin protein 13	0.004	0.0162	0.0162
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.0255	0.0634
Echinococcus multilocularis	neuropeptide receptor A26	0.0033	0.0103	0.0103
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0042	0.0177	0.0177
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0031	0.0093	0.0231
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0041	0.0168	0.0168
Toxoplasma gondii	hypothetical protein	0.0031	0.0093	0.3173
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Echinococcus multilocularis	serotonin receptor	0.0033	0.0103	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0367	0.0911
Echinococcus granulosus	regulator of G protein signaling 7	0.0041	0.0168	0.0168
Plasmodium falciparum	lysophospholipase, putative	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0794	0.0794
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.0322	0.0799
Echinococcus granulosus	protein kinase c eta type	0.004	0.0162	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Trypanosoma cruzi	serine peptidase, putative	0.0031	0.0093	0.0231
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0103	0.0103
Schistosoma mansoni	opsin-like receptor	0.0033	0.0103	0.0103
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0534	0.4027	1
Brugia malayi	Ras association domain family 1 isoform A	0.004	0.0162	0.0162
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.0103	0.0103
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.1296	1	1
Entamoeba histolytica	hypothetical protein	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0284	0.2072	0.2072
Echinococcus multilocularis	unc 13 (munc13)	0.0045	0.0203	0.0203
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0031	0.0093	0.0231
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0057	0.0293	0.0293
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0057	0.0293	0.0293
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0041	0.0168	0.0168
Loa Loa (eye worm)	melatonin receptor type 1A	0.0033	0.0103	0.0103
Echinococcus granulosus	axis inhibition protein axin	0.0041	0.0168	0.0168
Schistosoma mansoni	fatty-acid amide hydrolase	0.0156	0.1071	0.1071
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0534	0.4027	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0093	0.0093
Loa Loa (eye worm)	TYRA-2 protein	0.0033	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0367	0.0911
Echinococcus granulosus	neuropeptide s receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	PXA domain-containing protein	0.0041	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.0174	0.1206	0.1206
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0156	0.1071	0.2592
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0103	0.0103
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0156	0.1071	0.266
Loa Loa (eye worm)	hypothetical protein	0.0161	0.111	0.111
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0087	0.0525	0.0525
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Plasmodium falciparum	lysophospholipase, putative	0.0534	0.4027	1
Brugia malayi	G-protein coupled receptor	0.0033	0.0103	0.0103
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0037	0.0093
Echinococcus multilocularis	axis inhibition protein axin	0.0041	0.0168	0.0168
Schistosoma mansoni	axis inhibition protein axin	0.0041	0.0168	0.0168
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0033	0.0103	0.0103
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0024	0.0037	0.0348
Trypanosoma cruzi	serine peptidase, putative	0.0031	0.0093	0.0231
Schistosoma mansoni	hypothetical protein	0.0033	0.0103	0.0103
Toxoplasma gondii	diacylglycerol kinase, putative	0.004	0.0162	0.5539
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0042	0.0172	0.0172
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0031	0.0093	0.0093
Brugia malayi	larval opioid receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.01	0.0633	0.0633
Loa Loa (eye worm)	hypothetical protein	0.004	0.0162	0.0162
Echinococcus granulosus	Regulator of G protein signaling 20	0.0041	0.0168	0.0168
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0293	0.0728
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0103	0.0103
Brugia malayi	Dopamine receptor	0.0033	0.0103	0.0103
Brugia malayi	Serotonin receptor	0.0033	0.0103	0.0103
Leishmania major	hypothetical protein, conserved	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0042	0.0177	0.0177
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0534	0.4027	1
Echinococcus granulosus	serotonin receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	diacylglycerol kinase theta	0.004	0.0162	0.0162
Entamoeba histolytica	hypothetical protein	0.0041	0.0168	0.0416
Brugia malayi	RhoGEF domain containing protein	0.004	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0033	0.0103	0.0103
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0093	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0093	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0168	0.0168
Schistosoma mansoni	hypothetical protein	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Schistosoma mansoni	rac gtpase activating protein	0.004	0.0162	0.0162
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0168	0.0168
Brugia malayi	Amidase family protein	0.0156	0.1071	0.1071
Onchocerca volvulus		0.004	0.0162	0.0303
Plasmodium falciparum	esterase, putative	0.0534	0.4027	1
Trypanosoma cruzi	amidase, putative	0.0156	0.1071	0.266
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0033	0.0103	0.0103
Entamoeba histolytica	protein kinase, putative	0.0057	0.0293	0.0728
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0042	0.0177	0.0177
Brugia malayi	Dopamine receptor protein 2	0.0033	0.0103	0.0103
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.0103	0.0103
Echinococcus multilocularis	regulator of G protein signaling 7	0.0041	0.0168	0.0168
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0168	0.0168
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0293	0.0293
Echinococcus granulosus	protein kinase c iota type	0.0097	0.0609	0.0609
Echinococcus multilocularis	regulator of G protein signaling	0.0041	0.0168	0.0168
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.0103	0.0103
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0156	0.1071	0.266
Echinococcus multilocularis	RNA directed DNA polymerase	0.0121	0.0794	0.0794
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0127	0.0844	0.0844
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0031	0.0093	0.0231
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.0103	0.0103
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1296	1	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0103	0.0103
Toxoplasma gondii	hypothetical protein	0.0031	0.0093	0.3173
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0103
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0156	0.1071	0.2592
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0168	0.0168
Brugia malayi	AKH receptor	0.0033	0.0103	0.0103
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.004	0.0162	0.0162
Onchocerca volvulus		0.0087	0.0525	0.2142
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0121	0.0794	0.0794

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.5 uM	Antiproliferative activity against HUVEC	ChEMBL.	17981046
IC50 (functional)	= 0.8 uM	Antiproliferative activity against rat aortic smooth muscle cells	ChEMBL.	17981046
IC50 (functional)	= 1.6 uM	Antiproliferative activity against mouse NIH3T3 cells	ChEMBL.	17981046

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 533146

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 516079