Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | hypothetical protein | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0068 | 0.5568 | 0.5568 |
Plasmodium falciparum | hexose transporter | 0.0104 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Wolbachia endosymbiont of Brugia malayi | orotate phosphoribosyltransferase | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 0.8505 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0068 | 0.5568 | 0.5568 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0092 | 0.8505 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0092 | 0.8505 | 0.8505 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 0.8505 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0068 | 0.5568 | 0.5568 |
Schistosoma mansoni | glucose transport protein | 0.0104 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Brugia malayi | translation initiation factor 4E | 0.0068 | 0.5568 | 0.5568 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0068 | 0.5568 | 0.5568 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.1308 | 0.1308 |
Leishmania major | glucose transporter, lmgt3 | 0.0032 | 0.1308 | 0.1538 |
Leishmania major | glucose transporter, lmgt1 | 0.0032 | 0.1308 | 0.1538 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0068 | 0.5568 | 0.5568 |
Schistosoma mansoni | glucose transport protein | 0.0104 | 1 | 1 |
Echinococcus granulosus | General substrate transporter | 0.009 | 0.8228 | 0.8228 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 0.8505 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0104 | 1 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0104 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0068 | 0.5568 | 0.6547 |
Wolbachia endosymbiont of Brugia malayi | amidophosphoribosyltransferase | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0068 | 0.5568 | 0.6547 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0092 | 0.8505 | 1 |
Plasmodium vivax | hexose transporter | 0.0104 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Trypanosoma brucei | glucose transporter 1E | 0.0032 | 0.1308 | 0.1538 |
Trichomonas vaginalis | sugar transporter, putative | 0.0032 | 0.1308 | 0.1308 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Echinococcus multilocularis | General substrate transporter | 0.009 | 0.8228 | 0.8228 |
Loa Loa (eye worm) | sugar transporter | 0.0104 | 1 | 1 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 0.8505 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 0.8505 |
Schistosoma mansoni | glucose transport protein | 0.0104 | 1 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0092 | 0.8505 | 1 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 0.8505 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0068 | 0.5568 | 0.5568 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0068 | 0.5568 | 0.5568 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0068 | 0.5568 | 0.6547 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0068 | 0.5568 | 0.5 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 0.8505 |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0092 | 0.8505 | 0.8505 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Treponema pallidum | phosphoribosylpyrophosphate synthetase | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0068 | 0.5568 | 0.5568 |
Trichomonas vaginalis | sugar transporter, putative | 0.0032 | 0.1308 | 0.1308 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0068 | 0.5568 | 0.6547 |
Trichomonas vaginalis | glucose transporter, putative | 0.0032 | 0.1308 | 0.1308 |
Leishmania major | glucose transporter, lmgt2 | 0.0032 | 0.1308 | 0.1538 |
Trichomonas vaginalis | glucose transporter, putative | 0.0032 | 0.1308 | 0.1308 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.007 | 0.5905 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Trypanosoma brucei | glucose transporter 2A | 0.0032 | 0.1308 | 0.1538 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.1308 | 0.1308 |
Onchocerca volvulus | 0.0092 | 0.8505 | 1 | |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.007 | 0.5905 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0068 | 0.5568 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0068 | 0.5568 | 0.6547 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0092 | 0.8505 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0092 | 0.8505 | 1 |
Treponema pallidum | adenine phosphoribosyltransferase | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | sugar transporter, putative | 0.0032 | 0.1308 | 0.1308 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 1 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0068 | 0.5568 | 0.5568 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0092 | 0.8505 | 1 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0092 | 0.8505 | 0.8505 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0068 | 0.5568 | 0.6547 |
Leishmania major | xanthine phosphoribosyltransferase | 0.0092 | 0.8505 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0092 | 0.8505 | 1 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0092 | 0.8505 | 0.8505 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1308 | 0.1538 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0032 | 0.1308 | 0.1538 |
Trypanosoma cruzi | hexose transporter | 0.0032 | 0.1308 | 0.1538 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 87.31 % | Antimarial activity against multidrug resistant Plasmodium yoelii in Swiss mouse assessed as suppression of parasitaemia at 96 mg/kg, im after 4 days | ChEMBL. | 18054238 |
Activity (functional) | = 87.31 % | Antimarial activity against multidrug resistant Plasmodium yoelii in Swiss mouse assessed as suppression of parasitaemia at 96 mg/kg, im after 4 days | ChEMBL. | 18054238 |
Activity (functional) | = 92.38 % | Antimarial activity against multidrug resistant Plasmodium yoelii in Swiss mouse assessed as suppression of parasitaemia at 96 mg/kg, po after 4 days | ChEMBL. | 18054238 |
Activity (functional) | = 92.38 % | Antimarial activity against multidrug resistant Plasmodium yoelii in Swiss mouse assessed as suppression of parasitaemia at 96 mg/kg, po after 4 days | ChEMBL. | 18054238 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.